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OfflineLawnPhenom
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muscimol additction
    #13479095 - 11/13/10 03:55 PM (13 years, 7 months ago)

Hey, been creeping one the site for awhile. Just started posting and hunting.  Found my first active the other day big jim.  But before that if found amanita muscaria var g.  Now the question, since benzos and alcohol are GABA antagonist both physically additive.. And from what i understand so isn't muscimol. So does muscimol also have that potential?


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InvisibleaNeway2sayHooray
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Re: muscimol additction [Re: LawnPhenom]
    #13479117 - 11/13/10 04:00 PM (13 years, 7 months ago)

Interesting thought....

With that logic kava kava  would be addictive. I know lots of polynesians partake of awa habitually but Ive never heard anything about withdrawl.

hmm

Does long term use of GHB cause dependence? anyone care to chime in?


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Mad_Larkin said:  Death is just a thang.
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MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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OfflineLawnPhenom
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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479132 - 11/13/10 04:03 PM (13 years, 7 months ago)

I've read on the net that kava is addictive.


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InvisibleaNeway2sayHooray
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Re: muscimol additction [Re: LawnPhenom]
    #13479147 - 11/13/10 04:07 PM (13 years, 7 months ago)

Really? I dont recall ever hearing that. There are liver toxicity issues but those have been dis proven by an ethnobotanist that I hold in high standing. EDIT: at least not physically addictive.

Got a source?


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Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

Edited by aNeway2sayHooray (11/13/10 04:09 PM)

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Offlinemorrowasted
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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479153 - 11/13/10 04:09 PM (13 years, 7 months ago)

im addicted to muscimol

i just eat em all the time. cant help myself with those things











































jk. somehow I have a hard time believing someone could have that happen to them. that drug sucks

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OfflineLawnPhenom
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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479156 - 11/13/10 04:09 PM (13 years, 7 months ago)

cant remember of find where i heard it but i did find link to ghb addiction withdrawl

http://www.doctordeluca.com/Library/DetoxEngage/GHB_Detox.htm[/url]


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OfflineLawnPhenom
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Re: muscimol additction [Re: morrowasted]
    #13479159 - 11/13/10 04:11 PM (13 years, 7 months ago)

maybe someone using low doses for sleep aid.  I've also read people using low doses for ptsd


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InvisibleaNeway2sayHooray
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Re: muscimol additction [Re: morrowasted]
    #13479162 - 11/13/10 04:11 PM (13 years, 7 months ago)

I know someone addicted to DXM...

Well he takes DXM way to often but he isnt anywhere near as bad as the guy from intervention...He doesnt suck dick for DXM or anything but the negative consequences are getting pretty severe..He has some liver issues, he just found out recently.


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Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479175 - 11/13/10 04:14 PM (13 years, 7 months ago)

i would believe dxm or ghb addiction way before muscimol addiction. i have done all three.

i guess anything is possible, man

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Offlinepropensity
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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479178 - 11/13/10 04:15 PM (13 years, 7 months ago)

Quote:

aNeway2sayHooray said:
I know someone addicted to DXM...

Well he takes DXM way to often but he isnt anywhere near as bad as the guy from intervention...He doesnt suck dick for DXM or anything but the negative consequences are getting pretty severe..He has some liver issues, he just found out recently.




That was the most pathetic shit I've ever seen.

Besides the duster episode of intervention.


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Re: muscimol additction [Re: propensity]
    #13479196 - 11/13/10 04:18 PM (13 years, 7 months ago)

Quote:

propensity said:
Quote:

aNeway2sayHooray said:
I know someone addicted to DXM...

Well he takes DXM way to often but he isnt anywhere near as bad as the guy from intervention...He doesnt suck dick for DXM or anything but the negative consequences are getting pretty severe..He has some liver issues, he just found out recently.




That was the most pathetic shit I've ever seen.

Besides the duster episode of intervention.





That guy came on the shroomery, I forget his name let me find it. He had a facebook and myspace and everything.


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479200 - 11/13/10 04:19 PM (13 years, 7 months ago)



--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: morrowasted]
    #13479218 - 11/13/10 04:24 PM (13 years, 7 months ago)

We had DXM ben on here and we permabanned him. :nonono:

Shame on you pris. You should have made it temporary.


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Re: muscimol additction [Re: morrowasted]
    #13479222 - 11/13/10 04:24 PM (13 years, 7 months ago)

Sorry to derail the thread.

Back on topic... I can see DXM addicition because of the NMDA antagonist effects.

I see your point about it being difficult to become addicted to muscimol/muscarine because the effects sometimes arent pleasant.... but can it produce physical dependence is the question at hand.


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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OfflineLawnPhenom
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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479240 - 11/13/10 04:29 PM (13 years, 7 months ago)

thats what im saying i know most don't like but some do. Does it have the potential to be addictive? Any body know?


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Offlinepropensity
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Re: muscimol additction [Re: LawnPhenom]
    #13479244 - 11/13/10 04:30 PM (13 years, 7 months ago)

Why do you want to know?


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Re: muscimol additction [Re: propensity]
    #13479250 - 11/13/10 04:31 PM (13 years, 7 months ago)

just curious. I do like it as a sleep aid, sleep like a baby at a few grams.


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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479251 - 11/13/10 04:31 PM (13 years, 7 months ago)

I just read an interesting little bit of info about the sigma-1 receptor,after clicking through a dxm page on wikipedia.

"The only known endogenous ligand of the sigma-1 receptor is the potent hallucinogen dimethyltryptamine (DMT), though endogenous neuroactive steroids such as dehydroepiandrosterone (DHEA) and pregnenolone can also activate the receptor"


my mind is awash in theories after listening to "True Hallucinations" on Tape the other day for the first time in like 6 years.


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: LawnPhenom]
    #13479258 - 11/13/10 04:33 PM (13 years, 7 months ago)

Quote:

LawnPhenom said:
just curious. I do like it as a sleep aid, sleep like a baby at a few grams.





Really? I have issues sleeping sometimes.

I have some that I harvested a while back. What's your method of preparation?


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479273 - 11/13/10 04:37 PM (13 years, 7 months ago)

Dehydrate, grind up lot, mix with applesauce imbibe. found tea gives me liquid shits


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OfflineRonaldFuckingPaul
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Re: muscimol additction [Re: LawnPhenom]
    #13479278 - 11/13/10 04:39 PM (13 years, 7 months ago)

hey can any of you guys give me a link to the DXM intervention episode?


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OfflineLawnPhenom
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Re: muscimol additction [Re: RonaldFuckingPaul]
    #13479296 - 11/13/10 04:42 PM (13 years, 7 months ago)

/url]

what the?


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Edited by LawnPhenom (11/13/10 04:44 PM)

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Re: muscimol additction [Re: LawnPhenom]
    #13479311 - 11/13/10 04:46 PM (13 years, 7 months ago)

Quote:

LawnPhenom said:
Dehydrate, grind up lot, mix with applesauce imbibe. found tea gives me liquid shits





Mine are already dehydrated. So you dont do any fancy preaparation or drying? I know some people dry in an oven to help decarboxylation from ibotenic acid to muscimol.

I dried mine in a dehydrator with the heating element removed.But they are a few years old now. It is amanita season here though...


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Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: LawnPhenom]
    #13479316 - 11/13/10 04:47 PM (13 years, 7 months ago)

Muscimol is actually a GABA agonist, not antagonist, hence the CNS depressive effects (a GABA antagonist would produce stimulation). In moderate, spaced doses I doubt it's addictive in the same sense as sedatives. Physiologically, you'll have receptor density changes but psychologically you won't be suffering withdrawal. Muscimol and others are used in some animal experiments and there are never psychopharmacology reports on behavior effects from "addiction".

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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479321 - 11/13/10 04:50 PM (13 years, 7 months ago)

that right i partially dehydrated on high 140f then baked door open at 200 till cracker dry. like 15-20 min


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Edited by LawnPhenom (11/13/10 04:54 PM)

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Re: muscimol additction [Re: Arden]
    #13479333 - 11/13/10 04:53 PM (13 years, 7 months ago)

thanks for the correction and info


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InvisibleaNeway2sayHooray
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Re: muscimol additction [Re: Arden]
    #13479338 - 11/13/10 04:54 PM (13 years, 7 months ago)

Quote:

Arden said:
Muscimol is actually a GABA agonist, not antagonist, hence the CNS depressive effects (a GABA antagonist would produce stimulation). In moderate, spaced doses I doubt it's addictive in the same sense as sedatives. Physiologically, you'll have receptor density changes but psychologically you won't be suffering withdrawal. Muscimol and others are used in some animal experiments and there are never psychopharmacology reports on behavior effects from "addiction".





Thanks for chiming in and clearing that up... I am glad OP asked this question though, its got me reading on pharmacology and chemistry again.


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: Arden]
    #13479367 - 11/13/10 05:03 PM (13 years, 7 months ago)

One of the physical symptoms of GABA agonist withdrawal is convulsions though.

Maybe muscimol just doesn't mimic the function of GABA well enough for your body to decrease its normal GABA levels.


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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479491 - 11/13/10 05:48 PM (13 years, 7 months ago)

Quote:

aNeway2sayHooray said:
Sorry to derail the thread.

I can see DXM addicition because of the NMDA antagonist effects.

.




after more reading this statement means something completely different to me.. Wouldnt DXM help opiate addiction since it is an NMDA antagonist? I know Ive heard of taking DXM when trying to kick opiate dependence...hmm  I am so confused.


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479530 - 11/13/10 05:57 PM (13 years, 7 months ago)

i know dxm and opiates get you higher than just opiates


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Re: muscimol additction [Re: LawnPhenom]
    #13479538 - 11/13/10 06:00 PM (13 years, 7 months ago)

And ibogaine lowers opiate tolerence

as well as being anti-addictive of course.


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479550 - 11/13/10 06:04 PM (13 years, 7 months ago)

Theres a mixture called Morphidex (morphine with DXM) that increases the pain killing effects of the morphine.

Personally I wouldn't want the ratio to be 1:1 for recreational purposes. I would take 50-60mg of DXM with whatever dose of the opiate.


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Re: muscimol additction [Re: Moo456]
    #13479581 - 11/13/10 06:13 PM (13 years, 7 months ago)

Ah that reminds me I also read of Ibogaine increasing the analgesia of morphine...

hmm


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: Moo456]
    #13479585 - 11/13/10 06:14 PM (13 years, 7 months ago)

i dont take opiates anymore never got addicted physically but watched many people. the shit steals your money and eats your soul you become a slave to the shit. but have done dxm and opiates to 6o mg perks and about 80 dxm i was overwhelmed like the first time i ever did a 30mg perk


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Re: muscimol additction [Re: LawnPhenom]
    #13479608 - 11/13/10 06:19 PM (13 years, 7 months ago)

I trying to kick a serious heroin habit.... I am on suboxone and its been working but I would really like to try ibogaine and get off the suboxone as well.Ive had some interest in it for a few years but now that I am in the throws of physical addiction it might be time to experiment...


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: aNeway2sayHooray]
    #13479852 - 11/13/10 07:16 PM (13 years, 7 months ago)

ever think of just toughing out the withdrawl old school a few days of hell you may feel like and want to die but you wont, just get it over with.  heroin is a life long struggle unless you find out why you went for the drug you'll never beat it


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Re: muscimol additction [Re: LawnPhenom]
    #13479992 - 11/13/10 07:51 PM (13 years, 7 months ago)

I would love to just stick out the WD and be free of it and actually see why I should be off it but I am afraid I wont be able to take it and I would just go score some dope.

Ive never been through complete withdrawl,I get a day or 2 into it and cant take not being able to sleep compounded on top of immense physical pain,no appetite puking,shitting ect. ect...

wouldnt an intense ibogaine experience kinda take place of needing to experience the pain of WD to bee 100% free of it?

i


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: aNeway2sayHooray]
    #13480001 - 11/13/10 07:53 PM (13 years, 7 months ago)

I need to go to that Buddhist temple in thailand... "The worlds toughest rehab"  :lol:


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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Re: muscimol additction [Re: aNeway2sayHooray]
    #13480015 - 11/13/10 07:55 PM (13 years, 7 months ago)

Just in the last few weeks since Ive been taking my suboxone regularly and not doing dope,Ive noticed my emotions on the shroomery have went from "apathetic" "depressed" to "happy" and "content"

suboxone or not,I feel one more step closer to being done with this shit and start living again.


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

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