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GreenMachine
The Magician



Registered: 03/26/09
Posts: 1,298
Loc: A peninsula
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Re: LSD and Cocaine... [Re: 7yler]
#13390182 - 10/26/10 12:47 PM (13 years, 3 months ago) |
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-------------------- Look behind you, do you see it?
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eyes in the sky

Registered: 03/18/10
Posts: 33
Loc: England
Last seen: 12 years, 2 months
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Quote:
GreenMachine said: Acid+Cocaine
=
What. The. Hell? I don't even know what to think of this...
-------------------- Control Is An Illusion, Order A Comforting Lie, From Chaos, Through Chaos, Into Chaos We Fly
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blazenn
rawdog the whale.


Registered: 05/13/09
Posts: 4,584
Loc:
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Quote:
eyes in the sky said:
Quote:
GreenMachine said: Acid+Cocaine
=
What. The. Hell? I don't even know what to think of this...
it isn't to inspire thoughts, it's just fucking hilarious
i fucking lolllllllllllllllllld
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AZrooj
AZ/WA



Registered: 09/02/05
Posts: 788
Loc: USA Washington
Last seen: 8 years, 5 months
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Re: LSD and Cocaine... [Re: blazenn]
#13390534 - 10/26/10 02:02 PM (13 years, 3 months ago) |
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Yeah i would have to say this is a horrible combo myself. But then again i think coke is horrible by itself also.
-------------------- Power booster, I'm talking to god and more.
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Bassfreak
ManBearPig



Registered: 08/24/10
Posts: 18,014
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Re: LSD and Cocaine... [Re: AZrooj]
#13390954 - 10/26/10 03:45 PM (13 years, 3 months ago) |
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Quote:
AZrooj said: Yeah i would have to say this is a horrible combo myself. But then again i think coke is horrible by itself also. 
yeah but u havent done it...so u really dont know
lol everyone in this thread saying its a bad combo are by people who have never mixed the 2...shut the fuck up if u havent ever done it cuz u dont know...your input is irrelevant
but that randy savage video was hilarious...WTF? like hes def on sumthing, way out there
-------------------- Tom Brady is a God Free Tom Brady
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AZrooj
AZ/WA



Registered: 09/02/05
Posts: 788
Loc: USA Washington
Last seen: 8 years, 5 months
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Re: LSD and Cocaine... [Re: Bassfreak]
#13391737 - 10/26/10 06:50 PM (13 years, 3 months ago) |
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Your right I haven't done the two at the same time because coke sucks ass by itself, so why mix it LSD?
-------------------- Power booster, I'm talking to god and more.
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Austrip
P. Sub


Registered: 08/05/10
Posts: 1,247
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Re: LSD and Cocaine... [Re: Bassfreak]
#13392120 - 10/26/10 08:00 PM (13 years, 3 months ago) |
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Quote:
Bassfreak said:
lol everyone in this thread saying its a bad combo are by people who have never mixed the 2...shut the fuck up if u havent ever done it cuz u dont know...your input is irrelevant
Who are you to say who's input is relevant? its a public forum.
Back on topic... I actually don't agree with this combo because these 2 substances specifically don't seem to mix together well on a chemical level. Granted I have never tried it personally, and I have good reason not to with this information.
Am I the only one noticing this...
Quote:
The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter protein....
...Cocaine binds tightly at the dopamine transporter forming a complex that blocks the transporter's function. The dopamine transporter can no longer perform its reuptake function, and thus dopamine accumulates in the synaptic cleft. This results in an enhanced and prolonged postsynaptic effect of dopaminergic signaling at dopamine receptors on the receiving neuron.
Now if you read this instead of bypassing straight past the facts, it says that cocaine forms a block at the dopamine transporters, that blocks function.
LSD on the other hand, is known and thought to effect several of the 5-HT receptors, and in some causes a flooding of serotonin, while it blocks others.
When I read this...
Quote:
MCSteveyC said: There was 40.... i started off by taking 16 thats when my brain melted, but when i took some coke it straightened my head so i took another 12 and at the end another 12... i was trppin till sunday
I can only seem to keep coming back to these facts.
I don't know what the OP's usual dose of cid is, but 16 hits of good blot would be enough to melt any of my friends into a puddle of psychedelic goo. Let alone all 40.
I would almost be willing to say that the coke brought you back down, which certainly seems to be what happened. due to how it effects brain chemistry (as stated above) I think the coke actually blocked the release of serotonin when you actually wanted to release more (I would on 16 hits that's for sure)
With all that said, it's the OP's droogs, do what you want with them! Just all these people bitching should learn to relax. Theres 2 sides to any argument, just because someone doesn't agree doesn't make their post any less relevant then any of yours.
Peace.
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BothHands
Dog Coffee



Registered: 10/28/09
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Re: LSD and Cocaine... [Re: Austrip] 1
#13392188 - 10/26/10 08:14 PM (13 years, 3 months ago) |
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Wow, you couldn't be more wrong.
Yes, cocaine blocks the dopamine, norepinephrine, and serotonin transporter proteins, but it doesn't have any binding affinity to the 5-HT2A receptor. This is the primary receptor involved in the action of psychedelics. Cocaine should have no affect on psychedelics if used after the dose.
Now if you use cocaine on a daily basis, that's a completely different situation. Cocaine increases the level of serotonin in the synapses. Serotonin CAN bind to the 5-HT2A receptors. By increasing your level of serotonin for an extended period of time, you can cause the 5-HT2A receptors (as well as all the other serotonin receptors) to develop a tolerance.
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drr


Registered: 05/20/09
Posts: 8,444
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Quote:
GreenMachine said: Acid+Cocaine
=
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Austrip
P. Sub


Registered: 08/05/10
Posts: 1,247
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Re: LSD and Cocaine... [Re: BothHands]
#13392267 - 10/26/10 08:30 PM (13 years, 3 months ago) |
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Quote:
BothHands said: Wow, you couldn't be more wrong.
Yes, cocaine blocks the dopamine, norepinephrine, and serotonin transporter proteins, but it doesn't have any binding affinity to the 5-HT2A receptor. This is the primary receptor involved in the action of psychedelics. Cocaine should have no affect on psychedelics if used after the dose.
Now if you use cocaine on a daily basis, that's a completely different situation. Cocaine increases the level of serotonin in the synapses. Serotonin CAN bind to the 5-HT2A receptors. By increasing your level of serotonin for an extended period of time, you can cause the 5-HT2A receptors (as well as all the other serotonin receptors) to develop a tolerance.
Couldnt be more wrong? wow thats a bit rude, pretty sure I could if I tried 
Wasn't trying to be 100% correct, I was just trying to stimulate some more productive discussion on the matter. And adding my 2 cents
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Austrip
P. Sub


Registered: 08/05/10
Posts: 1,247
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Re: LSD and Cocaine... [Re: BothHands]
#13392323 - 10/26/10 08:43 PM (13 years, 3 months ago) |
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Quote:
BothHands said: but it doesn't have any binding affinity to the 5-HT2A receptor. This is the primary receptor involved in the action of psychedelics.
What about the 5-HT1A, 5-HT2C, 5-HT5A, and 5-HT6 receptors?
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BothHands
Dog Coffee



Registered: 10/28/09
Posts: 13,177
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Re: LSD and Cocaine... [Re: Austrip]
#13392347 - 10/26/10 08:49 PM (13 years, 3 months ago) |
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I'm quite positive the answer is no. But even if it does, LSD has a much higher binding affinity. It'll just knock the cocaine right off the receptors. It makes no difference.
The only way for cocaine to interfere with LSD is if you use it all day ever day for weeks before your dose. It has SRI activity, and because of this it can increase your tolerance in the same way that a daily regimen of SSRI antidepressants can. But only if it's used all day every day. (cocaine has a short half life, while antidepressants have a half life well over 24 hours)
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Austrip
P. Sub


Registered: 08/05/10
Posts: 1,247
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Re: LSD and Cocaine... [Re: BothHands]
#13392388 - 10/26/10 08:58 PM (13 years, 3 months ago) |
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Quote:
BothHands said: I'm quite positive the answer is no. But even if it does, LSD has a much higher binding affinity. It'll just knock the cocaine right off the receptors. It makes no difference.
The only way for cocaine to interfere with LSD is if you use it all day ever day for weeks before your dose. It has SRI activity, and because of this it can increase your tolerance in the same way that a daily regimen of SSRI antidepressants can.
Nice summary 
This still has me questioning whether or not there aren't many more interactions going on with this combo that we are still yet to discover...
Quote:
In addition to the mechanism shown on the above chart, cocaine has been demonstrated to bind as to directly stabilize the DAT transporter on the open outward-facing conformation whereas other stimulants (namely phenethylamines) stabilize the closed conformation. Further, cocaine binds in such a way as to inhibit a hydrogen bond innate to DAT that otherwise still forms when amphetamine and similar molecules are bound. Cocaine's binding properties are such that it attaches so this hydrogen bond will not form and is blocked from formation due to the tightly locked orientation of the cocaine molecule. Research studies have suggested that the affinity for the transporter is not what is involved in habituation of the substance so much as the conformation and binding properties to where & how on the transporter the molecule binds
and here...
Quote:
It also functions on the binding sites to the dopamine & serotonin sodium dependent transport area as targets as separate mechanisms from its reuptake of those transporters
anything you can add on that?
Cheers.
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BothHands
Dog Coffee



Registered: 10/28/09
Posts: 13,177
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Re: LSD and Cocaine... [Re: Austrip]
#13392419 - 10/26/10 09:04 PM (13 years, 3 months ago) |
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I really don't get what you're asking.
The red says it inhibits the DOPAMINE transport protein. Then the bolded section just explains the mechanism. What does that have to do with the SEROTONIN 2A receptor?
As for this:
Quote:
It also functions on the binding sites to the dopamine & serotonin sodium dependent transport area as targets as separate mechanisms from its reuptake of those transporters
It binds to the serotonin transport protein. That's a protein that takes serotonin out of the synapse. But the serotonin transport protein is completely different and separate to a serotonin RECEPTOR. Binding to a transport protein has no effect on the receptors. It just increases serotonin in the synapse. But LSD binds with a higher affinity than serotonin, so the serotonin wouldn't get in the way.
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Austrip
P. Sub


Registered: 08/05/10
Posts: 1,247
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Re: LSD and Cocaine... [Re: BothHands]
#13392459 - 10/26/10 09:13 PM (13 years, 3 months ago) |
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I guess in the red I was pointing out that Cocaine has traits in how it affects the DAT, which otherwise are not so when bound with amphetamines or similar.
Could just be how I'm reading it.
Quote:
Binding to a transport protein has no effect on the receptors. It just increases serotonin in the synapse. But LSD binds with a higher affinity than serotonin, so the serotonin wouldn't get in the way.
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BothHands
Dog Coffee



Registered: 10/28/09
Posts: 13,177
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Re: LSD and Cocaine... [Re: Austrip]
#13392547 - 10/26/10 09:31 PM (13 years, 3 months ago) |
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Quote:
Austrip said: I guess in the red I was pointing out that Cocaine has traits in how it affects the DAT, which otherwise are not so when bound with amphetamines or similar.
The DAT is the dopamine transport protein, and has absolutely no bearing on how well psychedelics work. In fact, at recreational doses, LSD has no noticeable interaction with ANY part of the dopamine system at all.
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PsilocybinMike
T.F.Y.Q.A


Registered: 02/18/08
Posts: 2,602
Last seen: 7 years, 10 months
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Quote:
AlmostAsCoolAs said: Waste of coke man, save it for after or another time.
Seriously. I am not a huge fan of coke and have only done it a dozen or so times give or take and I once tried this combo and swore I never would again. I did the coke first and felt fucking awesome then I decided to eat 1 hit of some pretty strong alex grey doses and within 2 hours or so of eating that I felt awful. I had that "I can't fucking wait for this trip to end" feeling but at the same time I still felt like doing more coke, cause that's what coke does.
Anyway as I continue to do more coke, no matter how much I do, I can still not shake that feeling. I eventually gave up, and ate some xanax to try and come down from the coke and kill the trip. I ended up just sitting there feeling so physically uncomfortable and restless until I was able to sleep. More xanax was needed.
summary:
cocaine + LSD = 
Do them separately. IMO cocaine is best left to be done alone except with alcohol. I don't even like to smoke weed when I do coke (and I smoke lots of weed on any drug), so take that with as many grains of salt as you wish.
Maybe that's why I don't do coke that much...
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baaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaammmm http://www.youtube.com/watch?v=pVZBTAYm3rw
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blazenn
rawdog the whale.


Registered: 05/13/09
Posts: 4,584
Loc:
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its obvious you particularly don't like coke, i wouldn't expect you to like it on lsd in fact i'd imagine quite the opposite would happen. and the same goes for everybody else here that still keeps fucking saying "the 2 DO NOT go to together, therefore it's a BAD combination for EVERYONE"
idc about which one blocks which fucking receptors, those factors do not go through my mind when i'm frying, and for the record it's very rare that i'm even around coke. haven't seen it in person in over a year, none of my friends ever do it. hell im prolly the only person in my current group of friends that used to do it.
im just sick of people saying so confidently that nobody can enjoy coke + lsd just because they themselves don't even like coke. NO SHIT SHERLOCK OF COURSE YOU WONT LIKE LSD AND COKE IF YOU DONT EVEN FUCKING LIKE COKE!!!!!!!!!!!11!!!!!!111111!!!1FUCKINGONE
not everybody likes dxm, not everybody likes weed, not everbody likes getting drunk for god sakes.
how can people be so fucking judge mental on this forum sometimes? i swear, some people on here act so peaceful and accepting of things they agree with then you bring up the topic of cocaine and everybody's like NOPE NOT GOOD DONT DO IT NOPE NO ONE CAN ENJOY IT CUZ IT'S BAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD
gtfo you fucking 1970s propoganda believing fools.
(this post is to everyone not just the person i quickreplied)
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PsilocybinMike
T.F.Y.Q.A


Registered: 02/18/08
Posts: 2,602
Last seen: 7 years, 10 months
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Re: LSD and Cocaine... [Re: blazenn]
#13395268 - 10/27/10 01:20 PM (13 years, 3 months ago) |
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Quote:
blazenn said: its obvious you particularly don't like coke, i wouldn't expect you to like it on lsd in fact i'd imagine quite the opposite would happen. and the same goes for everybody else here that still keeps fucking saying "the 2 DO NOT go to together, therefore it's a BAD combination for EVERYONE"
idc about which one blocks which fucking receptors, those factors do not go through my mind when i'm frying, and for the record it's very rare that i'm even around coke. haven't seen it in person in over a year, none of my friends ever do it. hell im prolly the only person in my current group of friends that used to do it.
im just sick of people saying so confidently that nobody can enjoy coke + lsd just because they themselves don't even like coke. NO SHIT SHERLOCK OF COURSE YOU WONT LIKE LSD AND COKE IF YOU DONT EVEN FUCKING LIKE COKE!!!!!!!!!!!11!!!!!!111111!!!1FUCKINGONE
not everybody likes dxm, not everybody likes weed, not everbody likes getting drunk for god sakes.
how can people be so fucking judge mental on this forum sometimes? i swear, some people on here act so peaceful and accepting of things they agree with then you bring up the topic of cocaine and everybody's like NOPE NOT GOOD DONT DO IT NOPE NO ONE CAN ENJOY IT CUZ IT'S BAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD
gtfo you fucking 1970s propoganda believing fools.
(this post is to everyone not just the person i quickreplied)
What about my response gave you the impression I don't like coke? Of course I like coke, or I wouldn't have done it 15-20 times or so over the course of 6-7 years. Every time I've done it it wasn't just a little bit, we'd stay up all night and do a lot. The reason I tend to avoid it is because it is possibly the worst drug (to my knowledge) to come off of and it just gives you that more more more feeling.
If anyone wants to come by and chop me up a couple fat rails of (relatively) pure cocaine then I'm all for it. I will even serve snacks and refreshments.
p.s
I really admire your style of writing. Do mommy and daddy know you're using their computer on an 18+ website?
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baaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaammmm http://www.youtube.com/watch?v=pVZBTAYm3rw
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blazenn
rawdog the whale.


Registered: 05/13/09
Posts: 4,584
Loc:
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umm probably that first line......."Seriously. I am not a huge fan of coke "
and this "I had that "I can't fucking wait for this trip to end" feeling but at the same time I still felt like doing more coke, cause that's what coke does.
Anyway as I continue to do more coke, no matter how much I do, I can still not shake that feeling. "
ive had that feeling all night of wanting more blow (who hasnt?) but it's never affected me negatively, well cept for a night that me and my cousin got a ball and we were going through it pretty fast and at one point i had a really strange feeling in my head and my heart and thought for a second i might be OD'ing (LOL) i didnt have a problem stopping snorting that night tho and i honestly have never had a problem stopping when i want to, after one more . but idk being a pothead first and foremost always helped me out with any negative parts of coke, whenever i was ready to pass out id roll a fat j and do just that.
i understand cokes not for everyone and i'm in no way recommending anyone to try it, the addiction side of it is FUCKED UP but that doesn't mean it can't be used responsibly. cause i have used it responsibly, never regularly, only occasionally through the past few years.
i just hate to hear people use their own experiences to say EVERYBODY else will react the same way they did, it's just absurd.
im done w/ the essays now, all the talking's makin me feel like a cokehead
Edited by blazenn (10/27/10 01:27 PM)
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