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Offlinex7x_x7x
x7x, my problem child.
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Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N
    #12366083 - 04/10/10 06:36 AM (14 years, 1 month ago)

http://www.psychointegrator.com/?p=3#comment-392


Does psilocybin promote neurogenesis?
June 26th, 2008 by fernando
New Psilocybin Neurogenesis Study Begins at the University of South Florida

Researchers Juan Sanchez-Ramos PhD, MD and Briony Catlow MS at the University of South Florida in Tampa have just started an exciting new study to see if psilocybin can help promote the birth and development of new brain cells (neurogenesis) in an area of the adult brain called the hippocampus, which is associated with learning and memory. The psilocybin that is being used in this study is coming from an unused portion of a gram of psilocybin that MAPS purchased several years ago for $12,250 and then donated to the University of Arizona for Dr. Francisco Moreno’s psilocybin/OCD study.

The official title of the new study is “ Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and Neurogenesis.” It is based on the findings of several researchers who have shown that hippocampal-mediated learning and memory is related to the generation of new neurons in the adult brain. In experiments with laboratory animals, inhibition of neurogenesis with a toxic drug resulted in deficits in specific forms of memory. This provides evidence for the notion that promoting neurogenesis might improve some aspects of memory and cognition. The proposition that psilocybin impacts cognition, and stimulates hippocampal neurogenesis, is based on the evidence that psilocybin mimics the neurotransmitter serotonin, which–when acting on specific serotonin receptor subtypes (most likely the Serotonin 2A receptor)–is involved in the regulation of neurogenesis in the hippocampus. Were looking forward to hearing about the results from this fascinating study

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Offlinex7x_x7x
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: x7x_x7x]
    #12366087 - 04/10/10 06:38 AM (14 years, 1 month ago)

$12,250 for 1 gram!


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cultivando en la miseria

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InvisibleApollyphelion
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning a [Re: x7x_x7x]
    #12366109 - 04/10/10 06:53 AM (14 years, 1 month ago)

I would've sold it to them for 12,000.


--------------------

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Offlineorganicchemist25
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: x7x_x7x]
    #12366138 - 04/10/10 07:11 AM (14 years, 1 month ago)

damn that is some serious loot for a gram. can they really do efficent, conclusive testing with only a gram???

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OfflineSubconscious
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: organicchemist25]
    #12366182 - 04/10/10 07:35 AM (14 years, 1 month ago)

Quote:

FunGuy2Buy said:
damn that is some serious loot for a gram. can they really do efficent, conclusive testing with only a gram???




You do know they mean a gram of pure Psilocybin, not a gram of mushrooms.

A heavy dose according to erowid is 35mg+, a light dose about 4-8mg. In retrospect a gram of psilocybin isn't really a huge amount, but it is still enough to dose at least 20 times, but probably a bit more- in the range of 50 or so at normal doses.

It may not be the most conclusive study, but it's a start.

They did get ripped off though.

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OfflineBiffzilla
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: Subconscious]
    #12366208 - 04/10/10 07:44 AM (14 years, 1 month ago)

suckers


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- Show me the honey -
===================================================================

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Offlinedill705
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: x7x_x7x]
    #12366257 - 04/10/10 08:03 AM (14 years, 1 month ago)

This is a super awesome study. I hope I catch future developments.


--------------------
My advice is to find those things that give pleasure and do them often without too much attachment and relax and wait for the show to end.

-Icelander-

I like free markets and all. Truly I do, at least in general, but there needs to be some kind of oversight in recognition of sustainability. Life works the same way, on a bunch of sustainable systems. Why not honor what made us what we are and take some lessons? Nature FTW!

~dill705~

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OfflineApostle
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: dill705]
    #12366381 - 04/10/10 09:02 AM (14 years, 1 month ago)

can some one some up what they are saying in more lamens terms.


Im gonna swallow my pride here and admit that i dont know what the test is trying to prove.


What i took from it is that psilicibin can improve your learning for some reason.

Did they say that reason.


whats this  "Hippocampal-Dependent Learning and Neurogenesis"??


& this

hippocampal-mediated learning ??


i know what this means  "generation of new neurons in the adult brain" and that is pretty exciting.



on a side note ive always thougt itd be interesting to monitor someones brain activity during a trip.

They say tops humans use 10% of their brain, most alot less. I dont know why but ive always strongly believed that during my most intense trips mine was much higher, and that maybe a CaT Scan (or watever its called) could prove this.


And i dont mean they (shrooms) made me super smart, because the information was too much to process anyways. Nor do i believe that , if true, this phenomena would be exclusive to myself

But i  do belive that my overwhelming body loads where a result of how intensly and at such great speed my mind was processing information. as well as my million mile an hour thinking process, and my ever changing unsually intese feelings of joy, awe, melancholy, and bewilderment

surely all that going on simultaneously must have used over 10% of my brain


i know it sounds like rubbish, just something ive wondered about


--------------------


Google: Pippa Bacca

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OfflineSubconscious
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: Apostle]
    #12366416 - 04/10/10 09:14 AM (14 years, 1 month ago)

Quote:

Hologram said:
They say tops humans use 10% of their brain, most alot less. I dont know why but ive always strongly believed that during my most intense trips mine was much higher, and that maybe a CaT Scan (or watever its called) could prove this.


And i dont mean they (shrooms) made me super smart, because the information was too much to process anyways. Nor do i believe that , if true, this phenomena would be exclusive to myself

But i  do belive that my overwhelming body loads where a result of how intensly and at such great speed my mind was processing information. as well as my million mile an hour thinking process, and my ever changing unsually intese feelings of joy, awe, melancholy, and bewilderment

surely all that going on simultaneously must have used over 10% of my brain


i know it sounds like rubbish, just something ive wondered about





That is a myth, humans don't only use 10% of their brain. Unfortunately I, or anyone else for that matter, cannot explain with great detail how exactly psychedelics work. But- the whole 10% of your brain thing is a very old claim with no scientific evidence to back it up and is essentially 100% false.

I don't mean to be a dick, but when people regurgitate stupid lines like that it sounds really stupid. Just like when ignorant people start saying things like "LSD makes you think you're a glass of orange juice" or whatever similar uneducated statement someone feels the need to chime in on.

Again, I'm not trying to be an asshole but with information so freely available this day and age it takes about 5 minutes to at least get a basic understanding of something. 

Sorry

Edited by Subconscious (04/10/10 09:17 AM)

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InvisibleSimplepowa
In Pursuit of Knowledge


Registered: 03/06/09
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: Apostle]
    #12366417 - 04/10/10 09:14 AM (14 years, 1 month ago)

Nice study !

Started in June 2008?

We will ear news of this soon I believe!

:thumbup:


--------------------
Carl Sagan - "Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people."

---

Robert Pirsig - "When one person suffers from a delusion it is called insanity. When many people suffer from a delusion it is called religion."

---

Brian Cox - "[One] problem with today’s world is that everyone believes they have the right to express their opinion AND have others listen to it. The correct statement of individual rights is that everyone has the right to an opinion, but crucially, that opinion can be roundly ignored and even made fun of, particularly if it is demonstrably nonsense."

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OfflineApostle
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: Simplepowa]
    #12366429 - 04/10/10 09:18 AM (14 years, 1 month ago)

Nah i understand


I just had no idea it was a myth

:gc:


bastards lied to us again


always discrediting human ingenuity. Like saying ancients had help from aliens cause we're too dumb to figure out how they made shit.


w/e



:hippie:


--------------------


Google: Pippa Bacca

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OfflineCosmicLion
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: x7x_x7x]
    #12366688 - 04/10/10 10:45 AM (14 years, 1 month ago)

Too bad this study was in 2008.

Spent a few minutes on Google, I can't find any recent info on it.

Anyone have any luck finding resources or updates about this study?


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OfflineNewfound_wonder
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: CosmicLion]
    #12366743 - 04/10/10 11:02 AM (14 years, 1 month ago)

Humans use more than 10% of their brain, but I don't know how much of that brain activity produces useful work.

Getting your brain to work right is more than just increasing the amplitude of action potentials.  Your brain needs to make sure that your neural networks firing in proper synchrony and harmony so you can effectively transduce and analyze signals and coordinate motor output.  But this research is fueled by observations of drug users of the past and present.  We studied the effect of drugs on behavior before we studied the effect of drugs on your brain.  These molecules change the way you think, for better or for worse.  If we can control those changes and maximize the beneficial changes and minimize the detrimental changes then we can find a more efficient means of increasing our intelligence and capacity for critical thought.

Honestly though, trying to understand how molecular signaling influences gene expression in the interconnected network of cells we call our nervous system is not easy at all.  I would venture to say that the animal nervous system is one of the most complicated systems that we know of.


--------------------
If it's good for fungus, it's good for us...

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OfflineMZA
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: CosmicLion]
    #12367302 - 04/10/10 12:44 PM (14 years, 1 month ago)

Quote:

CosmicLion said:
Too bad this study was in 2008.

Spent a few minutes on Google, I can't find any recent info on it.

Anyone have any luck finding resources or updates about this study?



Found this:
Quote:

Zeno Sanchez-Ramos, M.D. – Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and Neurogenesis
A. Does Psilocybin Impact Neurogenesis in Adult Hippocampus? Selective serotonin uptake inhibitors (SSRIs) are known to stimulate the production of new neurons in the hippocampus by increasing synaptic concentration of serotonin (5-HT). The delay in the appearance of anti-depressant effects corresponds to the time required to generate new neurons. However, it is not clear which of the many serotonergic receptors in the hippocampus are responsible for the enhanced neurogenesis. The current study evaluated the effects of the acute and chronic administration of 5HT2A agonists psilocybin and 251-NBMeO and the 5HT2A/C antagonist ketanserin on hippocampal neurogenesis. To investigate the effects of acute drug administration mice received a single injection of varying doses of psilocybin, 251-NBMeO, ketanserin or saline followed by i.p. injections of 75 mg/kg bromodeoxyuridine (BrdU) for 4 consecutive days followed by euthanasia two weeks later. For chronic administration 4 injections of psilocybin, ketanserin or saline were administered weekly over the course of one month. On days following drug injections mice received an injection of 75 mg/kg BrdU and were euthanized two weeks after the last drug injection. Unbiased estimates of BrdU+ and BrdU/NeuN+ cells in the dentate gyrus revealed a significant dose dependent reduction in the level of neurogenesis after acute 5HT2A receptor agonist or antagonist administration. Interestingly, chronic administration of psilocybin increased the number of new born neurons in the dentate gyrus while the antagonist suppressed hippocampal neurogenesis, suggesting that the 5HT2A receptor appears to be involved in the regulation of hippocampal neurogenesis.

B. Does Psilocybin Affect Hippocampal-Dependent Learning? Aberrations in brain serotonin (5-HT) neurotransmission have been implicated in psychiatric disorders including anxiety, depression and deficits in learning and memory. Many of these disorders are treated with drugs which promote the availability of 5-HT in the synapse. However, it is not clear which of the 5-HT receptors are involved in behavioral improvements. The current study aimed to investigate the effects of psilocybin, a 5HT2A receptor agonist on hippocampal-dependent learning. Mice received a single injection of psilocybin (0.1, 0.5, 1.0 or 1.5 mg/kg), ketanserin (a 5HT2A/C antagonist) or saline 24 hours before habituation to the environment and subsequent training and testing on the fear conditioning task. Trace fear conditioning is a hippocampal-dependent task in which the presentation of the conditioned stimulus (CS, tone) is separated in time by a trace interval to the unconditioned stimulus (US, shock). All mice developed contextual and cued fear conditioning; however, mice treated with psilocybin extinguished the cued fear conditioning more rapidly than saline treated mice. Interestingly, mice given the 5HT2A/C receptor antagonist ketanserin showed less of cued fear response than saline and psilocybin treated mice. Future studies should examine the temporal effects of acute and chronic psilocybin administration on hippocampal-dependent learning tasks.




--------------------
My high's takin' signs and the shit's about to kick
I'm gaspin' for air, my vision disappears,
I'm blinkin' and I'm thinkin'--Yeah!


Waiting for the sun on a Spanish caravan
Solar eclipse and I feel like starin' man
Who's that man in the windowpane
Got somethin' on his tongue and it's startin' to stain

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OfflineCosmicLion
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Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: MZA]
    #12367405 - 04/10/10 01:06 PM (14 years, 1 month ago)

Quote:

MZA said:
Found this





Nice dude, good find! :crazy2:


--------------------
:peace:    :peace:

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InvisibleveggieM

Registered: 07/25/04
Posts: 17,538
Re: Effects of Psilocybin and other Selective Serotonin Agonists on Hippocampal-Dependent Learning and N [Re: x7x_x7x]
    #12367452 - 04/10/10 01:14 PM (14 years, 1 month ago)

This thread has been closed.

Reason:
Story from June 2008

Posts in News are limited to current news stories/articles.

Thanks.

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