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Offlineasmith4011
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2c-i and MAOI
    #12123509 - 03/01/10 08:32 PM (14 years, 30 days ago)

i was wondering how safe it would be to take 2c-i along with an MAO inhibitor. ive heard it can be potentially dangerous, if so what are the negative consequences and what factors contribute to this risk (dosage of the MAOI, 2c-i, etc.)

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Offlinepretzel_king
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Re: 2c-i and MAOI [Re: asmith4011]
    #12123585 - 03/01/10 08:42 PM (14 years, 30 days ago)

Ok did a little google search found this on erowid.
"Do not take 2C-I if you are currently taking an MAOI. MAOIs are most commonly found in the prescription anti-depressants Nardil (phenelzine), Parnate (tranylcypromine), Marplan (isocarboxazid), Eldepryl (l-deprenyl), and Aurorex or Manerix (moclobemide). Ayahuasca also contains MAOIs (harmine and harmaline). 2C-I and MAOIs are a potentially dangerous combination. Check with your doctor if you are not sure whether your prescription medication is an MAOI". So as the other guy said DONT, and thanks for correcting me on this one its always good to have people looking out for other people.

Edited by pretzel_king (03/01/10 09:12 PM)

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OfflineInnoculus
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Re: 2c-i and MAOI [Re: pretzel_king]
    #12123717 - 03/01/10 08:53 PM (14 years, 30 days ago)

Dude.  it is deadly.  Don't tell him it's probably okay.  What the fuck?

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OfflineInnoculus
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Re: 2c-i and MAOI [Re: Innoculus]
    #12123740 - 03/01/10 08:56 PM (14 years, 30 days ago)

Seriously, what if he's some super impressionable type dude and that's all he needed to hear to try it?  I'm not saying that's the case but before you give any verdict at all on the subject, you've gotta know what you're talking about, specifically.

And I'll be damned if I let myself be the reason somebody dies on drugs.

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Offlinepretzel_king
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Re: 2c-i and MAOI [Re: Innoculus]
    #12123834 - 03/01/10 09:05 PM (14 years, 30 days ago)

Alright dude sorry. From what I am aware is that you can take MAOI with shrooms and such. I was guessing that same principle would apply to a phenethylamine. Sorry for giving out that tidbit. Lets just both agree that ITS NOT GOOD IDEA.

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OfflineInnoculus
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Re: 2c-i and MAOI [Re: pretzel_king]
    #12123889 - 03/01/10 09:12 PM (14 years, 30 days ago)

I don't think it's even a very good idea to do it with Mescaline.  As far as I know, it's safe to use with the naturally occuring psychedelic tryptamines, and LSD.  It has unique effects with cannabis, and I've only ever heard bad things about combining it with Phens, or RCs.

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Offlinerobinmccready
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Re: 2c-i and MAOI [Re: Innoculus]
    #12123980 - 03/01/10 09:24 PM (14 years, 30 days ago)

im just wondering..what is it in the body that makes the 2 a deadly combination?


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OfflineInnoculus
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Re: 2c-i and MAOI [Re: robinmccready]
    #12126240 - 03/02/10 08:12 AM (14 years, 30 days ago)

That's something someone else will need to answer.  I've just heard up and down that 2c-i and similar chemicals mixed with an MAOI are asking for trouble.

If it means anything at all, I'm quite certain that it is harmful for the same reason that you shouldn't mix amphetamines with MAOIs.

Psychedelic Phenethylamines are closely related to amphetamines, structurally.  Mescaline and similar substances are often referred to as "psychedelic amphetamines", as well, which is a clue in the direction of DON'T DO THAT YOU MIGHT DIE.

And hell, even if you don't die, I'm sure it has the potential to be a hell of a mind numbing experience, which I wouldn't wanna go through, myself.  I have a feeling the nausea would be absolutely overwhelming if it didn't induce instant and violent retching.

Syrian rue is nauseating by itself.  2c-i is also known to cause abdominal cramps among other physical discomfort.

I have experience, separately, with both 2c-i, in large amounts, and S. Rue mixed with psychedelics.

Both have the potential to be excruciatingly sickening if taken under the wrong circumstances, so even if I'm talking out my ass and they are not in fact deadly, I can assure you that the combination would have you so sick you'd wish you were dead.

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Invisiblethedudenj
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Re: 2c-i and MAOI [Re: Innoculus]
    #12126590 - 03/02/10 09:37 AM (14 years, 30 days ago)

risky as fuck its do able for sure tho first off youd wanna use caapi second you would only want to use maybe  2mg of 2c-i thats the risky part finding the amount of 2C-i that when combined that it wont kill you or cause horrible problems.


yes you can mix caapi and MDMA i spun fire poi the day after ayahuasca while on MDMA. the MDMA was a small amount and the ayahuasca was the day before. tho you can totally take em closer together just dosage is the key or its deadly


--------------------

"You all are just  puppets... You have no heart...and cannot feel any pain...""
you may think thats pain you feel but you must have a heart to feel true pain and that pain wont be yours

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Offlineasmith4011
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Re: 2c-i and MAOI [Re: thedudenj]
    #12127720 - 03/02/10 01:22 PM (14 years, 30 days ago)

It seems that the problems with taking an maoi along with a drug such as mdma lies in the release of enormous levels of serotonin caused by mdma along with the inability to metabolize it caused by the maoi. it seems that with drugs such as 2c-i and mescaline which are serotonin agonists, not serotonin releasers like mdma, the inability to metabolize the serotonin caused by the maoi wouldnt cause health problems even though the chemicals themselves are phenthylamines. i have no research to support this it just seems logical to me because people say its fine to take lsd with an maoi and the primary action of both lsd and drugs such as 2c-i and mescaline are the same (serotonin agonists).

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Offlinepretzel_king
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Re: 2c-i and MAOI [Re: asmith4011]
    #12127849 - 03/02/10 01:45 PM (14 years, 30 days ago)

Yeah my guess would be the structure of phenethylamines in general.

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Invisiblethedudenj
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Re: 2c-i and MAOI [Re: pretzel_king]
    #12128046 - 03/02/10 02:15 PM (14 years, 29 days ago)



--------------------

"You all are just  puppets... You have no heart...and cannot feel any pain...""
you may think thats pain you feel but you must have a heart to feel true pain and that pain wont be yours

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OfflineInnoculus
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Re: 2c-i and MAOI [Re: asmith4011]
    #12128051 - 03/02/10 02:15 PM (14 years, 29 days ago)

Quote:

asmith4011 said:
It seems that the problems with taking an maoi along with a drug such as mdma lies in the release of enormous levels of serotonin caused by mdma along with the inability to metabolize it caused by the maoi. it seems that with drugs such as 2c-i and mescaline which are serotonin agonists, not serotonin releasers like mdma, the inability to metabolize the serotonin caused by the maoi wouldnt cause health problems even though the chemicals themselves are phenthylamines. i have no research to support this it just seems logical to me because people say its fine to take lsd with an maoi and the primary action of both lsd and drugs such as 2c-i and mescaline are the same (serotonin agonists).





How can you assume to know the mechanism of action of 2c-i?  Who has studied 2c-i to that extent?

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Offlineasmith4011
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Re: 2c-i and MAOI [Re: Innoculus]
    #12128221 - 03/02/10 02:41 PM (14 years, 29 days ago)

i wasnt assuming its just what ive heard
http://en.wikipedia.org/wiki/Psychedelic_drugs
i dont know how accurate that article is but 2c-b is listed under the serotonin agonists category and im guessing that applies to 2c-i as well.
2c-i isnt a serotonin agonist?

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OfflineInnoculus
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Re: 2c-i and MAOI [Re: asmith4011]
    #12128301 - 03/02/10 02:50 PM (14 years, 29 days ago)

Well it may be a serotonin agonist.  Frankly, whether it is or not isn't the issue at all.

The question at hand is if that is it's only mechanism of action.
How can we know, either way?  Why take the risk?  Why not just eat more 2c-i?  It's not exactly hard to come by, and it's dirt cheap, considering.

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Offlinepretzel_king
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Re: 2c-i and MAOI [Re: Innoculus]
    #12128433 - 03/02/10 03:08 PM (14 years, 29 days ago)

Yeah considering if you get it yourself a 20mg size dose would be in the range of 2-5 dollars, which in my experience is a pretty good trip. Also who knows maybe it releases some serotonin and dopamine, in my experience it has had some MDMA like qualities. When combining MAOI's with things best leave it to the throughly researched pysch's (such as DMT, LSD, etc...). Even then caution is not to be taken lightly.

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OfflineInnoculus
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Re: 2c-i and MAOI [Re: pretzel_king]
    #12128805 - 03/02/10 04:13 PM (14 years, 29 days ago)

Yeah I've had some overly intense and long experiences with mushrooms and syrian rue.

Definitely not to be trifled with.

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Offlineoxalic32
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. [Re: Innoculus]
    #12130359 - 03/02/10 08:07 PM (14 years, 29 days ago)

.

Edited by oxalic32 (12/18/10 09:33 PM)

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OfflineSupreme Slammage
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Re: 2c-i and MAOI [Re: asmith4011]
    #12130553 - 03/02/10 08:34 PM (14 years, 29 days ago)

Quote:

asmith4011 said:
i was wondering how safe it would be to take 2c-i along with an MAO inhibitor. ive heard it can be potentially dangerous, if so what are the negative consequences and what factors contribute to this risk (dosage of the MAOI, 2c-i, etc.)





Hmmmm sounds 100% unsafe as in DO NOT TAKE 2C-x and MAOI.  That would be like and SSRI or amphetamines and MAOI.  BAD BAD COMBOS!


--------------------
Solar Layering METHOD!!!
TO INFINITY AND BEYOND

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OfflineInnoculus
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Re: 2c-i and MAOI [Re: Supreme Slammage]
    #12130693 - 03/02/10 08:56 PM (14 years, 29 days ago)

Dasss what I saidddd, fool.

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Invisiblethedudenj
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Re: 2c-i and MAOI [Re: Innoculus]
    #12131643 - 03/02/10 11:17 PM (14 years, 29 days ago)

Quote:

Innoculus said:
Yeah I've had some overly intense and long experiences with mushrooms and syrian rue.

Definitely not to be trifled with.







Yeah I've had some overly intense yet perfect and long experiences with mushrooms and syrian rue.

Definitely not to be trifled with. indeed


--------------------

"You all are just  puppets... You have no heart...and cannot feel any pain...""
you may think thats pain you feel but you must have a heart to feel true pain and that pain wont be yours

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OfflineInnoculus
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Re: 2c-i and MAOI [Re: thedudenj]
    #12132383 - 03/03/10 02:31 AM (14 years, 29 days ago)

After having visited that point, it's almost arbitrary to label any one experience as perfect.

If you do it right, you take back the realization that every experience is perfect.

Not to be trifled with, double indeed, though.

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OfflinePsychedelicSpirit
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Re: 2c-i and MAOI [Re: thedudenj]
    #12132609 - 03/03/10 04:55 AM (14 years, 29 days ago)

Yeah, it just doesn't sound like a good idea.  At the very least we know that 2C-I produces euphoria, so it's likely doing SOMETHING with your serotonin, and considering how little we know about this chemical, I would HIGHLY suggest that you don't become the first person to research this combination.


--------------------
Reality is a crutch for people who can't handle drugs.

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InvisibleMoo456
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Re: 2c-i and MAOI [Re: asmith4011]
    #12133258 - 03/03/10 09:32 AM (14 years, 29 days ago)

Im not going to say 2c-i is safe with MAOI's, but I would bet my life that it isnt deadly. Its like a heavier 2c-b molecule. It works the same way as any other psychedelic.

Regardless of that, I wouldnt take 2c-i anyway because there are a few reports of thyroid problems that may be caused by its relation to thyroxine.

The point has already been made that the substance is so inexpensive it doesnt need potentiation. However I would have no reservations about taking a moderate dose of 2c-b(probably the most expensive 2c) with a MAOI.


--------------------

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Invisiblethedudenj
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Re: 2c-i and MAOI [Re: Moo456]
    #12133481 - 03/03/10 10:26 AM (14 years, 29 days ago)

yeah i dont think any one hear can say its safe mixing alot of these RC with maoi is really risky


--------------------

"You all are just  puppets... You have no heart...and cannot feel any pain...""
you may think thats pain you feel but you must have a heart to feel true pain and that pain wont be yours

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OfflineInnoculus
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Re: 2c-i and MAOI [Re: thedudenj]
    #12135189 - 03/03/10 03:05 PM (14 years, 28 days ago)

Well.. now that the crowd of reason has found it's way here, I think my job is done.

/thread

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