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Offlinesoapyluvsyou
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TCA's
    #1143346 - 12/15/02 03:00 PM (14 years, 5 months ago)

Do TCA's (trycyclic antidepressants) interfere w/ shrooms?


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Offlinesoapyluvsyou
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Re: TCA's [Re: soapyluvsyou]
    #1148301 - 12/17/02 09:39 AM (14 years, 5 months ago)

help me... :blush:)
 


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Offlinemonoamine
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Re: TCA's [Re: soapyluvsyou]
    #1149401 - 12/17/02 04:03 PM (14 years, 5 months ago)



--------------------
People think that if you just say the word "hallucinations" it explains everything you want it to explain and eventually whatever it is you can't explain will just go away.It's just a word,it doesn't explain anything...
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Re: TCA's [Re: monoamine]
    #1151145 - 12/18/02 09:30 AM (14 years, 5 months ago)

So Imipramine would have the same effect on psilocybin as it would on lsd?


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Offlinemonoamine
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Re: TCA's [Re: soapyluvsyou]
    #1152614 - 12/18/02 06:33 PM (14 years, 5 months ago)

As far as I know,there has never been a scientific study about the effects of combining antidepressants and psychedelics.I doubt you will find a satisfactory answer anywhere.
SSRI's tend to reduce the effects of psychedelics while TCA's often highten the effects.No one really know why because they both block the reuptake of serotonin,but TCA's are considered "dirty" drugs in pharmacology speak because they also have a strong effect on norepinephrine.I think imipramine is more selective for norepinephrine than serotonin.This effect on norepinephrine might potentiate the stimulant qualities of psychedelics (btw,LSD is usually considered more stimulating than psilocin), or it might be because of some other mechanism entirely.
If you are taking imipramine,I'm assuming you have some kind of depression. I would advise you to not trip,but if you are going to anyway,start low on the mushies to gauge how the combonation of imipramine and psilocin effects you.


--------------------
People think that if you just say the word "hallucinations" it explains everything you want it to explain and eventually whatever it is you can't explain will just go away.It's just a word,it doesn't explain anything...
Douglas Adams


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Mushrooms, Mycology and Psychedelics >> The Psychedelic Experience

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