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Offlinedwtk
it all rolls into one
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Registered: 02/24/07
Posts: 4,482
Loc: Franklin's Tower
Last seen: 1 year, 7 months
Trial drug may help smokers kick butts
    #11419017 - 11/09/09 03:31 PM (7 years, 11 months ago)

Quote:

The National Institute on Drug Abuse, a division of the National Institutes of Health, gave Nabi BioPharmaceuticals a $10 million grant to take its anti-nicotine vaccine,

NicVAX, to Phase III clinical trials.
According to the National Institutes of Health, in Phase III trials, the treatment is "given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely." It's also the last step before the drug can go before the FDA for approval.

NicVAX is designed to stimulate the immune system to generate antibodies that latch on to nicotine in a smoker's body and actually prevent nicotine from ever entering the brain. The testing began last week.




the rest of the article: http://www.cnn.com/2009/HEALTH/11/09/anti.nicotine.vaccine/index.html


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Offlinedwtk
it all rolls into one
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Registered: 02/24/07
Posts: 4,482
Loc: Franklin's Tower
Last seen: 1 year, 7 months
Re: Trial drug may help smokers kick butts [Re: dwtk]
    #11419023 - 11/09/09 03:31 PM (7 years, 11 months ago)

I wonder if they'll develop vaccines for hard drugs?


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Offlineshah
Alchemist

Registered: 04/27/04
Posts: 112
Loc: Goa, India
Last seen: 7 years, 28 days
Re: Trial drug may help smokers kick butts [Re: dwtk]
    #11419174 - 11/09/09 03:55 PM (7 years, 11 months ago)

depending on your definition of "hard drug" I think the addiction of tobacco and the consenquences are as, if not a lot worse then most hard drugs.


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OfflineLanc3r117
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Registered: 10/10/08
Posts: 174
Last seen: 1 month, 29 days
Re: Trial drug may help smokers kick butts [Re: dwtk]
    #11419195 - 11/09/09 03:59 PM (7 years, 11 months ago)

.


Edited by Lanc3r117 (12/10/09 04:03 PM)


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OfflineConaman12
Male


Registered: 06/25/07
Posts: 367
Last seen: 4 years, 7 months
Re: Trial drug may help smokers kick butts [Re: Lanc3r117]
    #11419272 - 11/09/09 04:10 PM (7 years, 11 months ago)

Wouldn't the people on it still go through withdrawal since the drug isn't entering their brain?


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OfflineLanc3r117
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Registered: 10/10/08
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Re: Trial drug may help smokers kick butts [Re: Conaman12]
    #11419280 - 11/09/09 04:11 PM (7 years, 11 months ago)

That's what I was curious about too. Either way, this article made me want a cigarette!


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OfflineSimulacra541
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Registered: 01/28/09
Posts: 265
Last seen: 3 years, 3 months
Re: Trial drug may help smokers kick butts [Re: Lanc3r117]
    #11419429 - 11/09/09 04:31 PM (7 years, 11 months ago)

Quote:

Lanc3r117 said:
"sympathetic person behind the wheel." This tank rushes through the forest as fast as it can destroying all the trees in site, but stops as they hit an deer. This tank driver decides that since we eat deer, it should be taken care of. This one deer gets nurtured back to health; meanwhile, animals which are trying to finish off the deer are being murdered by the driver.







How the hell did a deer get hit by a tank?


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InvisibleLe_Canard
The Duk Abides


Registered: 05/17/03
Posts: 94,392
Loc: Earthfarm 1 Flag
Re: Trial drug may help smokers kick butts [Re: Conaman12]
    #11419461 - 11/09/09 04:36 PM (7 years, 11 months ago)

Quote:

Conaman12 said:
Wouldn't the people on it still go through withdrawal since the drug isn't entering their brain?




I imagine so.


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OfflineLanc3r117
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Registered: 10/10/08
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Re: Trial drug may help smokers kick butts [Re: Simulacra541]
    #11419686 - 11/09/09 05:15 PM (7 years, 11 months ago)

Quote:

Simulacra541 said:
Quote:

Lanc3r117 said:
"sympathetic person behind the wheel." This tank rushes through the forest as fast as it can destroying all the trees in site, but stops as they hit an deer. This tank driver decides that since we eat deer, it should be taken care of. This one deer gets nurtured back to health; meanwhile, animals which are trying to finish off the deer are being murdered by the driver.







How the hell did a deer get hit by a tank?




lmao, idk, it was just a delusion of mine to set up the story. I guess the deer could have jumped, but that ruins the point. the deer is supposed to represent a weak point in that reality. my metaphorical world is a little off the wall right now.


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Offlinerawrrawr
Stranger
Registered: 09/19/09
Posts: 148
Last seen: 1 month, 4 days
Re: Trial drug may help smokers kick butts [Re: Lanc3r117]
    #11420248 - 11/09/09 06:39 PM (7 years, 11 months ago)

Ignorance at its finest.  Almost ALL drugs are first researched with government financing.  From there, individual companies attempt to refine them for commercial use.

Quote:

Lanc3r117 said:
It's fucking stupid. If Nabi BioPharmaceuticals had a product people really need then they'd find they're own funding for it, but the fucking government makes it their deal to give out tax payer money to try to get us from smoking our cigarettes.

I know I'm never taking a fucking government financed drug to quit cigarettes. That just screams "I'm a medicine and if I didn't have a ton of money thrown at my research then nobody would want to take me!" How about people just stop smoking cigs if they want to?

Our government is keeping companies and products alive which should not have survived.

My metaphor: the government is a big tank with a "sympathetic person behind the wheel." This tank rushes through the forest as fast as it can destroying all the trees in site, but stops as they hit an deer. This tank driver decides that since we eat deer, it should be taken care of. This one deer gets nurtured back to health; meanwhile, animals which are trying to finish off the deer are being murdered by the driver.

Most of the other animals were killed in the deer's defense. The deer finally get's better, so he's let out into the woods. As he runs into the woods he realizes most the animals in there are gone, except when he does find them they are the most ferocious, evolved forms of animals that lived there. Anyways, the little deer dies because all he knows how to do is suck milk from a bottle and none of the other animals have sympathy for him because he sided with the most naive form of existence in the entire world. A human government fighting for itself. All the tanker wanted to do was protect his feelings (and probably a lashing from the honey when he gets home) but that deer should have been Left 4 Dead, or at least eaten...




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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 12,058
Re: Trial drug may help smokers kick butts [Re: dwtk]
    #11420335 - 11/09/09 06:53 PM (7 years, 11 months ago)

The problem with smoking is that nicotine plays a very small role in the addiction.

If nicotine was the main factor, nicotine replacement therapy (patches, gums etc) wouldn't be such a dismal failure.


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...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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Invisiblebuddhabadger
Evil Overlord

Registered: 01/16/09
Posts: 491
Loc: The Forest
Re: Trial drug may help smokers kick butts [Re: badchad]
    #11421507 - 11/09/09 09:37 PM (7 years, 11 months ago)

Quote:

badchad said:
The problem with smoking is that nicotine plays a very small role in the addiction.

If nicotine was the main factor, nicotine replacement therapy (patches, gums etc) wouldn't be such a dismal failure.




Quote:

Lanc3r117 said:
It's fucking stupid. If Nabi BioPharmaceuticals had a product people really need then they'd find they're own funding for it, but the fucking government makes it their deal to give out tax payer money to try to get us from smoking our cigarettes.

I know I'm never taking a fucking government financed drug to quit cigarettes. That just screams "I'm a medicine and if I didn't have a ton of money thrown at my research then nobody would want to take me!" How about people just stop smoking cigs if they want to?

Our government is keeping companies and products alive which should not have survived.

bizarro-land metaphor snipped





Are you two huffing gas or something? I'd ask what you're smoking but your posts make me think you either don't smoke at all or haven't been smoking long.
Please go smoke for twenty years* then come talk about "How about people just stop smoking cigs if they want to?"
Were it not for nicotine patches and lozenges I (and several other smokers I know personally) would probably either still be smoking or be in jail for assault.
Look, bottom line here: If the governments of the US, Canada and the various European countries were truly serious about getting people to quit, they'd subsidise smoking cessation measures.
As for that notion that nicotine itself isn't the addictive part, please, please cite your reference. ALL the medical/scientific research I've read indicates the complete and utter opposite.

*don't actually do this


--------------------
- I don't abuse drugs; in fact, I think I treat them quite nicely. -


Edited by buddhabadger (11/10/09 01:47 AM)


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OfflineFastfirebird
Porn Star
Male


Registered: 11/11/08
Posts: 425
Loc: NC Mountains
Last seen: 5 years, 9 months
Re: Trial drug may help smokers kick butts [Re: buddhabadger]
    #11424857 - 11/10/09 11:06 AM (7 years, 11 months ago)

I hope it works i would realy like to quit smoking and ive tried a lot of the other stuff and none of it seems to work for me.


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Invisiblebuddhabadger
Evil Overlord

Registered: 01/16/09
Posts: 491
Loc: The Forest
Re: Trial drug may help smokers kick butts [Re: Fastfirebird]
    #11426017 - 11/10/09 02:52 PM (7 years, 11 months ago)

Quote:

Fastfirebird said:
I hope it works i would realy like to quit smoking and ive tried a lot of the other stuff and none of it seems to work for me.





I quit two years ago after smoking 2-3 packs a day for twenty years.
The first two weeks I used the patch, and since then I've used lozenges. I still use the lozenges fairly frequently, especially since two of our housemates smoke like chimneys, but it's better than giving up and going back to smoking.
Just keep trying, you can do it.

(you may or may not wish to wear the patch to bed... VIVID dreams. Most detailed I've ever had)


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- I don't abuse drugs; in fact, I think I treat them quite nicely. -


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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 12,058
Re: Trial drug may help smokers kick butts [Re: buddhabadger]
    #11427193 - 11/10/09 06:30 PM (7 years, 11 months ago)

Quote:

buddhabadger said:

As for that notion that nicotine itself isn't the addictive part, please, please cite your reference. ALL the medical/scientific research I've read indicates the complete and utter opposite.

*don't actually do this





Rather than asking you whether or not you huff gas, I'll simply ask you whether you have ever read an actual, peer-reviewed clinical trial (or study) involving nicotine?

In a systematic review of the effectiveness of nicotine replacement therapy The british medical journal reviewed studies involving 27657 smokers.  At 6 months, only 6.7% quit smoking using nicotine replacement therapy (patch, lozenge, gum etc.) (BMJ, 2009 338b 1024).  Hughes et al.  (tobacco control, 2003 12:21-27) analyzed over 100 studies, and found quit rates between 7-8% with nicotine replacement products.  If you look at the actual clinical trials done by the pharma companies themselves, nicotine replacement therapys only get quit rates 10-15% over placebo.  If we assume nicotine is the sole reason people smoke, these are extremely low numbers.

The question is:  If its only the nicotine that people are addicted to, why is it so hard to quit using the patch, or gum, or lozenges?  If you are only addicted to nicotine, then simply taking nicotine should make it easy to quit.

The reason (likely) has to due with numerous "smoking associated cues".  People like the smell, they like the taste, they associate smoking with certain activities.

In fact, in clinical studies, smoking DE-nicotinized cigarettes eliminates and reduces craving, and are perceived to be just as pleasurable as nicotine-containing cigarettes.

If you'd like to get further into it, Dar and Frenk (psychopharm 2004, 173:18-26) have found that under blinded conditions (when people don't know what they're getting), not a single study has ever shown that humans will self-administer (voluntarily take) nicotine.  This is very strong evidence that, contrary to popular belief, people don't particularly like nicotine.  Its certainly questionable whether its the single, primary cause behind smoking.  That has been shown time and time again in the lab.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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