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OfflineCosmicLion
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Tylenol (acetaminophen) is a cannabinoid!
    #11321198 - 10/25/09 11:02 PM (8 years, 1 month ago)

So my doctor knows what's up with my lifestyle.

He told me how at a recent conference he learned how acetaminophen works by acting on the endo-cannabinoid system.

I looked it up and sure enough it is true, I thought that was pretty sweet. I still don't advocate its regular use but its an interesting fact.

Wikepedia: Acetaminophen

Quote:

[Acetaminiphen] also modulates the endogenous cannabinoid system.[37] Paracetamol is metabolized to AM404, a compound with several actions; most important, it inhibits the uptake of the endogenous cannabinoid/vanilloid anandamide by neurons. Anandamide uptake would result in the activation of the main pain receptor (nociceptor) of the body, the TRPV1




Anandamide - The Bodies Natural THC


AM404 — a metabolite of acetaminophen


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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: CosmicLion]
    #11321218 - 10/25/09 11:06 PM (8 years, 1 month ago)

Interesting- it interferes with the receptors, right?
Which explains why it's less fun to get high if you are sick- and taking Tylenol.


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Offlinefeifen

Registered: 10/18/08
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: CosmicLion]
    #11321229 - 10/25/09 11:07 PM (8 years, 1 month ago)

I'd still tell a person to smoke weed for their headache instead of taking Tylenol. Doesn't do shit for me. Weed makes my migraines so much more manageable.


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Invisiblepwnasaurus
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: feifen]
    #11321239 - 10/25/09 11:08 PM (8 years, 1 month ago)

I find Ibuprofen works extremely well, but acetaminophen is absolutely useless.


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OfflineCosmicLion
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: Doc_T]
    #11321257 - 10/25/09 11:11 PM (8 years, 1 month ago)

Quote:

Doc_T said:
Interesting- it interferes with the receptors, right?
Which explains why it's less fun to get high if you are sick- and taking Tylenol.




That makes sense.

It says its an uptake inhibitor for anandamide. So if it isn't getting taken up that means more anandamide must be in the synapse.

If the synapse is filled with extra anandamide it makes sense that there won't be as much room for THC. It all depends on the affinity each has for the cannabinoid receptor.

Who knows? Get high!  :gethigh:


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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: feifen]
    #11321267 - 10/25/09 11:13 PM (8 years, 1 month ago)

Quote:

feifen said:
I'd still tell a person to smoke weed for their headache instead of taking Tylenol. Doesn't do shit for me. Weed makes my migraines so much more manageable.




I don't get migraines, but my experience has been that if I'm sick enough to take meds, I'm not going to get 'high'. I still smoke, but it just isn't the same. I usually take acetaminophen, but maybe I'll try ibuprofen instead. See if there's a difference. I don't take stuff like that often, it won't be soon.
For ordinary muscle pain, weed and a beer. :thumbup:


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OfflineChubba
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: feifen]
    #11321269 - 10/25/09 11:13 PM (8 years, 1 month ago)

Quote:

I'd still tell a person to smoke weed for their headache instead of taking Tylenol. Doesn't do shit for me. Weed makes my migraines so much more manageable.




I wouldn't recommend smoking for ANY medical condition, there's just far too much nasty shit released that is counter productive, especially for common cold/flu or anything respiratory.

Vape or eating are the way of the future for medicine.


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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: Chubba]
    #11321275 - 10/25/09 11:14 PM (8 years, 1 month ago)

^^^ I recently tried baking it, and I love it! Way nicer than smoking.


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OfflineCosmicLion
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: Chubba]
    #11321285 - 10/25/09 11:16 PM (8 years, 1 month ago)

Quote:

Chubba said:
Vape or eating are the way of the future for medicine.




I've had edibles but never made any myself.

I JUST finished my first lb of butter though.

And some dank olive oil w/ extra kif.

Hoping to use as an alternative to smoking for a while.


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OfflineEnvix
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: Doc_T]
    #11321289 - 10/25/09 11:17 PM (8 years, 1 month ago)

does that mean acetaminophen could raise tolerance to cannabis if used frequently?


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Offlinefeifen

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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: Chubba]
    #11321291 - 10/25/09 11:18 PM (8 years, 1 month ago)

Quote:

Chubba said:
Quote:

I'd still tell a person to smoke weed for their headache instead of taking Tylenol. Doesn't do shit for me. Weed makes my migraines so much more manageable.




I wouldn't recommend smoking for ANY medical condition, there's just far too much nasty shit released that is counter productive, especially for common cold/flu or anything respiratory.

Vape or eating are the way of the future for medicine.




Uh..... what? I only said for headaches. I get bad migraines and the only thing that helps me manage them is weed or opiates and weed is more practical.

As for being actual sick I would recommend vaping or eating as well... ever try and smoke while you have a cold? I have and my body hated me while I was smoking. I felt better afterwards though lol


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Invisiblepwnasaurus
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: feifen]
    #11321321 - 10/25/09 11:26 PM (8 years, 1 month ago)

My buddy just baked 2 pumpkin pies with a half oz in each.  I can't wait to partake!


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OfflineChubba
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: feifen]
    #11321353 - 10/25/09 11:31 PM (8 years, 1 month ago)

Quote:

Uh..... what? I only said for headaches. I get bad migraines and the only thing that helps me manage them is weed or opiates and weed is more practical.




Yeah, even for headaches, when you got something wrong in your body you don't want to inhale all the byproducts of combustion.

Weed is an amazing thing, but lighting anything on fire releases a shitload of nasties.


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Offlinefeifen

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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: Chubba]
    #11321407 - 10/25/09 11:41 PM (8 years, 1 month ago)

Quote:

Chubba said:
Quote:

Uh..... what? I only said for headaches. I get bad migraines and the only thing that helps me manage them is weed or opiates and weed is more practical.




Yeah, even for headaches, when you got something wrong in your body you don't want to inhale all the byproducts of combustion.

Weed is an amazing thing, but lighting anything on fire releases a shitload of nasties.




Eh, not worried about it. I'm gonna die anyway and I'm not gonna wait 10-20 minutes to vape if I have a killer migraine :facepalm:


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OfflineChubba
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: feifen]
    #11321440 - 10/25/09 11:47 PM (8 years, 1 month ago)

Quote:

Eh, not worried about it. I'm gonna die anyway and I'm not gonna wait 10-20 minutes to vape if I have a killer migraine :facepalm:




Yeah, pretty much it's a personal decision. Some people decide to smoke ciggies despite knowing the damage, people drink to excess, people blaze to excess etc.

I think vaporizers have their place within the general population for medicine. I think in the future when it's all legalized, doctors will NEVER prescribe smoking, it will be vapes or eating.

I definitely believe potheads that get respiratory illnesses often should invest in a vape, getting high as fuck all day/everyday without the discomfort and damage of smoke = golden. Before vapes, I used to turn a 7 day common cold into a 1 month long sickness by smoking bongs all day.


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Offlinefeifen

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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: Chubba]
    #11321488 - 10/25/09 11:55 PM (8 years, 1 month ago)

I usually just use my volcano when I want to blaze but sometimes I feel like smoking a piece ya know or if I just wanna get high RIGHT THEN.

Otherwise It's almost exclusively vape. Rarely edibles but sometimes I'll make 'em.

I haven't been sick in years so I'm gonna have to say marijuana doesn't effect my ability to fight off diseases.


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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: feifen]
    #11321523 - 10/26/09 12:02 AM (8 years, 1 month ago)

Quote:

Envix said:
does that mean acetaminophen could raise tolerance to cannabis if used frequently?





Just the sort of question Big Pharma could answer if they were allowed to market appropriately.

"Pot smokers who treated their headaches with TOAXALOT found relief 50% faster, in 25% of cases studied." Try TOAXALOT today!!1!"


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OfflineGumbyM
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: CosmicLion]
    #11321847 - 10/26/09 01:08 AM (8 years, 1 month ago)

Too bad acetaminophen doesn't do a damn thing. Some people in the FDA are lobbying to pull it off the shelves. People keep taking too much and damaging their livers


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Invisibleniteowl
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: Gumby]
    #11321882 - 10/26/09 01:17 AM (8 years, 1 month ago)

I have NEVAR gotten any relief from Tylenol
ibuprofen is the way to go y'all :yesnod:


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OfflineCosmicLion
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Re: Tylenol (acetaminophen) is a cannabinoid! [Re: niteowl]
    #11321930 - 10/26/09 01:25 AM (8 years, 1 month ago)

Quote:

niteowl said:
ibuprofen is the way to go y'all :yesnod:




QFT.

And in a bad situation you can take up to 4 over-the-counter pills at a time to equal one "prescription grade" dose, all without fear of destroying your liver.


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