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Offline5HTSynaptrip
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St John's Wort + Shrooms = better.
    #11212434 - 10/09/09 02:34 AM (8 years, 2 months ago)

So I've been taking St John's Wort for a while and ate some shrooms not long ago and wanted to share the info.  The trip was amazing, I felt so happy that it was unlike any other trip I've ever done.  Intense visuals too, very intense. 

It has been shown that some of the alkaloids in the plant are mao-a and mao-b inhibitors, although not very strong, this could be part of the potentiation but I think it has more to do with this.  I just read a study "Mechanism of Action of St John’s Wort in Depression" by Veronika Butterweck that stated a few different experiments showed St John's Wort actually caused an upregulation of 5-HT2 and 5-HT1a receptors.  Psilocin is for sure a substrate of 5-HT2 receptors and I think this what leads to the the better trip since there are more of them.


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Science is a way of thinking much more than it is a body of knowledge. - My hero, who will be forever remembered, Carl Sagan.



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Offlinepfxtc
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Re: St John's Wort + Shrooms = better. [Re: 5HTSynaptrip]
    #11212459 - 10/09/09 02:38 AM (8 years, 2 months ago)

i've heard vary differing things about st. johns wart

seems to be more of a placebo effect

but i take it

so

:shrug:


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Life-long trip report


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OfflineEdgeChaos
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Re: St John's Wort + Shrooms = better. [Re: pfxtc]
    #11212533 - 10/09/09 02:54 AM (8 years, 2 months ago)

Was the trip clarity effected at all?


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Offline5HTSynaptrip
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Re: St John's Wort + Shrooms = better. [Re: EdgeChaos]
    #11212584 - 10/09/09 03:04 AM (8 years, 2 months ago)

The thing that was so striking was I only took 1.75 grams because I wanted a light trip.  It ended up being one of the most visually intense shroom trips I've ever had, and it was by far the most blissful.  It was almost like MDMA, no bullshitting.  VERY intense trip and my buddy who took the other half had no where near the same intensity of a trip.

I have been taking the wort regularly for a while though, I doubt one dose would do much.


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Science is a way of thinking much more than it is a body of knowledge. - My hero, who will be forever remembered, Carl Sagan.



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OfflineEdgeChaos
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Re: St John's Wort + Shrooms = better. [Re: 5HTSynaptrip]
    #11212617 - 10/09/09 03:12 AM (8 years, 2 months ago)

4g piracatam + 300mg rue extract + .5g mush. felt like 3g mush.

Have you ever taken rue with the mush?


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Offline5HTSynaptrip
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Re: St John's Wort + Shrooms = better. [Re: EdgeChaos]
    #11212704 - 10/09/09 03:29 AM (8 years, 2 months ago)

No but I don't know if I'd take a potent MAOI on shrooms.  Sometimes it can be a rough ride for me and having to do it 12+ hours would be insane.


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Science is a way of thinking much more than it is a body of knowledge. - My hero, who will be forever remembered, Carl Sagan.



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OfflineEdgeChaos
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Re: St John's Wort + Shrooms = better. [Re: 5HTSynaptrip]
    #11212756 - 10/09/09 03:40 AM (8 years, 2 months ago)

How much wort do you take normally?



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Re: St John's Wort + Shrooms = better. [Re: EdgeChaos]
    #11214032 - 10/09/09 11:09 AM (8 years, 2 months ago)

I take about 4 grams of the plant material.  A lot of research has shown that more than just hyperforin/hypericin attribute to the AD effects and that is probably from the other flavinoids.


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Science is a way of thinking much more than it is a body of knowledge. - My hero, who will be forever remembered, Carl Sagan.



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InvisibleBiG_StroOnZ
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Re: St John's Wort + Shrooms = better. [Re: 5HTSynaptrip]
    #11214140 - 10/09/09 11:39 AM (8 years, 2 months ago)

Try Syrian Rue, l-deprenyl, or moclobemide if you think St John's makes psychedelics better.


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Offline13.step
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Re: St John's Wort + Shrooms = better. [Re: BiG_StroOnZ]
    #11214482 - 10/09/09 12:48 PM (8 years, 2 months ago)

Interesting,i once took some LSA,6 HBWR while i was on st. johns wort.It was a strange trip.Another person took 4 seeds of the same batch and tripped fine,i only got some paranoia and became introspective as fuck.The morning after was one of the best afterglows i had in my life though.

Maybe it's a dose thing,i was on 600mg daily of plant material.From what i know st. johns wort acts like tricyclic anitdeps.


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OfflineEdgeChaos
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Re: St John's Wort + Shrooms = better. [Re: BiG_StroOnZ]
    #11214918 - 10/09/09 02:07 PM (8 years, 2 months ago)

Quote:

BiG_StroOnZ said:
Try Syrian Rue, l-deprenyl, or moclobemide if you think St John's makes psychedelics better.





I always thought since l-deprenyl was an irreversible MAOI it was more dangerous than rue.


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InvisibleBiG_StroOnZ
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Re: St John's Wort + Shrooms = better. [Re: EdgeChaos]
    #11214973 - 10/09/09 02:14 PM (8 years, 2 months ago)

Quote:

EdgeChaos said:
Quote:

BiG_StroOnZ said:
Try Syrian Rue, l-deprenyl, or moclobemide if you think St John's makes psychedelics better.





I always thought since l-deprenyl was an irreversible MAOI it was more dangerous than rue.




It actually has some neuro-protective properties. I would rather use Rue or Moclobemide though


--------------------
"We can accept God becoming Man to save Man, but not Man becoming God to save Himself."
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