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OfflinemotamanM
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Cocaine vaccine may reduce 'use'
    #11192707 - 10/06/09 12:23 PM (8 years, 18 days ago)

Cocaine vaccine may reduce 'use'

A vaccine to treat cocaine use helps some addicts to halve their dependency on the drug, researchers say.

Doctors at Yale University School of Medicine gave the vaccine to 55 cocaine addicts and found that 38% were able to achieve the necessary antibody levels.

Animal and human studies have suggested that high levels of anti-cocaine antibodies in the blood can stop addicts experiencing a high.

But the researchers say the addicts would need repeat injections.

The study published in the journal of the American Medical Association says the Yale doctors conducted a 24 week trial of an experimental vaccine.

Randomly assigned

A total of 115 cocaine and opiate-dependent individuals were enrolled and randomly assigned to receive five vaccinations of the active vaccine or five vaccinations of a dummy treatment over 12 weeks.

“ They don't destroy, they neutralize the cocaine and make it vulnerable to a cholinesterase enzyme which will then break it down ”
Dr Thomas Korsten, Baylor College of Medicine

Cocaine is flushed out the body in about three days so the doctors tested all the addicts urine for metabolised cocaine three times a week for 24 weeks.

Of the 55 people who completed the course 21 (38%) attained antibody levels of 43 micrograms per millilitre or higher.

Those with that level of antibodies had significantly more cocaine-free urine samples (45%) between week nine and 16 of the study than individuals who had lower antibodies (35%) and those who received dummy treatments.

Cocaine use halved

The proportion of participants who reduced their cocaine use by half was significantly greater among those treated with the active vaccine - 53% compared to 23% in the placebo group.

The researchers said about 40% of the participants achieved antibody levels of 20 micrograms per millilitre.

They said this was enough to combat one to two doses of cocaine which should be enough to prevent relapses in many patients.

Dr Thomas Korsten, of Baylor College of Medicine who started the study while he was at Yale, said: "While these antibodies are in the blood targeting cocaine - the drug does not have an effect.

"They don't destroy, they neutralize the cocaine and make it vulnerable to a cholinesterase enzyme which will then break it down.

"The vaccine binds the cocaine so that it can't effect the brain, the heart or any other organ.

"This is the first successful placebo controlled test of a vaccine for cocaine."

Two years of treatment

The adverse events associated with the vaccine were mild to moderate with the most frequent complaint being hardening and tenderness at the injection site.

Dr Korsten said: "We think most people will need two years of treatment with the vaccine - bearing in mind there is an average six to eight years of abuse before they come for treatment.

"It's only at week eight that we get full levels of blocking antibodies.

"We have already tried the vaccine with a different carrier supplied by Merck Pharmaceuticals - this is based on the meningitis virus and it is provoking much better levels of antibodies.

"We are excited because of all the other drugs we can design antibody vaccines for.

"All the other drugs of addiction should work except alcohol because that molecule is too small to make an antibody to it."
.

http://news.bbc.co.uk/2/hi/health/8291681.stm


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Offlinesmurfyshmu
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Re: Cocaine vaccine may reduce 'use' [Re: motaman]
    #11192795 - 10/06/09 12:39 PM (8 years, 18 days ago)

So basically, you made it suck to do the drug. Thanks guys.


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Offlinejustablip
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Re: Cocaine vaccine may reduce 'use' [Re: smurfyshmu]
    #11192958 - 10/06/09 01:07 PM (8 years, 18 days ago)

yeah, but they probably don't give it to people unless they ask for it.


--------------------
[quote]Little angel, go away...
Come again some other day...
Devil has my ear today...
I'll never hear a word you say...
He Promised I would find a little solace and some peace of mind...
Whatever. just as long as I don't feel so desperate and ravenous.
I'm so Weak and powerless over you...
[/quote] -MJK


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Invisibledemon6fire
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Re: Cocaine vaccine may reduce 'use' [Re: justablip]
    #11192976 - 10/06/09 01:10 PM (8 years, 18 days ago)

Quote:

justablip said:
yeah, but they probably don't give it to people unless they ask for it.



Just wait.  If courts can order people to be chemically castrated, they surely can order people to get vaccinated 'against' cocaine.


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OfflineDragonChaser
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Re: Cocaine vaccine may reduce 'use' [Re: demon6fire]
    #11193406 - 10/06/09 02:27 PM (8 years, 18 days ago)

Quote:

demon6fire said:
Quote:

justablip said:
yeah, but they probably don't give it to people unless they ask for it.



Just wait.  If courts can order people to be chemically castrated, they surely can order people to get vaccinated 'against' cocaine.





I was just about to make a similar point.

Rehab used to be optional too... now its still optional, but your choice is "do rehab, or do time behind bars".  How long will it be before its "do rehab with vaccinations or do time behind bars".


--------------------
My name is Mud


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OfflineTwiztidsage
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Re: Cocaine vaccine may reduce 'use' [Re: DragonChaser]
    #11193536 - 10/06/09 02:46 PM (8 years, 18 days ago)

I think it is awesome.


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Offlineb2x
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Re: Cocaine vaccine may reduce 'use' [Re: Twiztidsage]
    #11193899 - 10/06/09 03:43 PM (8 years, 18 days ago)

This isn't a bad thing.  Cocaine is, based on almost a centuries worth of anecdotal and research derived evidence, insanely addictive.  And its not anything like cannabis either, where you could potentially smoke a whole pound in a sitting and still go to work the next day, cocaine can actually kill you.  Stop your heart cold.

At the point where addicts help create more addicts, and help ruin more lives, why wouldn't society want to curb this clear danger?  Less theft due to addicts needing a hit, less gang violence, fewer yearly drug related deaths, etc.

Drugs in society shouldn't be a big deal as long as said drug doesn't negatively impact society at large. 

Cannabis doesn't impact society at large in a negative way, I'd actually say it effects society positively.

Cocaine, on the other hand, definitely effects everything negatively.  The only legitimate use for cocaine is in medicine and even then there's only only one-two uses (as a local anasthetic in nasal surgery and more rarely in eye surgery - generally though synthetics work better so cocaine is used very rarely - too high a risk for cardiovascular toxicity [ie might fuck your heart up]).

I will certainly be much more upset if say they figured out something similar to 'vaccinate' the effects of psychotropics (THC, LSD, Psilocybin, etc).  But as far as cocaine goes, fuck it.  Its a shitty drug anyway.


--------------------
Orthodoxy is Unconsciousness
-G. Orwell

Man is born free, and he is everywhere in chains.  Those who think themselves the masters of others are indeed greater slaves than they.
-J. J. Rousseau

Resistance to tyrants is obedience to God.

The man who fears no truth has nothing to fear from lies.
-T. Jefferson


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OfflineMagick
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Re: Cocaine vaccine may reduce 'use' [Re: b2x]
    #11194527 - 10/06/09 05:25 PM (8 years, 18 days ago)

It doesn't matter. You're right cocaine is horribly addictive and is a widespread problem, but ultimately it is your choice whether to do it or not, and if we ever get to the point where people are forced to take a vaccine which will render the drug ineffective, well that's against so many human rights.

Humans chase highs - whether it be in heroin, pot, stimulants, mushrooms, sex rock & roll religion caffeine knowledge or anything else in between. A vaccine to remove the high of a drug is the worst thing imaginable -- it's a nightmare in fact!

(Ftw I do 'not' do coke)


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Offlinelearningtofly
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Re: Cocaine vaccine may reduce 'use' [Re: demon6fire]
    #11194548 - 10/06/09 05:27 PM (8 years, 18 days ago)

Quote:

demon6fire said:
Quote:

justablip said:
yeah, but they probably don't give it to people unless they ask for it.



Just wait.  If courts can order people to be chemically castrated, they surely can order people to get vaccinated 'against' cocaine.




the supreme court ruled that its unconstitutional to sterilize people if that's what you're referring to


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OfflineTwiztidsage
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Re: Cocaine vaccine may reduce 'use' [Re: b2x]
    #11195650 - 10/06/09 08:08 PM (8 years, 18 days ago)

Quote:

b2x said:
This isn't a bad thing.  Cocaine is, based on almost a centuries worth of anecdotal and research derived evidence, insanely addictive.  And its not anything like cannabis either, where you could potentially smoke a whole pound in a sitting and still go to work the next day, cocaine can actually kill you.  Stop your heart cold.

At the point where addicts help create more addicts, and help ruin more lives, why wouldn't society want to curb this clear danger?  Less theft due to addicts needing a hit, less gang violence, fewer yearly drug related deaths, etc.

Drugs in society shouldn't be a big deal as long as said drug doesn't negatively impact society at large. 

Cannabis doesn't impact society at large in a negative way, I'd actually say it effects society positively.

Cocaine, on the other hand, definitely effects everything negatively.  The only legitimate use for cocaine is in medicine and even then there's only only one-two uses (as a local anasthetic in nasal surgery and more rarely in eye surgery - generally though synthetics work better so cocaine is used very rarely - too high a risk for cardiovascular toxicity [ie might fuck your heart up]).

I will certainly be much more upset if say they figured out something similar to 'vaccinate' the effects of psychotropics (THC, LSD, Psilocybin, etc).  But as far as cocaine goes, fuck it.  Its a shitty drug anyway.




Genius.


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Offlinedurian_2008
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Re: Cocaine vaccine may reduce 'use' [Re: Twiztidsage]
    #11195981 - 10/06/09 09:01 PM (8 years, 18 days ago)

People are afraid of attenuated viruses, thimerosol, and adjuvants, in a vaccine made from a mild strain of flu.

Quote:

this is based on the meningitis virus




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Offlinedurian_2008
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Re: Cocaine vaccine may reduce 'use' [Re: durian_2008]
    #11196073 - 10/06/09 09:16 PM (8 years, 18 days ago)

Quote:

They don't destroy, they neutralize the cocaine and make it vulnerable to a cholinesterase enzyme which will then break it down.




Would taking cocaine result in cholinesterase depletion?

Quote:

A cholinesterase inhibitor (or "anticholinesterase") suppresses the action of the enzyme. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death (examples are some snake venoms, and the nerve gases sarin and VX).

http://en.wikipedia.org/wiki/Cholinesterase_enzyme





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Offlineblujay
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Re: Cocaine vaccine may reduce 'use' [Re: durian_2008]
    #11197659 - 10/07/09 01:10 AM (8 years, 18 days ago)

It's just like liver failure.

Yay! I used so much now I have to use twice as much!


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InvisibleDutchie3k
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Re: Cocaine vaccine may reduce 'use' [Re: blujay]
    #11201415 - 10/07/09 05:42 PM (8 years, 17 days ago)

For one, in my opinion cocaine is a pretty shitty ass drug experience, wholly unenjoyable for me.

However more importantly I've seen several people very, very dear to me sell their fucking souls to coke.  Any responsible drug user knows that addiction is not some monster lurking out there waiting to snatch you up against your will; it's more or less your own decision (informed or not...)

I wouldn't even consider denying someone a second chance for that reason alone though.  Anything *VOLUNTARY* that might allow an addict to overcome a long-standing addiction deserves a good deal of consideration, if you ask me.

The possible implications of something like this are pretty scary though.
Improvements upon the vaccine --> applied to other drugs --> made mandatory like disease vaccinations? *shudder*


--------------------
"The Edge... there is no honest way to explain it because the only people who really know where it is are the ones who have gone over.  The others - the living - are those who pushed their control as far as they felt they could handle it, and then pulled back, or slowed down, or did whatever they had to when it came time to choose between Now and Later"


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OfflineFastfirebird
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Re: Cocaine vaccine may reduce 'use' [Re: Dutchie3k]
    #11206138 - 10/08/09 09:07 AM (8 years, 16 days ago)

^ now that is SCARY.


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OfflineHumility
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Re: Cocaine vaccine may reduce 'use' [Re: motaman]
    #11206642 - 10/08/09 11:44 AM (8 years, 16 days ago)

Terence made audio recordings about this, about "immunizing" people against being able to experience the effects of specific chemicals.

This is a great tool for the free market, a terrible weapon in the hands of the evil.  I'd rather be shot with a gun than shot with one of their needles.  Either way, they gotta catch me first, and I run fast cause I don't shoot back :smile:.


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InvisibleSociety
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Re: Cocaine vaccine may reduce 'use' [Re: Humility]
    #11207448 - 10/08/09 02:08 PM (8 years, 16 days ago)

Stop being drug elitists.  There is nothing wrong with enjoying cocaine, even if you're addicted.  The government should simply not have the power to tell you that you cannot take a substance, be it LSD or cocaine.

Cocaine is not a social problem.  The drug war is a social problem.


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Offlinedurian_2008
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Re: Cocaine vaccine may reduce 'use' [Re: demon6fire]
    #11214561 - 10/09/09 01:01 PM (8 years, 15 days ago)

Quote:

demon6fire said:
Just wait.  If courts can order people to be chemically castrated, they surely can order people to get vaccinated 'against' cocaine.



This vaccine is also comparable to a castration (or a lobotomy), in that it robs you of a natural faculty, which allows to enjoy something.

Unlike the surgeries, though, vaccines are usually administered as a prophylaxis - in other words, to prevent a disease.

You were vaccinated against measles, whooping cough, etc., before you were allowed to enroll in school.

Proof of vaccination is required in many workplaces.

Could sober people be pressured to take the shot, in the name of prevention?

Did you know that rehabbers are already a popular hiring quota, because of tax incentives?


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