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Offlinedeadatdusk
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Mescaline and wellbutrin
    #11157205 - 09/30/09 01:26 PM (14 years, 4 months ago)

Does anyone know the potential drug interactions between mescaline and a DNRI like wellbutrin?  I know mescaline has an affinity for certain dopamine and norepinephrine receptors.  Wellbutrin being that it blocks reuptake on these receptors would it have a potentiating effect, diminished effect, no effect, or cause a serious adverse reaction?  Can anyone help with this?


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Offlinestarfirex
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Registered: 09/04/09
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Re: Mescaline and wellbutrin [Re: deadatdusk]
    #11157219 - 09/30/09 01:29 PM (14 years, 4 months ago)

I take Wellbutrin often.  I also take mescaline often, but I haven't had the chance to try together.  I don't think Mescaline has affinity for the dopamine and Nor receptors, it is listed solely as a 5-HT2a Serotonin Receptor Agonist.  So they should be ok.  But let me know......  By the way, I think Wellbutrin feels like crappy, weak MDMA.


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Offlinegrrr31
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Re: Mescaline and wellbutrin [Re: deadatdusk]
    #11157450 - 09/30/09 02:10 PM (14 years, 4 months ago)

Yu are correct about the dopamine issue. I have been seeking information on this topic too, on several different forums, and have not received an answer grounded in research or personal knowledge, though several people have kindly offered opinions, and speculations.  I would really like to know the answer to this question!!


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Offlinegrrr31
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Re: Mescaline and wellbutrin [Re: grrr31]
    #11157465 - 09/30/09 02:11 PM (14 years, 4 months ago)

Wiki says:


Wellbutrin, Zyban) is an atypical antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist.[2][3] Bupropion belongs to the chemical class of aminoketones and is similar in structure to the stimulant cathinone, to the anorectic diethylpropion, and to phenethylamines in general.


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