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ShroomDoom
Friend of the Medicine



Registered: 06/07/04
Posts: 4,435
Loc: A Psychedelic State
Last seen: 1 year, 8 months
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Does Mescaline have a similar toxicity profile to MDMA?
#9316123 - 11/26/08 10:54 AM (15 years, 2 months ago) |
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someone told me that:
"Mescaline is actually a close chemical relative to MDMA (it is trimethoxy-phenethylamine, and MDMA by that chemical nomenclature is 3,4-methoxy-phenethylamine). It also acts almost identically to MDMA, its only difference being that it is a specific 5-HT reuptake inhibitor, it targets 5-HT2A, specifically in cortical neurons (whereas MDMA non-specifically targets all 5-HT neurons).
Its toxicity profile is actually very similar to MDMA, except that it also posses some similar effects to potent harmaline (scopalamine, etc.) MAOIs .. which lead to irreversible ocular damage, and a few other things. The other problem is that if you take mescaline in the form of peyote cactus, you are also ingesting hundreds of the other alkaloids in peyote, some of which have similar activity to mescaline, some which have no activity at all, and some which have toxic activity when P-450 metabolized. So all in all, the toxic profile of mescaline is relatively similar to MDMA."
i think they are full of shit.
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wildchild68
lion in a coma



Registered: 11/19/07
Posts: 5,115
Last seen: 9 years, 9 months
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: ShroomDoom]
#9316147 - 11/26/08 11:00 AM (15 years, 2 months ago) |
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I definitely don't think so.
To my knowledge, it doesn't release heaps of serotonin like MDMA does.
Even though the two drugs are structurally similar, their mode of action is different.
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krypto2000
Unknown


Registered: 12/05/06
Posts: 11,579
Last seen: 4 years, 3 months
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: wildchild68]
#9316179 - 11/26/08 11:10 AM (15 years, 2 months ago) |
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Isn't MDMA an amphetamine, not a phenethylamine? 3,4-methylenedioxy-N-methylamphetamine.
Either way, I'm quite sure that's bs. I've never heard of mescaline being dangerous before. It does not release serotonin or deplete your reserves either way which is what causes the damage from mdma.
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Noteworthy
Sophyphile


Registered: 10/05/08
Posts: 5,599
Last seen: 11 years, 1 month
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: krypto2000]
#9316214 - 11/26/08 11:19 AM (15 years, 2 months ago) |
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amphetamine = alpha-methyl-phenethylamine
mescaline doesn't do any of that shit bro
slap that boy!
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starfirex
Cactus Hippy



Registered: 09/04/09
Posts: 635
Loc: New Mexico
Last seen: 8 years, 8 months
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: ShroomDoom]
#11074954 - 09/17/09 04:39 AM (14 years, 5 months ago) |
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Quote:
ShroomDoom said: someone told me that:
"Mescaline is actually a close chemical relative to MDMA (it is trimethoxy-phenethylamine, and MDMA by that chemical nomenclature is 3,4-methoxy-phenethylamine). It also acts almost identically to MDMA, its only difference being that it is a specific 5-HT reuptake inhibitor, it targets 5-HT2A, specifically in cortical neurons (whereas MDMA non-specifically targets all 5-HT neurons).
Its toxicity profile is actually very similar to MDMA, except that it also posses some similar effects to potent harmaline (scopalamine, etc.) MAOIs .. which lead to irreversible ocular damage, and a few other things. The other problem is that if you take mescaline in the form of peyote cactus, you are also ingesting hundreds of the other alkaloids in peyote, some of which have similar activity to mescaline, some which have no activity at all, and some which have toxic activity when P-450 metabolized. So all in all, the toxic profile of mescaline is relatively similar to MDMA."
i think they are full of shit.
A little bit of misinformation in this post. Mescaline (and LSD and Psilocybin/Psilocin) are 5-HT2a receptor AGONISTS. They bind to the receptor and one theory is that they cause hallucination by causing standing waves across the synapse. Kind of like the signal bounces back and forth across the nerve synapse. A 5-HT2a reuptake inhibitor will stop the psychedelic effects, i.e. Seroquel, an anti-psychotic and Trazodone, an anti-depressant and anti-anxiety drug are examples.
-------------------- If the neighbors complain 'cause the music is too loud, turn it up so you can't hear them bitch. ~ I'm blowing my mind....one ass-kicking trip at a time....
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The Centre
I am



Registered: 10/04/08
Posts: 1,746
Last seen: 2 years, 11 months
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: starfirex]
#11075296 - 09/17/09 08:19 AM (14 years, 5 months ago) |
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They are about as similar as psilocin is to DMT... (Infact, mush and DMT is MORE related than Mesc and MDMA...)
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thedudenj
Man of the Woods

Registered: 08/18/04
Posts: 14,684
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: The Centre]
#11075795 - 09/17/09 10:22 AM (14 years, 5 months ago) |
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maybe if you took them as much as a kandi kid took e their might be damage if you took E as occasionally as people take mescaline there wouldnt be a risk of damage either. i can say that taking every weekend cant be good for you. having taken p torch the past two weekends i gota say its better to space it out way more
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  "You all are just puppets... You have no heart...and cannot feel any pain..."" you may think thats pain you feel but you must have a heart to feel true pain and that pain wont be yours
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The Centre
I am



Registered: 10/04/08
Posts: 1,746
Last seen: 2 years, 11 months
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: The Centre]
#11076428 - 09/17/09 12:13 PM (14 years, 5 months ago) |
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Yea, and INGESTING that much cactus, impossible...
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thedudenj
Man of the Woods

Registered: 08/18/04
Posts: 14,684
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: The Centre]
#11076624 - 09/17/09 01:04 PM (14 years, 5 months ago) |
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Quote:
The Centre said: Yea, and INGESTING that much cactus, impossible...
?
its totally possible just not very likely specially if someone has access to crystal mesc. theres many a stupid raver that would take it more then once a week im sure for months
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  "You all are just puppets... You have no heart...and cannot feel any pain..."" you may think thats pain you feel but you must have a heart to feel true pain and that pain wont be yours
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tittysnacks74
Stranger

Registered: 06/05/09
Posts: 111
Last seen: 13 years, 21 days
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: ShroomDoom]
#11076669 - 09/17/09 01:11 PM (14 years, 5 months ago) |
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Quote:
ShroomDoom said:
i think they are full of shit.
ding ding ding! tell him what he's won...
The confidence the mescaline is not a harmful alkaloid. The dose required to produce harmful effects are pretty damn near impossible to ingest from natural sources.
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MacGruber
hehehehe

Registered: 06/22/09
Posts: 80
Last seen: 10 years, 4 months
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: tittysnacks74]
#11076813 - 09/17/09 01:37 PM (14 years, 5 months ago) |
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Yes. Both are hardly toxic at all. You would have to eat a crazy amount to do any harm.
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krypto2000
Unknown


Registered: 12/05/06
Posts: 11,579
Last seen: 4 years, 3 months
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: MacGruber]
#11076833 - 09/17/09 01:41 PM (14 years, 5 months ago) |
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Don't you have to eat only about 10x the average dose on both? Something like a gram of mdma and 10g of mescaline. That's very achievable.
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The Centre
I am



Registered: 10/04/08
Posts: 1,746
Last seen: 2 years, 11 months
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: thedudenj]
#11077371 - 09/17/09 02:59 PM (14 years, 5 months ago) |
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Quote:
thedudenj said:
Quote:
The Centre said: Yea, and INGESTING that much cactus, impossible...
?
its totally possible just not very likely specially if someone has access to crystal mesc. theres many a stupid raver that would take it more then once a week im sure for months
Once a week for months IMHO probably won't cause any harm. I'm talking once off lethal dose. I can bet there is many a Shaman who takes it once a week...
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ReoSpeedwagon153


Registered: 02/04/06
Posts: 2,098
Loc: Chetumal, Mexico
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Re: Does Mescaline have a similar toxicity profile to MDMA? [Re: The Centre]
#11077635 - 09/17/09 03:38 PM (14 years, 5 months ago) |
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There's a guy on the nexus who has been taking it every day for three weeks.
Says there is little to no tolerance.
-------------------- “I thought naming myself ‘ReoSpeedwagon153’ on a forum was a funny idea in 2006.”
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