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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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Prozac/SSRI after MDMA
    #11060972 -

I've only ever done MDMA once, in the form of white powder inside a capsule, and it was very pure (we had it tested.) After I came down, my friend gave me a Prozac to take. He explained to me why this was important but I don't remember why exactly - it has to do with reducing neurotoxicity right?

Well anyway, my question is - does it have to be Prozac, or can it be another SSRI such as Zoloft? I have some MDMA that I plan to do this weekend at a festival, but I'm not sure if I can get a hold of any Prozac. But I could get a hold of Zoloft or something else similar. Would this do the same thing that Prozac would, and be a good thing to take after the roll is over? Or does it have to Prozac, specifically?

I also take a magnesium supplement before hand to suppress the grinding. Is there anything else I should know about to take before or after the roll?

Sorry if these seem like dumb questions. I'm not that "E"ducated, yet.

Thanks in advance :smile:

Edited by SpikeTheSenses (09/14/09 10:16 PM)

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Re: MDMA and Prozac Question [Re: SpikeTheSenses]
    #11061063 -

I just take MDMA and have fun with it.  I never really do anything special for before/after/whathaveyou.  Just don't take it too often (or too much) and you're fine.

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Re: MDMA and Prozac Question [Re: FilthyAnalSex]
    #11061241 -

Yeah its not a necessary thing for you to take some Prozac after you roll.

Just go to sleep!


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WakaWaka

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Re: Prozac/SSRI after MDMA [Re: SpikeTheSenses]
    #11061254 -

Have never heard any benefit of taking ssri with combination of psychedelics. Im sure your "neurotoxicity" levels will be satisfactory.


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Who you jivin' with that cosmic debris?

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Re: Prozac/SSRI after MDMA [Re: Aleph1]
    #11061397 -

Interesting. Thanks for the responses. When I took the Prozac it seemed to help the next day; I didn't feel drained, or have a headache, or anything like that. The one time I tried a pressed E pill without any Prozac afterward I got a terrible stomach ache and migraine the next day and was feeling slightly depressed, but that may be because it turned out to be mostly DXM with only a bit of MDMA.

What kinds of things do you normally experience the day after a roll? Sadness, memory loss, headaches, stomach aches, etc, anything? I've read about potential things that can happen but have never heard anyone's personal experiences.

I guess it would be a good experiment to try it w/o the Prozac afterward to see how it affects me the next day. I would just hate for it to end in me feeling like shit, lol.

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Re: Prozac/SSRI after MDMA [Re: SpikeTheSenses]
    #11061448 -

Think its more of a placebo effect. Day after I roll I just recount how much of a pig I was night before with stupid smirk on my face.


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Who you jivin' with that cosmic debris?

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Re: Prozac/SSRI after MDMA [Re: Aleph1]
    #11061822 -

I found this on Erowid. But I'm not sure if it's saying that taking Prozac afterward is good or not. It seems so, but I can't understand half of this molecular jargon. Can anyone tell me what this means?

"Some people take SSRIs (selective serotonin reuptake inhibitors) several hours after taking MDMA in an attempt to reduce or block suspected neurotoxicity (brain cell damage).

The time course of damaging events in rats can be seen by administering SSRIs, such as fluoxetine and citalopram, after MDMA. Pretreatment with fluoxetine (Prozac) or citalopram (Celexa) has been shown to block the neurotoxicity of MDMA, probably by blocking interactions of MDMA with SERT. More interestingly, fluoxetine remains almost fully protective if given 3 or 4 hours after MDMA. By 4 hours, most of the MDMA-induced release of 5-HT and DA has already occurred and increases in extracellular free radicals and lipid peroxidation (the alteration of fat molecules by free radicals) can be measured. Nevertheless, the administration of fluoxetine at this point decreases subsequent extracellular oxidative stressand long-term 5-HT depletions. Fluoxetine will still be partially protective if given 6 hours after MDMA but has no protective effect 12 hours after administration. "
http://www.erowid.org/chemicals/mdma/mdma_neurotoxicity1.shtml#timecourse

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Re: Prozac/SSRI after MDMA [Re: SpikeTheSenses]
    #11061986 -

SpikeTheSenses said:
I found this on Erowid. But I'm not sure if it's saying that taking Prozac afterward is good or not. It seems so, but I can't understand half of this molecular jargon. Can anyone tell me what this means?

"Some people take SSRIs (selective serotonin reuptake inhibitors) several hours after taking MDMA in an attempt to reduce or block suspected neurotoxicity (brain cell damage).

The time course of damaging events in rats can be seen by administering SSRIs, such as fluoxetine and citalopram, after MDMA. Pretreatment with fluoxetine (Prozac) or citalopram (Celexa) has been shown to block the neurotoxicity of MDMA, probably by blocking interactions of MDMA with SERT. More interestingly, fluoxetine remains almost fully protective if given 3 or 4 hours after MDMA. By 4 hours, most of the MDMA-induced release of 5-HT and DA has already occurred and increases in extracellular free radicals and lipid peroxidation (the alteration of fat molecules by free radicals) can be measured. Nevertheless, the administration of fluoxetine at this point decreases subsequent extracellular oxidative stressand long-term 5-HT depletions. Fluoxetine will still be partially protective if given 6 hours after MDMA but has no protective effect 12 hours after administration. "
http://www.erowid.org/chemicals/mdma/mdma_neurotoxicity1.shtml#timecourse


Its basically saying that using Prozac has been shown to be neuro-protective if taken within 6 hours of MDMA wearing off. After 6 there is little benefit. AKA keep doing what your doing with the prozac (or other SSRIs), it seems to be beneficial.


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Erowid, the drug layman's bible.
:drugnerd::boobs::whack::eatingout::whack::boobs::drugnerd:

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Re: Prozac/SSRI after MDMA [Re: tokenpoke]
    #11061996 -

do not take a SSRI unless u have a chemical unbalance.me personaly i would never take a SSRI.


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:vaped::jointsmile::bongload::ganja::jah:im what u might call a "pothead":potleaf::getstoned::gethigh:

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Re: Prozac/SSRI after MDMA [Re: 420_psychonaut]
    #11062075 -

Stop taking the prescription. Cold turkey. You will feel amazing in 2 weeks.  I used to take celexa, but started forgetting my pill somedays and would get insane body/brain shocks, extremely similar to what I experiance on ANY hallucinogen when I am in total darkness. Sort of a electronic glitching buzz with a body tingle to match. 

Anyway, I decided to stop taking the celexa because I did not want to be on a prescription for years and years.  I suffered the ZAPS for about a week and a 1/2 until I got them no more.

Just get plenty of exercise in place of the prozac/SSRI. I reccomend dancing to some heavy fullon psytrance. GMS and Kindzadza are my medication now.


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Look behind you, do you see it?:unbelievable:

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Re: Prozac/SSRI after MDMA [Re: GreenMachine]
    #11062120 -

GreenMachine said:
Stop taking the prescription. Cold turkey. You will feel amazing in 2 weeks.  I used to take celexa, but started forgetting my pill somedays and would get insane body/brain shocks, extremely similar to what I experiance on ANY hallucinogen when I am in total darkness. Sort of a electronic glitching buzz with a body tingle to match. 

Anyway, I decided to stop taking the celexa because I did not want to be on a prescription for years and years.  I suffered the ZAPS for about a week and a 1/2 until I got them no more.

Just get plenty of exercise in place of the prozac/SSRI. I reccomend dancing to some heavy fullon psytrance. GMS and Kindzadza are my medication now.



Oh no, I don't take any SSRI's on a regular basis. I was just talking about taking them in the circumstance of taking MDMA, since from what I (kind of) understood, they protect the brain from neurotoxicity and make it so your serotonin levels get back to normal faster after taking MDMA. Normally it takes about a week (maybe longer?) for your brain to be back to it's normal state after taking MDMA, but I think taking an SSRI helps to make that time period shorter.

I was on Celexa for "stress-induced stomach aches" for a few months about a year ago (a complete bullshit diagnosis), and that shit fucked me up taking it everyday so I got off of it ASAP. I've only ever taken another SSRI the one time I did MDMA.

But by the way - it's really not safe to just stop taking an anti depressant cold turkey. You need to gradually decrease the dosage level by small increments every few days or weeks until you are completely done. I'm pretty sure that just quitting the medication abruptly can have potentially serious side effects.

Edited by SpikeTheSenses (09/15/09 02:32 AM)

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Re: Prozac/SSRI after MDMA [Re: SpikeTheSenses]
    #11062172 -

not too serious. Im still here and very much "sane". Feeling better than I did before I took medication thats for sure.:grin:


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Look behind you, do you see it?:unbelievable:

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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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