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InvisibleveggieM

Registered: 07/26/04
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FDA approves new ADHD drug
    #6602784 - 02/23/07 06:08 PM (14 years, 17 days ago)

February 23, 2007 - kotv.com
FDA Approves ADHD Drug; Company Says Abuse Less Likely

WASHINGTON (AP) _ A new amphetamine-based drug to treat attention deficit hyperactivity disorder won federal approval Friday. It's harder to abuse than older stimulants, the manufacturer says.

The Food and Drug Administration approved Vyvanse, also known as lisdexamfetamine, agency spokeswoman Susan Cruzan said. The drug is made by Shire PLC.

Shire hopes the drug will extend its lucrative ADHD franchise once its top-selling Adderall XR begins facing competition from lower-priced generic versions in 2009. Shire plans to move patients from the older to the newer drug at the time, company spokesman Matt Cabrey said this week.

Shire said it tried to limit the drug's potential for misuse. It tested the drug on adults with a history of abusing stimulants to assess its ``likeability.'' Results suggest the drug delays the onset and limits the intensity of amphetamine-like effects, the company said.

Vyvanse works by gradually releasing its active ingredient, d-amphetamine, after the drug has been swallowed and comes into contact with enzymes in the digestive tract.

Unless it's swallowed, Vyvanse remains inactive. Shire believes that will curtail its potential for abuse by users who snort or inject crushed pills.

Despite those measures, the Drug Enforcement Administration has proposed making Vyvanse a Schedule II drug, a class that includes cocaine, methadone, methamphetamine and other drugs with a high potential for abuse.

Other ADHD medicines, including Adderall and Ritalin, also are Schedule II drugs.

Vyvanse's label will bear a ``black-box'' warning, the government's strongest, Cruzan said. Details were not immediately available.

The label of Adderall XR bears a warning because of safety concerns related to amphetamine abuse as well as the risk of sudden death in patients with heart defects.

FDA approval of Vyvanse came the same week that the agency asked all manufacturers of ADHD drugs to warn patients and their parents of mental and heart problems associated with use of the medicines.

Britain's Shire said earlier this month it would spend roughly $2.6 billion to buy New River Pharmaceuticals Inc., the Radford, Va., company that originally developed Vyvanse.


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InvisibleBoom
just a tester
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Registered: 06/16/04
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Re: FDA approves new ADHD drug [Re: veggie]
    #6602840 - 02/23/07 06:21 PM (14 years, 17 days ago)

Nice, sounds like something that'd be great if you chewed it up a little


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Offline2FiNiTe
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Re: FDA approves new ADHD drug [Re: Boom]
    #6602937 - 02/23/07 06:52 PM (14 years, 17 days ago)

When you snort a pill it goes through your nasal passages into your throat and stomach (thats why u get a drip). making it inactive until it hits the stomach doesn't really accomplish much, you can chew or snort this. Probably better off chewing but Im sure if there is a coating you can take it off. Things like oxycontin are the same way, its potential for abuse is lessened because they put a coating on it that stops you from snorting it, but fortunately you can stick it under your tongue for a minutes or so and presto no more coating.


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"Ours is a world of nuclear giants and ethical infants. We know more about war that we know about peace, more about killing that we know about living."

General Omar N. Bradley


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OfflineViveka
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Re: FDA approves new ADHD drug [Re: 2FiNiTe]
    #6603484 - 02/23/07 09:00 PM (14 years, 17 days ago)

Quote:

Vyvanse works by gradually releasing its active ingredient, d-amphetamine, after the drug has been swallowed and comes into contact with enzymes in the digestive tract.

Unless it's swallowed, Vyvanse remains inactive. Shire believes that will curtail its potential for abuse by users who snort or inject crushed pills.




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InvisibleParanoidAndroid
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Registered: 03/10/05
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Re: FDA approves new ADHD drug [Re: veggie]
    #6603981 - 02/23/07 11:03 PM (14 years, 17 days ago)

When there is a will, there is a way.


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Every individual reacts differently to every chemical.
Know your Body - Know your Mind - Know your Substance - Know your Source.


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Invisiblefastfred
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Re: FDA approves new ADHD drug [Re: ParanoidAndroid]
    #6604823 - 02/24/07 07:10 AM (14 years, 16 days ago)

What about that new amphetamine patch they have? That's probably pretty hard to abuse...


-FF


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OfflineExplosiveMango
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Re: FDA approves new ADHD drug [Re: fastfred]
    #6604974 - 02/24/07 10:05 AM (14 years, 16 days ago)

shouldn't it be lisdexamphetamine and not lisdexamfetamine?


--------------------
Know your self.
Know your substance.
Know your source.

The most distorted perspective possible is the perspective that yours is not distorted.


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OfflineSchwip
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Re: FDA approves new ADHD drug [Re: ExplosiveMango]
    #6605543 - 02/24/07 02:46 PM (14 years, 16 days ago)

hmmm...wonder what stomach enzyme is used to break it down.....

bet a little soak in Hcl acid would free the amps of their binders :laugh:


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"MAN! You know there aint no such thing as left over crack!"



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InvisibleStroFun
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Registered: 07/11/06
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Re: FDA approves new ADHD drug [Re: Schwip]
    #6611669 - 02/26/07 08:47 AM (14 years, 14 days ago)

lol you guys are hilarious!


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Invisibleenlightened seed
Utopia is a state of mind
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Re: FDA approves new ADHD drug [Re: veggie]
    #6919415 - 05/15/07 01:20 PM (13 years, 9 months ago)

good thing the FDA approved it that must mean its safe!!! haha


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OfflineDrewwyann
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Re: FDA approves new ADHD drug [Re: enlightened seed]
    #6919527 - 05/15/07 01:49 PM (13 years, 9 months ago)

hahaha i thought that comment was funny. hooray laughter!


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OfflineQuake3
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Re: FDA approves new ADHD drug [Re: Drewwyann]
    #6919933 - 05/15/07 03:20 PM (13 years, 9 months ago)

So I guess sticking this up my ass is out of the question?


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InvisibleCloud9
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Re: FDA approves new ADHD drug [Re: Quake3]
    #6922818 - 05/16/07 02:31 AM (13 years, 9 months ago)

don't let the man put you down, stick whatever you want up your ass, that'll show em.


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InvisibleBanez
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Re: FDA approves new ADHD drug [Re: StroFun]
    #6922916 - 05/16/07 02:54 AM (13 years, 9 months ago)

thats what i thought when oxycontin was supposed to be a "less likely to be abused drug"


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InvisibleMrKite1
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Registered: 03/02/04
Posts: 1,384
Loc: AK
Re: FDA approves new ADHD drug [Re: Banez]
    #6925331 - 05/16/07 04:24 PM (13 years, 9 months ago)

I bet it still kicks ass. If you don't mind swallowing you're speed that is. After all not every abuser is after that initial rush amphetamines provide.
I love my 15mg Dexedrine spansules and I'll happily gobble them without defeating any time release mechanisms.
Besides, have a look at the below quote. *Makes a point of looking around for some Vyvanse caps or hitting the doc up for some*

Quote:

A 25 mg strength Vyvanse capsule is molecularly equivalent to 10 mg Dexedrine Spansules (both the aforementioned pharmaceuticals are about 7.425 mg dextroamphetamine). However, this molecular equivalence is not a bioequivalence ratio; as it turns out, the AUC for the aforementioned pharmaceuticals is equivalent, however, the peak exposure of dextroamphetamine in Vyvanse is about 50% higher than Dexedrine Spansules.




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When the going gets weird, the weird turn pro.


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Invisibleenlightened seed
Utopia is a state of mind
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Registered: 05/04/07
Posts: 2,117
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Re: FDA approves new ADHD drug [Re: MrKite1]
    #7340372 - 08/27/07 02:28 PM (13 years, 6 months ago)

A friend of mine who's prescribed Adderall XR was given a brochure with a coupon last time he went to the doc for a month (30 pills) worth of "Vyvanse" at the fantastic price of free 99! Going to have to check it out!!  :rockon:


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Offlinesmokescreen
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Re: FDA approves new ADHD drug [Re: ExplosiveMango]
    #10925647 - 08/24/09 12:29 PM (11 years, 6 months ago)

Quote:

ExplosiveMango said:
shouldn't it be lisdexamphetamine and not lisdexamfetamine?




They spell it that way so people don't see the amphetamine!  same goes for vicks inhailers!


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