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 Asante
low dose - high adventure
 
Registered: 02/06/02
Posts: 72,775
Loc: The Netherlands 
Last seen: 23 hours, 20 minutes
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 Re: Researchers work on cocaine vaccine  [Re: badchad]
#7831509 - 01/04/08 11:41 AM (13 years, 25 days ago) |
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Quote:
The obvious problem (which you mentioned) is addiction. Anything that produces euphoria is likely to have a high abuse liability because face it, why wouldn't you want to feel good all the time?
If there are no negative consequences to the drug, if it didn't lead to escalating use, comedowns and stuff, would addiction potential be that big of a concern?
It would be strictly psychological addiction, but without a comedown.
Instead what you would get is that neuroplasticity makes a slightly elevated mood the new norm, if you take it for a couple of months or so.
If the drug doesn't actually downregulate, your brain will become accustomed to being upregulated and over time define that as the new baseline state.
If your brain is used to episodes of  you will become more capable of feeling due to neuroplasticity. If you're accustomed to  however, your pathways will atrophy as your brain gears towards the state in exactly the same way. Short of neurosurgery perpetual isn't possible, but you sure can elevate the general feeling tone and experience your psychologic highs and lows from that elevated level.
If you can keep yourself happier somehow for a few years, your brain will be predisposed to making you feel happy. To a limited extent you can unlearn suffering or become very good at it.
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 badchad
Mad Scientist
Registered: 03/02/05
Posts: 13,029
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Re: Researchers work on cocaine vaccine [Re: Asante]
#7831577 - 01/04/08 12:05 PM (13 years, 25 days ago) |
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Quote:
Wiccan_Seeker said:
If there are no negative consequences to the drug, if it didn't lead to escalating use, comedowns and stuff, would addiction potential be that big of a concern?
No. But the difficulty in achieving all that is what makes it a pipe dream.
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...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did.
Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27.
...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.
Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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jasonpwnd
Learnin'
Registered: 08/10/07
Posts: 499
Loc: the flip side
Last seen: 10 years, 27 days
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Re: Researchers work on cocaine vaccine [Re: Asante]
#7831790 - 01/04/08 01:32 PM (13 years, 25 days ago) |
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Quote:
Wiccan_Seeker said:
If there are no negative consequences to the drug, if it didn't lead to escalating use, comedowns and stuff, would addiction potential be that big of a concern?
It would be strictly psychological addiction, but without a comedown.
Sounds like THC? Minus the escalating use, you'd have to use it a lot to get the constantly happy effects. Too bad you can build tolerance so easily though..
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Disclaimer: Everything I say is a lie intended to make my e-reputation more prestigious.
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Infrared
sleeping
Registered: 07/15/02
Posts: 12,988
Loc: Chicago, USA 
Last seen: 7 years, 2 months
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Re: Researchers work on cocaine vaccine [Re: Asante]
#7832624 - 01/04/08 05:40 PM (13 years, 25 days ago) |
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they put up a piece of paper at the methadone clinic i go to about this... apparently they are looking for volunteers for their clinical trial.. and not just cocaine addicts.. but pretty much addicts of all kinds
fuck this shit.. i hope it fails miserably.. or it kills everyone who takes it.
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When chemistry is outlawed.. Only outlaws have chemistry
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smokescreen
80's Transformer
Registered: 08/13/09
Posts: 827
Loc: north carolina
Last seen: 2 months, 7 days
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Re: Researchers work on cocaine vaccine [Re: Asante]
#10856061 - 08/13/09 10:37 PM (11 years, 5 months ago) |
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consider the implications of a psychedelic "vaccine". This shot or whatever form it may be in would have to cover alot of chemicals! Look at how many shulgin made.. then consider how many more possibilities are out there. Ok let's just figure it "blocks" LSD, psilocin, and MDMA - the three major ones. Psilocin is basically an orally active form of DMT, an indigenous and important neural transmitter involved in dreaming and who knows what else. You can kind of group LSD with that also, though nowhere near as close to DMT as shrooms. Think about the possibility of NEVER dreaming again... we're talking insanity. I don't know where MDMA chimes in here, but what if the vaccine somehow blocked the empathy emotion somewhat as a side-effect. What would a human be without that emotion. This is scary shit.
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 "Let's get together and feel alright"   
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MichiaelJackson
Cynic
Registered: 06/27/09
Posts: 175
Last seen: 11 years, 4 months
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Re: Researchers work on cocaine vaccine [Re: smokescreen]
#10856159 - 08/13/09 10:51 PM (11 years, 5 months ago) |
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Am I the only person who finds this shit scary as fucking hell?
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Wanna hear something depressing? One out of four Shroomerites wants to lock me in a government cage for using a substance they don't like.
Hard to believe, right? Read it for yourself:
http://www.shroomery.org/forums/showflat.php/Number/7874721#Post7874721
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Asante
low dose - high adventure
Registered: 02/06/02
Posts: 72,775
Loc: The Netherlands
Last seen: 23 hours, 20 minutes
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Re: Researchers work on cocaine vaccine [Re: CosmicFool]
#10857858 - 08/14/09 06:39 AM (11 years, 5 months ago) |
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Wait, wait, wait..
Somebody snorts 100mg of cocaine and every single cocaine molecule will be attacked by the immune system?
That sounds very dangerous to me in itself. The number of virus particles in the most severe flu is millions upon millions of times smaller than the number of cocaine molecules in 100mg of blow.
Directly or indirectly, this will cost lives.
--------------------
CDC COVID SELF-CHECKER COVID MAIN THREAD #2
Get 1 month's supplies in case of illness or calamity and help loved ones.
Strengthen your friendship ties - and exchange more favors and advice !
SEARCH ENGINE SUPPORT TICKETS STORE SPONSORS/VENDORS AMANI
personal Ethereum gifts w/o strings attached are very welcome at:
0x9e107aC7656A4b2Fc295Ef5157f06B8E313D7aFa Ethereum?
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