Home | Community | Message Board

Cannabis Seeds - Original Sensible Seeds
Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: North Spore Bulk Substrate, North Spore Mushroom Grow Kits & Cultivation Supplies   Left Coast Kratom Buy Kratom Extract, Kratom Powder For Sale   PhytoExtractum Kratom Powder for Sale, Maeng Da Thai Kratom Leaf Powder   Unfolding Nature Unfolding Nature: Being in the Implicate Order   Kraken Kratom Red Vein Kratom   Original Sensible Seeds Autoflowering Cannabis Seeds, Bulk Cannabis Seeds, Feminized Cannabis Seeds, High THC Strains, USA West Coast Strains

Jump to first unread post Pages: 1 | 2 | 3  [ show all ]
OfflineBruce6000
DaGoodDaBombDaBuddha


Registered: 07/05/08
Posts: 348
Last seen: 2 years, 2 months
Psilocybin Production, 1st & 2nd flushes
    #10846614 - 08/12/09 04:59 PM (12 years, 2 months ago)

Ok, Here's a question that's been nagging me for a while. This is pretty much all I know about the pharmacology of mushrooms, psilocybin breaks down into psilocin, the active compound responsible for the effects of the trip. Here's something I read, that in the 1st flush of the organism's lifecycle, psilocybin production peaks and psilocin is at its lowest levels, and in the 2nd flush, psilocin production peaks, and psilocybin is at its lowest levels. Pharmalogically speaking, do mushrooms from the 2nd flush differ to those from the 1st flush, in any way? Can anyone confirm this or elaborate please?


--------------------
Nothing can enslave you other than your unguided attention


Edited by Bruce6000 (08/12/09 05:01 PM)


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleCH HELL
Brain Sturgeon
Male User Gallery


Registered: 10/02/08
Posts: 6,610
Loc: mars Flag
Trusted Cultivator
Re: Psilocybin Production, 1st & 2nd flushes [Re: Bruce6000]
    #10846811 - 08/12/09 05:22 PM (12 years, 2 months ago)

You are way off on all points.  Cubes contain Psilocybin and Psilocin,  Psilocin oxidizes much faster/easier than Psilocybin.  With MS the actives will be different from shroom to shroom and flush to flush.
CH


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleSebastien
Don't look!
Male


Registered: 01/12/09
Posts: 759
Re: Psilocybin Production, 1st & 2nd flushes [Re: CH HELL]
    #10846906 - 08/12/09 05:32 PM (12 years, 2 months ago)

Quote:

CH HELL said:
You are way off on all points.  Cubes contain Psilocybin and Psilocin,  Psilocin oxidizes much faster/easier than Psilocybin.  With MS the actives will be different from shroom to shroom and flush to flush.
CH



Psilocin is the most visual-inducing out of the two, right? Is this why when mushrooms are eaten fresh, the visuals are often stronger than the same mushrooms dried?


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleCH HELL
Brain Sturgeon
Male User Gallery


Registered: 10/02/08
Posts: 6,610
Loc: mars Flag
Trusted Cultivator
Re: Psilocybin Production, 1st & 2nd flushes [Re: Sebastien]
    #10847011 - 08/12/09 05:50 PM (12 years, 2 months ago)

Quote:

Sebastien said:
Quote:

CH HELL said:
You are way off on all points.  Cubes contain Psilocybin and Psilocin,  Psilocin oxidizes much faster/easier than Psilocybin.  With MS the actives will be different from shroom to shroom and flush to flush.
CH



Psilocin is the most visual-inducing out of the two, right? Is this why when mushrooms are eaten fresh, the visuals are often stronger than the same mushrooms dried?





Yes cubes contain both psilocybin and psilocin.  Psilocin is more active but cubes only contain a small amount that is why cyan's are way more potent than cubes.  The drying process will destroy psilocin before the psilocybin,  but if dried properly should only lose a small amount.
CH


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleAlexP
 User Gallery


Registered: 06/04/09
Posts: 2,270
Loc: Europe
Re: Psilocybin Production, 1st & 2nd flushes [Re: Sebastien]
    #10847033 - 08/12/09 05:52 PM (12 years, 2 months ago)

Our organism breaks down Psilocybin to form Psilocin by dephosphorylation.


--------------------
"To feel today what one felt yesterday isn't to feel - it's to remember today what was felt yesterday, to be today's living corpse of what yesterday was lived and lost." Fernando Pessoa

"When one creates phantoms for oneself, one puts vampires into the world, and one must nourish these children of a voluntary nightmare with one's blood, one's life, one's intelligence, and one's reason, without ever satisfying them." Eliphas Levi

"The joy of life consists in the exercise of one's energies, continual growth, constant change, the enjoyment of every new experience. To stop means simply to die. The eternal mistake of mankind is to set up an attainable ideal." Aleister Crowley

"The Universe is an artistic catharsis." Artifex Infinitum


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleCH HELL
Brain Sturgeon
Male User Gallery


Registered: 10/02/08
Posts: 6,610
Loc: mars Flag
Trusted Cultivator
Re: Psilocybin Production, 1st & 2nd flushes [Re: AlexP]
    #10847106 - 08/12/09 06:03 PM (12 years, 2 months ago)

Quote:

AlexP said:
Our organism breaks down Psilocybin to form Psilocin by dephosphorylation.





Big words AlexP.  You may be correct I know what dephosphorylation is but it can only happen while the shroom is actually growing,  after you pick a shroom I would love to be able to convert all the psilocybin to psilocin but it doesn't work like that.
CH


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleSebastien
Don't look!
Male


Registered: 01/12/09
Posts: 759
Re: Psilocybin Production, 1st & 2nd flushes [Re: CH HELL]
    #10847122 - 08/12/09 06:05 PM (12 years, 2 months ago)

Quote:

CH HELL said:
Quote:

AlexP said:
Our organism breaks down Psilocybin to form Psilocin by dephosphorylation.





Big words AlexP.  You may be correct I know what dephosphorylation is but it can only happen while the shroom is actually growing,  after you pick a shroom I would love to be able to convert all the psilocybin to psilocin but it doesn't work like that.
CH



Doesn't it naturally occur during digestion? I am nearly positive I read so coming from a TC. I may very well be wrong.


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleCH HELL
Brain Sturgeon
Male User Gallery


Registered: 10/02/08
Posts: 6,610
Loc: mars Flag
Trusted Cultivator
Re: Psilocybin Production, 1st & 2nd flushes [Re: Sebastien]
    #10847139 - 08/12/09 06:09 PM (12 years, 2 months ago)

Quote:

Sebastien said:
Quote:

CH HELL said:
Quote:

AlexP said:
Our organism breaks down Psilocybin to form Psilocin by dephosphorylation.





Big words AlexP.  You may be correct I know what dephosphorylation is but it can only happen while the shroom is actually growing,  after you pick a shroom I would love to be able to convert all the psilocybin to psilocin but it doesn't work like that.
CH



Doesn't it naturally occur during digestion? I am nearly positive I read so coming from a TC. I may very well be wrong.





Please link that for me.


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleAlexP
 User Gallery


Registered: 06/04/09
Posts: 2,270
Loc: Europe
Re: Psilocybin Production, 1st & 2nd flushes [Re: Sebastien]
    #10847162 - 08/12/09 06:11 PM (12 years, 2 months ago)



--------------------
"To feel today what one felt yesterday isn't to feel - it's to remember today what was felt yesterday, to be today's living corpse of what yesterday was lived and lost." Fernando Pessoa

"When one creates phantoms for oneself, one puts vampires into the world, and one must nourish these children of a voluntary nightmare with one's blood, one's life, one's intelligence, and one's reason, without ever satisfying them." Eliphas Levi

"The joy of life consists in the exercise of one's energies, continual growth, constant change, the enjoyment of every new experience. To stop means simply to die. The eternal mistake of mankind is to set up an attainable ideal." Aleister Crowley

"The Universe is an artistic catharsis." Artifex Infinitum


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleSebastien
Don't look!
Male


Registered: 01/12/09
Posts: 759
Re: Psilocybin Production, 1st & 2nd flushes [Re: AlexP]
    #10847195 - 08/12/09 06:15 PM (12 years, 2 months ago)



Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlinecyb3rtr0n
searching for truth
Male User Gallery


Folding@home Statistics
Registered: 05/06/09
Posts: 1,794
Last seen: 3 years, 5 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: Bruce6000]
    #10847236 - 08/12/09 06:22 PM (12 years, 2 months ago)

OP.

you might find this article/study helpful..

VARIATION OF PSILOCYBIN AND PSILOCIN LEVELS WITH
REPEATED FLUSHES (HARVESTS) OF MATURE SPOROCARPS
OF PSILOCYBE CUBENSIS (EARLE) SINGER
By: JEREMY BIGWOOD and MICHAEL W. BEUG
http://archives.mycotopia.net/discus/messages/5/levels_and_flushes-141925.pdf

Quote:

Summary
Analysis of Psilocybe cubensis (Earle) Singer grown in controlled culture
showed that the level of psilocin was generally zero in the first (or sometimes
even the second) fruiting of the mushroom from a given culture and that the
level reached a maximum by the fourth flush. The level of psilocybin, which
was nearly always at least twice the level of psilocin, showed no upward or
downward trend as fruiting progressed, but was variable over a factor of four.
Samples obtained from outside sources had psilocybin levels varying by over
a factor of ten from one collection to the next.




Quote:

Conclusions
We found that the level of psilocybin and psilocin varies by over a
factor of four among various cultures of Psilocybe cubensis grown under
rigidly controlled conditions, while specimens from outside sources varied
tenfold. It is clear that entheogenic (Ruck et al., 1979) and recreational users
of this species have no way of predicting the amount of psilocybin and psilotin
they are ingesting with a given dry weight of the mushroom. It thus
seems likely that variations in the subjective experience will not only come
from the effects of set and setting but will also stem in very real measure
from large dosage differences.




Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlineelectrics
wave rider
Male User Gallery


Registered: 12/02/08
Posts: 1,609
Loc: In front of my Computer
Last seen: 2 years, 7 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: cyb3rtr0n]
    #10847288 - 08/12/09 06:32 PM (12 years, 2 months ago)

That supports what I've read that no psilocin is produced in the first flush only psilocybin which in later flushes psilocin is only active in the fresh mushroom oxidizes back into psilocybin during drying only to have our bodies turn it back into psilocin after ingesting...I could be way wrong it's been some time since these issues were of interest to me........e


--------------------
"Listen now I'm talking I've been here for weeks, waiting in this growing crowd staring at my feet, The world around me is Turning I'm just standing still, The time has come for changes do something or I will" Phish


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleCH HELL
Brain Sturgeon
Male User Gallery


Registered: 10/02/08
Posts: 6,610
Loc: mars Flag
Trusted Cultivator
Re: Psilocybin Production, 1st & 2nd flushes [Re: AlexP]
    #10847300 - 08/12/09 06:34 PM (12 years, 2 months ago)

Quote:

AlexP said:
http://www.erowid.org/plants/mushrooms/mushrooms_faq.shtml





:shrug: It doesn't say any thing about dephosphorylation after picking,  unless they think that MAOI's remove the phosphorous cell from psilocybin.
Any way they are two separate compounds only different by one cell,  if you came up with some thing to remove this cell and keep it stable then you will be on to some thing.
CH


Extras: Filter Print Post Remind Me! Notify Moderator Top
OfflineBruce6000
DaGoodDaBombDaBuddha


Registered: 07/05/08
Posts: 348
Last seen: 2 years, 2 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: CH HELL]
    #10847503 - 08/12/09 07:05 PM (12 years, 2 months ago)

Thanks for elaborating. My post was based on something that I had read and didn't know if there was any truth to it. Either way, thanks for clarifying.


--------------------
Nothing can enslave you other than your unguided attention


Extras: Filter Print Post Remind Me! Notify Moderator Top
OfflineBruce6000
DaGoodDaBombDaBuddha


Registered: 07/05/08
Posts: 348
Last seen: 2 years, 2 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: Sebastien]
    #10847527 - 08/12/09 07:09 PM (12 years, 2 months ago)

Quote:

Sebastien said:
Quote:

CH HELL said:
Quote:

AlexP said:
Our organism breaks down Psilocybin to form Psilocin by dephosphorylation.





Big words AlexP.  You may be correct I know what dephosphorylation is but it can only happen while the shroom is actually growing,  after you pick a shroom I would love to be able to convert all the psilocybin to psilocin but it doesn't work like that.
CH



Doesn't it naturally occur during digestion? I am nearly positive I read so coming from a TC. I may very well be wrong.




BTW- I've read the same thing, that digestion removes the phosphorous atoms from psilocybin turning it into psilocin.


--------------------
Nothing can enslave you other than your unguided attention


Edited by Bruce6000 (08/12/09 07:09 PM)


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleCH HELL
Brain Sturgeon
Male User Gallery


Registered: 10/02/08
Posts: 6,610
Loc: mars Flag
Trusted Cultivator
Re: Psilocybin Production, 1st & 2nd flushes [Re: Bruce6000]
    #10847574 - 08/12/09 07:15 PM (12 years, 2 months ago)

Quote:

Bruce6000 said:
Quote:

Sebastien said:
Quote:

CH HELL said:
Quote:

AlexP said:
Our organism breaks down Psilocybin to form Psilocin by dephosphorylation.





Big words AlexP.  You may be correct I know what dephosphorylation is but it can only happen while the shroom is actually growing,  after you pick a shroom I would love to be able to convert all the psilocybin to psilocin but it doesn't work like that.
CH



Doesn't it naturally occur during digestion? I am nearly positive I read so coming from a TC. I may very well be wrong.




BTW- I've read the same thing, that digestion removes the phosphorous atoms from psilocybin turning it into psilocin.




Please I need to read that.  I don't think it is possible,  if it was then psilocybin would be just as potent as psilocin.  I just want a link,  please.
CH


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleAlexP
 User Gallery


Registered: 06/04/09
Posts: 2,270
Loc: Europe
Re: Psilocybin Production, 1st & 2nd flushes [Re: CH HELL]
    #10847583 - 08/12/09 07:16 PM (12 years, 2 months ago)

Quote:

CH HELL said:
Quote:

AlexP said:
http://www.erowid.org/plants/mushrooms/mushrooms_faq.shtml





:shrug: It doesn't say any thing about dephosphorylation after picking,  unless they think that MAOI's remove the phosphorous cell from psilocybin.
Any way they are two separate compounds only different by one cell,  if you came up with some thing to remove this cell and keep it stable then you will be on to some thing.
CH




I was just saying what I read. They say that after ingesting the mushrooms, psilocybin looses its phosphorus cell and then becomes psilocin. My answer was to let Sebastien know what happens to psilocybin when it enters our organism as he said psilocin is the molecule which produces more visuals of the two.

Yes, you'd have to make it stable if you were to convert psilocybin to psilocin as psilocin breaks up so much easier.


--------------------
"To feel today what one felt yesterday isn't to feel - it's to remember today what was felt yesterday, to be today's living corpse of what yesterday was lived and lost." Fernando Pessoa

"When one creates phantoms for oneself, one puts vampires into the world, and one must nourish these children of a voluntary nightmare with one's blood, one's life, one's intelligence, and one's reason, without ever satisfying them." Eliphas Levi

"The joy of life consists in the exercise of one's energies, continual growth, constant change, the enjoyment of every new experience. To stop means simply to die. The eternal mistake of mankind is to set up an attainable ideal." Aleister Crowley

"The Universe is an artistic catharsis." Artifex Infinitum


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleAlexP
 User Gallery


Registered: 06/04/09
Posts: 2,270
Loc: Europe
Re: Psilocybin Production, 1st & 2nd flushes [Re: AlexP]
    #10847604 - 08/12/09 07:19 PM (12 years, 2 months ago)

CH Hell, if you look under the psilocybin picture, on the link I posted you'll find it. :smile:


--------------------
"To feel today what one felt yesterday isn't to feel - it's to remember today what was felt yesterday, to be today's living corpse of what yesterday was lived and lost." Fernando Pessoa

"When one creates phantoms for oneself, one puts vampires into the world, and one must nourish these children of a voluntary nightmare with one's blood, one's life, one's intelligence, and one's reason, without ever satisfying them." Eliphas Levi

"The joy of life consists in the exercise of one's energies, continual growth, constant change, the enjoyment of every new experience. To stop means simply to die. The eternal mistake of mankind is to set up an attainable ideal." Aleister Crowley

"The Universe is an artistic catharsis." Artifex Infinitum


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleCH HELL
Brain Sturgeon
Male User Gallery


Registered: 10/02/08
Posts: 6,610
Loc: mars Flag
Trusted Cultivator
Re: Psilocybin Production, 1st & 2nd flushes [Re: AlexP]
    #10847653 - 08/12/09 07:26 PM (12 years, 2 months ago)

Quote:

AlexP said:
CH Hell, if you look under the psilocybin picture, on the link I posted you'll find it. :smile:





Thanks Alex,  I guess I missed that.  It still doesn't make any rational sense.  Psilocin is 1.4 x stronger but if psilocybin breaks down during digestion in to psilocin then they should be the same,  right?


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleAlexP
 User Gallery


Registered: 06/04/09
Posts: 2,270
Loc: Europe
Re: Psilocybin Production, 1st & 2nd flushes [Re: CH HELL]
    #10847684 - 08/12/09 07:30 PM (12 years, 2 months ago)

By weight. Psilocin is 1.4 times stronger than psilocybin by weight. The psilocin molecule is as strong as the psilocybin's but weighs less.

Edit:

Quote:

Erowid: This is the case with psilocin, because each molecule of psilocin is lighter yet has the same effect as each molecule of psilocybin, it is said to be more potent.





Edited by AlexP (08/12/09 07:33 PM)


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlineparkernitefly
Jam Master
Male User Gallery


Registered: 07/10/09
Posts: 115
Loc: In the zone
Last seen: 1 year, 4 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: CH HELL]
    #10847821 - 08/12/09 07:49 PM (12 years, 2 months ago)

Quote:

CH HELL said:
Quote:

Sebastien said:
Quote:

CH HELL said:
Quote:

AlexP said:
Our organism breaks down Psilocybin to form Psilocin by dephosphorylation.





Big words AlexP.  You may be correct I know what dephosphorylation is but it can only happen while the shroom is actually growing,  after you pick a shroom I would love to be able to convert all the psilocybin to psilocin but it doesn't work like that.
CH



Doesn't it naturally occur during digestion? I am nearly positive I read so coming from a TC. I may very well be wrong.





Please link that for me.





Man all this preaching of BS and misinformation is making me sick.

It's fucking EVERYWHERE on this site!!!! Ridiculous!


--------------------
Formula: 0  :gethigh:


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleAlexP
 User Gallery


Registered: 06/04/09
Posts: 2,270
Loc: Europe
Re: Psilocybin Production, 1st & 2nd flushes [Re: parkernitefly]
    #10847861 - 08/12/09 07:55 PM (12 years, 2 months ago)

If you find misinformation on this site then you should leave. If you don't want to leave then shut up. If you still think it's all BS then you need to open your mind and learn. If you can't learn then... the end.


--------------------
"To feel today what one felt yesterday isn't to feel - it's to remember today what was felt yesterday, to be today's living corpse of what yesterday was lived and lost." Fernando Pessoa

"When one creates phantoms for oneself, one puts vampires into the world, and one must nourish these children of a voluntary nightmare with one's blood, one's life, one's intelligence, and one's reason, without ever satisfying them." Eliphas Levi

"The joy of life consists in the exercise of one's energies, continual growth, constant change, the enjoyment of every new experience. To stop means simply to die. The eternal mistake of mankind is to set up an attainable ideal." Aleister Crowley

"The Universe is an artistic catharsis." Artifex Infinitum


Extras: Filter Print Post Remind Me! Notify Moderator Top
Invisibleprismism
 User Gallery


Registered: 05/11/09
Posts: 5,568
Re: Psilocybin Production, 1st & 2nd flushes [Re: parkernitefly]
    #10847921 - 08/12/09 08:02 PM (12 years, 2 months ago)

Quote:

parkernitefly said:
Man all this preaching of BS and misinformation is making me sick.

It's fucking EVERYWHERE on this site!!!! Ridiculous!




this forum is for discussion. we are all trying to learn.


--------------------
ephemeral anomalous


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlineelectrics
wave rider
Male User Gallery


Registered: 12/02/08
Posts: 1,609
Loc: In front of my Computer
Last seen: 2 years, 7 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: prismism]
    #10848841 - 08/12/09 10:13 PM (12 years, 2 months ago)

Exactly!! we are all trying to learn..-parkernighfly- but I guess you already know it all..so why worry yourself with our misinformation and you're 31 posts.....e


--------------------
"Listen now I'm talking I've been here for weeks, waiting in this growing crowd staring at my feet, The world around me is Turning I'm just standing still, The time has come for changes do something or I will" Phish


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlineveda_sticks
Cultivator
Male User Gallery


Folding@home Statistics
Registered: 07/29/07
Posts: 14,191
Loc: UK Flag
Last seen: 1 year, 9 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: electrics]
    #10848879 - 08/12/09 10:16 PM (12 years, 2 months ago)

Quote:

Chemistry

Psilocybin (O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine) is a prodrug that is converted into the pharmacologically active compound psilocin in the body by dephosphorylation.[2] This chemical reaction takes place under strongly acidic conditions or enzymatically by phosphatases in the body. Psilocybin is a zwitterionic alkaloid that is soluble in water, moderately soluble in methanol and ethanol, and insoluble in most organic solvents.

Albert Hofmann, the well-known chemist who discovered and experimented with LSD, was the first to recognize the importance and chemical structure of the pure compounds psilocybin and psilocin. Hofmann was aided in this process by his willingness to ingest extracts isolated from Psilocybe.




nuf said


--------------------

PF TEK - writeup by EvilMushroom666
Lets Grow Mushrooms - RogerRabbit & RoadKills website with sample videos plus the full PF TEK video series. Alot of great information - BUY THE DVD
Cakes can and will pin! - So you think cakes suck for pins. Your wrong
Franks Simple Coir/Verm Tek
Franks Proper Pasturisation Tek
Franks Spawning To Bulk - Monotub
Professor Pinheads RTV Injection Port Tek
Foo Mans No Soak WBS Prep Tek


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlineveda_sticks
Cultivator
Male User Gallery


Folding@home Statistics
Registered: 07/29/07
Posts: 14,191
Loc: UK Flag
Last seen: 1 year, 9 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: veda_sticks]
    #10848931 - 08/12/09 10:25 PM (12 years, 2 months ago)

Quote:

Chemistry

Psilocin can be obtained by dephosphorylation of natural psilocybin under strongly acidic or under alkaline conditions (hydrolysis). Another synthetic route uses the Speeter-Anthony tryptamine synthesis starting from 4-hydroxyindole.

Psilocin is relatively unstable in solution due to its phenolic hydroxy (-OH) group. In the presence of oxygen it readily forms bluish and dark black degradation products. Similar products are also formed under acidic conditions in the presence of oxygen and Fe3+ ions (Keller's reagent).




--------------------

PF TEK - writeup by EvilMushroom666
Lets Grow Mushrooms - RogerRabbit & RoadKills website with sample videos plus the full PF TEK video series. Alot of great information - BUY THE DVD
Cakes can and will pin! - So you think cakes suck for pins. Your wrong
Franks Simple Coir/Verm Tek
Franks Proper Pasturisation Tek
Franks Spawning To Bulk - Monotub
Professor Pinheads RTV Injection Port Tek
Foo Mans No Soak WBS Prep Tek


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleCH HELL
Brain Sturgeon
Male User Gallery


Registered: 10/02/08
Posts: 6,610
Loc: mars Flag
Trusted Cultivator
Re: Psilocybin Production, 1st & 2nd flushes [Re: parkernitefly]
    #10848945 - 08/12/09 10:27 PM (12 years, 2 months ago)

Quote:

parkernitefly said:
[quote

Man all this preaching of BS and misinformation is making me sick.

It's fucking EVERYWHERE on this site!!!! Ridiculous!





Well genius correct us then,  making BS comments doesn't help anyone and makes you look like an ass!


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlinetelekid
very gnar

Registered: 01/24/09
Posts: 342
Last seen: 8 years, 7 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: veda_sticks]
    #10848946 - 08/12/09 10:28 PM (12 years, 2 months ago)

also worthy of posting is Shulgin's words from Tihkal:


"There are two generalizations implicit here, one of which I am quite at peace with, but the other is both complex and disturbing. The OK item is the casual equation between the hydroxy compound psilocin, the acetate ester, and the phosphate ester, psilocybin. As I had discussed in the CZ-74 to CEY-19 entries in 4-HO-DET, there is no proof that the ester goes to the indolol metabolically, but it is a good guess, and there have been no demonstrated differences in their pharmacology. Ditto here, with psilocin and psilocybin. I have explored both of them as pure chemicals, and I find them completely interchangeable as to their pharmacological properties."

when in doubt, turn to Shulgin.


--------------------


my easy lids


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlinetelekid
very gnar

Registered: 01/24/09
Posts: 342
Last seen: 8 years, 7 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: telekid]
    #10849046 - 08/12/09 10:44 PM (12 years, 2 months ago)

also:



--------------------


my easy lids


Edited by telekid (08/12/09 10:46 PM)


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlineveda_sticks
Cultivator
Male User Gallery


Folding@home Statistics
Registered: 07/29/07
Posts: 14,191
Loc: UK Flag
Last seen: 1 year, 9 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: telekid]
    #10849163 - 08/12/09 11:03 PM (12 years, 2 months ago)

that was an awesome vid, id like to see more talks by him


--------------------

PF TEK - writeup by EvilMushroom666
Lets Grow Mushrooms - RogerRabbit & RoadKills website with sample videos plus the full PF TEK video series. Alot of great information - BUY THE DVD
Cakes can and will pin! - So you think cakes suck for pins. Your wrong
Franks Simple Coir/Verm Tek
Franks Proper Pasturisation Tek
Franks Spawning To Bulk - Monotub
Professor Pinheads RTV Injection Port Tek
Foo Mans No Soak WBS Prep Tek


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleSebastien
Don't look!
Male


Registered: 01/12/09
Posts: 759
Re: Psilocybin Production, 1st & 2nd flushes [Re: veda_sticks]
    #10849403 - 08/12/09 11:51 PM (12 years, 2 months ago)

Basically, parkernitefly just got told. Parkernitely, clearly, you assume that anything you are unaware of is false...


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleTacoHerder
Bluedavenger
Male User Gallery


Registered: 06/10/09
Posts: 10,107
Re: Psilocybin Production, 1st & 2nd flushes [Re: Sebastien]
    #10849452 - 08/13/09 12:00 AM (12 years, 2 months ago)

thta vid was the shit. i would love to hang out w/ that guy in his lab. Maybe smoke some bud with him too...


--------------------
TO ALL CULTIVATORS, EVERYTHING YOU NEED TO KNOW http://www.shroomery.org/forums/showflat.php/Number/10899385
We need more member like mycochef, he is truly a kind giving person. Just ask Noobie, mycochef hooked him up big time!
Fastest Cultivation WINNER!!!! NoOneKnowsHowToAct won it twice, must be doing something right:super:

Shoot me a pm if you would like a powerful custom laser built. :smile: 4th pic is a 1.3W 445nm laser burning thru some plastic makeup containers. Yes I was wearing proper safety goggles, otherwise I would be blind right now.


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleTacoHerder
Bluedavenger
Male User Gallery


Registered: 06/10/09
Posts: 10,107
Re: Psilocybin Production, 1st & 2nd flushes [Re: TacoHerder]
    #10849456 - 08/13/09 12:01 AM (12 years, 2 months ago)

ok no more needs to be said, everyone is wrong sometimes. Lets all watch our manners next time.


--------------------
TO ALL CULTIVATORS, EVERYTHING YOU NEED TO KNOW http://www.shroomery.org/forums/showflat.php/Number/10899385
We need more member like mycochef, he is truly a kind giving person. Just ask Noobie, mycochef hooked him up big time!
Fastest Cultivation WINNER!!!! NoOneKnowsHowToAct won it twice, must be doing something right:super:

Shoot me a pm if you would like a powerful custom laser built. :smile: 4th pic is a 1.3W 445nm laser burning thru some plastic makeup containers. Yes I was wearing proper safety goggles, otherwise I would be blind right now.


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlineveda_sticks
Cultivator
Male User Gallery


Folding@home Statistics
Registered: 07/29/07
Posts: 14,191
Loc: UK Flag
Last seen: 1 year, 9 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: TacoHerder]
    #10849458 - 08/13/09 12:01 AM (12 years, 2 months ago)

Quote:

TacoHerder said:
thta vid was the shit. i would love to hang out w/ that guy in his lab. Maybe smoke some bud with him too...




screw the weed, im sure he could whip up some very interesting chemicals to try


--------------------

PF TEK - writeup by EvilMushroom666
Lets Grow Mushrooms - RogerRabbit & RoadKills website with sample videos plus the full PF TEK video series. Alot of great information - BUY THE DVD
Cakes can and will pin! - So you think cakes suck for pins. Your wrong
Franks Simple Coir/Verm Tek
Franks Proper Pasturisation Tek
Franks Spawning To Bulk - Monotub
Professor Pinheads RTV Injection Port Tek
Foo Mans No Soak WBS Prep Tek


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleTacoHerder
Bluedavenger
Male User Gallery


Registered: 06/10/09
Posts: 10,107
Re: Psilocybin Production, 1st & 2nd flushes [Re: veda_sticks]
    #10849504 - 08/13/09 12:07 AM (12 years, 2 months ago)

this is true, or just mix the THC w/ Psilocin. that would be some good weed to smoke. get some good tasting smoke and a nice kick afterwards...


--------------------
TO ALL CULTIVATORS, EVERYTHING YOU NEED TO KNOW http://www.shroomery.org/forums/showflat.php/Number/10899385
We need more member like mycochef, he is truly a kind giving person. Just ask Noobie, mycochef hooked him up big time!
Fastest Cultivation WINNER!!!! NoOneKnowsHowToAct won it twice, must be doing something right:super:

Shoot me a pm if you would like a powerful custom laser built. :smile: 4th pic is a 1.3W 445nm laser burning thru some plastic makeup containers. Yes I was wearing proper safety goggles, otherwise I would be blind right now.


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlinetelekid
very gnar

Registered: 01/24/09
Posts: 342
Last seen: 8 years, 7 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: TacoHerder]
    #10849582 - 08/13/09 12:20 AM (12 years, 2 months ago)

or, as he describes in one of his books- hypothetically you could squeeze citrus juice on to certain lichens and create your own THC.


--------------------


my easy lids


Extras: Filter Print Post Remind Me! Notify Moderator Top
InvisibleTacoHerder
Bluedavenger
Male User Gallery


Registered: 06/10/09
Posts: 10,107
Re: Psilocybin Production, 1st & 2nd flushes [Re: telekid]
    #10849597 - 08/13/09 12:23 AM (12 years, 2 months ago)

i wish i used more then 10% of my brain like him...


--------------------
TO ALL CULTIVATORS, EVERYTHING YOU NEED TO KNOW http://www.shroomery.org/forums/showflat.php/Number/10899385
We need more member like mycochef, he is truly a kind giving person. Just ask Noobie, mycochef hooked him up big time!
Fastest Cultivation WINNER!!!! NoOneKnowsHowToAct won it twice, must be doing something right:super:

Shoot me a pm if you would like a powerful custom laser built. :smile: 4th pic is a 1.3W 445nm laser burning thru some plastic makeup containers. Yes I was wearing proper safety goggles, otherwise I would be blind right now.


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlinetelekid
very gnar

Registered: 01/24/09
Posts: 342
Last seen: 8 years, 7 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: TacoHerder]
    #10849626 - 08/13/09 12:30 AM (12 years, 2 months ago)

yeah, the man is a genius and a saint. truly paving the way for mental exploration and chemical innovation. speaking of which, i'm sure most of the community has seen this mushroom related article from him. sorry to hijack this thread but this too is very relevant on the capabilities and science of how mushrooms form (completely customizable) compounds. Brilliant.


Check it!


--------------------


my easy lids


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlineveda_sticks
Cultivator
Male User Gallery


Folding@home Statistics
Registered: 07/29/07
Posts: 14,191
Loc: UK Flag
Last seen: 1 year, 9 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: telekid]
    #10849686 - 08/13/09 12:40 AM (12 years, 2 months ago)

Quote:

4-Hydroxy-5-methoxy-N,N-dimethyltryptamine, Psilocybe mushrooms, Psilocin
Dear Dr. Shulgin:

I have been puzzled, why this compound (4-HO-5-methoxy-N,N-dimethyltryptamine) wasn't included in TIHKAL -- for me it looks very appealing. Have you by the way, ever looked into cathinone (beta-keto-amphetamine) analogues of some of the psychedelic amphetamines (DOB, TMA-2, etc.) The MDMA-analogue (Methylone) is active indeed, do you think the 2,4-5-substitution pattern could be applied onto the CATs?

_Anon_

Dear _Anon_,

I totally agree with you.

4-Hydroxy-5-methoxy-N,N-dimethyltryptamine would be a fascinating compound to explore. The reason it's not in TIKHAL is that it is virtually unknown. The only report of it in the chemical literature was a paper published by Marc Julia's group at the Pasteur Institute in 1965. They reported the synthesis and physical properties of the compound but to my knowledge it has never been explored in any way. The synthesis is quite a frightening thing. It starts with ortho-vanillin and takes approximately 10 steps to get to the 4,5-HO-MeO-DMT. I'm not surprised that no one has pursued the compound.

However there is a very interesting study that took place in Leipzig about 15 years ago. Jochen Gartz, a mushroom explorer whom I know quite well, has done some fascinating studies with Psilocybe species by raising them on solid media containing strange tryptamines that are alien to the mushroom. Apparently the enzymes that are responsible for the 4-hydroxy group of psilocin are indifferent to what it is they choose to 4-hydroxylate. He has taken things like DPT or DIPT and put them in the growth media and the fruiting bodies that came out contain 4-hydroxy-DPT or 4-hydroxy-DIPT instead of psilocin. In fact, he has a patent on the process. These active compounds are made by the mushroom so they really are natural and yet they never have been observed in nature. I'll give you even odds that if you put spores of a psilocybe species on cow droppings loaded with 5-MeO-DMT you would come out with mushrooms containing 4,5-HO-MeO-DMT. This way you avoid a 10 step synthesis by growing a psychoactive mushroom that contains no illegal drug.

Your idea of making analogues of the psychoactive amphetamines with the carbonyl that is characteristic of CAT would probably be a disappointment. Cathinone itself is rather unstable because there is a primary amine and a ketone in the same molecule. It will tend to dimerize and become inactive. In the example of METHYLONE (as with methcathinone) the amine is a secondary amine and the compound is quite stable. But all of the psychoactive amphetamines (except for MDMA) are primary amines.





very interesting,


--------------------

PF TEK - writeup by EvilMushroom666
Lets Grow Mushrooms - RogerRabbit & RoadKills website with sample videos plus the full PF TEK video series. Alot of great information - BUY THE DVD
Cakes can and will pin! - So you think cakes suck for pins. Your wrong
Franks Simple Coir/Verm Tek
Franks Proper Pasturisation Tek
Franks Spawning To Bulk - Monotub
Professor Pinheads RTV Injection Port Tek
Foo Mans No Soak WBS Prep Tek


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlinetelekid
very gnar

Registered: 01/24/09
Posts: 342
Last seen: 8 years, 7 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: veda_sticks]
    #10849885 - 08/13/09 01:15 AM (12 years, 2 months ago)

yeah its something to think about. 5-meo-dmt is still unscheduled in the US and many other places. one could potentially do an A/B extraction on say, yopo, or virola, and mix the resulting goodies with the growth medium, OR perhaps just use the shredded plant matter as part of the substrate itself. I have to wonder how that would work, being that the places where 5-meo-dmt occur naturally typically have large amounts of DMT also (which would just 4-hydroxylate into psilocin), and harmala alkaloids, which could make things very intense if they made their way into the mushrooms too.


--------------------


my easy lids


Extras: Filter Print Post Remind Me! Notify Moderator Top
Offlineelectrics
wave rider
Male User Gallery


Registered: 12/02/08
Posts: 1,609
Loc: In front of my Computer
Last seen: 2 years, 7 months
Re: Psilocybin Production, 1st & 2nd flushes [Re: telekid]
    #10851207 - 08/13/09 09:27 AM (12 years, 2 months ago)

Shulgin is the shit!!! Man would I love to know how much he knows the man is beyond genius!! hopefully someday I will have the opportunity to meet such a man as Shulgin or even Shulgin himself!!....e


--------------------
"Listen now I'm talking I've been here for weeks, waiting in this growing crowd staring at my feet, The world around me is Turning I'm just standing still, The time has come for changes do something or I will" Phish


Extras: Filter Print Post Remind Me! Notify Moderator Top
Jump to top Pages: 1 | 2 | 3  [ show all ]

Shop: North Spore Bulk Substrate, North Spore Mushroom Grow Kits & Cultivation Supplies   Left Coast Kratom Buy Kratom Extract, Kratom Powder For Sale   PhytoExtractum Kratom Powder for Sale, Maeng Da Thai Kratom Leaf Powder   Unfolding Nature Unfolding Nature: Being in the Implicate Order   Kraken Kratom Red Vein Kratom   Original Sensible Seeds Autoflowering Cannabis Seeds, Bulk Cannabis Seeds, Feminized Cannabis Seeds, High THC Strains, USA West Coast Strains


Similar ThreadsPosterViewsRepliesLast post
* How Do I Case for 2nd Flush?? resin 2,728 6 10/22/13 03:08 AM
by Pestile
* 2nd. flush on casing? knurd 2,225 5 11/26/05 01:42 PM
by Oatman2000
* Need tips on the 2nd flush. Ughh, beady little pin Northernsoul 3,095 1 03/10/02 06:31 AM
by Glacius
* preparation for 2nd flush
shirley knott
5,167 13 12/09/02 04:19 PM
by shirley knott
* just harvested 2nd flush blkrain 1,604 4 02/05/03 02:05 PM
by SixCee
* 2nd flush cakes look different? wigbinner 2,607 3 07/18/01 02:22 PM
by J_Twista
* 2nd Flush Probs NugDumper 1,885 2 08/08/01 11:40 PM
by MattyB
* How do I get good 2nd flushes? Northernsoul 3,446 2 12/17/02 03:19 PM
by Northernsoul

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: Shroomism, george castanza, RogerRabbit, FooMan, mushboy, fahtster, LogicaL Chaos, 13shrooms, stonesun, wildernessjunkie, cronicr, Pastywhyte, bodhisatta
2,339 topic views. 45 members, 264 guests and 44 web crawlers are browsing this forum.
[ Print Topic | ]
Search this thread:

Copyright 1997-2021 Mind Media. Some rights reserved.

Generated in 0.058 seconds spending 0.012 seconds on 16 queries.