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Offlinedrenaline
shroomitist

Registered: 10/06/02
Posts: 81
Loc: A Moon of Jupiter
Last seen: 12 years, 4 months
Question for any biochemists out there...
    #1015772 - 11/02/02 02:21 PM (14 years, 1 month ago)

Does anyone know what the metabolic pathways are that produce psilocybin? With this knowledge, it might be possible to include certain additives in the substrate that would greatly increase potency.


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OfflineStS
treetoker
Male User Gallery

Registered: 08/01/00
Posts: 1,821
Loc: Earth
Last seen: 6 years, 7 months
Re: Question for any biochemists out there... [Re: drenaline]
    #1015793 - 11/02/02 02:31 PM (14 years, 1 month ago)

This really should have been posted in Advanced Cultivation. If you interested in something like this, check out THIS document in the Grow/Find section.


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"You took too much, man....too much, too much!"


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OfflineTheta
TranscendentalExplorer

Registered: 10/29/02
Posts: 352
Last seen: 10 years, 11 months
Re: Question for any biochemists out there... [Re: drenaline]
    #1015997 - 11/02/02 04:17 PM (14 years, 1 month ago)

In reply to:

Does anyone know what the metabolic pathways are that produce psilocybin? With this knowledge, it might be possible to include certain additives in the substrate that would greatly increase potency.



I've seen several accounts of the tryptamine inclusion in substrate increasing psilocybin content in the mushroom.

In organisms, tryptamine is formed by the decarboxylation (removal of carboxyl group) of l-tryptophan. In the shroom, I believe that tryptamine is then the bio-precursor of psilocybin. The specific synthetic pathways through which this occurs I am unfamiliar with.

Perhaps l-tryptophan supplementation would be something to consider for experimentation?


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InvisibleTinMan
Stranger

Registered: 10/01/02
Posts: 2,956
Loc: Russia
Re: Question for any biochemists out there... [Re: Theta]
    #1016011 - 11/02/02 04:25 PM (14 years, 1 month ago)

Yes... there is a text on this site that deals with "doping" mushrooms in order to increase their potency. Also, this is more along the lines of organic chemistry, but it does deal w/ biological chemistry...


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Offlineshroomerman
dopaminecatalyst

Registered: 09/16/02
Posts: 397
Loc: florida
Last seen: 13 years, 9 months
Re: Question for any biochemists out there... [Re: TinMan]
    #1016069 - 11/02/02 04:55 PM (14 years, 1 month ago)

So do they sell Tryptamine HCL at Lowes or Home Depot?


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"Someone please help me stop laughing!!!"


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Offlineellisdee625
enthusiast
Registered: 03/28/02
Posts: 271
Last seen: 13 years, 11 months
Re: Question for any biochemists out there... [Re: shroomerman]
    #1016121 - 11/02/02 05:26 PM (14 years, 1 month ago)

they sell it at health food stores. it has been discontinued, but everyone around here still has it.


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Have a smurfy day!!!


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Offlinedrenaline
shroomitist

Registered: 10/06/02
Posts: 81
Loc: A Moon of Jupiter
Last seen: 12 years, 4 months
Re: Question for any biochemists out there... [Re: Theta]
    #1016129 - 11/02/02 05:31 PM (14 years, 1 month ago)

The link that STS gave is very informative on this topic...It's an interesting prospect.


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InvisibleSixTango
Mycota

Registered: 01/21/02
Posts: 1,996
Loc: A little North of Paradis...
Re: Question for any biochemists out there... [Re: drenaline]
    #1016140 - 11/02/02 05:37 PM (14 years, 1 month ago)

In no way is the raccoon one of them biochem - whatchamacallits, BUT;

As we all know ~~ Psilocybin and its dephosphorylated cousin, psilocin, are the principal active constituents of the entheogenic Psilocybes. They are indole derivatives whose biosynthetic precursor is the amino acid L-tryptophan

Synthetic routes to psilocybin and psilocin analogs, 4-phosphoryloxy-N,N-diethyltryptamine (the diethyl analog of psilocybin) and 4-hydroxy-N,N-diethyltryptamine (the diethyl analog of psilocin).



Molecular structure of amino acid L-tryptophan.Known chemically as 2-amino-3-indolyl-propanoic acid.

:grin:
6T  :tongue: 


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~whiskey river rafting, hot tubbing, dirty dancing & spending money on - wild women - having fun & just gonna waste the rest~


Edited by SixTango (11/02/02 06:02 PM)


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Offlinedrenaline
shroomitist

Registered: 10/06/02
Posts: 81
Loc: A Moon of Jupiter
Last seen: 12 years, 4 months
Re: Question for any biochemists out there... [Re: SixTango]
    #1016296 - 11/02/02 06:45 PM (14 years, 1 month ago)

The Racoon is pretty smart for an old feller


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InvisibleTinMan
Stranger

Registered: 10/01/02
Posts: 2,956
Loc: Russia
Re: Question for any biochemists out there... [Re: drenaline]
    #1016343 - 11/02/02 07:01 PM (14 years, 1 month ago)

Hes pretty smart for an old raccoon...


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InvisibleSixTango
Mycota

Registered: 01/21/02
Posts: 1,996
Loc: A little North of Paradis...
Re: Question for any biochemists out there... [Re: drenaline]
    #1016345 - 11/02/02 07:02 PM (14 years, 1 month ago)

Thanx. Q........."old" in relationship to what? 6T


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~whiskey river rafting, hot tubbing, dirty dancing & spending money on - wild women - having fun & just gonna waste the rest~


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InvisibleAlkaloids
3,4,5-trimethoxyphenethylamine
Male

Registered: 11/16/98
Posts: 743
Loc: pubis mons
Re: Question for any biochemists out there... [Re: drenaline]
    #1016368 - 11/02/02 07:11 PM (14 years, 1 month ago)

I'll see if I can find some references..
I do know that Ps species do have an enzyme that selectively adds a -OH (hydroxy group) to the 4 position on the benzene ring. Actually i think it is some kind of oxidoreductase, but ya didn't hear that from me, cause I didn't tell ya. ha ha no biochemist. just somebody who likes to read more than sniff paint.


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InvisibleSixTango
Mycota

Registered: 01/21/02
Posts: 1,996
Loc: A little North of Paradis...
Re: Question for any biochemists out there... [Re: Alkaloids]
    #1016414 - 11/02/02 07:46 PM (14 years, 1 month ago)

Fungi can only absorb small molecules through their walls. Thus, they find and absorb organic molecules appropriate to their needs, either immediately or following some form of enzymic alteration outside the thallus. The small molecules are then absorbed, used directly or reconstituted into organic molecules within the cell.

Because of the huge range of potential food sources, fungi have evolved enzymes suitable for the environments in which they are usually found. The range of enzymes, though wide in may species, is not sufficient for survival in all environments.

Fungi excrete a complex array of related enzymes for digestion. The enzymes tend to be present in multiple forms, based on a single genetic sequence, and include a range of isoenzymes, which arise from different genetic sequences.

The molecules absorbed through the plasmamembrane tend to be smaller than 5,000 Da, so only simple sugars, amino acids, fatty acids and other small molecules can be taken up following digestion. The molecules are taken up in solution.

6T  :tongue:
 


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~whiskey river rafting, hot tubbing, dirty dancing & spending money on - wild women - having fun & just gonna waste the rest~


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Offlineviscid
dikaryon

Registered: 09/23/02
Posts: 731
Loc: the mycological center of...
Last seen: 9 years, 11 months
Re: Question for any biochemists out there... [Re: ellisdee625]
    #1016751 - 11/02/02 10:27 PM (14 years, 1 month ago)

they really sold tryptamine hcl in stores?
not tryptophan?
what?


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