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Offlineasdfzapine
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Registered: 03/12/09
Posts: 6
Last seen: 13 years, 10 months
mixing shrooms with clozapine
    #9961229 - 03/12/09 09:15 PM (15 years, 20 days ago)

Ive researched about taking shrooms while in treatment with clozapine (150mg a day for 7 months) and I havent found any experience or anything.
What Ive found is that Psilocin is an 5-HT1A and 5-HT2A/2C agonist, while clozapine is a 5-HT2A receptor  antagonists (Am I right?).
Does this mean that a trip in psilocybe cubensis will be altered while in clozapine treatment? Does anyone has any information on this?
Any help or additional information will be appreciated.

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Offlineasdfzapine
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Last seen: 13 years, 10 months
Re: mixing shrooms with clozapine [Re: asdfzapine]
    #10098464 - 04/03/09 12:34 AM (14 years, 11 months ago)

no one with any info?
Sorry for the double post.

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Offlinefrisky_
don't panic.

Registered: 11/01/07
Posts: 732
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Re: mixing shrooms with clozapine [Re: asdfzapine]
    #10098751 - 04/03/09 02:50 AM (14 years, 11 months ago)

If you don't mind me asking...

what are you on clozapine for??


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:piggy:your horse is too tall:piggy:
:piggie:and your brain is too small:piggie:

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Offlineasdfzapine
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Re: mixing shrooms with clozapine [Re: frisky_]
    #10114143 - 04/06/09 12:27 AM (14 years, 11 months ago)

I'm having clozapine for depression treatment (not for schizophrenia)

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OfflineAdrianPsy
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Registered: 02/10/09
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Re: mixing shrooms with clozapine [Re: asdfzapine]
    #10114617 - 04/06/09 03:40 AM (14 years, 11 months ago)

clozapine is classed as an antipsycotic isn't it?

Don't they block the effects of psychedelics?


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:mushroom2:    That's why I always recommend a psychedelic experience because it makes you realize that all you've learned is in fact just learned and not necessarily the truth. - Bill Hicks    :mushroom2:

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OfflineLSDreamer
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Re: mixing shrooms with clozapine [Re: AdrianPsy]
    #10115807 - 04/06/09 10:21 AM (14 years, 11 months ago)

Quote:

Clozapine is used principally in treating treatment-resistant schizophrenia,[4] a term generally used for the failure of symptoms to respond satisfactorily to at least two different antipsychotics;[5] It clearly has been shown to be more effective in reducing symptoms of schizophrenia than the older typical antipsychotics, with maximal effects in those who have responded poorly to other medication; though the relapse rate is lower and patient acceptability better, this has not translated to significant observed benefits in global functioning.[4]

It is also used for reducing the risk of suicide in patients judged to belong to a high risk group with chronic risk for suicidal behavior. Clozapine was shown to prolong the time to suicidal attempt significantly greater than olanzapine.

Clozapine works well against positive (e.g. delusions, hallucinations) and negative (e.g. emotional and social withdrawal) symptoms of schizophrenia. It has no dyscognitive effect often seen with other psychoactive drugs and is even able to increase the capabilities of the patient to react to this environment and thereby fosters social rehabilitation.




Nothing in there indicates that you should be taking mushrooms. Clozapine will likely completely cancel out the mushrooms and if you're on this shit, you probably shouldn't stop taking it in order to trip. And even if it didn't, you probably shouldn't trip if you need clozapine.


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InvisibleLand_Crab
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Registered: 08/29/04
Posts: 2,194
Loc: U.S.
Re: mixing shrooms with clozapine [Re: asdfzapine]
    #10116372 - 04/06/09 11:54 AM (14 years, 11 months ago)

Logic would seem to dictate that an (atypical) antipsychotic eliminates or greatly diminishes the effects of psychedelics such as mushrooms.  However, the reduction in effects is either proportional or only occurs with a sufficient dose of the antipsychotic and if you're taking it for a disorder unrelated to schizophrenia then the dose you're taking is likely significantly lower than that which would be prescribed for schizophrenia.  So the effects should be diminished but the diminution could be very small.

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Offlineasdfzapine
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Registered: 03/12/09
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Re: mixing shrooms with clozapine [Re: Land_Crab]
    #10274194 - 05/02/09 04:39 PM (14 years, 10 months ago)

I finally ate about 4 - 4,5 grs of psilocybe cubensis and no effects at all (just feel a little sedated)
Thanks for the info anyway

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Offlineasdfzapine
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Re: mixing shrooms with clozapine [Re: asdfzapine]
    #12075874 - 02/22/10 08:49 AM (14 years, 1 month ago)

UPDATE:
I stopped taking clozapine about 3 months ago. The last weekend I ate 3,5 grs of psilocybe cubensis and finally tripped, but the effects only last for about 3 hours, while my friends, who ate the same amount, tripped for about 5-6 hours. I think that the clozapine effects are somehow still present.
I'll try it again in the future and post any new info

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Offlineegodeathflux
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Re: mixing shrooms with clozapine [Re: asdfzapine]
    #12085354 - 02/23/10 07:23 PM (14 years, 1 month ago)

Some drugs have permanent side effects, SSRIs(common type of anti-depressant) can cause long term imbalances and they negate the effects of psilocybin.
There is no research on the subject, if there is it's classified as part of a mind control program in some government dungeon somewhere..


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"Atrophic interludes weave through my life far too often, for me to fight the biggest enemies"




"Standing on the corner of 5th and Vermouth"


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OfflineCamKron
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Registered: 02/03/09
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Re: mixing shrooms with clozapine [Re: egodeathflux]
    #12085398 - 02/23/10 07:30 PM (14 years, 1 month ago)

are you on any ssri?
i think benzo's also influence how you feel shrooms


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:cool: :mushroom2: :cool: All Pics And Advice Is Just Google Research :cool: :mushroom2: :cool: :mushroom2:

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Offlineasdfzapine
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Re: mixing shrooms with clozapine [Re: CamKron]
    #12095910 - 02/25/10 02:26 PM (14 years, 1 month ago)

I stopped SSRI about a year ago. Clozapine about 3 months ago. While on SSRI, Clozapine and a few other anti-depressant, I felt nothing with shrooms, LSD, MDMA and mescaline.

this was my first try with psychodelics after stopping taking anti-depressants, and finally felt the effects of shrooms. I'll try other psychodelics in the future too.

Edited by asdfzapine (02/25/10 02:31 PM)

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