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cubeladd
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Registered: 08/21/05
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Loc: Sunny ol' England
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Serotonin delpletion and psychedelics
#5035252 - 12/08/05 05:48 PM (18 years, 3 months ago) |
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As far as I know they work by binding to serotonin at the 5-HT receptor sites, therby forming a new chemical which is taken into the next cell causing its strange effeects. This would suggest that once the drug has been metabolised there would be nothing more to bind to Serotonin and therefore normal Serotonin uptake would resume.
However I've seen so many posts where people have mentioned things relating to getting serotion production back on track after taking psychedelics etc. Can someone please clear this up once and for all?
-------------------- "The only thing I'm high on is Love for my Son and Daughters. Yes, a little LSD is all I need." -Marge Simpson
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dblaney
Human Being
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Posts: 7,894
Loc: Here & Now
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Re: Serotonin delpletion and psychedelics [Re: cubeladd]
#5035686 - 12/08/05 07:09 PM (18 years, 3 months ago) |
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I think they're just misled. For the next couple days after tripping, I would imagine (imagine being the key word, I'm not an expert) that the receptor sites have to re-regulate themselves. Sometimes people take 5-HTP, but really there's nothing to worry about except with MDMA, and even then, you're body will readjust itself after a few days, 5-HTP and tryptophan just help.
-------------------- "What is in us that turns a deaf ear to the cries of human suffering?" "Belief is a beautiful armor But makes for the heaviest sword" - John Mayer Making the noise "penicillin" is no substitute for actually taking penicillin. "This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln
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Divided_Sky
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Re: Serotonin delpletion and psychedelics [Re: dblaney]
#5037170 - 12/09/05 12:19 AM (18 years, 3 months ago) |
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Psychedelics don't cause seratonin release so they do not deplete it. In fact, mescaline and related phenethylamines don't even act on 5-ht sites, they act on epinephrine and norepinephrine sites.
-------------------- 1. "After an hour I wasn't feeling anything so I decided to take another..." 2. "We were feeling pretty good so we decided to smoke a few bowls..." 3. "I had to be real quiet because my parents were asleep upstairs..."
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Veter
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Re: Serotonin delpletion and psychedelics [Re: dblaney]
#5037204 - 12/09/05 12:25 AM (18 years, 3 months ago) |
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The problem is, like you said, it has strange effects. The lack of studying done on the topic prevents us from knowing exactly how it psychedelics work exactly. Consider that all, or most psychedelics work by simply fitting into serotonin receptor sites, and then the effects ensue, but the effects range dramatically from drug to drug. Indeed, there is a lot to be studied about psychadelics.
-------------------- Let the Demons have their place, if so, it's angels you'll create.
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spooky
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Re: Serotonin delpletion and psychedelics [Re: Veter]
#5037500 - 12/09/05 01:39 AM (18 years, 3 months ago) |
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i thoroughly agree veter...much more research needs to happen for us to really understand their effects....i have noticed that after particularly "hard" trips i suffered symptoms similar to that of having taken MDMA the day before...i.e. serotonin depletetion, but after mild trips i havent noticed any difference in my mindset, but mostly i just feel a slight "afterglow" after most psychedelic use.
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ChuangTzu
starvingphysicist
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Re: Serotonin delpletion and psychedelics [Re: Divided_Sky]
#5037660 - 12/09/05 02:22 AM (18 years, 3 months ago) |
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Quote:
Divided_Sky said: mescaline and related phenethylamines don't even act on 5-ht sites, they act on epinephrine and norepinephrine sites.
That's completely wrong. All psychedelic phenethylamines have strong affinities for the 5HT2a receptor and there is no reason to suspect that their psychedelic actions are not mediated by this receptor. In drug discrimination studies with rats, identification of DOI and DOM are blocked by administration of a 5HT2a antagonist. DOI has the 3rd highest affinity for 5HT2a of any known compound.
The feelings which linger after a psychedelic has been metabolized and excreted from your body may have something to do with neural plasticity and/or rates of gene expression. It has been shown that LSD alters the rate of gene expression for at least 3 genes in the rat prefrontal cortex. It is likely that that other psychedelics do so as well.
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FreedomFight
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Registered: 07/03/05
Posts: 427
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Re: Serotonin delpletion and psychedelics [Re: ChuangTzu]
#5038258 - 12/09/05 08:36 AM (18 years, 3 months ago) |
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Tzu, could you explain what you mean by LSD altering the rate of gene expression in prefrontal cortex?
-------------------- I do not grow anything illegal. I do not sell anything. I am, however, a very curious individual. I also try to be helpful.
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badchad
Mad Scientist
Registered: 03/02/05
Posts: 13,377
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Re: Serotonin delpletion and psychedelics [Re: FreedomFight]
#5038317 - 12/09/05 08:49 AM (18 years, 3 months ago) |
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My guess is that he's referring to the Nichols and Sanders-Bush paper: http://www.ncbi.nlm.nih.gov/entrez/query...4518&query_hl=3
Or any type of similar research.
To put it very simply: Every protein in the body is encoded for by a gene (whether it be a neurotransmitter, hormone, etc.). Giving a dose of LSD was/has been shown to alter these patterns of gene expression.
Whether they contribute to the acute effects of the drug is questionable.
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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ambros
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Registered: 09/09/03
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Re: Serotonin delpletion and psychedelics [Re: badchad]
#5039733 - 12/09/05 02:18 PM (18 years, 3 months ago) |
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What causes tolerance?
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Psiloman
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Re: Serotonin delpletion and psychedelics [Re: ambros]
#5039902 - 12/09/05 02:52 PM (18 years, 3 months ago) |
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Quote:
ambros said: What causes tolerance?
Propably the retraction of 5HT2a receptors in the synaptic membrain.If a receptor of this kind is "overstimulated",the cell draws it in ,so it can receive no more of the substance that stimulated it.
At least thats the current theory i think!
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Herbus
...
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Re: Serotonin delpletion and psychedelics [Re: Psiloman]
#5039933 - 12/09/05 03:04 PM (18 years, 3 months ago) |
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I feel quite happy after tripping thank you very much.
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