Home | Community | Message Board


This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Kraken Kratom Shop: Red Vein Kratom

Jump to first unread post Pages: 1
Some of these posts are very old and might contain outdated information. You may wish to search for newer posts instead.
Offlinecubeladd
Stranger
Registered: 08/21/05
Posts: 962
Loc: Sunny ol' England
Last seen: 16 years, 7 months
Serotonin delpletion and psychedelics
    #5035252 - 12/08/05 05:48 PM (18 years, 3 months ago)

As far as I know they work by binding to serotonin at the 5-HT receptor sites, therby forming a new chemical which is taken into the next cell causing its strange effeects. This would suggest that once the drug has been metabolised there would be nothing more to bind to Serotonin and therefore normal Serotonin uptake would resume.

However I've seen so many posts where people have mentioned things relating to getting serotion production back on track after taking psychedelics etc. Can someone please clear this up once and for all?


--------------------
"The only thing I'm high on is Love for my Son and Daughters. Yes, a little LSD is all I need."
-Marge Simpson

Extras: Filter Print Post Top
Invisibledblaney
Human Being

Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
Re: Serotonin delpletion and psychedelics [Re: cubeladd]
    #5035686 - 12/08/05 07:09 PM (18 years, 3 months ago)

I think they're just misled. For the next couple days after tripping, I would imagine (imagine being the key word, I'm not an expert) that the receptor sites have to re-regulate themselves. Sometimes people take 5-HTP, but really there's nothing to worry about except with MDMA, and even then, you're body will readjust itself after a few days, 5-HTP and tryptophan just help.


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln

Extras: Filter Print Post Top
OfflineDivided_Sky
Ten ThousandThings

Registered: 11/02/03
Posts: 3,171
Loc: The Shining Void
Last seen: 15 years, 9 months
Re: Serotonin delpletion and psychedelics [Re: dblaney]
    #5037170 - 12/09/05 12:19 AM (18 years, 3 months ago)

Psychedelics don't cause seratonin release so they do not deplete it. In fact, mescaline and related phenethylamines don't even act on 5-ht sites, they act on epinephrine and norepinephrine sites.


--------------------
1. "After an hour I wasn't feeling anything so I decided to take another..."
2. "We were feeling pretty good so we decided to smoke a few bowls..."
3. "I had to be real quiet because my parents were asleep upstairs..."

Extras: Filter Print Post Top
OfflineVeter
Stranger
 User Gallery

Registered: 02/10/05
Posts: 462
Last seen: 8 years, 6 months
Re: Serotonin delpletion and psychedelics [Re: dblaney]
    #5037204 - 12/09/05 12:25 AM (18 years, 3 months ago)

The problem is, like you said, it has strange effects. The lack of studying done on the topic prevents us from knowing exactly how it psychedelics work exactly.
Consider that all, or most psychedelics work by simply fitting into serotonin receptor sites, and then the effects ensue, but the effects range dramatically from drug to drug.
Indeed, there is a lot to be studied about psychadelics.


--------------------
Let the Demons have their place, if so, it's angels you'll create.

Extras: Filter Print Post Top
Offlinespooky
junglist

Registered: 10/04/05
Posts: 282
Last seen: 16 years, 1 month
Re: Serotonin delpletion and psychedelics [Re: Veter]
    #5037500 - 12/09/05 01:39 AM (18 years, 3 months ago)

i thoroughly agree veter...much more research needs to happen for us to really understand their effects....i have noticed that after particularly "hard" trips i suffered symptoms similar to that of having taken MDMA the day before...i.e. serotonin depletetion, but after mild trips i havent noticed any difference in my mindset, but mostly i just feel a slight "afterglow" after most psychedelic use.

Extras: Filter Print Post Top
OfflineChuangTzu
starvingphysicist
Male User Gallery

Folding@home Statistics
Registered: 09/04/02
Posts: 3,060
Last seen: 10 years, 5 months
Re: Serotonin delpletion and psychedelics [Re: Divided_Sky]
    #5037660 - 12/09/05 02:22 AM (18 years, 3 months ago)

Quote:

Divided_Sky said:
mescaline and related phenethylamines don't even act on 5-ht sites, they act on epinephrine and norepinephrine sites.




That's completely wrong. All psychedelic phenethylamines have strong affinities for the 5HT2a receptor and there is no reason to suspect that their psychedelic actions are not mediated by this receptor. In drug discrimination studies with rats, identification of DOI and DOM are blocked by administration of a 5HT2a antagonist. DOI has the 3rd highest affinity for 5HT2a of any known compound.

The feelings which linger after a psychedelic has been metabolized and excreted from your body may have something to do with neural plasticity and/or rates of gene expression. It has been shown that LSD alters the rate of gene expression for at least 3 genes in the rat prefrontal cortex. It is likely that that other psychedelics do so as well.

Extras: Filter Print Post Top
InvisibleFreedomFight
Strange

Registered: 07/03/05
Posts: 427
Re: Serotonin delpletion and psychedelics [Re: ChuangTzu]
    #5038258 - 12/09/05 08:36 AM (18 years, 3 months ago)

Tzu, could you explain what you mean by LSD altering the rate of gene expression in prefrontal cortex?


--------------------
I do not grow anything illegal.
I do not sell anything.
I am, however, a very curious individual.
I also try to be helpful.

Extras: Filter Print Post Top
Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,377
Re: Serotonin delpletion and psychedelics [Re: FreedomFight]
    #5038317 - 12/09/05 08:49 AM (18 years, 3 months ago)

My guess is that he's referring to the Nichols and Sanders-Bush paper:
http://www.ncbi.nlm.nih.gov/entrez/query...4518&query_hl=3

Or any type of similar research.

To put it very simply: Every protein in the body is encoded for by a gene (whether it be a neurotransmitter, hormone, etc.). Giving a dose of LSD was/has been shown to alter these patterns of gene expression.

Whether they contribute to the acute effects of the drug is questionable.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436

Extras: Filter Print Post Top
Invisibleambros
Stranger
Registered: 09/09/03
Posts: 79
Re: Serotonin delpletion and psychedelics [Re: badchad]
    #5039733 - 12/09/05 02:18 PM (18 years, 3 months ago)

What causes tolerance?

Extras: Filter Print Post Top
OfflinePsiloman
member
Male
Registered: 04/11/03
Posts: 1,116
Loc: Europe
Last seen: 10 years, 6 months
Re: Serotonin delpletion and psychedelics [Re: ambros]
    #5039902 - 12/09/05 02:52 PM (18 years, 3 months ago)

Quote:

ambros said:
What causes tolerance?




Propably the retraction of 5HT2a receptors in the synaptic membrain.If a receptor of this kind is "overstimulated",the cell draws it in ,so it can receive no more of the substance that stimulated it.

At least thats the current theory i think!

Extras: Filter Print Post Top
OfflineHerbus
...

Registered: 10/19/04
Posts: 1,477
Loc: Reading the map...
Last seen: 10 years, 2 months
Re: Serotonin delpletion and psychedelics [Re: Psiloman]
    #5039933 - 12/09/05 03:04 PM (18 years, 3 months ago)

I feel quite happy after tripping thank you very much.


--------------------
...

Extras: Filter Print Post Top
Jump to top Pages: 1

Kraken Kratom Shop: Red Vein Kratom


Similar ThreadsPosterViewsRepliesLast post
* The Psychedelic Experience Forum (Tripper's FAQ, Psychedelic Library and Rules) READ BEFORE POSTING! RoseM 14,082 7 10/06/16 10:36 PM
by PrimalSoup
* How do shrooms work? Seratonine? Frood 6,998 7 07/27/02 01:50 AM
by mjshroomer
* Will Seratonin get you high?
( 1 2 all )
sunshine 2,264 21 12/25/05 03:29 AM
by ChuangTzu
* Can mixing damage serotonin receptors? optikal_trip 6,790 13 07/11/05 06:43 PM
by Psiloman
* Depleted Seratonin - Cyans = No trip? headset 1,201 10 12/21/04 11:36 PM
by headset
* Psychedelic serotonin agonists partially causing nausea? sharppixy 863 1 12/13/05 05:58 AM
by Oakbear
* Serotonin and Mushroom Use
( 1 2 all )
thedude100 18,765 23 08/29/16 09:37 PM
by MagicDave
* Serotonin levels?
( 1 2 all )
HeavyToilet 5,448 22 05/19/04 11:39 PM
by Xlea321

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: psilocybinjunkie, Rose, mushboy, LogicaL Chaos, Northerner, bodhisatta
1,430 topic views. 1 members, 27 guests and 23 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.025 seconds spending 0.007 seconds on 14 queries.