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InvisibleMOTH
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Monkey's that glow green actually exist now
    #10410856 - 05/27/09 10:37 PM (14 years, 9 months ago)

From Reuters Newservice:

WASHINGTON (Reuters) – Japanese researchers have genetically engineered monkeys whose hair roots, skin and blood glow green under a special light, and who have passed on their traits to their offspring, the first time this has been achieved in a primate.

They spliced a jellyfish gene into common marmosets, and said on Wednesday they hope to use their colony of glowing animals to study human Parkinson's disease and amyotrophic lateral sclerosis or ALS.

Erika Sasaki and Hideyuki Okano of the Keio University School of Medicine in Japan used a virus to carry the gene for green fluorescent protein into monkey embryos, which were implanted into a female monkey, and four out of five were born with the gene throughout their bodies.

One fathered a healthy baby that also carried the new genes, they reported in Thursday's issue of the journal Nature.

"The birth of this transgenic marmoset baby is undoubtedly a milestone," stem cell expert Dr. Gerald Schatten, of the University of Pittsburgh School of Medicine, and Shoukhrat Mitalipov, of Oregon Health and Sciences University, wrote in a commentary in Nature.

"Transgenic marmosets are potentially useful models for research into infectious diseases, immunology and neurological disorders, for example," they wrote.

INCURABLE DISEASES

"I am most interested in Parkinson's disease and ALS," Okano told reporters in a telephone briefing. Both are incurable nerve diseases. But Okano said animals could be created to study a range of diseases.

The researchers used marmosets because they reproduce quickly, reaching sexual maturity in about a year.

"At the moment we use mice with mutant genes that are associated with Parkinson's to search for new drugs to treat the condition," Dr. Kieran Breen, director of Research and Development at Britain's Parkinson's Disease Society, said in a statement.

"Because non-human primates are much closer to humans than mice genetically, the successful creation of transgenic marmosets means that we will have a new animal model to work with."

Last year, the discoverers of the green fluorescent protein won the Nobel Prize in chemistry -- Japanese-born Osamu Shimomura of the Marine Biological Laboratory in Woods Hole, Massachusetts, Martin Chalfie of Columbia University in New York and Roger Tsien of the University of California, San Diego.

The protein glows under blue and ultraviolet light, allowing researchers to illuminate tumor cells, trace toxins and to monitor genes as they turn on and off.

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OfflineRandomHero
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Re: Monkey's that glow green actually exist now [Re: MOTH]
    #10410872 - 05/27/09 10:40 PM (14 years, 9 months ago)

this is crazy.

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InvisibleEntropymancer
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Registered: 07/16/05
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Re: Monkey's that glow green actually exist now [Re: MOTH]
    #10410887 - 05/27/09 10:43 PM (14 years, 9 months ago)

Old news. I'm pretty sure they came up with glow in the dark monkeys back around '05.

Still nuts though.

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InvisibleMOTH
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Re: Monkey's that glow green actually exist now [Re: RandomHero]
    #10410888 - 05/27/09 10:43 PM (14 years, 9 months ago)

It's trippy to fathom how integrated genetic manipulation might increasingly become within our society over the next 100-200 years or so.

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InvisibleMOTH
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Re: Monkey's that glow green actually exist now [Re: Entropymancer]
    #10410897 - 05/27/09 10:44 PM (14 years, 9 months ago)

Quote:

Entropymancer said:
Old news.




New to me!  And I'm sure others.

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InvisibleMOTH
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Re: Monkey's that glow green actually exist now [Re: MOTH]
    #10410905 - 05/27/09 10:45 PM (14 years, 9 months ago)

WAIT A FREAKING MINUTE this isn't old news...

Quote:

WASHINGTON (Reuters) – Japanese researchers have genetically engineered monkeys whose hair roots, skin and blood glow green under a special light, and who have passed on their traits to their offspring, the first time this has been achieved in a primate.




Wed May 27, 7:28 pm ET

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OfflineI AM SWIM
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Re: Monkey's that glow green actually exist now [Re: MOTH]
    #10410910 - 05/27/09 10:46 PM (14 years, 9 months ago)

japanese really like the future, not only that but anything that glows is the future, and the future is now.


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InvisibleEntropymancer
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Re: Monkey's that glow green actually exist now [Re: MOTH]
    #10410923 - 05/27/09 10:48 PM (14 years, 9 months ago)

Ah, I see. The new news is that the glowing monkeys made glowing babies :strokebeard:

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InvisibleMOTH
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Re: Monkey's that glow green actually exist now [Re: Entropymancer]
    #10410950 - 05/27/09 10:53 PM (14 years, 9 months ago)

Quote:

Entropymancer said:
Ah, I see. The new news is that the glowing monkeys made glowing babies :strokebeard:




Indeed...good for them!  :laugh: Genetic engineering is really interesting to me.  Have they made anything else really weird like this?

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InvisibleEntropymancer
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Re: Monkey's that glow green actually exist now [Re: MOTH]
    #10410987 - 05/27/09 11:00 PM (14 years, 9 months ago)

They've made all kinds of things glow in the dark. They really love that phosphorescent green chromophore gene.  There's a similar gene that makes things glow red, but that hasn't been as widely messed-around with.

The main use for these glowing genes is to tie their expression to the production of specific other proteins, so we can see under a microscope where and when different proteins get made.  I think the glowing animals are mostly for eye-candy. In fact, I know they have red- and green-glowing fish that they want to release commercially as a new line of pets :shake:

Most of the stuff they're dong with genetic engineering is more on the practical side, like getting yeast or E coli to mass-produce complicated proteins from other species so we can study them (synthesizing high yields of proteins is not really a practical approach, so we have other genetically-modified organisms do it for us).

And then there's Monsanto's line of sterile crops, so they can force farmers to buy new seeds every year rather than plant seeds from the harvest for the next season (that one really pisses me the hell off... I think it's currently working its way onto the market now).

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InvisibleGumby
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Re: Monkey's that glow green actually exist now [Re: MOTH]
    #10411047 - 05/27/09 11:09 PM (14 years, 9 months ago)

I work with mice that have dopamine cells that glow green. They have a green rabbit too. I think Japan is responsible for that...




And pigs:


And mice/rats:



And fish:



You can actually buy "glo fish" in stores. They are genetically modified zebra danios. They are quite awesome. I plan to do an all green freshwater planted tank with black gravel full of the neon orange ones. I'll take pics of it if I ever get the money to do it. Those fish aren't cheap, about $6-$8 each. They are actually copyrighted and sterile so you can't breed them. They were originally created to be an indicator of polluted water sources.

They were supposed to turn orange in the presence of pollutants because they are very easy to see in dark water when they are orange. Not sure what ever happened with that.

The way science is going now, you can put GFP into almost any animal's genome to make them glow green under the right spectrum of light. Crazy shit. Genetics research is getting insane. I could go into the details of how my lab genetically engineered a virus to label cells, but that might compromise their research. So I'll shut up.

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OfflineCubie
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Re: Monkey's that glow green actually exist now [Re: Gumby]
    #10411087 - 05/27/09 11:13 PM (14 years, 9 months ago)

I cant wait for glowing humans!

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InvisibleSet
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Re: Monkey's that glow green actually exist now [Re: MOTH]
    #10411128 - 05/27/09 11:19 PM (14 years, 9 months ago)

Let's not forget the transparent frog..




Oh, those Japanese.


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    classic LOVELINE

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InvisibleDepthToTheCore
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Re: Monkey's that glow green actually exist now [Re: Set]
    #10411160 - 05/27/09 11:25 PM (14 years, 9 months ago)

The Japanese are on a completely different level, i can't wait to go there next year.

12,400 7/11's, beat that.

:lol:


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"Those who dance are considered insane by those who cannot hear the music." - George Carlin

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Offlinelearningtofly
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Re: Monkey's that glow green actually exist now [Re: Set]
    #10411170 - 05/27/09 11:26 PM (14 years, 9 months ago)

The Simpsons already did it.


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InvisibleSet
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Re: Monkey's that glow green actually exist now [Re: DepthToTheCore]
    #10411193 - 05/27/09 11:30 PM (14 years, 9 months ago)

I lived in Yokohama for 3 weeks with a host family, it was bananas.

What was really cool is we stayed at their grandparent's villa on Mt. Fuji in the woods for a few days.  That was fucking :awesome:!

You'll have a blast there man!  :thumbup:


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    classic LOVELINE

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InvisibleDepthToTheCore
JeeBuzz
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Re: Monkey's that glow green actually exist now [Re: Set]
    #10411214 - 05/27/09 11:33 PM (14 years, 9 months ago)

Oh man im so exicted, my girlfriend just went there for 2.5 weeks, and now we are going together next year.

Im sooooo pumped for the food, i've heard its INSANE.

Did you go to one of the 7/11's? My girlfriend tells me they are like mini-supermarkets, stocked every 24 hours with the freshest and most delicious food ever.

I can't wait!


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"Those who dance are considered insane by those who cannot hear the music." - George Carlin

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OfflineCubie
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Re: Monkey's that glow green actually exist now [Re: DepthToTheCore]
    #10411259 - 05/27/09 11:38 PM (14 years, 9 months ago)

7/11.. fresh.......... lol

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InvisibleSet
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Re: Monkey's that glow green actually exist now [Re: DepthToTheCore]
    #10411270 - 05/27/09 11:40 PM (14 years, 9 months ago)

lol dude it's awesome

Nah, never went to a 7-11 there (that I remember, anyway).  The grocery stores there are hilarious though!  There's a giant section reserved for rice :lol:.  The candy aisle is awesome, Japan definitely has the edge on sweets.

Food in Japan is amazing if you love seafood.


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InvisibleDepthToTheCore
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Re: Monkey's that glow green actually exist now [Re: Cubie]
    #10411279 - 05/27/09 11:41 PM (14 years, 9 months ago)

Im not kidding.

The food in 7/11's here are a disgrace, but over there its apparently completely different.



Looks pretty good to me, the dude at the counter even heats it up for you.

Win.


--------------------


"Those who dance are considered insane by those who cannot hear the music." - George Carlin

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