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Can I trip and never come back on mushrooms?
YES AND NO!
On one hand, you will always come down from your trip. That's something you can count on! There is no chemical way for you to just "keep" tripping, it's just not possible. Your body will metabolize the drug fully and no traces of it will remain in your system after 2-4 days due to its relatively short halflife in the body.
On the other hand, many people do have after-effects from doses of mushrooms, some call it the "afterglow", but that can be a bit misleading. Extended high dosages may prompt some cognitive impairment and HPPD (Hallucinogen Persisting Perceptual Disorder) and possibly some emotional liability due to effects on the Serotonin system. Usually temporary, these fade with cessation of use over a period of a few months.
Depending on your frame of mind, the questions you might have asked yourself while tripping, how focused you are on trivial things, how focused you are on the present, you can either feel euphoric, like you've accomplished something, or you may feel depressed, like you aren't as far along your path as you should be.
The latter (depressed) situation isn't really a horrible thing in itself, it just means you need to take a look at the way in which you are leading your life and probably make some lifestyle changes for the better... Rather than seeking medication to immediately "fix" your brain, attempt to work through the cause of the feelings. Your depression, albiet temporary, has occured for a reason and shrugging it off will take far more energy than applying what knowledge you have and integrating what you have learned into the way you live.
I always think of mushrooms as one of the greatest psychotherapy tools available to mankind! The ability to change already rests within you, but the ability to know WHAT to change is a lot harder to decipher! Mushrooms will give you the answers, it's up to you to figure out the questions :)