Psilocybe Mushroom FAQ
Version 2.01, HTML Version
Last update: 13. July 2004
Original HTML: 30 Sept 1996
by
nipo@brahman.nullnet.fi (Most of the writing)
gnosis@brahman.nullnet.fi (Layout, additions)
jfarrell@nym.lycaeum.org (HTML for the Lycaeum)
Thanks to
baabo@brahman.nullnet.fi (For shroom descriptions)
Tatu (For shroom descriptions)
ppennane@cc.helsinki.fi (For the Tryptamine FAQ)
dr303@cleveland.freenet.edu (For alkaloid content figures)
lamont@hyperreal.com (For neuropharmacology)
Mushroom John (For countless corrections)
All the other net-people who added or corrected info
Especially our fellow innerspace astronauts
Index
- Credits
- Disclaimer
- Foreword
- History
- Etymology
- Chemistry
- Psychology
- Legality
- Botany
- Mushroom Guide
- Psilocybian Mushroom Resources
- Picking Mushrooms
- Drying Mushrooms
- Dosage
- Effects
- Consumption
- Preparation for the Voyage
- Music and the Voyage
- During the Voyage
- Warning
- Miscellaneous Questions
- Further Reading
- References
- Endnotes
.oOo. Notes .oOo.
This FAQ is far from complete, and we ask those with information to add or fix to contact us. All comments and thoughts welcome. Schizophrenic alternation between "I" and "we" is due to the file being written by two people, not permanent brain damage from mushrooms. =) This file is purposely not in the usual question-answer, clearly-divided subsections, everything-referenced, no-cute-ASCII-pics format usually used for FAQs. Instead, it's more relaxed and loose, which in our opinion makes for a much better read. Enjoy!
.oOo. Disclaimer .oOo.
For info only. I hope someday humanity reaches the point where there are no restrictions, laws or censorship. Just read the foreword and get an attitude & altitude.
.oOo. Updates .oOo.
What's new since version 2.0:
- Removed an erronous table from the chemistry section (wrong interpretation of a source, A.Y. Leung, A.H. Smith & A.G. Paul, "Production of Psilocybin in Psilocybe baeocystis Saprophytic Culture" J Pharm Sci 54: 1576 (1965)).
- Various other corrections throughout the FAQ
What's new since version 1.2:
- Countless corrections were made to all aspects of this FAQ.
.oOo. Foreword .oOo.
FOREWORD: THINK!><><>>><><>><><<<><><<<>>><PSYHC.EDEL.AI<><<>><<>>><<<>><<<><<>>><<<> What is it? viewpoint the Ps(i)kedelia^^enTHEOgens(genia)vokal.BO.lary/nx |BODY| [greek]-PSYCHE-DELEIN *humphry OSMOND 1956 (soul) (show) in his letter to Aldous Huxley "To fathom hell or soar angelic, Just take a pinch of psychedelic." ion ____IN tokzikat(-/ ) EBRIATION ....... psychotomimetik ... psycholytik -__--IN- . peak experience alteredstate EN THE O GEN "gOd within" ekstasis (theos) pharma "be_koming" psyk (gen) physi => {god is love} biol soci theworld /// conciousness OLOKI[greekLOGOS:knowledge] physio.GNOMY of (SIKe:DELIA) crispvague im/possibility spaceufouniverse 2.birth Iindividualme eyeopening visionsinsights otherworldly heaven&hell planetmotherearth beyondwords DRUGS?ENTHEOGENS?PSIKEDELIX?SUBSTANCES? LSD Psilocin harmaline what MDMA Mescaline ibogaine ever CANNABIS Psilocybin DMT ... entheogens.psychedelics.hallucinogens@non.addictive.non.harmful "...a psychedelic drug is one which, without causing physical addiction, craving, major physiological disturbances, delirium, disorientation, or amnesia, more or less reliably produces thought, mood, and perceptual changes otherwise rarely experienced exept in dreams, contemplarive and religious exaltation, flashes of vivid involuntary memory, and acute psychoses." PsychedelicDrugsReconsidered Lester Grinspoon James B Bakalar ? n o[t]i t a n n i c . u l l a . h ! . h a l l u c i n a t i o n . sPIRITUAL Philo.sophic rETINA apertures "...ie. the product of "the phleghms of thought perceptual processes." IN THE BRAIN. colors magnified feelings of strange feelings. strange feelings. wavy motion of objects strange thoughts: visions/insights: 2-D visuals: objects differ absence of normal thought; color/switches; 3-D objects mutate| Perceptions not connected absence of reality| to the ,real, world*invisiblelandscapetheothersidedirectaxessunconsciousgodspacelifedeathuf[Gnosis says: If that fails to make sense, read it again until it does... which may take a while.]
.oOo. History .oOo.
Hallucinogenic mushrooms have probably been in existence exactly as long as humanity. Ancient pictures of mushroom-headed humanoids have been found in caves in the Sahara. Siberian shamans use[d] fly agarics to enlighten the path to the spiritworld. In Central and Southern America use of psilocybin mushrooms (and other hallucinogens) was common until the arrival of Spaniards who spread the Catholic faith with sword and fire and forbade the use.
Spanish priest Bernardino de Sahagun (ca. 1500 AD) on the use of hallucinogenic mushrooms by the Aztecs:
The first thing to be eaten at the feast were small black mushrooms that they called nanacatl and bring on drunkenness, hallucinations and even lechery; they ate these before the dawn...with honey; and when they began to feel the effects, they began to dance, some sang and others wept.... When the drunkenness of the mushrooms had passed, they spoke with one another of the visions they had seen.
On use of alcohol:
If a youth appeared intoxicated in public... he was punished by being beaten to death with stick or garrotte before all other youths assembled there...to serve as an example.
Only old people were allowed to drink the alcoholic beverage pulque. Sahagun has an error in his writings, the mushrooms were not ingested with food:
It is an ancient custom for people to eat mushrooms and these they ate in a trice, as is said. They had had no food exept some cacao drunk the night before. They ate these mushrooms with honey.
The Aztecs (1400-1521) took other hallucinogenic drugs such as tlapatl, mixitl grain and peyotl or peyote, use of which originated from the north of Mexico, where it had been in use since 300 B.C. "Mushroom stones" in which figures under the cap of a mushroom are depicted have been found even from an earlier era (1000-500 B.C.) The purpose of these sculptures is not certain, but these stones may have been religious objects.
The Codex Vienna Mixtec manuscript (ca. 13th-15th century) depicts the ritual use of the teonanácatl by the Mixtec gods. The god known as 7 Flower (his name presented in the pictoral language as seven circles and a flower) was the Mixtec god for hallucinatory plants, especially the divine mushroom, and is depicted with a pair of mushrooms in his hand.
The Aztec also had their god for the entheogens, Xochipilli, Prince of Flowers. He was the divine patron of "the flowery dream" as the Aztecs called the ritual hallucinatory trance.
Mushrooms ingested by the Nahuautl speaking Aztecs probably belonged to the genus Psilocybe or Panaeolus, and quite possibly Conocybe.Although currently popular as it is quite easy to cultivate, Psilocybe cubensis was not introduced to America until the arrival of the Europeans and their cattle. However, Dr. Richard Evans Schultes (1989, Pers. Comm. To JWA), states that this mushroom has been observed fruiting on deer droppings, so it is possible that it could already have been in the Americas prior to the arrival of the Spanish. Today indians regard Stropharia cubensis inferior to Ps. mexicana for it grows in dung.
In the beginning of twentieth century interest in psychoactive mushrooms stirred. The teonanácatl was first identified as Lophophora williamsii or peyote, and it was thought that Sahagun had mistaken the cactus for mushrooms. Finally ethnobotanist Richard Evan Schultes and ethnobotanist Plasius Paul Reko traveled for the mushrooms to Oaxaca, and their collections were mixed species according to Singer. The two sheets at Farlow Herbarium at Harvard University included specimens of Panaeolus sphrinctrinus, Psilocybe cubensis, Psilocybe caerulescens and what appears to be some specimens of Psilocybe mexicana. They found out that mushroom ceremonies -- veladas -- were still being held in the area.
A decade after World War II, after long search the mycophile family of R. Gordon Wasson came to little Village of Huatla de Jimenez, and Wasson and his friend Allan Richardson attended a velada held by curandera Maria Sabina.
Information about the mushrooms soon spread. Psilocybin and psilocin were found and their analogues were synthesized. Experimentation with the mushrooms and the synthesized substances began and magic mushrooms were soon part of the 60's 'psychedelic' movement, i.e. every second middle class kid was opening the doors of perception and [ab]using hallucinogenic drugs.
.oOo. Etymology .oOo.
/ ët'e-möl'e-jë / 1. the origin and history of words. The name of the genus "Psilocybe" comes from the Greek words psilos (bare) and kube (head), warped into New Latin to form "psilocybe". Literally translated, this means "bald head", which I suppose comes from their appearance. A rather inaccurate comparison if you ask me, most bald people don't have big pointy nipples on top of cone-shaped heads, even if they're from Remulok, but I digress...
The best known hallucinogens in Psilocybe mushrooms are the chemicals psilocybin and psilocin, which are discussed at length in the next part. There remains a minor controversy about the spelling of their names. Psilocybin and psilocin are both alkaloids (nitrogen-containing substances found in nature), and an effort in the 70's aimed to convert all alkaloid names so that they end in -ine, like cocaine, caffeine, morphine, etc. The names should thus be "psilocybine" and "psilocine"; yet "psilocybine" is used very rarely even in modern authoritative works, and I have seen "psilocine" in print exactly once. If anybody has some idea about the current situation and the Korrekt(tm) spelling, please inform me.
.oOo. Chemistry .oOo.
The primary active ingredients of Psilocybe mushrooms are psilocybin and psilocin, and to a lesser extent baeocystin and norbaeocystin. The ratio of psilocybin to psilocin varies from species to species, even from specimen to speimen within one collection of the same species. The primary difference is that psilocin is unstable and it breaks down when the mushroom is dried, while psilocybin lasts much longer (a 115-year old mushroom sample was found to contain some). The two moleculs are equally psychoactive, since one molecule of psilocybin breaks down into one molecule of psilocin. But in terms of weight, we find that:
molecular weight of psilocybin molecular weight of psilocin | = | 284.3 204.3 | = 1.391 |
So by weight psilocin is around 1.4 times more potent. The formula for calculating total potency, ignoring [nor]baeocystin, is thus:
(psilocybin) (1.4 * psilocin) = total potency in 'psilocybin units'
Now, here's the structural diagram for psilocybin:

In the body, the phosphorus part is chopped off ("dephosphorylated") by the enzyme alkaline phosphatase, turning it into our other friend:

Psilocybin and psilocin are part of the tryptamine family (indole (C8H7N) & ethylamine side chain). They bear close resemblance to the neurotransmitter serotonin. How these substances work is, I have come to believe, still quite obscure. Primary effect seems to be the inhibition of neurotransmitter serotonin (5-hydroxytryptamine aka 5-HT), i.e. a 5-HT2A post-synaptic agonist that mimics the effects to 5-HT to put it in jargon. This is the working hypothesis for LSD-25 at the moment and it's probably true for psilocybin as well. These substances also present some cross-tolerance.
As a good psychedelic should, psilocybin, psilocin and psilocybian mushrooms have low toxicity -- in tests with mice, doses up to 200 mg of psilocybin/kg of body (in average human terms (65 kg) 13 grams) have been injected intravenously without lethal effects. The ED50 : LD50 ratio is 641 according to the NIOSH Registry of Toxic Effects; compare this with 9637 for vitamin A, 4816 for LSD, 199 for aspirin and 21 for nicotine. Poisoning, at least physically, is thus not a problem.
Then we have the two other significant indole alkaloids:
Unlike psilocybin, baeocystin is somewhat unstable, and decays noticeably with age. And then we have baeocystin's close chemical cousin:
In other words, baeocystin and norbaeocystin are just psilocybin with one methyl and two methyls respectively lopped off. And unfortunately for all you synthesis experts, while baeocystin and norbaeocystin do not have DEA control numbers they do both come under the Controlled Substance Analogue Act.
When dephosphorylated, they turn into 4-hydroxy-N-methyltryptamine and 4-hydroxytryptamine. All 4 substances are presumed hallucinogenic, but less so than psilocin or psilocybin. Very little work seems to have been done on them (Chemical Abstracts averages a cite a year, with most of them of the variety "baeocystin found in Psilocybe totallyobscuralis"). There has been some speculation on the 'net about them, and a possible correlation between nausea and the amount of baeocystin has been found. We hope to be able to investigate the question further for the next version.
These are just the four "biggies".
There are also other chemicals present in mushrooms, but which and in which concentration is still very much in darkness.
The effects of psilocybin can be potentiated (made stronger) by taking them with a monoamine oxidase inhibitor (MAOI). The potency is roughly doubled, according to most reports. The best known MAOIs are harmine and harmaline from the plant Peganum harmala (Syrian rue). Combining MAOIs and tryptamines is an unsafe activity; not only are there are number of substances you must avoid during use to prevent a serious hypertensive crisis, but the long-term health effects are unknown. If you wish to know more, consult the Tryptamine FAQ. Personally, I doubt it's worth the risk, if you pick or grow shrooms it's easy to get enough shrooms for a double dose.
.oOo. Psychology .oOo.
"Nature's Perfect Entheogen(TM)"
Psilocybin is juuust fine. I've tried several psychoactive drugs, including hash, LSD-25 and psilocybin. Hash usually doesn't do much - sends me into a half sleep with silly thoughts and spacey soundscape added to music... LSD doesn't do it to me either. It's probably OK if you are after low dose recreation -- partying and such... High doses -- too blunt, like a mental power tool. It cracks up open your head; Starring You and Your Brain for 12 hours. Every perception magnified thousandfold -- it's ... it's a bit too intense. !INTENSE! is the keyword. It doesn't accept any apologies or mistakes ... too harsh. I often felt like I had been immersed in some chemical, into a substance so pure and efficient it has no place in nature. Too pure. 12 hours of LSD-25 acid-bath makes you really tired... physically and mentally. But psilocybin, mm-mm, it's juuuuust fiiiine.
Voyage to the spiritworld ... visions and travels, awesome mental hallucinations. It's a direct ISDN-link to the mother earth, forgiving, gentle substance. You hear the chanting of the planet and the spirit of the mushroom. It's a product of the nature, untied to the actions of men and women roaming this planet. Your body disconnected from the circuit, you may often forget it exists. Six hours -- not too short, not too long. Perfect.
It should be noted that like all 'major' hallucinogens, psilocybin can precipitate psychotic episodes and uncover or aggravate previous mental illness. If you're stressed out or depressed, don't take mushrooms; if you have schizophrenia or something, DO NOT take mushrooms.
ACID IS NOT FOR EVERY BRAIN .... ONLY THE HEALTHY, HAPPY, WHOLESOME, HANDSOME, HOPEFUL, HUMOROUS, HIGH-VELOCITY SHOULD SEEK THESE EXPERIENCES. THIS ELITISM IS TOTALLY SELF- DETERMINED. UNLESS YOU ARE SELF-CONFIDENT, SELF-DIRECTED, SELF-SELECTED, PLEASE ABSTAIN.
--Timothy Leary, Ph.D.
I think this applies to mushrooms as well. Mushrooms and acid will open your doors of perception, and once open you can never truly close them again. They are more than a purely recreational drug.
.oOo. Legality .oOo.
Here's a list of the places we know about. Much of this is 'off the net' and may thus be more or less flawed. "Y" means it is legal, "N" means it is illegal, "?" means their status is unclear.