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Offlinethunderfox
Student of Perception

Registered: 12/04/09
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Significant! LSD/Shrooms damage your brain permanently!
    #11822361 - 01/13/10 04:19 PM (3 years, 4 months ago)

Quote:

There is evidence that LSD, MDMA, and other hallucinogens can produce visual problems even in people who do not have HPPD. So far, experiments have not been conducted with drugs other than LSD. Dr. Henry Abraham, the leading researcher on the topic of HPPD (and the originator of the term), did two experiments on LSD-related visual disorders. In both experiments, he used three groups of subjects. The comparison or 'control' group had never taken LSD. The second group consisted of former LSD users who had never experienced visual problems and who said they hadn't taken LSD in a long time. The final group consisted of LSD users who reported HPPD symptoms.

The first test measured the ability of the groups to distinguish colors. The control group scored the best, the former LSD users fell in the middle, and the HPPD group scored the worst. The results were statistically significant with a P < 0.001, which theoretically means that there was less than 1 in 1000 chance that the measured differences were caused by random chance. [Abstract]

The second test measured the ability of each group to distinguish light flicker. A light was rapidly strobed on and off. Above a certain frequency subjects perceived the flashing light to be on continuously. Again, the control group performed best, the former LSD users fell in the middle, and the HPPD subjects scored the worst. The results were again statistically significant (P<0.001). [Abstract]

These experiments seem to show that even HPPD-free LSD users may be experiencing long-term changes in their vision. It is not known why these changes are so distracting to people with HPPD while not being bothersome to other LSD users. It is very important to note, however, that not much research has been done in this area and these results have not been confirmed by other research.

Speculation: These results are difficult to explain. They would seem to point to a slow degradation in perception caused by LSD. HPPD seems to have very rapid onset in many cases, often after very few LSD experiences. It would be interesting to see if the strength of distortions could be correlated to total LSD experiences. It would also be interesting to do longitudinal studies of current LSD users to see how their perceptions change. There is a PhD thesis in the making for somebody!




http://www.erowid.org/psychoactives/health/hppd/hppd_faq.shtml#hppdfree
http://www.erowid.org/references/refs_view.php?ID=1232
http://www.erowid.org/references/refs_view.php?ID=1245

What do you think? How does this influence your opinion on using LSD/shrooms (how often etc.)?

Thunderfox


--------------------
Trading B+ spore prints.
Looking for Penis Envy print.


Edited by thunderfox (01/13/10 04:27 PM)


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OfflineB0RNR3ADY
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: thunderfox]
    #11822419 - 01/13/10 04:26 PM (3 years, 4 months ago)

Hmmm sounds plausible,
I know that I have developed mild HPPD symptoms after using 2C-E
However I dont regard the symptoms as a problem at all, their quite entertaining :smile:


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Offlineteeter
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: thunderfox]
    #11822449 - 01/13/10 04:30 PM (3 years, 4 months ago)

Visual disturbances don't really bother me. I have them fairly strongly, but its just not a big deal. They are so easy to ignore and I barely notice them unless I think about it. Plus this isn't brain damage, its just a change in perception. LSD works in the brain by setting off a chain reaction, only a very small percentage of the already minute dose of LSD crosses the blood-brain barrier. Following that logic, it would be easy to assume that some of these effects could be long lasting. Who cares though? Any informed user knows the risks: mild possiblity of psychosis, risk of bad trips and risk of HPPD. There are no bad physical effects and LSD has not been shown to actually damage the brain in any function way. This study mearly shows that effects can be persistant. This isn't making the people in the study dumber, its just changing their vision a bit. If you do a lot of acid, your perception may be permanently altered, you may also have some trippier thought patterns and a new ability to understand complex topics and visualize things, creativity may be improved. The study shows that LSD effects are persistant, we already knew that. It doesn't point to brain damage. If I change the tires on your car, I haven't damaged it, I've just made a minor change. My life isn't ruined because I perceive mild fractals all over blank surfaces and because I see colors in the dark.


--------------------
"If the doors of perception were cleansed every thing would appear to man as it is, infinite. For man has closed himself up, till he sees all things through narrow chinks of his cavern." - William Blake

"Psychedelics helped me to escape.. albeit momentarily.. from the prison of my mind. It over-rode the habit patterns of thought and I was able to taste innocence again. Looking at sensations freshly without the conceptual overly was very profound." - Ram Das


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OfflineLSDreamerM
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: thunderfox]
    #11822466 - 01/13/10 04:32 PM (3 years, 4 months ago)

HPPD is not necessarily damage. Everybody who uses psychedelics knows about HPPD. Few people ever develop it, and few of the people who do care that they do, meaning the number of people who have their lives disrupted by HPPD is vanishingly small. You have more of a chance being injured in a car wreck.


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InvisibleShad0w
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: teeter]
    #11822490 - 01/13/10 04:35 PM (3 years, 4 months ago)

Quote:

Who cares though?




I like your attitude.:mushroom2:


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Offlinethunderfox
Student of Perception

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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: teeter]
    #11822492 - 01/13/10 04:36 PM (3 years, 4 months ago)

Ok, i was not talking about phisical damage. LSD people definitly cannot  process visual data as good as people who have not used LSD. The question is: Do the advantages top the disadvantages?

To
Quote:

teeter said:
If I change the tires on your car, I haven't damaged it



If one of your weel always points a bit to the right, so that "the way your car drives is altered", it is damaged.

Thunderfox


--------------------
Trading B+ spore prints.
Looking for Penis Envy print.


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Offlineteeter
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: thunderfox]
    #11822512 - 01/13/10 04:38 PM (3 years, 4 months ago)

Quote:

LSDreamer said:
HPPD is not necessarily damage. Everybody who uses psychedelics knows about HPPD. Few people ever develop it, and few of the people who do care that they do, meaning the number of people who have their lives disrupted by HPPD is vanishingly small. You have more of a chance being injured in a car wreck.




Way more of a chance of being in a car crash. The chance of getting HPPD is like that chance of getting in a car wreck, just this year, not ever. The chance of giving a shit is even smaller. Its so not a big deal. Since you aren't high from [insert psychedelic] the visuals just stop being all that distracting. Plus they are far less intense than under the influence and you also quickly get used to them. If anything, it just makes you better at doodling and its fun to watch the tracers on people's hands when they are vigorously talking with their hands and boring you to death with their babble.

Quote:

Shad0w said:
Quote:

Who cares though?




I like your attitude.:mushroom2:




I like it too! :tongue:

Quote:

thunderfox said:
Ok, i was not talking about phisical damage. LSD people definitly cannot  process visual data as good as people who have not used LSD. The question is: Do the advantages top the disadvantages?

To
Quote:

teeter said:
If I change the tires on your car, I haven't damaged it



If one of your weel always points a bit to the right, so that "the way your car drives is altered", it is damaged.

Thunderfox




Good counter with the tires. I however feel that the advantages far outweigh the disadvantages. The only people who dislike HPPD are people who have it REALLY bad to the point where its an impairment and also get anxiety about it due to the "When the fuck will I comedown, OH SHIT!!!" factor.


--------------------
"If the doors of perception were cleansed every thing would appear to man as it is, infinite. For man has closed himself up, till he sees all things through narrow chinks of his cavern." - William Blake

"Psychedelics helped me to escape.. albeit momentarily.. from the prison of my mind. It over-rode the habit patterns of thought and I was able to taste innocence again. Looking at sensations freshly without the conceptual overly was very profound." - Ram Das


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InvisibleShad0w
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: thunderfox]
    #11822516 - 01/13/10 04:39 PM (3 years, 4 months ago)

Short Answer : The answer varies from individual. Most of it is opinion.

Mine is that whatever negative effect it MIGHT have on my mind, Are most assuredly, trumped by the enormous positive effects it has had on my mind. :thumbup:


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Offlineteeter
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: Shad0w]
    #11822550 - 01/13/10 04:43 PM (3 years, 4 months ago)

Quote:

Shad0w said:
Short Answer : The answer varies from individual. Most of it is opinion.

Mine is that whatever negative effect it MIGHT have on my mind, Are most assuredly, trumped by the enormous positive effects it has had on my mind. :thumbup:




TRUE DAT! :discorex: :awecid: :lsd:


--------------------
"If the doors of perception were cleansed every thing would appear to man as it is, infinite. For man has closed himself up, till he sees all things through narrow chinks of his cavern." - William Blake

"Psychedelics helped me to escape.. albeit momentarily.. from the prison of my mind. It over-rode the habit patterns of thought and I was able to taste innocence again. Looking at sensations freshly without the conceptual overly was very profound." - Ram Das


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InvisibleBenzine
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: teeter]
    #11822730 - 01/13/10 05:07 PM (3 years, 4 months ago)

Something funny about this, I was doing MDMA a lot last year and I had some pretty bad hppd even after I stoped and for a few months. Than I did some strong mushrooms and had a rly good trip (hadnt done shrooms in a while and never done shrooms this potent of quality) and after that in the next weeks I noticed the xtc induced hppd which was bad was not worsened by doing shrooms, which are much more hallucinogenic, but it was fixed. For the first time in a while I had no hppd at all. Psilocybin fixed my receptors. I havnt done shrooms sense and I rly want to and I hope that they might fix the hppd I have now. Ive had it again ever sense I have done 2C E. And Iv also done a lot of acid and lately been doing Mescaline but they didnt have that fixing of hppd that shrooms gave me. I hope that it would happen again next time I do em and wasnt just a 1 time thing they had to offer


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Offlineoxalic32
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. [Re: Benzine]
    #11823885 - 01/13/10 07:48 PM (3 years, 4 months ago)

.


Edited by oxalic32 (12/19/10 11:57 PM)


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OfflineLizardman
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: oxalic32]
    #11824109 - 01/13/10 08:25 PM (3 years, 4 months ago)

The title is patently stupid, sorry.
Where do shrooms appear in the text you quoted?
The study is entirely about LSD.
Also, there's no brain damage involved.
Brain damage is an organic phenomenon, this is more of psychological issue. There has never been any evidence of LSD neurotoxicity, and i highly doubt there ever will.

As far as permanent perceptive changes are concerned, they do happen of course.
We already knew that (given that we have been smart enough to do our research, which is easy as pie nowadays).
One thing that strikes me about all studies regarding perceptive changes from acid is that most impairments affect areas that will not make you function any worse or otherwise pose a problem.
An exception are the few people who experience very severe forms of HPPD all the time and have trouble reading or making out details because their visuals get in the way.
Such cases are one of the reasons why i don't trip often, but not the most important one.
I don't feel the need to trip more than every couple of years in the first place- this isn't like weed, booze, amphetamines or other habituating substances, where all you retain from the high is a memory of "feels good man" and get the urge to do it again.
It's something that produces lasting experience and detailed, clear memories of your impressions, something that can inspire me for years.
It produces something instead of inspiring more and more consumption.
So tripping is always a conscious decision for me, not an act of indulging in a habit.
It's something i do when i have reached a specific point in my life, a time when i feel the need to once more go to my limits and undergo a rite of passage, as well as an experiment with substances that have always intrigued me.
It's about encountering something new and unique, an expedition into the unknown to expand my horizon.
So the main reasons why i trip would get lost if i did so all the time.
That's why i don't worry about such findings.
If i'd be tripping every weekend, this might be different, but the few people who do so have decided this for themselves and are both aware of and willing to live with the consequences (or at least they should be).


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InvisibleScudreloaded
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: Lizardman]
    #11824435 - 01/13/10 09:20 PM (3 years, 4 months ago)

sometimes i wish i had HPPD


--------------------
We were somewhere around Barstow on the edge of the desert when the drugs began to take hold. - Hunter S. Thompson

- believe what you may but take the internet with a grain of salt


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Offlinealexithymia
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: Scudreloaded]
    #11824482 - 01/13/10 09:26 PM (3 years, 4 months ago)

Honestly, giving up a minute fraction of my visual ability is worth a lifetime of enlightenment in my opinion.


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InvisibleScudreloaded
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: alexithymia]
    #11824556 - 01/13/10 09:37 PM (3 years, 4 months ago)

I agree with myself more spiritually than before my entheogen experiences that i do feel have awakened me to new things and thought patterns in life.
Think about it guys. We see and know of things some don't within the world.


--------------------
We were somewhere around Barstow on the edge of the desert when the drugs began to take hold. - Hunter S. Thompson

- believe what you may but take the internet with a grain of salt


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Offlineteeter
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: Scudreloaded]
    #11825369 - 01/13/10 11:44 PM (3 years, 4 months ago)

Quote:

Scudreloaded said:
sometimes i wish i had HPPD




Its mad fun. When I'm bored I throw on The Universe (history channel) and listen to trippy particle physics and stuff like that while I make tracers with my laser pointer. :aweoverdose:


--------------------
"If the doors of perception were cleansed every thing would appear to man as it is, infinite. For man has closed himself up, till he sees all things through narrow chinks of his cavern." - William Blake

"Psychedelics helped me to escape.. albeit momentarily.. from the prison of my mind. It over-rode the habit patterns of thought and I was able to taste innocence again. Looking at sensations freshly without the conceptual overly was very profound." - Ram Das


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InvisibleScudreloaded
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: teeter]
    #11825437 - 01/13/10 11:52 PM (3 years, 4 months ago)

i don't feel like shrooms give effects that i feel the day after. other than maybe just coming back to reality.
the 2c-b illies i had once i had flashes of pink tin the sky whenever i'd stand up after a while of sitting. Wouldnt mind stuff a long the lines of that again.
Cant find LSD which is a bummer to me, i'll keep looking.
Never had an day after Ketamine effects either.


--------------------
We were somewhere around Barstow on the edge of the desert when the drugs began to take hold. - Hunter S. Thompson

- believe what you may but take the internet with a grain of salt


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OfflineMykologist
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: Shad0w]
    #11825497 - 01/14/10 12:00 AM (3 years, 4 months ago)

I'm not going to stop tripping mushrooms a couple times a year just because I wont be able to sit in a lab testing room and tell some PhD if the light in front of me is flashing fast enough. :wtf:

A few things I don't like about the study:

-no estimates on the amount/frequency of LSD use

-doesn't explain why HPPD patients scored WORSE when both have ingested the same chemical
and (a little farther fetched...)

-we're comparing LSD users' vision to that of "regular," sober peoples vision to standardize "impairment." I agree with what some of what I've heard on this thread, perspective change. This is the same reason why younger children score proportionally higher on IQ tests; because their psychology is so much different than an adult's.

meh who gives a damn. I haven't noticed a THING. Literally, I haven't noticed any physical repercussions of my drug use other than some lag during times of heavy pot use.

I'm not the one to care if my vision is impaired to some obscure degree that I can't notice in everyday life. I see nature, it's still beautiful (if not more beautiful) as when I was a kid. I read books and my mind is doing just lovely.


Quote:

Shad0w said:
Short Answer : The answer varies from individual. Most of it is opinion.

Mine is that whatever negative effect it MIGHT have on my mind, Are most assuredly, trumped by the enormous positive effects it has had on my mind. :thumbup:



Stole the motherfucking words outta my ass.
Myk


--------------------


Where would you rather be?


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InvisibledeCypher
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: Mykologist]
    #11825889 - 01/14/10 12:53 AM (3 years, 4 months ago)

Yeah, it does seem like LSD tends to degrade visual change response time in its users for a long period of time after its use... presumably this is similar to how trails work; neurons in the visual cortex are stimulated for much longer than normal under the influence of the psychedelic which leaves an after-image of whatever you are viewing and having this effect persist during sobriety makes it harder to tell when the sensory event that caused the original firing of the neuron in the visual cortex has stopped occurring.

However, it's unclear how much LSD usage is required to reach this point during ordinary life and whether this finding also applies to other psychedelics.  The benefits of responsible LSD usage far outweigh the possibility of this minor degradation in response time IMO, however, unless you're an air-traffic controller, pilot, racecar driver, or something equally ridiculous that requires extreme visual acuity.  If you're extremely concerned about it then minimize your dosage and frequency of use of LSD or preferably switch to another psychedelic.


--------------------
We are all in the gutter, but some of us are looking at the stars.


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Invisibleappleorange
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Re: Significant! LSD/Shrooms damage your brain permanently! [Re: deCypher]
    #11826350 - 01/14/10 02:09 AM (3 years, 4 months ago)

teeter,

is HPPD permanent? can you describe to me what it is like? never heard or met anyone who had it.


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