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You'd need a couple of pounds to get somewhat near a smokeable dose. There's plenty of other legal alternatives to extract from, look up the plant phallaris grass or the Erowid vaults for good extraction candidates.
k. trout says Desmanthus Ill. is so variable in content, that it could be nearly zero % and not even worth it. desmanthus leptolobus is said to be much more reliable, containing maybe as much as .1 or .2%