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OfflineQuake3
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Synthetic cannabinoid 100-800x more potent than THC
    #6886237 - 05/07/07 08:18 PM (16 years, 10 months ago)

http://en.wikipedia.org/wiki/HU_210

Quote:

HU-210 actually stimulates cell growth in the brain's hippocampus region, an opposite effect of drugs like alcohol, nicotine, heroin, and cocaine.




Quote:

HU-210 is a potent analgesic with many of the same effects as natural THC. This means that HU-210 could potentially be used in medicine as an alternative to medical marijuana, however its much stronger and longer lasting effects compared to those of THC could make appropriate titration of dosage difficult. Also due to the fact that HU-210 is a CB1 full agonist as opposed to THC which is a partial agonist, the sedative effects of HU-210 are much more prominent, meaning that while fatal overdoses of THC itself are unlikely, they would be possible with HU-210.




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InvisibleDNKYD
Turtle!

Registered: 09/23/04
Posts: 12,326
Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Quake3]
    #6886246 - 05/07/07 08:20 PM (16 years, 10 months ago)

Fuck the synthetics. Give me all natural herb and a warm vape.

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Offlinemasteroflight
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Posts: 164
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: DNKYD]
    #6886279 - 05/07/07 08:26 PM (16 years, 10 months ago)

give me all natural herb and a joint/pipe/bong... fuck vape

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OfflineNobodyCares
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Posts: 1,919
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Quake3]
    #6886378 - 05/07/07 08:42 PM (16 years, 10 months ago)

All I have to say is this analogy:

heroin:morphine::HU-210:THC

Do we really need the weed equivalent of heroin?


--------------------
The story goes, or the way that I was told
There was a king that always felt too high and then he fell too low
And so he called all the wise men to the hall
And begged them for a gift to end the rises and the falls
But here’s the thing, they came back with a ring
It was simple and was plainly unbefitting of a king
Engraved in black, it had no front or back
But there were words around the band that said
Just know: This Too Shall Pass


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OfflineAlCapwn
ID Reset, take that subpoena


Registered: 02/03/07
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: NobodyCares]
    #6886397 - 05/07/07 08:45 PM (16 years, 10 months ago)

Yes.


--------------------
Huuuuurrrrrr!

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OfflineNobodyCares
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: AlCapwn]
    #6886410 - 05/07/07 08:46 PM (16 years, 10 months ago)

If you say so, I guess there really isn't much about drugs that anyone would consider necessary.


--------------------
The story goes, or the way that I was told
There was a king that always felt too high and then he fell too low
And so he called all the wise men to the hall
And begged them for a gift to end the rises and the falls
But here’s the thing, they came back with a ring
It was simple and was plainly unbefitting of a king
Engraved in black, it had no front or back
But there were words around the band that said
Just know: This Too Shall Pass


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OfflineAlCapwn
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: NobodyCares]
    #6886499 - 05/07/07 09:01 PM (16 years, 10 months ago)

I was just kidding, but imagine ODing on THC, how too fucking stoned you'd be.


--------------------
Huuuuurrrrrr!

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OfflineNobodyCares
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: AlCapwn]
    #6886504 - 05/07/07 09:02 PM (16 years, 10 months ago)

Well, considering how I felt the few times I did manage to actually smoke too much, I would equate it more to tripping way too hard more so than being way too stoned.


--------------------
The story goes, or the way that I was told
There was a king that always felt too high and then he fell too low
And so he called all the wise men to the hall
And begged them for a gift to end the rises and the falls
But here’s the thing, they came back with a ring
It was simple and was plainly unbefitting of a king
Engraved in black, it had no front or back
But there were words around the band that said
Just know: This Too Shall Pass


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Invisiblebuckwheat
Cynically Insane

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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Quake3]
    #6886938 - 05/07/07 10:23 PM (16 years, 10 months ago)

That sounds like hell. High doses of pot aren't very fun

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OfflineKind Sir
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: buckwheat]
    #6887125 - 05/07/07 10:52 PM (16 years, 10 months ago)

I like how 210 is half of 420


--------------------
Peace.Love.Life.

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Invisibleshroomhead0069
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: NobodyCares]
    #6887242 - 05/07/07 11:17 PM (16 years, 10 months ago)

yes
i need to shoot it brah :boomboom:
pace from tha lot
:bom:shiva:bom:


--------------------
where my drugs at, poach monkey



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OfflineGastronomicus
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: shroomhead0069]
    #6887254 - 05/07/07 11:20 PM (16 years, 10 months ago)

20 bucks says this gets legalized and people OD/get addicted to it.


--------------------
Make my Funk the P Funk, I wants to get Funked up

LAGM2024

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Invisibleshroomhead0069
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Gastronomicus]
    #6887293 - 05/07/07 11:28 PM (16 years, 10 months ago)

i've been using it
and it's a little disappointing to say the least


--------------------
where my drugs at, poach monkey



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Invisiblelearning_byte
click here
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Gastronomicus]
    #6887333 - 05/07/07 11:36 PM (16 years, 10 months ago)

Dude I just can imagine, put some mix of some high grade kief, some hash oil and some of this bomb cannabinoid. :drooling:


--------------------

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InvisibleTeragon
Noddy

Registered: 02/20/01
Posts: 36,253
Loc: Lost in the Patterns
Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Gastronomicus]
    #6887338 - 05/07/07 11:37 PM (16 years, 10 months ago)

Quote:

Gastronomicus said:
20 bucks says this gets legalized and people OD/get addicted to it.






you have no idea what you are talking about. i will take that bet.


--------------------
need that cash to feed them jones.

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OfflineAstral Piper
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: NobodyCares]
    #6887762 - 05/08/07 01:50 AM (16 years, 10 months ago)

Quote:

NobodyCares said:
Do we really need the weed equivalent of heroin?




We do if the pharmaceutical industry expects to make billions from sales of synthetic THC products.

Save your seeds, and toss them out the car window every time you feel like taking a handful with you when riding to the store to get some milk. Let those bitches grow!! Cannabis plants ranged globally without any problem before the twentieth century, so let's just get out of its way and we won't have to count on Pfizer or Merck to give us whatever benefits they are now discovering from cannabinoids.

BTW, I read an article last week which mentioned that THC is now linked to REDUCING cancerous tumors in lung cancer patients. Now THAT'S what I'm talking about!!


--------------------
Syd Barrett at his final appearance with Pink Floyd on December 22, 1967:


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InvisibleAsante
Omnicyclion prophet
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Quake3]
    #6888111 - 05/08/07 07:40 AM (16 years, 10 months ago)




Hmmm.. for cannabis chemistry it isn't overly difficult to synthesize..

If a joint has 10mg THC then the HU-210 equivalent is 12.5-100 micrograms, lets say there's a median 25.000-50.000 doses per gram, so that one gram is about as strong as ten kilos of weed. Longer lasting and more stoned that THC too..

Imagine the equivalent of 100 kilos of weed in a test tube! Finally there's an ultrapotent form of THC, rivalling fentanyls in potency.


--------------------
Omnicyclion.org
higher knowledge starts here

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OfflineAninator
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Astral Piper]
    #6888146 - 05/08/07 07:55 AM (16 years, 10 months ago)

Quote:



BTW, I read an article last week which mentioned that THC is now linked to REDUCING cancerous tumors in lung cancer patients. Now THAT'S what I'm talking about!!




yes! My brother in law read that too! HOW FUCKIN SWEET IS THAT! my life is perfect now

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Offlinetonyperez420
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Registered: 11/03/04
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: DNKYD]
    #6888183 - 05/08/07 08:13 AM (16 years, 10 months ago)

Quote:

DNKYD said:
Fuck the synthetics. Give me all natural herb and a warm vape.




Warm vape :thumbup:
with a big rock of black Hash :thumbup::thumbup::thumbup:

Quote:

masteroflight said:
give me all natural herb and a joint/pipe/bong... fuck vape




vapes high are far superior then joint/pipe/bong
you probably still believe in beepers... get with the times!

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InvisibleAsante
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: tonyperez420]
    #6888388 - 05/08/07 09:23 AM (16 years, 10 months ago)

Get with the times, aye! HU-210 might be vaporized more readily, for instance with a simple bic lighter, and might for instance be sold on 1x1 inch "blotter" sheets of rice paper, where a 1/10 x 1/10 inch piece upon vaporization gives you the effect of a good-sized joint.

I made an ID pic of it, for those who like compact faqs:




--------------------
Omnicyclion.org
higher knowledge starts here

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Invisibleniteowl
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: DNKYD]
    #6889442 - 05/08/07 02:41 PM (16 years, 10 months ago)

Quote:

DNKYD said:
Fuck the synthetics.




--------------------
Live for the moment you are in now
Don't be bogged down by your past
Don't be afraid of what lies in your future

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Offlineclorox
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: niteowl]
    #6889545 - 05/08/07 03:09 PM (16 years, 10 months ago)

i want some.


--------------------


These walls, such they be, are crawling with geometric hallucinations.

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OfflineCepheus
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Asante]
    #6889700 - 05/08/07 03:57 PM (16 years, 10 months ago)

why do alkanes potentiate things?

In this example the THC group has a 'dimethylheptyl' group attached to the benzene on the THC.

what about methyl-fentanyl?

why also, does the position of the group affect the potency?


--------------------
"I only ever hope to reach equilibrium, in Nature's matrix, in line with the meridian" ~ Jehst

:sun: "...and I know that I have to keep breathing, as tomorrow the sun will rise, who knows what the tide will bring?" :sun:

Free Spore Ring Europe
Send any spare spore prints you might have and help the distribution :grin:

Open Source. Freedom.  GNU/Linux

Addicting is not a word.

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InvisibleAsante
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Cepheus]
    #6889871 - 05/08/07 04:54 PM (16 years, 10 months ago)

Quote:

why do alkanes potentiate things?

In this example the THC group has a 'dimethylheptyl' group attached to the benzene on the THC.

what about methyl-fentanyl?

why also, does the position of the group affect the potency?





Pharmacologically active drugs basically are chemical keys which fit onto receptors of your cells, and when such a key is in place an activation or de-activation of a process in your body takes place.

But, there is variability in receptors (locks) which allows for a group of molecules to be able to act as keys. Then there ofcourse arises the issue that some molecules will fit better than others.

If a molecule fits a receptor better, then less of the substance is needed to produce the desired effect, and the drug typically is more potent. Also, if an alteration of a molecule results in higher availability to those receptors, potency goes up too.

Lets take opiates as an example.

Morphine, the natural alkaloid, is active in a 5-25mg dose. A synthetic opioid, pethidine, is about 1/5 as strong. Heroin, which is made by heating morphine with acetic anhydride, is 2-3x as potent.

On the quest for better opioids, one of the more promising families of compounds were the derivatives of fentanyl. Fentanyl itself is a staggering 80x as potent as morphine. Here are some variations on the molecule:


<img src=http://www.shroomery.org/forums/files/06-45/307362457-fentanyls.gif>


This is only the tip of the iceberg, thousands of variations are possible.

Fentanyl is mostly broken down by cleaving the phenethyl-group off the piperidine. One can hinder that by adding a methyl group, because this gets in the way of the enzymes. Then you get alpha-methylfentanyl, which indeed is more potent, at 200x morphine. This is making an increase on availability.

If you however stick that methyl in the 3-position of the piperidine ring it will fit the "lock" far better than fentanyl itself. It fits so well in fact that it is 3.000x more potent than morphine, and three grams of this 3-methylfentanyl in fact are a million doses. (or in other words, one gram 3-MF is equivalent to a kilo of pure heroin or 3 kilos of high quality street heroin.



Quote:

In this example the THC group has a 'dimethylheptyl' group attached to the benzene on the THC.




They want this dimethylheptyl-tail on the cannabinoid molecules, because it is an optimized form, it fits the receptor very well, thats why you see it recur in many different THC analogs. And this tail fits that three-ring "body" really well, and the hydroxylated "head" (which is kinda pre-metabolized) is the finishing touch. Thats why this molecule is so potent: it fits the receptor (CB1 in this case) far better than THC does.


There are a thousand things more to it, but this basically is the main theme. Given the potency of HU-210 I wouldn't be surprised if one day molecules are found that are several thousand times more potent than THC, but they probably will have a novel structure. If they are relatively easy to synthesize and have good oral bioavailability and effects, you might be looking at one of the world's most popular recreational drugs of the future.

But HU-210 already might be a lot like this one:

Quote:

CP 55,940, is a cannabinoid which mimics the effects of naturally occurring THC (the psychoactive compound found in marijuana). CP 55,940 was created by Pfizer in 1974 and was never marketed because of its highly psychoactive nature. It is currently used by scientists to study cannabinoid effects in biology. Some effects that have been noted are a greatly decreased rates of lever pressing in exposed mice, and a greater reaction to opiates in exposed mice. CP-55940 is 40 times more potent than Δ9-THC, and fully antagonized by rimonabant (SR141716A) (Life Sci 1996;58:1239-47; last update 010106). CP 55940 produces cannabis-like effects in humans at a dose of 0.25 - 1 milligram and could potentially be used as a legal alternative to medicinal marijuana but is unlikely to be marketed for this purpose due to its abuse potential.
structure





Imagine an ultrapotent cannabinoid of increased desirability over THC. HU-210 might be it.


--------------------
Omnicyclion.org
higher knowledge starts here

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OfflineRuNE
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Asante]
    #6890244 - 05/08/07 06:29 PM (16 years, 10 months ago)

That's awesome and all.... but half the fun of getting stoned is smoking that joint, or taking a nice rip from that bong.

I guess it'd be good in places where the smell would be a big no-no.  :shrug:


--------------------
~Happy sailing~

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OfflineNobodyCares
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: RuNE]
    #6890260 - 05/08/07 06:33 PM (16 years, 10 months ago)

Like planes, and schools. Places where you really need to get high.


--------------------
The story goes, or the way that I was told
There was a king that always felt too high and then he fell too low
And so he called all the wise men to the hall
And begged them for a gift to end the rises and the falls
But here’s the thing, they came back with a ring
It was simple and was plainly unbefitting of a king
Engraved in black, it had no front or back
But there were words around the band that said
Just know: This Too Shall Pass


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OfflineAJ4U
Cloud N9ne
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Re: Synthetic cannabinoid 100-800x more potent than THC [Re: NobodyCares]
    #6890318 - 05/08/07 06:46 PM (16 years, 10 months ago)

Quote:

NobodyCares said:
Like planes, and schools. Places where you really need to get high.




:clap: :thumbup:


--------------------

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