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Offlinetokyo_brites
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Preserving psilocybin and psilocin
    #5924503 - 08/02/06 07:49 AM (7 years, 11 months ago)

Assuming one was to obtain a fairly pure psilocybin extraction using aa methanol tekC what is the best way to preserve the extraction. How to prevent it from turning to psilocin. I understand that one of the biggest factors in the deterioration is oxidation. If you were to seal and use anti-oxidant packs how long should it last. Any ideas are appreciated. But no freezer any ideas excepting the freezer.


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OfflineAnnoA
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Re: Preserving psilocybin and psilocin [Re: tokyo_brites]
    #5924524 - 08/02/06 08:06 AM (7 years, 11 months ago)

If kept sealed, dry and dark, psilocybin wont degrade quickly.
Psilocybin is much more stable than psilocin.


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OfflineSinthetic
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Re: Preserving psilocybin and psilocin [Re: Anno]
    #5924692 - 08/02/06 10:06 AM (7 years, 11 months ago)

The best way is to keep it submerged in the methanol. If kept cool it should last for years.


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Invisiblefastfred
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Re: Preserving psilocybin and psilocin [Re: Sinthetic]
    #5924712 - 08/02/06 10:22 AM (7 years, 11 months ago)

> The best way is to keep it submerged in the methanol.

Methanol is poisonous. Very bad idea to store drugs in poisonous substances.


-FF


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OfflineSinthetic
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Re: Preserving psilocybin and psilocin [Re: fastfred]
    #5925059 - 08/02/06 01:10 PM (7 years, 11 months ago)

I didn't say you should eat the methanol. His extraction tek ends up with crystals at the bottom of a methanol solution. If you want to store long term keep them in the methanol.


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Offlinetokyo_brites
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Re: Preserving psilocybin and psilocin [Re: Sinthetic]
    #5927463 - 08/03/06 02:05 AM (7 years, 11 months ago)

Using the methanol tek produced crystals of extreme potency. I am not sure if they are psilocybin or psilocin. How would I know the difference, and when does this change occur to the extraction after a good methanol tek. Also if you were to store these crystals in a sealed, dry place in a metal box (dark, and somewhat cool). About how long will they last. What is the shortest time that they would noticably lose potency? Thanks.


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Re: Preserving psilocybin and psilocin [Re: tokyo_brites]
    #5927718 - 08/03/06 05:03 AM (7 years, 11 months ago)

They are psilocybin. Psilocin is not extracted very well at all by methanol.

Assuming you keep them dry and cool they will last for awhile. Your guess is probably as good as any as to how long they will last.


-FF


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InvisibleWholefoods
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Re: Preserving psilocybin and psilocin [Re: tokyo_brites]
    #5931582 - 08/04/06 04:09 PM (7 years, 11 months ago)

Quote:

tokyo_brites said:
Using the methanol tek produced crystals of extreme potency. I am not sure if they are psilocybin or psilocin. How would I know the difference, and when does this change occur to the extraction after a good methanol tek. Also if you were to store these crystals in a sealed, dry place in a metal box (dark, and somewhat cool). About how long will they last. What is the shortest time that they would noticably lose potency? Thanks.



What are you planning on doing? Barrying them in a hole somewhere?
= /


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Invisiblespecial_k
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Re: Preserving psilocybin and psilocin [Re: tokyo_brites]
    #5954968 - 08/11/06 10:40 PM (7 years, 11 months ago)

I don't want to hi-jack the thread but does any one actually have experience using this methanol tek? If so did the crystals and potency actually last a long time? I did an extraction with ethanol before but found that the goodies degraded quickly. I am concerned the same would happen here.


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OfflineBabo911
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Re: Preserving psilocybin and psilocin [Re: special_k]
    #5957812 - 08/13/06 12:23 AM (7 years, 11 months ago)

you are much better off using something like grain alcohol or hi proof for your extractions. This allows you to store and consume as well :smile:

that is my 2 cents


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Invisiblespecial_k
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Re: Preserving psilocybin and psilocin [Re: Babo911]
    #5960766 - 08/13/06 11:50 PM (7 years, 11 months ago)

yeah the extraction I did was with denatured alcohol. whoops I just looked up the contents of denatured alcohol and found that its mostly methanol not ethanol. hummm... now I'm confused.

Babo have you used hi proof ethanol for extraction before and found that the goodies stay very stable for many months or perhaps years?


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Invisibled4a2n0k
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Re: Preserving psilocybin and psilocin [Re: special_k]
    #5963381 - 08/14/06 06:59 PM (7 years, 11 months ago)

THE CRYSTALS OF THE GODS
Very good write up on this topic. There's also a shroomery thread where members who have preformed this extraction discuss it in detail, a proper search should turn it up.


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OfflineBlue_Shrooms
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Re: Preserving psilocybin and psilocin [Re: d4a2n0k]
    #5997475 - 08/25/06 11:22 PM (7 years, 10 months ago)

"The following method described shows an easy method to isolate pure psilocin from fungus in less than 4 hours. If a more pure product is wanted, the fairly pure psilocin can be recrystallized to produce large pure crystals.

20 grams of dried fungus is powdered in a coffee grinder to a fine powder. This is added to a glass container (~500 ml) along with 200 ml of distilled water and 40 ml distilled white vinegar (5% acidity). ~200 mg of vitamin C was also added to keep the psilocin from decomposing. This mixture was allowed to stir at room temperature for 1 hour and then the container was placed in a bath of boiling water to heat the mixture to 70 degrees C. After the mixture reached this temperature, it is filtered through multiple coffee filters (3-4 is good) and the filtered (be sure to squeeze out all the juice!) liquid is set into a cold water bath to cool it down. The extracted fungus is recovered and put into another container along with 150 ml water and 20 ml vinegar. This is again heated to 70 degrees C and then filtered as before. The filtrate is again cooled down and then added to the 1st extraction. The combined filtrates should give somewhere around 300 ml of liquid. Add about 30 ml of chloroform (xylene should also work, as psilocin is solubile in this as well) and begin stirring gently (you don't want emulsions, do you?). While stirring, SLOWLY add NaOH solution (~10 % NaOH is fine). I would suggest a drop by drop addition, as the pH can raise raphidly after a certain point. Target pH is 8, just try not to go over pH 9, as the alkaloids can decompose pretty fast at high pH. After the pH is at 8-9, continue to stir gently for about 20 minutes (electric stirrers are nice) and the psilocin will migrate into the chloroform (or xylene) layer. This is poured into a separatory funnel (or something similar) and the bottom chloroform layer is removed and set aside. The water layer is again stirred and 15 ml of chloroform is added for a second extraction. After 20 minutes of stirring, this is again separated in a separatory funnel and the chloroform recovered. These two chloroform extracts are combined and put into a small beaker. To this beaker, anhydrous MgSO4 is added (just oven dry epson salts in an oven at 450 degrees F for about an hour) to absorb any water. Usually only a gram or so is needed. Stir the chloroform with the MgSO4 for a minute or so and then filter through a "good quality" filter paper so you catch all the fine particles. The resulting chloroform layer will have a light yellow color. Now you have two choices:

You can evap the chloroform quickly to yield a fairly pure psilocin powder, or let it evaporate slowly to get larger and more pure crystals. Recrystallization can be carried out with methanol or a 3:1 heptane:chloroform. The recrystallized material is very pure and 20 mg is equivelent to 4-5 grams of mushrooms. Average yield for this method is about 60 mg of pure crystals (after recrystallization). The crystals do decompose at room temperature over time. The yellow crystals turn green in about a week or so if left out. To preserve the psilocin, put ~50 mg of psilocin in a small container and add ~50 mg ascorbic acid and 20 ml water. The psilocin will dissolve, but it does so slowly. You now have a solution with 2.5 mg psilocin per ml. This can be stored for many months in the refrigerator (possibly longer). An interesting note is that this "psilocin water" can be evaporated to give white needle crystals which don't seem to degrade at room temperature. Perhaps this is the way to stabilization!"

This guy says that vitamain C is the key

Swims next project after DMT!


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Offlinelordsmaylead
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Re: Preserving psilocybin and psilocin [Re: Blue_Shrooms]
    #5997616 - 08/26/06 12:04 AM (7 years, 10 months ago)

liquid nitrogen is the best way to preserve anything including human flesh check out your local cryo facility


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Invisiblefastfred
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Re: Preserving psilocybin and psilocin [Re: Blue_Shrooms]
    #6007207 - 08/29/06 05:33 AM (7 years, 10 months ago)

Quote:

Blue_Shrooms said:
"The following method described shows an easy method to isolate pure psilocin from fungus in less than 4 hours. If a more pure product is wanted, the fairly pure psilocin can be recrystallized to produce large pure crystals.




That isn't a good method. It has a number of problems.

1. Stronger acetic acid should be used. There is no reason to dilute it. Store bought distilled white vinegar is already pretty dilute (~5%), so you should use it straight rather than a less than 20% solution as described (~=0.8%).

2. 1 hour is nowhere long enough to do a decent extraction. I read a journal article that determined the proper time. I can't remember it exactly and don't have the cite handy, but 24-48 hours is a good length of time.

3. Basifying your solution with sodium hydroxide will destroy the product in short order. Psilocin is unstable in solution, especially alkaline solutions.

4. If you're going to basify you should use ammonia rather than NaOH.

4. Some papers have reported that chloroform won't extract psilocin, while others say it will. So it's a bit of a crap shoot. The solubility is probably related to the pH.

5. The mixture should be held at 70C for 30 min, not filtered right away. The psilocybin needs some time to be converted to psilocin. The chloroform won't extract psilocybin at all, so any that remains unconverted will be lost.


-FF


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