|
 Anno
Experimenter
Registered: 06/17/99
Posts: 24,064
Loc: my room
Last seen: 8 hours, 58 minutes
|
 Re: How Hallucinogenic Drugs Work [Re: delta9]
#3630535 - 01/15/05 09:01 AM (7 years, 4 months ago) |
|
|
Page 11:
Figure 3. Hallucinogenic drugs become involved in the processes by which brain cells?neurons?interact. Such an interaction takes place when one neuron contacts another chemically across a minute synaptic gap. There are many neurotransmitters that mediate synaptic transmission in the brain, but the one that hallucinogens seem to affect most readily is serotonin (5-hydroxytryptamine). This drawing shows an axon terminal of a serotonin-containing neuron (presynaptic neuron) contacting the cell body of one of its target neurons (postsynaptic neuron). Tryptophan, the amino acid precursor of serotonin, is brought to the presynaptic neuron through the blood. Serotonin is synthesized from tryptophan inside the axon terminal and stored in vesicles. When an action potential, generated in the cell body of the neuron, invades the axon terminal, the vesicles release their contents into the synaptic gap and interact with receptors embedded within the postsyinaptic neuron to produce either excitation or inhibition.
Page 12:
Figure 5. The picture of chemical neurotransmission shown in Figure 3 is complicated by the fact that the receptors in postsynaptic neurons can be of several different types. This schematic representation demonstrates how a molecule or serotonin (5-HT) might interact with three different types of serotonin receptors (5-HTIA, 5-HT IB and 5-HT2). Current research indicates that LSD and other hallucinogenic drugs exercise their critical action on serotonin neurotransmission by binding to the 5-HT2 receptor subtype.
Figure 6. The indole nucleus structure of the serotonin molecule is similar to that of the hallucinogenic drugs LSD, psilocin, and DMT shown in Figure 2. It is this similarity that originally led researchers (0 theorize that LSD was involved in the neurotransmission of serotonin in the brain.
|
Annom
※※※※※※
Registered: 12/22/02
Posts: 6,264
Loc: Europe
Last seen: 26 minutes, 48 seconds
|
Re: How Hallucinogenic Drugs Work [Re: delta9]
#3630539 - 01/15/05 09:05 AM (7 years, 4 months ago) |
|
|
Quote:
delta9 said:
Quote:
Anno said:
>Use an open format.
How about HTML  (not word html......)
That'll do for me. most ANYTHING is better than the idiotic mangling word does to data.
Hehehe, I'm not stupid(not all the time). I just tried to make clear that I put everything together, so you guys don't have to do that. It will be HTML of course. I use word until we have everything. Spelling check is handy!
|
delta9
Active Ingredient
 
Registered: 10/28/04
Posts: 5,390
Loc: California
Last seen: 1 year, 7 months
|
Re: How Hallucinogenic Drugs Work [Re: Annom]
#3630543 - 01/15/05 09:07 AM (7 years, 4 months ago) |
|
|
*nod* carry on. I am but a benefiting observer, and even if it were a word document, I would be just as happy that you put the effort forth for the community
--------------------
delta9
|
Anno
Experimenter
Registered: 06/17/99
Posts: 24,064
Loc: my room
Last seen: 8 hours, 58 minutes
|
Re: How Hallucinogenic Drugs Work [Re: Annom]
#3630549 - 01/15/05 09:10 AM (7 years, 4 months ago) |
|
|
I?ll do the references.
|
Anno
Experimenter
Registered: 06/17/99
Posts: 24,064
Loc: my room
Last seen: 8 hours, 58 minutes
|
Re: How Hallucinogenic Drugs Work [Re: Anno]
#3630573 - 01/15/05 09:17 AM (7 years, 4 months ago) |
|
|
Or not, since they are hopelessly unreadable.
|
Annom
※※※※※※
Registered: 12/22/02
Posts: 6,264
Loc: Europe
Last seen: 26 minutes, 48 seconds
|
Re: How Hallucinogenic Drugs Work [Re: Anno]
#3631100 - 01/15/05 11:40 AM (7 years, 4 months ago) |
|
|
How Hallucinogenic Drugs Work
Can someone check it?
Anno, can you replace this article http://www.shroomery.org/index/par/24307 with the new one? Let me know if I can help with anything!
I'll contact mjshroomer and replace this thread with the new one as soon as possbible
|
Anno
Experimenter
Registered: 06/17/99
Posts: 24,064
Loc: my room
Last seen: 8 hours, 58 minutes
|
Re: How Hallucinogenic Drugs Work [Re: Annom]
#3631469 - 01/15/05 01:40 PM (7 years, 4 months ago) |
|
|
Done and done.
|
 mjshroomer
Sage
Registered: 07/21/99
Posts: 13,774
Loc: gone with my shrooms
|
Re: How Hallucinogenic Drugs Work [Re: Annom]
#3632015 - 01/15/05 03:57 PM (7 years, 4 months ago) |
|
|
HI Annom,
Thanks for the work on the paper. I actually found the journal a few days ago in my file cabinet. What it was doing in there i do not knwo. I had planned on making a better copy.
Anyway. Good job.
Thanks Anno for moving o it to the front to replace the bad jpegs I made form an old xerox copy form a folder in my cabinets.
mj
|
Annom
※※※※※※
Registered: 12/22/02
Posts: 6,264
Loc: Europe
Last seen: 26 minutes, 48 seconds
|
Re: How Hallucinogenic Drugs Work [Re: mjshroomer]
#3634270 - 01/16/05 04:18 AM (7 years, 4 months ago) |
|
|
I think there is one(or more) page missing. There is no figure 4 for example. Can you check that?
|
mjshroomer
Sage
Registered: 07/21/99
Posts: 13,774
Loc: gone with my shrooms
|
Re: How Hallucinogenic Drugs Work [Re: Annom]
#3634465 - 01/16/05 07:52 AM (7 years, 4 months ago) |
|
|
Sorry annom,
My mistake. The Journal I have found is Readings from the Scientific American: Altered States of Awareness and the Article I thou was the above one is actually the Hallucinogenic Drugs by Frank Barron (The man who gave Tim Leary shrooms), Murray Jarvik and Sterling Bunnel and was from the April 1964 uissue of the Scientific American Journal.
I will look for fig. 4 in the files.
mj
|
mjshroomer
Sage
Registered: 07/21/99
Posts: 13,774
Loc: gone with my shrooms
|
Re: How Hallucinogenic Drugs Work [Re: mjshroomer]
#3635043 - 01/16/05 12:23 PM (7 years, 4 months ago) |
|
|
Annom,
Here is the missing figure.
It can be reposted int he front of the thread and then you can remove it from here.
Have a shroomy day,
mj
|
Annom
※※※※※※
Registered: 12/22/02
Posts: 6,264
Loc: Europe
Last seen: 26 minutes, 48 seconds
|
Re: How Hallucinogenic Drugs Work [Re: mjshroomer]
#3637542 - 01/16/05 11:54 PM (7 years, 4 months ago) |
|
|
Thank you very much!
How Hallucinogenic Drugs Work
I can't update your post, only admins can post full html codes. Anno? (I added figure 4.)
|
ummikko
sika joka eilenn? on pelkk?sika
Registered: 04/02/03
Posts: 1,222
Loc: Finland
Last seen: 2 years, 6 days
|
Re: How Hallucinogenic Drugs Work [Re: Annom]
#3640660 - 01/17/05 06:15 PM (7 years, 4 months ago) |
|
|
Good work.
If you haven't already, you might want to check a book called
50 years of LSD: Current status and perspectives of hallucinogens,
expecially an article 5-HT receptor interactions of D-LSD by S.J.Peroutka. The book is over ten years old, but it's still an excellent collection of hallucinogen-related research articles.
--------------------
"All substances are poisons; there is none which is not a poison. The right dose differentiates a poison and a remedy." -Paracelsius
|
Annom
※※※※※※
Registered: 12/22/02
Posts: 6,264
Loc: Europe
Last seen: 26 minutes, 48 seconds
|
Re: How Hallucinogenic Drugs Work [Re: ummikko]
#3642261 - 01/18/05 03:56 AM (7 years, 4 months ago) |
|
|
Thanks! It's on my Amazon wish list!
Price: $101.40 
|
Annom
※※※※※※
Registered: 12/22/02
Posts: 6,264
Loc: Europe
Last seen: 26 minutes, 48 seconds
|
Re: How Hallucinogenic Drugs Work [Re: ummikko]
#3642264 - 01/18/05 03:59 AM (7 years, 4 months ago) |
|
|
 My local drugs library has it! It's so amazing that they opened a public drug library in my city with more than 55000 books and articles about drugs and addiction.
|
DadeMurphy
H4x0r
Registered: 01/29/03
Posts: 908
Last seen: 2 years, 2 months
|
Re: How Hallucinogenic Drugs Work [Re: Annom]
#3706273 - 01/31/05 02:58 AM (7 years, 3 months ago) |
|
|
I thought I'd add this link:
From 2004.
It's an excellent and up-to-date summary of information on the hallucinogens, and how they work.
It's by David Nichols, creator of several LSD analogs that are more potent by weight than LSD itself!
http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=6318
--------------------
--------------------------------------------------
|
shymanta
Mad Scientist
Registered: 01/27/05
Posts: 904
|
Re: How Hallucinogenic Drugs Work [Re: DadeMurphy]
#3728623 - 02/04/05 12:09 AM (7 years, 3 months ago) |
|
|
This seems to be the best string to post this question.
Because of the complex tech-speak, it is difficult to tell exactly what the effects on serotonin are. Do Hallucinogens effect serotonin in a negative or positive way? (i.e. Do they deplete serotonin or act as an SSRI)?
|
ummikko
sika joka eilenn? on pelkk?sika
Registered: 04/02/03
Posts: 1,222
Loc: Finland
Last seen: 2 years, 6 days
|
Re: How Hallucinogenic Drugs Work [Re: shymanta]
#3750116 - 02/08/05 06:44 AM (7 years, 3 months ago) |
|
|
Generally, neither. I will try to explain this with help from googled pictures (sorry, I have nothing better that I can upload now, also sorry for possible bad english, it's not my native language)
When we talk about synaptic transmission/neurotransmitters, we're talking about chemical events between two neurons(nerve cells). The first is called the presynaptic neuron, the other is the postsynaptic neuron.
A single neuron, synapses at "terminal buttons", postsynaptic neuron not shown. The terminal buttons connect to the dendrites of another neuron ("receiving end").
SSRI:s inhibit serotonin from being taken back into the presynaptic neuron.
Some drugs stimulate certain synapses by increasing the release of a neurotransmitter from the presynaptic terminals (for example amphetamine causes dopamine release). If all neurotransmitter stored in an axon terminal is released and used, the presynaptic neuron is depleted(for a while), like you said.
Closeup on a synapse:
Now, hallucinogens don't have an effect on the presynaptic neuron. Instead, they resemble the neurotransmitter serotonin, and produce their effects by attaching to the serotonin reseptors on the postsynaptic neuron, and "activate" the receptor. That is, hallucinogens are serotonin agonists.
I couldn't find a good picture on this, anyway, here you can see the location of receptors on the postsynaptic membrane:
Okay, now contrast this mode of action to that of amphetamine which, as said, acts by releasing norepinephrine and dopamine from the presynaptic neurons. If the neurons have a low supply of these neurotransmitters, amphetamine is ineffective. However, even after the complete removal of the presynaptic neurons that release serotonin, hallucinogens still exert their full effect.
Hopefully this clarified things instead of confusing you more 
--------------------
"All substances are poisons; there is none which is not a poison. The right dose differentiates a poison and a remedy." -Paracelsius
Edited by ummikko (02/08/05 07:06 AM)
|
ummikko
sika joka eilenn? on pelkk?sika
Registered: 04/02/03
Posts: 1,222
Loc: Finland
Last seen: 2 years, 6 days
|
Re: How Hallucinogenic Drugs Work [Re: DadeMurphy]
#3750154 - 02/08/05 07:02 AM (7 years, 3 months ago) |
|
|
Excellent article, just what I've been looking for. 5 shrooms!
--------------------
"All substances are poisons; there is none which is not a poison. The right dose differentiates a poison and a remedy." -Paracelsius
|
redgreenvines
irregular verb
Registered: 04/08/04
Posts: 13,639
|
Re: How Hallucinogenic Drugs Work [Re: ummikko]
#3750226 - 02/08/05 07:38 AM (7 years, 3 months ago) |
|
|
all fine, so...
then what happens?
I was shocked to hear that once the kappa opiate receptor binding propensity of salvinorin was discovered that scientists said, "this is the psychedellic effect of salvia".
(all they had assembled was the primary binding site and nearly nothing about the real effects that we notice)
the interesting stuff (layering etc.) lies in what happens when the neurons are encouraged to keep firing after the excitatory stimulus has faded.
that applies to both serotoninergic and KOR chemical events which become interesting as the whole brain tissue begins to handle stimuli in a more resonant way.
--------------------
~~~~~
|
|
Previous
Index
Next
Threaded
Shop for: 
Edit 
Reply 
