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I might have some mushrooms in a couple of days, and I am on 300 mg of Wellbutrin XL. I was wondering if anyone knows if Wellbutrin has any interaction with mushrooms. Specifically, does Wellbutrin make it hard to trip? I have heard that SSRI's (selective seratonin reuptake inhibitors) decrease one's ability to trip, although others say that their ability to trip was unaffected. Thus, there seem to be conflicting views on this issue. Perhaps differing experiences are simply because antidepressants affect people differently, but, since no systematic study has been done, the differing experiences could be due to the different conditions under which the mushrooms were eaten.
Anyway, to make things more complicated, Wellbutrin is not an SSRI. Wellbutrin inhibits the reuptake of norepinephrine and dopamine. Thus, perhaps the effect that it has on one's ability to trip is different from other antidepressants.
Has anyone had any experiences taking mushrooms while on Wellbutrin? If so, please share them. I would greatly appreciate it. Incidentally, I am planning on skipping Wellbutrin doses for 2 days (that is, I will not take Wellbutrin the day before the mushrooms are consumed, or the day that the mushrooms are consumed). Perhaps I will report my experience here, if I feel it would be informative.
Thanks for reading,
P.S. I searched the message board for topics containing the word Wellbutrin, and, although a number of posts came up, none of them really addressed my question.
Thanks for the link, Ayrios. The information on that page seems very thorough and comprehensive.
I just have one question. On that page, under Bupropion (i.e. Wellbutrin), it says that "There are no known dangers from combining [hallucinogens] with Bupropion." That is reassuring, but I wonder if that also means that Wellbutrin does not decrease one's ability to trip. I only raise this point because I found an entry in Erowid's Experience Vault in which the person took mushrooms while on Wellbutrin, and was unable to trip.
The page also says it may act as a weak 5HT (serotonin) reuptake inhibitor. Mushrooms work by interacting with the serotonin. This could weaken the trip a bit but I think she'd have mentioned if a lot of people report it. A lot of people are on Wellbutrin and I'm inclined to believe that 'weak' really does mean weak in this situation. You probably wouldn't notice the small amount of weakening that may occur.
I know the OP is 6 years old but I'm replying because when I searched for the answer, I couldn't find it... so if anyone else is looking for an answer to whether Wellbutrin blocks the ability to trip, I can say that it doesn't. I take 300 mg daily and I had a level 2 on 7.5 grams wet.
-------------------- Pathological liar and expert at creating and photographing fake mushrooms.