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PsyDragon said:
I think at this stage, such conjecture is not only irresponsible, but kind of unethical to be publishing.

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trampis said:
In regards to ebola, I have to agree with the following comment...

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PsyDragon said:
I think at this stage, such conjecture is not only irresponsible, but kind of unethical to be publishing.

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Most of us on the site would like to see the drug culture be taken more seriously.
Outrageous claims such as this story will only hinder that progress.
If there were strong evidence supporting the claim I would have no issue with it.
Under the current circumstances, this headline will impede the movement.

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IoRhinz said:
Holy shit, how stupid can you guys be? Did you not read the article?

Last paragraph: Strong evidence suggests that cannabis can be a positive treatment for those suffering from Ebola, but all of which should be taken with a grain of salt. These are hypotheses, based on research involving other viruses, and not proven fact. Still, the argumentation is enough to warrant a clinical trial. Worst to worst, Ebola sufferers will smoke a bit of weed, which won’t make things worse…we hope.

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Ooooooooook trampis, thanks for speaking for the entire community here

this will impede the movement alright.....

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germx99 said:
Most decent Colorado dispensaries sell lab certified concentrates ranging anywhere from 60-85% cannabinoid content. With recreational laws in place, these same concentrates are available to the general public. Anyone over 21 can go and buy a gram of high purity hash and then encapsulate it for oral use to avoid coughing reactions. Considering there is a plethora of research for cannabis's antiviral properties, it probably wouldn't hurt for an ebola patient to swallow a few grams of hash over the course of their illness, as it would also relieve many of the secondary symptoms of the virus. Even if it doesn't actually cure ebola, current research strongly suggests that it can effectively treat the damage the virus does, thus decreasing the likelihood of mortality while a person recovers.

I've applied similar reasoning to reishi, given an equally clinically verifiable efficacy in treating retroviruses like AIDS, in addition to profound anti-inflammatory and immunomodlating effects. Idk why people are so quick to assume that suggesting Cannabis as an effective tool for fighting ebola is just stoner hogwash. Both cannabis and reishi have been used in Pan-Asian healthcare for thousands of years, reishi is often hailed as a king of all medicines, the Chinese name for it, "lingzhi" literally means supernatural mushroom. Natural products use dozens to hundreds of different chemical compounds to work their magic, whereas pharmaceutical preparations are often isolates of a single chemical. Given that ebola virus is unique between victims, would it not make far more sense to treat it with a wide range of known beneficial substances that are easily obtained for little cost as opposed to a single experimental one that is likely designed with the intention of exploiting the sick to generate profits and allow for distributors to pick and choose who can receive the 'cure?'

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well said!

also, new vaccines derived from rabies, that have no long term health studies on humans, and being made by GSK (Glaxo Smith Kline) the same company who did this EXACT SAME THING with H1N1 vaccines and got sued 30 billion in court because they later discovered a link to narcolepsy in children....yikes

Ill take the cannabinoids please

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spixce said:
Yeah it is hard to get Ebola if you sit on the couch all day eating Cheetos.

Come on now, weed has alot of medical uses but stoners exaggerate them to the extreme like for example they found out that it promotes appetite in aids patients they started saying shit like "weed cures aids man".

The pharmacological effects of weed do not cure or prevent Ebola in any way.  That article is a bunch of bullshit it has no credible sources at all. 

Even if cannabinoids could have a positive effect on Ebola smoking weed isn't gonna do shit for it maybe oral administration of pure THC or another cannabinoid but inhaling smoke is not something sick people should do and smoking anything can cause coughing which is not something you want someone with Ebola doing.   

I mean do they really think that weed cures every fucking medical problem on this whole planet. It doesn't cure cancer either if i did why didn't it cure Bob Marley's cancer.

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treesniper119 said:

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germx99 said:
Most decent Colorado dispensaries sell lab certified concentrates ranging anywhere from 60-85% cannabinoid content. With recreational laws in place, these same concentrates are available to the general public. Anyone over 21 can go and buy a gram of high purity hash and then encapsulate it for oral use to avoid coughing reactions. Considering there is a plethora of research for cannabis's antiviral properties, it probably wouldn't hurt for an ebola patient to swallow a few grams of hash over the course of their illness, as it would also relieve many of the secondary symptoms of the virus. Even if it doesn't actually cure ebola, current research strongly suggests that it can effectively treat the damage the virus does, thus decreasing the likelihood of mortality while a person recovers.

I've applied similar reasoning to reishi, given an equally clinically verifiable efficacy in treating retroviruses like AIDS, in addition to profound anti-inflammatory and immunomodlating effects. Idk why people are so quick to assume that suggesting Cannabis as an effective tool for fighting ebola is just stoner hogwash. Both cannabis and reishi have been used in Pan-Asian healthcare for thousands of years, reishi is often hailed as a king of all medicines, the Chinese name for it, "lingzhi" literally means supernatural mushroom. Natural products use dozens to hundreds of different chemical compounds to work their magic, whereas pharmaceutical preparations are often isolates of a single chemical. Given that ebola virus is unique between victims, would it not make far more sense to treat it with a wide range of known beneficial substances that are easily obtained for little cost as opposed to a single experimental one that is likely designed with the intention of exploiting the sick to generate profits and allow for distributors to pick and choose who can receive the 'cure?'

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well said!

also, new vaccines derived from rabies, that have no long term health studies on humans, and being made by GSK (Glaxo Smith Kline) the same company who did this EXACT SAME THING with H1N1 vaccines and got sued 30 billion in court because they later discovered a link to narcolepsy in children....yikes

Ill take the cannabinoids please

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DiscoBiscuitsTrip said:
I'm so sick of people claiming shit they read in blogs as fact haha.

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LMFAO

are you fucking kidding me? how is what you are proposing relevant to this situation exactly?

suggesting that smoking weed or vaporizing its extracts will kill people? (citation needed)

If someone has ebola and they consume cannabinoids, it will not cause them to die any faster, if anything it slows the cytokine storm on your immune system. Its more of a treatment than anything else.

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dark3st said:

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DiscoBiscuitsTrip said:
I'm so sick of people claiming shit they read in blogs as fact haha.

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People die because shut like this...

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give us a specific example of an ebola patient that is given cannabinoids and then is shown to rapidly deteriorate from the inside out, please.....

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trampis said:
I think they meant that people die from bogus information such as weed can protect you from Ebola...

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treesniper119 said:
LMFAO

are you fucking kidding me? how is what you are proposing relevant to this situation exactly?

suggesting that smoking weed or vaporizing its extracts will kill people? (citation needed)

If someone has ebola and they consume cannabinoids, it will not cause them to die any faster, if anything it slows the cytokine storm on your immune system. Its more of a treatment than anything else.

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dark3st said:

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DiscoBiscuitsTrip said:
I'm so sick of people claiming shit they read in blogs as fact haha.

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People die because shut like this...

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give us a specific example of an ebola patient that is given cannabinoids and then is shown to rapidly deteriorate from the inside out, please.....

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trampis said:
You're missing the point completely.

It's not about cannabinoids causing someone to die, but if someone were to be misinformed to the point that they believed smoking weed would prevent them from catching Ebola.

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trampis said:
So, I guess people who smoke weed never get sick

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treesniper119 said:
OMFG are you kidding me again? who is making conjectures and rampant speculations now?

If you were quarentined right now, and there is no known access to a widely available cure, why wouldn't you try everything in your power to treat and heal yourself?

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treesniper119 said:

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germx99 said:
Most decent Colorado dispensaries sell lab certified concentrates ranging anywhere from 60-85% cannabinoid content. With recreational laws in place, these same concentrates are available to the general public. Anyone over 21 can go and buy a gram of high purity hash and then encapsulate it for oral use to avoid coughing reactions. Considering there is a plethora of research for cannabis's antiviral properties, it probably wouldn't hurt for an ebola patient to swallow a few grams of hash over the course of their illness, as it would also relieve many of the secondary symptoms of the virus. Even if it doesn't actually cure ebola, current research strongly suggests that it can effectively treat the damage the virus does, thus decreasing the likelihood of mortality while a person recovers.

I've applied similar reasoning to reishi, given an equally clinically verifiable efficacy in treating retroviruses like AIDS, in addition to profound anti-inflammatory and immunomodlating effects. Idk why people are so quick to assume that suggesting Cannabis as an effective tool for fighting ebola is just stoner hogwash. Both cannabis and reishi have been used in Pan-Asian healthcare for thousands of years, reishi is often hailed as a king of all medicines, the Chinese name for it, "lingzhi" literally means supernatural mushroom. Natural products use dozens to hundreds of different chemical compounds to work their magic, whereas pharmaceutical preparations are often isolates of a single chemical. Given that ebola virus is unique between victims, would it not make far more sense to treat it with a wide range of known beneficial substances that are easily obtained for little cost as opposed to a single experimental one that is likely designed with the intention of exploiting the sick to generate profits and allow for distributors to pick and choose who can receive the 'cure?'

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well said!

also, new vaccines derived from rabies, that have no long term health studies on humans, and being made by GSK (Glaxo Smith Kline) the same company who did this EXACT SAME THING with H1N1 vaccines and got sued 30 billion in court because they later discovered a link to narcolepsy in children....yikes

Ill take the cannabinoids please

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What the fuck.

Let me jump in real quick on you guys who claims all sort of shit, because people like you are dangerous.

First, I'm pretty sure just by the way you write and believe in this crap that you do not hold a medical degree. Yes, big assumption here, prove me wrong. Extrapolating without having any evidence is not the normal behaviour of scientific mind, so oh well, let's see.


“Extraordinary claims require extraordinary evidence.”

― Carl Sagan

Second, I see that you are pro-cannabis and pro-disease (anti-vaxx) people advocating against vaccine. Wow, good job. We are falling on the 100% woo side of pseudoscience right here. If you did one fucking immunology/virology class in your lifetime you wouldn't say pure crap like this.

Now, you all say "what's the harm"! You could do the same with homeopathy and chiropractic or acupuncture and people really don't realize that placebo medication or techniques really do carry risk. And not a small one. Look at Steve Jobs. He was sure chemo was not the way to go and tried alternative medicine. Result, he died when he could have lived. His cancer was treatable sadly. A lots of people do like him and realize just in the end how modern medicine really is fabulous to have. Don't fall for the marketing of the "alternative".

Like Tim Minchin says so well: “You know what they call alternative medicine that's been proved to work? - Medicine.” (See:

And I will just lead this here too, because surely you guy know so much about what you talk about (yeah I guess not, bring in the anecdotal evidence of him taking dabs and not catching the flu what a logical fallacy) that you must surely know this, but why are you shutting your mouth about research that indicate that there is no effect from cannabinoids on viral disease or in fact, it worsened the progression of the disease either in vitro and in vivo.

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3. Conclusions

Cannabinoids are profoundly anti-inflammatory and impair many Ca2+-dependent enzyme systems which are central to inflammatory and cell-autonomous antiviral responses. When viral-induced host responses lead to immunopathology, as is seen in a rodent model of multiple sclerosis, TMEV-IDD, or in a persistent infection of the central nervous system caused by a non-lytic virus, BDV, cannabinoid treatment was beneficial.

In all other virus infections, both in vitro and in vivo, cannabinoid treatment led to disease progression, increased pathology, and sometimes to host death. Therefore, in many clinical settings, including latent infections caused by HIV-1 or HSV-1, and persistent infection of the liver caused by HCV, cannabinoids lead to worsened disease outcome.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903762/

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Marijuana, Cannabis sativa, elicits a variety of effects in experimental animals and humans. Delta-9-tetrahydrocannabinol (THC) is the major psychoactive component in marijuana. This substance has been shown, also, to be immunosuppressive and to decrease host resistance to bacterial, protozoan, and viral infections. Macrophages, T lymphocytes, and natural killer cells appear to be major targets of the immunosuppressive effects of THC. Definitive data which directly link marijuana use to increased susceptibility to infection in humans currently is unavailable. However, cumulative reports indicating that THC alters resistance to infection in vitro and in a variety of experimental animals support the hypothesis that a similar effect occurs in humans.

http://www.jni-journal.com/article/S0165-5728%2897%2900227-0/abstract

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Virus-infected animals treated with 100 mg/kg Delta-9-THC exhibited greater severity of herpes genitalis, higher mortalities and higher mean titres of virus shed from the vagina. Suppression of the humoral response to HSV-2 occurred in animals treated with this dose of drug when compared to virus-infected vehicle controls. A delay in the onset of the DHR to HSV-2 was observed in animals receiving 100 mg/kg Delta-9-THC when compared with those receiving vehicle. These results indicate that Delta-9-THC decreases host resistance to HSV-2 vaginal infection in the B6C3F1 mouse. This decreased resistance is associated with suppression of the immune response to primary infection with HSV-2.

http://vir.sgmjournals.org/content/66/12/2539.short

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It is widely recognized that various microorganisms including viruses have immunomodulatory effects and, under appropriate circumstances, may markedly suppress the immune response mechanisms. Cannabinoids present in marijuana also have immunomodulatory effects. In the present studies THC as well as its metabolic product 11-OH THC were studied in regard to their effects in vivo and in vitro on selected parameters of the immune response system known to be important in antiviral resistance, including immunity to retroviruses. Cannabinoids markedly suppressed the ability of murine macrophages to spread on glass (an important functional marker of macrophages) as well as to phagocytize yeast particles. Splenic macrophage cultures treated with the cannabinoids also were deficient in their ability to produce interleukin 1 on appropriate stimulation with bacterial LPS. Spleen cells capable of producing antibody to sheep erythrocytes when stimulated with this antigen in vitro were markedly affected when treated with graded doses of THC or 11-OH THC. Furthermore, the blastogenic responsiveness of normal mouse splenocytes to the T-cell mitogens Con A and PHA as well as the B-cell mitogen E. coli LPS was markedly suppressed by graded concentrations of the cannabinoids in doses that did not affect the viability of the cells. Natural killer cell activity of normal mouse spleen cells was also markedly inhibited by THC and 11-OH THC. Similarly, these cannabinoids suppressed the blastogenic responsiveness and NK activity of human peripheral blood leukocytes from normal individuals. The ability of mouse spleen cells to produce interferon on in vitro stimulation was also suppressed by THC. In addition, injection of THC into mice suppressed blastogenic responsiveness of spleen cells, NK activity, and the production of interferon by lymphoid cells. Thus, it was apparent that these cannabinoids had immunomodulatory effects, both in vivo and in vitro, at noncytotoxic small doses and impaired the ability of the lymphoid cells to express immune function necessary for antiviral resistance.

http://europepmc.org/abstract/MED/2840802

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Etc.

Nice anti-viral proprieties. Really nice. Suppress the immune system to let the disease progress even more.

What a mess this thread is.

Now, I can't wait for you guys to say: "But this has an agenda and it has been paid by the corporations against cannabis as a medication" like you guys always do when you don't know what to say against evidence that does against what you cherish a lot on this Earth, the dear cannabis.

Otherwise, I am open to continue the discussion if you bring me nice little source of papers in the literature that could point to anti-viral proprieties from the compounds founds in the cannabis plant.

Enjoy.

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Abstract

Delta-9-tetrahydrocannabinol (Δ9-THC), the psychoactive component of marijuana, is known to suppress the immune responses to bacterial, viral and protozoan infections, but its effects on fungal infections have not been studied. Therefore, we investigated the effects of chronic Δ9-THC treatment on mouse resistance to systemic Candida albicans (C. albicans) infection. To determine the outcome of chronic Δ9-THC treatment on primary, acute systemic candidiasis, c57BL/6 mice were given vehicle or Δ9-THC (16 mg/kg) in vehicle on days 1-4, 8-11 and 15-18. On day 19, mice were infected with 5×10(5) C. albicans. We also determined the effect of chronic Δ9-THC (4-64 mg/kg) treatment on mice infected with a non-lethal dose of 7.5×10(4) C. albicans on day 2, followed by a higher challenge with 5×10(5) C. albicans on day 19. Mouse resistance to the infection was assessed by survival and tissue fungal load. Serum cytokine levels were determine to evaluate the immune responses. In the acute infection, chronic Δ9-THC treatment had no effect on mouse survival or tissue fungal load when compared to vehicle treated mice. However, Δ9-THC significantly suppressed IL-12p70 and IL-12p40 as well as marginally suppressed IL-17 versus vehicle treated mice. In comparison, when mice were given a secondary yeast infection, Δ9-THC significantly decreased survival, increased tissue fungal burden and suppressed serum IFN-γ and IL-12p40 levels compared to vehicle treated mice. The data showed that chronic Δ9-THC treatment decreased the efficacy of the memory immune response to candida infection, which correlated with a decrease in IFN-γ that was only observed after the secondary candida challenge.

http://www.ncbi.nlm.nih.gov/pubmed/25057822

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Even in fungal infection THC seems worthless.

Plus, IL-12p40 mean interleukin 12, and its production was decreased.

You know, the molecule useful in the production and differentiation of T-Cell and many other things. But I don't need to explain this, you already know so much about the immune system treesniper.

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Simplepowa said:
Ouch.

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Abstract

Delta-9-tetrahydrocannabinol (Δ9-THC), the psychoactive component of marijuana, is known to suppress the immune responses to bacterial, viral and protozoan infections, but its effects on fungal infections have not been studied. Therefore, we investigated the effects of chronic Δ9-THC treatment on mouse resistance to systemic Candida albicans (C. albicans) infection. To determine the outcome of chronic Δ9-THC treatment on primary, acute systemic candidiasis, c57BL/6 mice were given vehicle or Δ9-THC (16 mg/kg) in vehicle on days 1-4, 8-11 and 15-18. On day 19, mice were infected with 5×10(5) C. albicans. We also determined the effect of chronic Δ9-THC (4-64 mg/kg) treatment on mice infected with a non-lethal dose of 7.5×10(4) C. albicans on day 2, followed by a higher challenge with 5×10(5) C. albicans on day 19. Mouse resistance to the infection was assessed by survival and tissue fungal load. Serum cytokine levels were determine to evaluate the immune responses. In the acute infection, chronic Δ9-THC treatment had no effect on mouse survival or tissue fungal load when compared to vehicle treated mice. However, Δ9-THC significantly suppressed IL-12p70 and IL-12p40 as well as marginally suppressed IL-17 versus vehicle treated mice. In comparison, when mice were given a secondary yeast infection, Δ9-THC significantly decreased survival, increased tissue fungal burden and suppressed serum IFN-γ and IL-12p40 levels compared to vehicle treated mice. The data showed that chronic Δ9-THC treatment decreased the efficacy of the memory immune response to candida infection, which correlated with a decrease in IFN-γ that was only observed after the secondary candida challenge.

http://www.ncbi.nlm.nih.gov/pubmed/25057822

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Even in fungal infection THC seems worthless.

Plus, IL-12p40 mean interleukin 12, and its production was decreased.

You know, the molecule useful in the production and differentiation of T-Cell and many other things. But I don't need to explain this, you already know so much about the immune system treesniper.

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However, Dr. Medveczky also stresses that THC can act as an immunosuppressant. So smoking marijuana could cause more harm than good to patients infected with these viruses, who often have weakened immune systems already.

Whether THC would be predominantly beneficial can only be tested in experimental animals (e.g. mice infected with the murine gamma herpesvirus). "We have not evaluated the effect of THC in an animal model yet," he said. "Therefore, our findings do not recommend that people take pot to prevent or treat cancers associated with gamma herpesviruses."

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Simplepowa said:
My first link is 2010.

Btw, even if the data is old, if it isn't still refuted it is what is currently standing as science, right now, in 2014.

And I like how you cut out the last part of your link:

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However, Dr. Medveczky also stresses that THC can act as an immunosuppressant. So smoking marijuana could cause more harm than good to patients infected with these viruses, who often have weakened immune systems already.

Whether THC would be predominantly beneficial can only be tested in experimental animals (e.g. mice infected with the murine gamma herpesvirus). "We have not evaluated the effect of THC in an animal model yet," he said. "Therefore, our findings do not recommend that people take pot to prevent or treat cancers associated with gamma herpesviruses."

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And that you provide a link that talk more about cancer than the anti-viral proprieties.

Nice try, but try again.

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The immediate early gene ORF 50 promoter activity was specifically inhibited by THC.

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Simplepowa said:
Can protect =/= protect.

We need studies to be done to have a definitive answer, I agree, but to jump to this conclusion (protect from ebola) early in the game is irresponsible.

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treesniper119 said:
here are sources that were provided in the original link, with doctors that are suggesting that cannabinoids warrant a clinical trial in the attempt to prevent or defend against the cytokine storm on the immune system during an ebola outbreak, as well as anti-viral potential.

“There is good scientific evidence that cannabinoids, and in particular Cannabidiol (CBD), may offer control of the immune system and in turn provide protection from viral infections (4). Cannabis has already been recognized to inhibit fungus and bacteria and can be considered a new class of antimicrobial because of the different mechanism of action from other antimicrobials. (1)

Ebola is a complex RNA viral organism that causes the cell to engulf it by pinocytosis, and then the virus hijacks the cell to replicate itself. This replication can involve many mutations in the RNA code that make it difficult to impossible to create an effective vaccine. There are U.S. Patents showing evidence that Cannabinoids have significant anti-viral activity. (3) (4)

Normally any virus infected cells will produce surface proteins that are identified as foreign. The Immune system attacks these cells when the surface protein is identified as foreign.  The Ebola virus infection causes the cell to produce proteins that hide the virus from the immune system. The viral proteins are sterically shielded, i.e. “hidden” from view, thereby hindering cellular (and thus viral) destruction by the immune system.  This mechanism allows the RNA virus to hide the infected cell by shielding it from view from the immune system.

The cause of death by this virus is the body’s own immune response to the viral infection. This is what causes the mortality and morbidity of this infection.  Subsequently, the virus triggers the immune killer cells to release the enzymes (cytokines) they hold. This release of enzymes causes other lymphocyte to release even more Cytokines in a Storm of release. This is properly termed a Cytokine Storm.

Causes small blood clots to form in all arterioles, called; DIC or Disseminated Intravascular Coagulation.
Causes a massive Coagulopathy where the blood will not to clot properly simultaneously with the DIC (Bleeding and clotting occur at the same time.) Toxic Shock Syndrome occurs when the cytokines release causes the blood vessels to dilate to such an extent that a shock state exists.

Cannabinoids are proven to reduce and prevent Toxic Shock and DIC (2)”

“The Ebola virus also attacks the adhesions between cells caused by the immune Killer cells to release of VEGF (Vascular Endothelial Growth Factor) which result in the destruction of the Tight Junction between cells and causes a fluid leakage between cells until bleeding occurs. The inhibition of VEGF by cannabinoids prevent the cellular junctions from haemorrhage.

Cannabinoids Inhibit VEGF and inhibit Glioma brain tumors growth by this mechanism. (6) It is reasonable to predict that inhibition of VEGF and other Cytokines by Cannabinoids during an Ebola infection will help the survival of this deadly disease.  (6 and 7) Stopping the release of Cytokines will be a key feature of treatment of this deadly disease.

The discovery and application of the Endocannabinoid Signalling System is proving to be the control of virtually all diseases of mankind. Cannabinoids are emerging as a new class of drugs that treat infections of bacteria, fungi and virus by different mechanisms of action not found in any other class of drug. (1)

Cannabinoids are proving to have significant cidal (killer) activity to many viruses, including hepatitis C and the HIV virus. Cannabinoids down-regulate (inhibit) the immune response to the infection (2) (3). The cited U.S. Patents (3 and 4) are proof that cannabinoids inhibit many different virus strains from replicating. These patents also prove cannabinoids decreases the body’s immune over stimulated response to the viral infection.  Claims that are made in these U.S. Patents include the following:

(refer to patent for exact quote.)

    A method of treating HIV disease by the direct inhibition of viral replication using a cannabinol derivative of claim 2. (see patent)
    The cannabinol derivatives of claim 10 wherein the cannabinol derivative of claim  is used to treat HIV disease by the direct inhibition of viral replication. (see patent)
    A method of treating diseases of immune dysfunction which are the result of infectious origin such as Simian Immunodeficiency Virus, Feline Immunodeficiency Virus, Herpes Simplex virus, Epstein-Barr virus, Cytomegalovirus, hepatitis B and C, influenza virus, rhinovirus and mycobacterial infections using the cannabinol derivatives of claim 2. (see patent)
    This United States Patent, proves cannabinoids treats this immune dysfunction that becomes what is known as a Cytokine Storm caused by different viral infections. (4)

In Summation; The US Patents prove down regulation of the immune system by cannabinoids may be a key in survival of HIV and may indeed translate into survival for Ebola patients. The direct Killing or Cidal effect of Cannabinoids is proven in HIV infections,(4) but not yet in Ebola. Inhibition of VEGF is crucial to prevent endothelial leakage and haemorrhage.

Because cannabis is so very safe especially under doctor supervision, I believe it is crucial for the medical community to start human trials on survivability of Ebola infected patients regardless of the political restraints.



David B. Allen M.D.
retired Cardiothoracic and Vascular Surgeon
Medical Director, Cannabis Sativa, Inc. (Cali215doc@gmail.com)



References

1)  Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study; Giovanni Appendino et al. The School of Pharmacy, University of London

2)  Protection Against Septic Shock and Suppression of Tumor Necrosis Factor α and Nitric Oxide Production by Dexanabinol (HU-211), a Nonpsychotropic Cannabinoid Ruth Gallily1,
Aviva Yamin1, Departments of Immunology The Hebrew University, Faculty of Medicine, Jerusalem,  Rehovot, Israel.

3)    Cannabinoid derivatives US patent 20070179135 A1

4)    Treatment of HIV and diseases of immune dysregulation US 20080108647 A1

5)    Curr Pharm Des. 2006;12(24):3135-46. Cannabinoids, immune system and cytokine network. Massi PVaccani AParolaro D, University of Insubria, Via A. da Giussano 10, 21052 Busto Arsizio (VA), Italy

6)    Cancer Res August 15, 2004 64; 5617 Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas Cristina Blázquez HYPERLINK “http://cancerres.aacrjournals.org/content/64/16/5617.full”1,

7)    How Cannabis Might Keep Coronary Stents Open Longer
www.cbds.com/…/how-cannabis-might-keep-coronary-stents-open-longer
Jun 10, 2014 David Allen M.D.

http://www.sciencemag.org/content/345/6202/1369.full

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treesniper119 said:
http://www.mtlblog.com/2014/10/smoking-marijuana-can-protect-you-from-ebola/

Not a day has gone by in the last few weeks without a mention of Ebola. Having made its way into North America, Ebola has become reached the top of the “to fear” list, making many worry that it will only be a matter of time before the disease dominates the continent. Effective vaccines and treatments for Ebola have yet to be discovered, though one may be hiding in plain sight: cannabis.

Cannabinoids in marijuana have gained more and more of a reputation as a way to control and aid one’s immune systems, specifically with diseases that target a body’s natural defense measures against viruses, like HIV. Dr. David B. Allen, medical director of Cannabis Sativa, Inc, and Brad Morehouse, founder of NewCure.org, both believe cannabis can combat Ebola in the same way.

First, a rundown on what Ebola is and does, so everyone understands the argument. Ebola is a virus that targets the RNA (which creates proteins) in cells, takes over, then begins to replicate itself. The virus is able to hide itself from virus killing cells by creating indivisibility cloak-like surface proteins, which makes fighting Ebola especially difficult for the body.

Another consequence of Ebola being an RNA virus is that it makes each strain unique to the individual infected, thus making the creation of a widely applicable vaccine incredibly difficult.

What makes Ebola deadly is the way in which one’s immune system reacts as time goes on. Aside from creating hemorrhaging and leaking between cells, Ebola primarily kills when a person’s body releases a massive amount of enzymes (a cytokine storm) and an overabundant, and fatal amount, of immune cells being activated.

That’s where marijuana comes in as a potential saving grace to those afflicted with Ebola. As Joe Martin points out, cannabis is contains natural antiretrovirals and is also an anti-inflammatory able to reduce the harm to the body caused by a cytokine storm.

Dr. Allen also notes that cannabis has already become a legitimate regulator of immune system processes for those infected with HIV, with the same processes being applicable to Ebola. Being a natural virus killer, Allen also notes how cannabis can prevent the other harmful consequences of Ebola, namely hemorrhaging and cell leaking.

So there is Strong evidence suggests that cannabis can be a positive treatment for those suffering from Ebola!

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Simplepowa said:
Can protect =/= protect.

We need studies to be done to have a definitive answer, I agree, but to jump to this conclusion (protect from ebola) early in the game is irresponsible.

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Primary research on the functioning of the CB2 receptor has focused on the receptor's effects on the immunological activity of leukocytes.[25] To be specific, this receptor has been implicated in a variety of modulatory functions, including immune suppression, induction of apoptosis, and induction of cell migration.[2] Through their inhibition of adenylyl cyclase via their Gi/Goα subunits, CB2 receptor agonists cause a reduction in the intracellular levels of cyclic adenosine monophosphate (cAMP).[26][27] Although the exact role of the cAMP cascade in the regulation of immune responses is currently under debate, laboratories have previously demonstrated that inhibition of adenylyl cyclase by CB2 receptor agonists results in a reduction in the binding of transcription factor CREB (cAMP response element-binding protein) to DNA.[25] This reduction causes changes in the expression of critical immunoregulatory genes[26] and ultimately suppression of immune function.[27]

https://en.wikipedia.org/wiki/Cannabinoid_receptor_type_2#Immune_System_2

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treesniper119 said:

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Simplepowa said:
Can protect =/= protect.

We need studies to be done to have a definitive answer, I agree, but to jump to this conclusion (protect from ebola) early in the game is irresponsible.

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The most recent studies show that the HIV and Ebola are similar in their ability to be become prohibited by cannabinoids.

I have provided many "up to date" links defending this position.

I believe i have proven this point well enough, a simple apology from simplepowa from calling me out like he did, just for helping others would suffice, and show the community what a respectable person he is when he is shown that his loud improper outdated position is incorrect.

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treesniper119 said:

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Simplepowa said:
Can protect =/= protect.

We need studies to be done to have a definitive answer, I agree, but to jump to this conclusion (protect from ebola) early in the game is irresponsible.

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treesniper119 said:
here are sources that were provided in the original link, with doctors that are suggesting that cannabinoids warrant a clinical trial in the attempt to prevent or defend against the cytokine storm on the immune system during an ebola outbreak, as well as anti-viral potential.

“There is good scientific evidence that cannabinoids, and in particular Cannabidiol (CBD), may offer control of the immune system and in turn provide protection from viral infections (4). Cannabis has already been recognized to inhibit fungus and bacteria and can be considered a new class of antimicrobial because of the different mechanism of action from other antimicrobials. (1)

Ebola is a complex RNA viral organism that causes the cell to engulf it by pinocytosis, and then the virus hijacks the cell to replicate itself. This replication can involve many mutations in the RNA code that make it difficult to impossible to create an effective vaccine. There are U.S. Patents showing evidence that Cannabinoids have significant anti-viral activity. (3) (4)

Normally any virus infected cells will produce surface proteins that are identified as foreign. The Immune system attacks these cells when the surface protein is identified as foreign.  The Ebola virus infection causes the cell to produce proteins that hide the virus from the immune system. The viral proteins are sterically shielded, i.e. “hidden” from view, thereby hindering cellular (and thus viral) destruction by the immune system.  This mechanism allows the RNA virus to hide the infected cell by shielding it from view from the immune system.

The cause of death by this virus is the body’s own immune response to the viral infection. This is what causes the mortality and morbidity of this infection.  Subsequently, the virus triggers the immune killer cells to release the enzymes (cytokines) they hold. This release of enzymes causes other lymphocyte to release even more Cytokines in a Storm of release. This is properly termed a Cytokine Storm.

Causes small blood clots to form in all arterioles, called; DIC or Disseminated Intravascular Coagulation.
Causes a massive Coagulopathy where the blood will not to clot properly simultaneously with the DIC (Bleeding and clotting occur at the same time.) Toxic Shock Syndrome occurs when the cytokines release causes the blood vessels to dilate to such an extent that a shock state exists.

Cannabinoids are proven to reduce and prevent Toxic Shock and DIC (2)”

“The Ebola virus also attacks the adhesions between cells caused by the immune Killer cells to release of VEGF (Vascular Endothelial Growth Factor) which result in the destruction of the Tight Junction between cells and causes a fluid leakage between cells until bleeding occurs. The inhibition of VEGF by cannabinoids prevent the cellular junctions from haemorrhage.

Cannabinoids Inhibit VEGF and inhibit Glioma brain tumors growth by this mechanism. (6) It is reasonable to predict that inhibition of VEGF and other Cytokines by Cannabinoids during an Ebola infection will help the survival of this deadly disease.  (6 and 7) Stopping the release of Cytokines will be a key feature of treatment of this deadly disease.

The discovery and application of the Endocannabinoid Signalling System is proving to be the control of virtually all diseases of mankind. Cannabinoids are emerging as a new class of drugs that treat infections of bacteria, fungi and virus by different mechanisms of action not found in any other class of drug. (1)

Cannabinoids are proving to have significant cidal (killer) activity to many viruses, including hepatitis C and the HIV virus. Cannabinoids down-regulate (inhibit) the immune response to the infection (2) (3). The cited U.S. Patents (3 and 4) are proof that cannabinoids inhibit many different virus strains from replicating. These patents also prove cannabinoids decreases the body’s immune over stimulated response to the viral infection.  Claims that are made in these U.S. Patents include the following:

(refer to patent for exact quote.)

    A method of treating HIV disease by the direct inhibition of viral replication using a cannabinol derivative of claim 2. (see patent)
    The cannabinol derivatives of claim 10 wherein the cannabinol derivative of claim  is used to treat HIV disease by the direct inhibition of viral replication. (see patent)
    A method of treating diseases of immune dysfunction which are the result of infectious origin such as Simian Immunodeficiency Virus, Feline Immunodeficiency Virus, Herpes Simplex virus, Epstein-Barr virus, Cytomegalovirus, hepatitis B and C, influenza virus, rhinovirus and mycobacterial infections using the cannabinol derivatives of claim 2. (see patent)
    This United States Patent, proves cannabinoids treats this immune dysfunction that becomes what is known as a Cytokine Storm caused by different viral infections. (4)

In Summation; The US Patents prove down regulation of the immune system by cannabinoids may be a key in survival of HIV and may indeed translate into survival for Ebola patients. The direct Killing or Cidal effect of Cannabinoids is proven in HIV infections,(4) but not yet in Ebola. Inhibition of VEGF is crucial to prevent endothelial leakage and haemorrhage.

Because cannabis is so very safe especially under doctor supervision, I believe it is crucial for the medical community to start human trials on survivability of Ebola infected patients regardless of the political restraints.



David B. Allen M.D.
retired Cardiothoracic and Vascular Surgeon
Medical Director, Cannabis Sativa, Inc. (Cali215doc@gmail.com)



References

1)  Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study; Giovanni Appendino et al. The School of Pharmacy, University of London

2)  Protection Against Septic Shock and Suppression of Tumor Necrosis Factor α and Nitric Oxide Production by Dexanabinol (HU-211), a Nonpsychotropic Cannabinoid Ruth Gallily1,
Aviva Yamin1, Departments of Immunology The Hebrew University, Faculty of Medicine, Jerusalem,  Rehovot, Israel.

3)    Cannabinoid derivatives US patent 20070179135 A1

4)    Treatment of HIV and diseases of immune dysregulation US 20080108647 A1

5)    Curr Pharm Des. 2006;12(24):3135-46. Cannabinoids, immune system and cytokine network. Massi PVaccani AParolaro D, University of Insubria, Via A. da Giussano 10, 21052 Busto Arsizio (VA), Italy

6)    Cancer Res August 15, 2004 64; 5617 Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas Cristina Blázquez HYPERLINK “http://cancerres.aacrjournals.org/content/64/16/5617.full”1,

7)    How Cannabis Might Keep Coronary Stents Open Longer
www.cbds.com/…/how-cannabis-might-keep-coronary-stents-open-longer
Jun 10, 2014 David Allen M.D.

http://www.sciencemag.org/content/345/6202/1369.full

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spixce said:
Isn't that similar to HU-210 the ingrediant in spice gold

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Unlike other cannabinoid derivatives, HU-211 does not act as a cannabinoid receptor agonist, but instead has NMDA antagonist effects.[3] It therefore does not produce cannabis-like effects, but is anticonvulsant and neuroprotective, and is widely used in scientific research as well as currently being studied for practical applications such as treatment of head injury or stroke or cancer.[4][5][6] It was shown to be safe in clinical trials[7] and is currently undergoing Phase I trials for the treatment of brain cancer.[8]

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HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol[3] by a group led by Professor Raphael Mechoulam at the Hebrew University.[4][5][6] HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action.[7] HU-210 is the (–)-1,1-dimethylheptyl analog of 11-hydroxy- Δ8- tetrahydrocannabinol; in some references it is called 1,1-dimethylheptyl- 11-hydroxytetrahydrocannabinol. The abbreviation "HU" stands for Hebrew University.

The (+) enantiomer of HU-210 has almost all of the cannabinoid activity, with the (−) enantiomer HU-211 being inactive as a cannabinoid but instead acting as an NMDA antagonist having neuroprotective effects.[8][9]

HU-210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal neural stem and progenitor cells likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. It was also indicated by this increased neural growth to entail antianxiety and antidepressant effects.[10]

HU-210, alongside other synthetic cannabinoids like WIN 55,212-2 and JWH-133, is implicated in preventing the inflammation caused by amyloid beta proteins involved in Alzheimer's disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through the activation of cannabinoid receptors, which prevents microglial activation that elicits the inflammation. In addition, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.[11]

HU-210 is a potent analgesic with many of the same effects as natural THC.

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treesniper119 said:

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treesniper119 said:

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Simplepowa said:
Can protect =/= protect.

We need studies to be done to have a definitive answer, I agree, but to jump to this conclusion (protect from ebola) early in the game is irresponsible.

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treesniper119 said:
here are sources that were provided in the original link, with doctors that are suggesting that cannabinoids warrant a clinical trial in the attempt to prevent or defend against the cytokine storm on the immune system during an ebola outbreak, as well as anti-viral potential.

“There is good scientific evidence that cannabinoids, and in particular Cannabidiol (CBD), may offer control of the immune system and in turn provide protection from viral infections (4). Cannabis has already been recognized to inhibit fungus and bacteria and can be considered a new class of antimicrobial because of the different mechanism of action from other antimicrobials. (1)

Ebola is a complex RNA viral organism that causes the cell to engulf it by pinocytosis, and then the virus hijacks the cell to replicate itself. This replication can involve many mutations in the RNA code that make it difficult to impossible to create an effective vaccine. There are U.S. Patents showing evidence that Cannabinoids have significant anti-viral activity. (3) (4)

Normally any virus infected cells will produce surface proteins that are identified as foreign. The Immune system attacks these cells when the surface protein is identified as foreign.  The Ebola virus infection causes the cell to produce proteins that hide the virus from the immune system. The viral proteins are sterically shielded, i.e. “hidden” from view, thereby hindering cellular (and thus viral) destruction by the immune system.  This mechanism allows the RNA virus to hide the infected cell by shielding it from view from the immune system.

The cause of death by this virus is the body’s own immune response to the viral infection. This is what causes the mortality and morbidity of this infection.  Subsequently, the virus triggers the immune killer cells to release the enzymes (cytokines) they hold. This release of enzymes causes other lymphocyte to release even more Cytokines in a Storm of release. This is properly termed a Cytokine Storm.

Causes small blood clots to form in all arterioles, called; DIC or Disseminated Intravascular Coagulation.
Causes a massive Coagulopathy where the blood will not to clot properly simultaneously with the DIC (Bleeding and clotting occur at the same time.) Toxic Shock Syndrome occurs when the cytokines release causes the blood vessels to dilate to such an extent that a shock state exists.

Cannabinoids are proven to reduce and prevent Toxic Shock and DIC (2)”

“The Ebola virus also attacks the adhesions between cells caused by the immune Killer cells to release of VEGF (Vascular Endothelial Growth Factor) which result in the destruction of the Tight Junction between cells and causes a fluid leakage between cells until bleeding occurs. The inhibition of VEGF by cannabinoids prevent the cellular junctions from haemorrhage.

Cannabinoids Inhibit VEGF and inhibit Glioma brain tumors growth by this mechanism. (6) It is reasonable to predict that inhibition of VEGF and other Cytokines by Cannabinoids during an Ebola infection will help the survival of this deadly disease.  (6 and 7) Stopping the release of Cytokines will be a key feature of treatment of this deadly disease.

The discovery and application of the Endocannabinoid Signalling System is proving to be the control of virtually all diseases of mankind. Cannabinoids are emerging as a new class of drugs that treat infections of bacteria, fungi and virus by different mechanisms of action not found in any other class of drug. (1)

Cannabinoids are proving to have significant cidal (killer) activity to many viruses, including hepatitis C and the HIV virus. Cannabinoids down-regulate (inhibit) the immune response to the infection (2) (3). The cited U.S. Patents (3 and 4) are proof that cannabinoids inhibit many different virus strains from replicating. These patents also prove cannabinoids decreases the body’s immune over stimulated response to the viral infection.  Claims that are made in these U.S. Patents include the following:

(refer to patent for exact quote.)

    A method of treating HIV disease by the direct inhibition of viral replication using a cannabinol derivative of claim 2. (see patent)
    The cannabinol derivatives of claim 10 wherein the cannabinol derivative of claim  is used to treat HIV disease by the direct inhibition of viral replication. (see patent)
    A method of treating diseases of immune dysfunction which are the result of infectious origin such as Simian Immunodeficiency Virus, Feline Immunodeficiency Virus, Herpes Simplex virus, Epstein-Barr virus, Cytomegalovirus, hepatitis B and C, influenza virus, rhinovirus and mycobacterial infections using the cannabinol derivatives of claim 2. (see patent)
    This United States Patent, proves cannabinoids treats this immune dysfunction that becomes what is known as a Cytokine Storm caused by different viral infections. (4)

In Summation; The US Patents prove down regulation of the immune system by cannabinoids may be a key in survival of HIV and may indeed translate into survival for Ebola patients. The direct Killing or Cidal effect of Cannabinoids is proven in HIV infections,(4) but not yet in Ebola. Inhibition of VEGF is crucial to prevent endothelial leakage and haemorrhage.

Because cannabis is so very safe especially under doctor supervision, I believe it is crucial for the medical community to start human trials on survivability of Ebola infected patients regardless of the political restraints.



David B. Allen M.D.
retired Cardiothoracic and Vascular Surgeon
Medical Director, Cannabis Sativa, Inc. (Cali215doc@gmail.com)



References

1)  Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study; Giovanni Appendino et al. The School of Pharmacy, University of London

2)  Protection Against Septic Shock and Suppression of Tumor Necrosis Factor α and Nitric Oxide Production by Dexanabinol (HU-211), a Nonpsychotropic Cannabinoid Ruth Gallily1,
Aviva Yamin1, Departments of Immunology The Hebrew University, Faculty of Medicine, Jerusalem,  Rehovot, Israel.

3)    Cannabinoid derivatives US patent 20070179135 A1

4)    Treatment of HIV and diseases of immune dysregulation US 20080108647 A1

5)    Curr Pharm Des. 2006;12(24):3135-46. Cannabinoids, immune system and cytokine network. Massi PVaccani AParolaro D, University of Insubria, Via A. da Giussano 10, 21052 Busto Arsizio (VA), Italy

6)    Cancer Res August 15, 2004 64; 5617 Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas Cristina Blázquez HYPERLINK “http://cancerres.aacrjournals.org/content/64/16/5617.full”1,

7)    How Cannabis Might Keep Coronary Stents Open Longer
www.cbds.com/…/how-cannabis-might-keep-coronary-stents-open-longer
Jun 10, 2014 David Allen M.D.

http://www.sciencemag.org/content/345/6202/1369.full

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your views and data are incorrect, apologize or sit there and act ignorant while refusing the scientific evidence warranting clinical trials on humans in defense against the ebola virus....

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Because blockade of the VEGF pathway constitutes one of the most promising antitumoral approaches currently available, the present findings provide a novel pharmacological target for cannabinoid-based therapies.

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Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis.

...

When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. Drugs such as bevacizumab and Ranibizumab can inhibit VEGF and control or slow those diseases.

https://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor

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AUTHORS' CONCLUSIONS:

Despite dronabinol being registered by at least some medicines regulatory authorities for the treatment of AIDS-associated anorexia, and some jurisdictions making allowances for the "medical" use of marijuana by patients with HIV/AIDS, evidence for the efficacy and safety of cannabis and cannabinoids in this setting is lacking. Such studies as have been performed have been of short duration, in small numbers of patients, and have focused on short-term measures of efficacy. Long-term data, showing a sustained effect on AIDS-related morbidity and mortality and safety in patients on effective antiretroviral therapy, has yet to be presented. Whether the available evidence is sufficient to justify a wide-ranging revisiting of medicines regulatory practice remains unclear.

https://www.ncbi.nlm.nih.gov/pubmed/23633327

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trampis said:
I'm pretty sure everyone would like to see clinical trials because that is the scientific evidence we have been requesting all along...

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Simplepowa said:
Hypothesis****

A theory include scientific evidence in the form of empirical data. Like the theory of evolution. Or gravity.

And treesniper, if you read my posts, I pretty much explained why I think it won't work. I could be wrong, but oh well. If you didn't understand shit of what I said, well damn I'm sorry for you, take a biochemistry classes sometimes.

I don't need to believe in anything, because I understand what is behind viral infection and the mechanism that take part in it.

And the "scientific evidence" you provide, I pretty much debunked half of the links and don't feel like doing the other part.

Cognitive dissonance much my man, cognitive dissonance much...

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Pffft, your a lousy observer, and you cherry picked and twisted references in attempt to suit your fallacious data all while shrugging off the exact references that defeat your position.

Weak sauce.

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treesniper119 said:

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Simplepowa said:
Can protect =/= protect.

We need studies to be done to have a definitive answer, I agree, but to jump to this conclusion (protect from ebola) early in the game is irresponsible.

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treesniper119 said:
here are sources that were provided in the original link, with doctors that are suggesting that cannabinoids warrant a clinical trial in the attempt to prevent or defend against the cytokine storm on the immune system during an ebola outbreak, as well as anti-viral potential.

“There is good scientific evidence that cannabinoids, and in particular Cannabidiol (CBD), may offer control of the immune system and in turn provide protection from viral infections (4). Cannabis has already been recognized to inhibit fungus and bacteria and can be considered a new class of antimicrobial because of the different mechanism of action from other antimicrobials. (1)

Ebola is a complex RNA viral organism that causes the cell to engulf it by pinocytosis, and then the virus hijacks the cell to replicate itself. This replication can involve many mutations in the RNA code that make it difficult to impossible to create an effective vaccine. There are U.S. Patents showing evidence that Cannabinoids have significant anti-viral activity. (3) (4)

Normally any virus infected cells will produce surface proteins that are identified as foreign. The Immune system attacks these cells when the surface protein is identified as foreign.  The Ebola virus infection causes the cell to produce proteins that hide the virus from the immune system. The viral proteins are sterically shielded, i.e. “hidden” from view, thereby hindering cellular (and thus viral) destruction by the immune system.  This mechanism allows the RNA virus to hide the infected cell by shielding it from view from the immune system.

The cause of death by this virus is the body’s own immune response to the viral infection. This is what causes the mortality and morbidity of this infection.  Subsequently, the virus triggers the immune killer cells to release the enzymes (cytokines) they hold. This release of enzymes causes other lymphocyte to release even more Cytokines in a Storm of release. This is properly termed a Cytokine Storm.

Causes small blood clots to form in all arterioles, called; DIC or Disseminated Intravascular Coagulation.
Causes a massive Coagulopathy where the blood will not to clot properly simultaneously with the DIC (Bleeding and clotting occur at the same time.) Toxic Shock Syndrome occurs when the cytokines release causes the blood vessels to dilate to such an extent that a shock state exists.

Cannabinoids are proven to reduce and prevent Toxic Shock and DIC (2)”

“The Ebola virus also attacks the adhesions between cells caused by the immune Killer cells to release of VEGF (Vascular Endothelial Growth Factor) which result in the destruction of the Tight Junction between cells and causes a fluid leakage between cells until bleeding occurs. The inhibition of VEGF by cannabinoids prevent the cellular junctions from haemorrhage.

Cannabinoids Inhibit VEGF and inhibit Glioma brain tumors growth by this mechanism. (6) It is reasonable to predict that inhibition of VEGF and other Cytokines by Cannabinoids during an Ebola infection will help the survival of this deadly disease.  (6 and 7) Stopping the release of Cytokines will be a key feature of treatment of this deadly disease.

The discovery and application of the Endocannabinoid Signalling System is proving to be the control of virtually all diseases of mankind. Cannabinoids are emerging as a new class of drugs that treat infections of bacteria, fungi and virus by different mechanisms of action not found in any other class of drug. (1)

Cannabinoids are proving to have significant cidal (killer) activity to many viruses, including hepatitis C and the HIV virus. Cannabinoids down-regulate (inhibit) the immune response to the infection (2) (3). The cited U.S. Patents (3 and 4) are proof that cannabinoids inhibit many different virus strains from replicating. These patents also prove cannabinoids decreases the body’s immune over stimulated response to the viral infection.  Claims that are made in these U.S. Patents include the following:

(refer to patent for exact quote.)

    A method of treating HIV disease by the direct inhibition of viral replication using a cannabinol derivative of claim 2. (see patent)
    The cannabinol derivatives of claim 10 wherein the cannabinol derivative of claim  is used to treat HIV disease by the direct inhibition of viral replication. (see patent)
    A method of treating diseases of immune dysfunction which are the result of infectious origin such as Simian Immunodeficiency Virus, Feline Immunodeficiency Virus, Herpes Simplex virus, Epstein-Barr virus, Cytomegalovirus, hepatitis B and C, influenza virus, rhinovirus and mycobacterial infections using the cannabinol derivatives of claim 2. (see patent)
    This United States Patent, proves cannabinoids treats this immune dysfunction that becomes what is known as a Cytokine Storm caused by different viral infections. (4)

In Summation; The US Patents prove down regulation of the immune system by cannabinoids may be a key in survival of HIV and may indeed translate into survival for Ebola patients. The direct Killing or Cidal effect of Cannabinoids is proven in HIV infections,(4) but not yet in Ebola. Inhibition of VEGF is crucial to prevent endothelial leakage and haemorrhage.

Because cannabis is so very safe especially under doctor supervision, I believe it is crucial for the medical community to start human trials on survivability of Ebola infected patients regardless of the political restraints.



David B. Allen M.D.
retired Cardiothoracic and Vascular Surgeon
Medical Director, Cannabis Sativa, Inc. (Cali215doc@gmail.com)



References

1)  Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study; Giovanni Appendino et al. The School of Pharmacy, University of London

2)  Protection Against Septic Shock and Suppression of Tumor Necrosis Factor α and Nitric Oxide Production by Dexanabinol (HU-211), a Nonpsychotropic Cannabinoid Ruth Gallily1,
Aviva Yamin1, Departments of Immunology The Hebrew University, Faculty of Medicine, Jerusalem,  Rehovot, Israel.

3)    Cannabinoid derivatives US patent 20070179135 A1

4)    Treatment of HIV and diseases of immune dysregulation US 20080108647 A1

5)    Curr Pharm Des. 2006;12(24):3135-46. Cannabinoids, immune system and cytokine network. Massi PVaccani AParolaro D, University of Insubria, Via A. da Giussano 10, 21052 Busto Arsizio (VA), Italy

6)    Cancer Res August 15, 2004 64; 5617 Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas Cristina Blázquez HYPERLINK “http://cancerres.aacrjournals.org/content/64/16/5617.full”1,

7)    How Cannabis Might Keep Coronary Stents Open Longer
www.cbds.com/…/how-cannabis-might-keep-coronary-stents-open-longer
Jun 10, 2014 David Allen M.D.

http://www.sciencemag.org/content/345/6202/1369.full

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Persons living with HIV/AIDS (PLWHA) frequently use cannabinoids, either recreationally by smoking marijuana or therapeutically (delta-9-tetrahydrocannabinol; Δ9-THC dronabinol). Previously, we demonstrated that chronic Δ9-THC administration decreases early mortality in male simian immunodeficiency virus (SIV)-infected macaques. In this study, we sought to examine whether similar protective effects resulted from chronic cannabinoid administration in SIV-infected female rhesus macaques. Clinical and viral parameters were evaluated in eight female rhesus macaques that received either Δ9-THC (0.18–0.32 mg/kg, intramuscularly, twice daily) or vehicle (VEH) starting 28 days prior to intravenous inoculation with SIVmac251. SIV disease progression was assessed by changes in body weight, mortality, viral levels in plasma and mucosal sites, and lymphocyte subsets. In contrast to our results in male animals, chronic Δ9-THC did not protect SIV-infected female rhesus macaques from early mortality. Markers of SIV disease, including viral load and CD4+/CD8+ ratio, were not altered by Δ9-THC compared to control females; however, females that received chronic Δ9-THC did not gain as much weight as control animals. In addition, Δ9-THC administration increased total CXCR4 expression in both peripheral and duodenal CD4+ and CD8+ T lymphocytes prior to SIV inoculation. Although protection from early mortality was not evident, chronic Δ9-THC did not affect clinical markers of SIV disease progression. The contrasting effects of chronic Δ9-THC in males versus females remain to be explained, but highlight the need for further studies to explore the sex-dependent effects of Δ9-THC and other cannabinoids on the HIV disease course and their implications for virus transmission.

http://online.liebertpub.com/doi/abs/10.1089/aid.2014.0108

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The suggestion that cannabis could be a cure for Ebola (emphasis on 'could be') hit a few news websites after Former New Mexico governor and one-time presidential candidate Gary Johnson -- who is now the president and CEO of Cannabis Sativa Inc, a company that produces medical and recreational marijuana – openly declared in a interview on Monday with Fox News that marijuana can be used to treat Ebola.

"We actually believe we have efficacy with regards to treating Ebola," he said.

http://www.ibtimes.co.in/marijuana-cures-ebola-hoax-unfounded-claims-go-viral-what-truth-611514

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And the doctor who write the news article you can't stop to quote, he is their medical director

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David B. Allen M.D.
retired Cardiothoracic and Vascular Surgeon
Medical Director, Cannabis Sativa, Inc.

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Well, that's funny.

Surely not writing this and extrapolating things for the money, no no no.

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HIV infects active immune cells that carry the viral receptor CD4, which makes these cells unable to fight off the infection. In order to spread, the virus requires that "resting" immune cells be activated. In advanced AIDS, HIV mutates so it can infect these resting cells, gaining entry into the cell by using a signaling receptor called CXCR4. By treating the cells with a cannabinoid agonist that triggers CB2, Dr. Costantino and the Mount Sinai team found that CB2 blocked the signaling process, and suppressed infection in resting immune cells.

Triggering CB1 causes the drug high associated with marijuana, making it undesirable for physicians to prescribe. The researchers wanted to explore therapies that would target CB2 only. The Mount Sinai team infected healthy immune cells with HIV, then treated them with a chemical that triggers CB2 called an agonist. They found that the drug reduced the infection of the remaining cells.

http://www.sciencedaily.com/releases/2012/03/120320195252.htm

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