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 Galactica
Myconaut
Registered: 07/13/03
Posts: 16
Loc: North AL
Last seen: 3 years, 9 months
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 I got a question about DXM 
#1712179 - 07/13/03 06:04 PM (6 years, 3 months ago) |
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if i drank 4 oz's of expired Pediatric Vicks 44m cough and Cold Relief would it give me the same efects of fresh/slightly aged or would it just make me sick. I am also going to smoke pot while i take this.
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Dank420
Shrooms...Mmm
Registered: 04/12/03
Posts: 548
Loc: 'burbs of philly
Last seen: 1 year, 7 months
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Re: I got a question about DXM [Re: Galactica]
#1712444 - 07/13/03 07:40 PM (6 years, 3 months ago) |
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Uh you don't want to drink that man, only vicks 44 cough. Not cold, cold will have other chems in it like pseudoephedrine, and acetaminophen, that you don't want, don't drink it unless your looking for 4 hours of hell, and possible long term dammagage..
..
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"I tried marijuana once. I did not inhale." -William Clinton.
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 Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Re: I got a question about DXM [Re: Dank420]
#1712865 - 07/13/03 10:09 PM (6 years, 3 months ago) |
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What are the active ingredients of Pediatric Vicks 44M and in what concentrations?
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VIgnisFatuusI
Cubist
Registered: 07/07/03
Posts: 50
Last seen: 5 years, 1 month
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You're going to want to find a bottle of robo or vicks that contains ONLY DXM. After consuming a bottle of robo with psuedoephedrine in it (8oz) I tell you, the terror and thought of dying was never more imminent. Make sure you only drink syrups containing only dxm. The only other type of cold med I've fucked around with heavilty that contained other chems in it is corisidin. But that was when I was relatively less experienced. I wouldn't even fuck around with DXM anymore these days. I only consume it every now and then when I literally have nothing better to do. Nonetheless, it had it's good days of use.
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deltron
Stoned Shroomer-.-
Registered: 07/11/03
Posts: 1,814
Loc: Colorado
Last seen: 2 years, 3 months
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get robo max strength....wait dont do DXM at all, it leaves holes in your brain
I finally learned this after about 7 times
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Host: I've heard whispers about the financial support your government receives from the drug industry.
Peruvian: Well, the irony of this, of course, is that this money, which is in the billions, is coming from your country. You see, you are the major purchaser of our national product, which is of course cocaine.
Host: On one hand, you're saying the United States government is spending millions of dollars to eliminate the flow of drugs onto our streets. At the same time, we are doing business with the very same goverment that is flooding our streets with cocaine.
Peruvian: Mmm-hmm, si, si. Let me show you a few other characters that are involved in this tragic comedy.
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DiMiTriSouljah
No left turn unstoned
Registered: 07/02/03
Posts: 1,057
Loc: ked in a Skin Pinata
Last seen: 1 month, 11 days
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Re: I got a question about DXM [Re: deltron]
#1713450 - 07/14/03 03:07 AM (6 years, 3 months ago) |
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"it leaves holes in your brain"
There has been no conclusive information leading anyone to believe that this is a factual statement.
--this is a fairly recent document from Erowid outlining the flaws in Mr. White's conclusions
I'm not saying that it doesn't. But nobody knows for sure that it does either.
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In the end, my friend, we'll all be together again.
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deltron
Stoned Shroomer-.-
Registered: 07/11/03
Posts: 1,814
Loc: Colorado
Last seen: 2 years, 3 months
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Well I don't like how it makes your brain and body just feel blah like after the high
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Host: I've heard whispers about the financial support your government receives from the drug industry.
Peruvian: Well, the irony of this, of course, is that this money, which is in the billions, is coming from your country. You see, you are the major purchaser of our national product, which is of course cocaine.
Host: On one hand, you're saying the United States government is spending millions of dollars to eliminate the flow of drugs onto our streets. At the same time, we are doing business with the very same goverment that is flooding our streets with cocaine.
Peruvian: Mmm-hmm, si, si. Let me show you a few other characters that are involved in this tragic comedy.
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Bigcheese042
prophet
Registered: 07/08/03
Posts: 29
Loc: space
Last seen: 2 years, 7 months
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What are the after affects of DXM? Can you be hungover? when i smoked and drank it, i felt sh*tty the day after. 
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barfightlard
tales of theinexpressible
Registered: 01/29/03
Posts: 8,659
Loc: Canoodia
Last seen: 9 months, 13 days
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Re: I got a question about DXM [Re: Bigcheese042]
#1714290 - 07/14/03 01:09 PM (6 years, 3 months ago) |
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Quote:
Bigcheese042 said:
What are the after affects of DXM? Can you be hungover? when i smoked and drank it, i felt sh*tty the day after.
I guess you could feel hungover, I don't think it would be like a booze hangover at all though. Worst thats happened to me was I got the shits once.
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"What business is it of yours what I do, read, buy, see, say, think, who I fuck, what I take into my body - as long as I do not harm another human being on this planet?" - Bill Hicks
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Malachi
stereotype
Registered: 06/19/02
Posts: 1,294
Loc: Around Minneapolis.
Last seen: 5 months, 1 day
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Re: I got a question about DXM [Re: barfightlard]
#1714774 - 07/14/03 03:10 PM (6 years, 3 months ago) |
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dxm will always be a time in my life that I shake my head over...
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The ultimate meaning of our being can only be fulfilled in the paradoxical leap beyond the tragic-demonic frustration. It is a leap from our side, but it is the self-surrendering presence of the Ground of Being from the other side.
- Paul Tillich
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Anonymous
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Post deleted by Administrator [Re: Malachi]
#1714988 - 07/14/03 04:15 PM (6 years, 3 months ago) |
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
YellowPurpleHills said: Cordicidin is the choice if you want to experience dxm without having to drink that nasty shit. Just take about 12-16 of the Cordicidin Pills and you will be gone for a long long time.
VERY BAD ADVICE.
Each Coricidin pill has 4mg of Chlorpheniramine maleate. 12 to 16 of these pills would include 48mg to 64mg of Chlorpheniramine maleate. That's a substantial overdose of an antihistamine / anticholinergic drug. Coricidin has killed people, as well as made people bleed from every orifice of their body. The problem with Chlorpheniramine is that you can't predict if you're hypersensitive to it, it has an extremely long half-life (12 to 15 hours) and it inhibits CYP-2D6.
Get a clue.
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Re: I got a question about DXM [Re: Bigcheese042]
#1715700 - 07/14/03 07:20 PM (6 years, 3 months ago) |
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Quote:
Bigcheese042 said:
What are the after affects of DXM? Can you be hungover? when i smoked and drank it, i felt sh*tty the day after.
DO NOT SMOKE DXM!
It decomposes into *toxic* vapours! Smoking DXM will only result in you inhaling toxic chemicals, without inhaling any DXM.
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cb9fl
Senior ChildMolestationExpert
Registered: 06/12/03
Posts: 3,104
Loc: florida
Last seen: 2 months, 24 days
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just be really carefull. you may not have the enzyme to break down dxm meaning you have a long bad high. i think i lack that enzyme as every time i've tried it, it last for a few days.
i did 450mg or 4.5g i forget (whichever is about two or three bottles worth) of research chemical dxm and got more screwed up than on any other drug. then i felt like shit for half a week.
if you can get ketamine try that instead. it's a much cleaner feeling.
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It is better to be hated for what you are than to be loved for what you are not. -Andre Gide
"Generosity is nothing else than a craze to possess. All which I abandon, all which I give, I enjoy in a higher manner through the fact that I give it away. To give is to enjoy possessively the object which one gives."
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cherokee
AmericaLovesFear
Registered: 10/25/02
Posts: 18,645
Loc: The ghetto
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Do you drink gasoline?
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That could have been your mom.
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Re: I got a question about DXM [Re: cb9fl]
#1716088 - 07/14/03 08:48 PM (6 years, 3 months ago) |
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450mg would be the dose.
You're right though. 2D6 deficient people can't convert DXM to DXO efficiently, so they have a higher DXM:DXO ratio. A number of studies have confirmed that DXM is unpleasant and has low abuse potential. DXO is the stuff that people enjoy.
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Anonymous
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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> have u experimented with Cordicidin yourself to say that people who use it bleed and all that stupid shit you said?
Why would I need to experiment with it myself to confirm that another person had bled from using Coricidin?
This is like calling me a moron because I say that lung cancer is a terminal illness even though I don't have lung cancer.
> Yes, i read that shit too
How do you know what I've read? You may have read some of the stuff I've read relevant to Chlorpheniramine, but I doubt you've read even half of what I've read about this drug.
> there were probably 2 cases of that happening and everyone exaggerated about Cordicidin
People have died from using Coricidin. Considering that DXM has been on the market and used as a psychedelic drug since the 1960s, it looks like Coricidin is the more dangerous product, if frequency of accidental deaths mean anything to you. There have been cases of people going into comas from as little as 20mg of Chlorphenirame (5 Coricidin pills).
The point still is that it is not worth taking an extra risk simply because cough syrup tastes bad. Do an extraction, get pure powder, order Dexalone, or put up with the taste.
> People I know eat that shit like candy and they are just fine!
Does that mean that they haven't been endagering themselves by using it? No. It simply means they haven't harmed themselves yet. I don't know the relative frequency of dangerous or harmful side effects from using Chlorpheniramine in addition to DXM, but it can be unpredictably dangerous in low doses to some people and using Chlropheniramine is, in fact, taking an extra unnecessary risk.
The danger of using Chlorpheniramine concurrently with DXM are that
1) Chlorpheniramine has a half-life between 12 - 15 hours. An overdose will produce toxic effects for a very long time.
2) Chlorpheniramine is metabolized by CYP450-2D6, which is the same enzyme responsible for the metabolism of DXM to DXO (and 3-methylmorphinal to 3-hydroxymorphinan). In normal and extensive metabolizers this will mean that it takes a longer time to metabolize DXM to DXO. This means an increased potential for side effects.
3) Behavioural toxicity is a known risk of using anticholinergic drugs.
4) Synergy between Chlorpheniramine and DXM / DXO could be dangerous.
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DiMiTriSouljah
No left turn unstoned
Registered: 07/02/03
Posts: 1,057
Loc: ked in a Skin Pinata
Last seen: 1 month, 11 days
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Phencyclidine is right. Chlorpheneramine Maleate (CPM) is bad stuff when taken in excess. Anticholinergic drugs include: OTC Dramamine, belladonna, datura, and a whole myriad of other delusionary drugs. This is a bad class of drugs to take in combination with dissociatives. Never just swallow a handful of little red pills when someone tells you that you can take up to 2g of DXM safely...because while DXM seems to be relatively safe in lower recreational doses over a span of time, when you add CPM there's no telling what the pharmacological effects would be, there are no studies done that I know of outlining the toxicity of DXM in combination with CPM.
Shit, why even bother with those nasty little things when you can refine it into freebase (careful!) or reacidify it into a new salt extremely easily. Just make sure you fully understand the procedure before you go about doing this (I'm sure it's not going to take very long).
I would never suggest taking DXM in anything but the pure form (read Agent Lemon's Extraction for an easy extraction from Robitussin).
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In the end, my friend, we'll all be together again.
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Yep. The most obvioius danger of combining both DXM and Chlorpheniramine is that both drugs are known to increase heart rate. IIRC, tachycardia is the most commonly found side effect of taking DXM at doses above 30mg. It also raises blood pressure. There's no need to add to this effect by using another drug which will increase the heart rate more, and which has a hell of a long half life. Anticholinergics are also well known for being rather unpredictable drugs. Why bother taking the extra risk?
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Anonymous
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
YellowPurpleHills said:
yes yes, you speak like a scientist
i can speak like that too, but i am just talking from experience with people
Science is based on what is observable, and thus based on experience. Don't give me bullshit that experience is more valuable than science, or what I read in medical journals, or pharmacology textbooks. Your anecdotal reports are useless compared to the thousands of facts that have been accumulated about anticholinergics by medical and pharmaceutical professionals over the years. Just because your friends have used Coricidin and haven't been seriously harmed by it, doesn't mean that it's safe. It also certainly does not mean that it's the safest way possible. The experience of your friends adds up to nothing.
Quote:
I know plenty of people who have done this safely, many times.
Wrong. You may know plenty of people who have done this without harming themselves, but I doubt that you have any clue about the safety of the drugs in question.
Quote:
plus, it doesn't matter what drug you eat cuz you shouldn't eat any drugs, they are not healthy.
Since people here know that taking psychedelic drugs is medically unnecessary, and involves risks, usually they want information that will help them minimize the risks. Taking an additional drug, which is also medically unnecessary; doesn't contribute to the desired effects; and may substantially increase the risks, is exactly the kind of thing that people on these forums want to avoid. Most people on these forums don't think that it doesn't matter whether or not they take drugs safely or unsafely. Most people here want to take drugs as safely as possible. Advising people to take Coricidin is, in fact, needlessly advising people to increase the risks associated with their recreational drug use. If you are not concerned with someone else's safety, you should at least consider the fact that usually people are concerned with their own safety. Which means that you shouldn't make bullshit claims. Fortunately, the majority of people here are bright enough to realize that simply because one poster's friends haven't seriously harmed themselves from a certain drug, doesn't mean that the drug is generally safe. People here trust science more than they trust babbling morons like yourself who vaugely suggest that anecdotal reports which lack the observation of harmful effects outweigh scientific evidence carefully gathered by professionals.
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That's why most are controlled by the government.
Anticholinergic drugs aren't seriously restricted because the abuse potential for these drugs is considered minimal. Most people consider drugs like Datura, Diphenhydramine, and Chlorpheniramine to be the worst of the worst. In general, the government doesn't have to worry about 20% of it's population turning into raving Chlorpheniramine addicts, because the drug sucks, and has a nasty side effects profile.
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Cracka_X
Spiritual Dirt Worshipper
Registered: 01/25/03
Posts: 8,361
Loc: Here
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Re: I got a question about DXM [Re: Galactica]
#1717114 - 07/15/03 01:52 AM (6 years, 3 months ago) |
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FUCK ROBOTRIPPING. It's not even FUN fucked up. You can't think or hold a thought for more an a couple seconds. Walking is completely fucked,which was kinda cool. BUT the whole trip itself is DUMB. Do something better with your life than waste a day with the utmost mindfuck imaginable. Music sucks ass when robotripping. All the highs in sound are shitty as hell.
Be smart man, save your body from anymore pain. Don't waste your time on a drug like that.
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Click here to check out lineups for Magnoliafest and Springfest in Live Oak, FL
The best way to live
is to be like water
For water benefits all things
and goes against none of them
It provides for all people
and even cleanses those places
a man is loath to go
In this way it is just like Tao
-Lao Tzu
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Anonymous
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Unfortunately, it is bodies who can metabolize Coricidin properly that are having problems also. Peope can be unpredictably sensitive to it. Nobody can take your advice because nobody can know in advance.
Cracka_X, I have never enjoyed a drug more than DXM. IMO, DXM is a much better drug than LSD or shrooms. YMMV.
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Dank420
Shrooms...Mmm
Registered: 04/12/03
Posts: 548
Loc: 'burbs of philly
Last seen: 1 year, 7 months
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Phencyclidine, just give up on YellowPurplePills, some people are just ignorant, and won't let anyone change their minds. I too enjoy DXM a lot. I've done it countless times, but I've only drank cough syrup maybe 4 times. You can buy it freebase over the net for cheap and then cap it your self. Very easy, and very cheap.
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"I tried marijuana once. I did not inhale." -William Clinton.
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Anonymous
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Post deleted by Administrator [Re: Dank420]
#1719840 - 07/15/03 11:22 PM (6 years, 3 months ago) |
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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You don't learn much about the safety of a drug simply by eating it. Go away, you're ignorant and you don't even understand why you're ignorant.
END TRANSMISSION
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deltron
Stoned Shroomer-.-
Registered: 07/11/03
Posts: 1,814
Loc: Colorado
Last seen: 2 years, 3 months
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I did it at school once, started feelin it during 5th period science adn somehow made it through, ditched the rest of the day
it was crazy shit i couldnt think or write
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Host: I've heard whispers about the financial support your government receives from the drug industry.
Peruvian: Well, the irony of this, of course, is that this money, which is in the billions, is coming from your country. You see, you are the major purchaser of our national product, which is of course cocaine.
Host: On one hand, you're saying the United States government is spending millions of dollars to eliminate the flow of drugs onto our streets. At the same time, we are doing business with the very same goverment that is flooding our streets with cocaine.
Peruvian: Mmm-hmm, si, si. Let me show you a few other characters that are involved in this tragic comedy.
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DrubuShrume
EAT ME - I'm afungi
Registered: 05/14/02
Posts: 449
Loc: Right where I need to be
Last seen: 2 years, 2 months
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Because unlike him, you are spreading "information" claiming that Coricidin(sp? like I care?) is healthy for certain people and not for certain people.
If you've read about it, then you would know that there is other active ingredients in it and the combination can be deadly. Just because you survived multiple times, the time you don't survive you won't be here to post "oops, I was wrong."
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AH HA....
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Anonymous
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Post deleted by Administrator [Re: DrubuShrume]
#1720323 - 07/16/03 02:05 AM (6 years, 3 months ago) |
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st0nedphucker
Rogue State
Registered: 04/17/03
Posts: 1,047
Loc: Wales (yes it is a countr...
Last seen: 1 year, 3 months
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I cant believe this is still going on....
I'd like to know what sources you were reading in regards to shrooms and LSD, by "the stories were nothing like the real deal" Do you mean they were a load of bullshit like "if you take LSD you go mad and you can die from eating yourself" if so its people like you who start these bloody stoires by spreading crap like that....
Quote:
it killed a few fuckers, but so did ecstasy, and acid
And by making a comment like that you simply demeaning yourself
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The punishment which the wise suffer, who refuse to take part in government, is to live under the government of worse men.
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Anonymous
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st0nedphucker
Rogue State
Registered: 04/17/03
Posts: 1,047
Loc: Wales (yes it is a countr...
Last seen: 1 year, 3 months
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My god you're worse off than I thought.....
I am well aware of deaths caused by ectasy, I do live in the UK where the media loves deaths which its caused.... (You have even posted one  )
Hence I dont touch the stuff. Anyway I asked you about the sources you were referring to in regards to mushrooms and LSD.
Yes when you choose to take a drug your taking a risk but you should be making an informed decision when and if you choose to take that risk.
Coricidin contains other active ingredients which are known to be able to cause death and if not some very nasty symptoms FACT, END OF STORY!!!!!
Everything else you have said is irrelevant
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The punishment which the wise suffer, who refuse to take part in government, is to live under the government of worse men.
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DiMiTriSouljah
No left turn unstoned
Registered: 07/02/03
Posts: 1,057
Loc: ked in a Skin Pinata
Last seen: 1 month, 11 days
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I don't want to flame anyone, but YellowPurpleHills, you are spreading some horrible misinformation.
"But it hasn't killed me or any of my friends."
Too much youthful idealism can be a bad thing. Just because you can huff Glade and maybe not die doesn't mean that it's not doing damage or that you should be doing it. But it's your body and if you don't care about it, me caring about it is going to do no good.
"i read about shrooms, and the stories were nothing like the real deal"
I hope you're not talking about this forum/website as being ignorant to the effects of mushrooms. You do know where you are, no?
"you people who are bashing me with the knowledge you've gained from reading have never tried CORDICIDIN but talk about it like it's the DEVIL"
I have read all the literature I can get my hands on about DXM, along with taking it in about every form imaginable (except smoking, which produces toxic vapors!! Never IV'ed it either). So please don't assume that you and your friends are the only ones that have done Coricidin.
"it killed a few fuckers, but so did ecstasy, and acid"
What a great empathetic outlook on responsible entheogen use. Where's your cite for people dying from acid by the way?
"Just like acid may make someone wind up in the woods with schitzophrenia (or so i read)"
Did you read this from the tabloids or one of those Drug Free commercials? Acid does not induce schitzophrenia. Hallucinogenics have been known to make cases of underlying (or active) schitzophrenia more severe.
"You take the risk of death or permanent damage with ANY drug you chose, ANY drug."
Again, incorrect. How about marijuana? Also, I have never heard of a case of either death or permanent damage arising from mushroom use either (unless it was setting based, i.e. some dumbshit eats 40g of azures his first time and decides to lay in the road in the middle of the night for a few hours).
Please, please, go to this website and stop this horrible chain of lies!
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In the end, my friend, we'll all be together again.
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nihilist
another systemof control
Registered: 06/23/03
Posts: 169
Loc: USA
Last seen: 4 years, 1 month
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YellowPurpleHills: Dude, very few drugs cause any damage. shrooms and marijuana cause none at all, especially to the brain.
Congratulations btw YPH, you are the first person stooooopid enough to get me to flame anyone. Go huff some air duster or something.
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neutralizer
Spiritual beinghaving a Humanexperience
Registered: 06/17/03
Posts: 635
Loc: This Planet Earth
Last seen: 2 years, 8 months
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If you're not woman/man enough to either put up with the taste of cough syrup, to extract it, or to get your hands on it some other way that does NOT have cordicidin in it, then you shouldn't be taking it in the first place.
That is, of course, unless you have a death wish for yourself or your friends, or the people who read your posts and think that cordicidin is just fine for them. Or unless you want said people to have a painful, horrible experience in which it's entirely possible they'll require professional medical attention. You need to think about the people who read your posts, BEFORE you post. If no one had called you out on your misinformation, I don't doubt that there'd be people who would think that the cordicidin warnings are just more of the DEA spreading their lies. And by the way I've used DXM several times - no, I haven't tried cordicidin and I won't, mainly because it's just stupid to risk it.
One of the basic purposes of shroomery.org is to stop the spread of misinformation about drugs. You are working against that purpose.
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There are things known, and there are things unknown, and in between are the doors - Morrison
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Anonymous
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Post deleted by Administrator [Re: neutralizer]
#1721394 - 07/16/03 11:47 AM (6 years, 3 months ago) |
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cb9fl
Senior ChildMolestationExpert
Registered: 06/12/03
Posts: 3,104
Loc: florida
Last seen: 2 months, 24 days
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well no need to argue that anymore YellowPurpleHills vs Science heh.
Anyways if a person is lacking in the enzyme that breakds down dxm is their a naturally occuring chemical or method to artificially reproduce that enzyme? Or to break down dxm to dxo before it's injested? I'm not looking for involved methods requiring a lab. Something more OTC.
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It is better to be hated for what you are than to be loved for what you are not. -Andre Gide
"Generosity is nothing else than a craze to possess. All which I abandon, all which I give, I enjoy in a higher manner through the fact that I give it away. To give is to enjoy possessively the object which one gives."
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
YellowPurpleHills said: i read about shrooms, and the stories were nothing like the real deal
Your point is meaningless when translating it to knowledge of physical effects. Generally, the phenomenology of the effects of eating a substance won't tell you whether or not a drug is safe, unless there is obviously something wrong. Not noticing harmful side effects doesn't mean that you can conclude something is safe. You really need to understand this: eating a drug tells you almost nothing about the toxicology of the drug. For example, the first time you ate MDMA (presuming that you have), did that tell you what enzymes metabolize it? No. You don't really have a point here.
I also have a problem with you saying that descriptions of mushroom trips you've read were nothing like eating it. Did you or did you not see pretty colours? Did you or did you not experience a dialation of time? Did you or did you not experience an altered state of consciousness? Obviously, nobody can describe exactly what eating a drug will be like for you, but most descriptions of trips of many drugs that I've read are more than "somewhat like" my own experiences. IMO, you greatly indulged in hyperbole in your claim.
Quote:
you people who are bashing me with the knowledge you've gained from reading have never tried CORDICIDIN but talk about it like it's the DEVIL
Wrong on both points. Regarding your accusation, I never said that Coricidn was the devil, or said that it was a very unsafe drug. I stated that it shouldn't be used because it involves adding extra risks to drug use. You do know that the first two side effects of DXM are tachycardia and hypertension right? You do know that Chlorpheniramine can cause tachycardia, right? You do know that tachycardia and hypertension when combined can be fatal, right?
Regarding your first point, once again, you don't learn much about the toxicity of the drug just from eating it. The phenomenology of a drug and the toxicology of a drug, are almost entirely separate things. I would easily trust the reports of a toxicologist who had never ingested Chlorpheniramine over your moronic babblings.
You're the ignorant one. I don't understand how you think you can learn anything about the toxicology of a drug simply from eating it.
Quote:
it killed a few fuckers, but so did ecstasy, and acid
So, even if MDMA is relatively safe, which it is, does that make it safe to combine DXM and MDMA when all you want to get high off is the DXM? Why bother taking the MDMA on top of it, when it's not part of your desired high, and when it increases the risks?
Quote:
and people are happily doing all of the above as we speak, come home, fall asleep, wake up the next day alive, and do it again and again.
Then they are morons like you.
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
YellowPurpleHills said:
Look at all those people who have died from eating these chemicals. Everyone is different. You take the risk of death or permanent damage with ANY drug you chose, ANY drug. With some, you just have to be extra cautious.
The point still is that in order to get high off DXM you do not have to ingest Chlorpheniramine! Why take the extra risk?
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Anonymous
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
YellowPurpleHills said:
i am speaking from first hand experience.
That doesn't fucking matter. How many times do I have to tell you this before you get it through your thick head? Think of this: someone who had had a friend die from using Coricidin could just as easily come on here and claim that Coricidin kills people left, right and center because the only friend they knew who used Coricidin died from it. This isn't correct. The sample size here is minimal. Learn about statistics. Also, in the case of a number of people who haven't noticed toxic side effects, then they simply haven't noticed. How do you know that DXM + Chlorpheniramine hasn't harmed your friends? Are you a doctor? No. Your credentials are: "My friends and I have eaten it." That's meaningless.
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to all those who are concidering Coricidin: yes it has two chemicals that when mixed at certain levels, are very bad for your health, even deadly
So then, why increase the risk by taking Coricidin?
Quote:
however, this is what I AM SAYING: I know people, including me who have tried it repedeatly, as many as 40 pills, and nothing unwanted has happened (maybe a damage in the liver from taking so many goddamn pills)
So, now you're saying, "Hey, maybe my friends and I have hurt ourself, but I don't know."
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i've spoken to people on DXM groups who have done the same. We think the reason why Coricidin is said to be so deadly is so people do not use it as a recreational drug.
Then why aren't people saying that DXM is deadly? It's almost as easy to obtain pure DXM HBr powder as it is to get Coricidin. I don't see any harm-reduction oriented websites claiming that pure DXM HBr is dangerous, like sites about Coricidin state.
Yes, though, you're right, people say that Coricidin is dangerous so that people won't use it. Chlorpheniramine is almost 100% useless as a recreational drug. Most people don't like anticholinergics.
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Because none of us in the group have suffered any of the stuff described in the medical journals, such as eyeball bleeding, not being able to sweat, death, etc...
And does that make you doubt that these events have occured or that they could possibly occur to you, or to someone who you callously advised to use Coricidin?
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So stop slamming me with your bullshit and talk to people who have tried Coricidin to make an educated judgement
Eating drugs does not mean that you are able to make an educated judgement about the drug. I suspect that the reasons for this are far beyond your intellectual capacity.
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based BOTH on experience and literature. Now you just look stupid making a half-ass judgement and slamming me for no goddamn reason, when I laid out the facts clearly and am not arguing with Coricidin being deadly.
You are the one who looks stupid. You are, in fact, absolutely clueless.
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Anonymous
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Post deleted by Administrator [Re: Galactica]
#1721634 - 07/16/03 01:11 PM (6 years, 3 months ago) |
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Once again, you clueless moron, you don't know shit about a drug just because you've eaten it.
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Anonymous
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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READ + EAT does not equal more knowledge than simply read. Are you claiming that you know more about Chlorpheniramine and DXM than say, a person with a doctorate in Pharmaceutical Chemistry?
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
YellowPurpleHills said:
Alright, regardless of what has been happening between the wanna be scientist and I on the topic of DXM
You don't need credentials to be a scientist. I'd say to call yourself a scientist, all you need to do is have a fulltime occupation where you apply the scientific method. I do.
You're a "wanna be expert", but you have a long fucking way to go.
Quote:
here is a good link on the sources of DXM to educate anyone who is urging to trip on DXM:
http://www.erowid.org/chemicals/dxm/dxm_info2.shtml
LOL. Are you trying to defeat yourself. From the URL you just provided:
High doses of Chlorpheniramine Maleate (CPM) can cause severe and life-threatening symptoms including seizures; shortness of breath or troubled breathing; weakness; loss of consciousness; severe dryness of mouth, nose, or throat; bleeding from skin, mouth, eyes, rectum, and vagina; and possibly death.
We have seen recommendations that no more than 24 mg of CPM be taken in a day.
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I've tried coricidin and Dex Alone. I wanted to avoid the extra chemicals in Coricidin, including the ever so controversial Chlorpheniramine Maleate, so I went for Dex Alone.
Why did you want to avoid them?
quote] It was horrible, so I never tried Dex Alone.
If you never tried it then how do you know it was horrible?
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ps. fuck you addict
LOL. The "addict" thing in the info is just the automatic title that comes up after you've had a certain number of posts. I certainly didn't put it there. If you're trying to demean me, you failed miserably.
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you are the one who is clueless. Overanalyze every goddamn thing i say by quoting each one of my sentences and breaking down each word without UNDERSTANDING what i am saying.
No, I'm pretty sure I understand what you are saying. I do have academic credientials in a field that is directly related to interpreting the English language. Do you?
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you know NOTHING about the drug you speak of
I knew the half-life of the drug. Did you? Did you know what enzyme is responsible for it's metabolism? What's the chemical structure of chlorpheniramine? What receptors does it bind to? What's it's efficacy?
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only the shit you've read. I'VE READ IT TOO
You clearly haven't read as much about Chlorpheniramine as I have. Tell me, how many pharmaceutical chemistry books do you have lying around your room? What about journal articles relating to Chlorpheniramine? How many private conversations have you had with pharmaceutical chemists about DXM and chlorpheniramine? I have a feeling that your answers to all three of the questions would be far less than my answers.
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Anonymous
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Re: I got a question about DXM [Re: cb9fl]
#1721810 - 07/16/03 02:12 PM (6 years, 3 months ago) |
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Quote:
cb9fl said:
well no need to argue that anymore YellowPurpleHills vs Science heh.
Yes, LOL.
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Anyways if a person is lacking in the enzyme that breakds down dxm is their a naturally occuring chemical or method to artificially reproduce that enzyme?
There might be. There aren't really many substances that are good enzyme induces. The polycyclic aromatic hydrocarbons in cigarette smoke are poweful inducers of P-450 (the family of enzymes that includes CYP-2D6), but I'm not certain about its effect of CYP-2D6 specifically.
BTW, this effect of cigarette smoke is the reason why smokers metabolise caffeine and theophyline (sic?) much faster than nonsmokers.
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Or to break down dxm to dxo before it's injested?
I have recently written a paper about this. I have not found one credible source documenting a method for converting DXM to DXO. Please see the link in my post "Chemists please review my paper" in the Other Drugs Discussion forum for more information.
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I'm not looking for involved methods requiring a lab. Something more OTC.
It really just looks like if you're CYP-2D6 deficient, that DXM probably isn't the drug for you. If you can get a hold of pure DXO, that's another story. Some jurisdictions may allow you to buy it as a bulk powder.
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Anonymous
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
YellowPurpleHills said:
look dude,
You have really bad reading comprehension.
I doubt it.
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I did try Dex Alone. I said I am not going to try it again cuz the pills were so huge.
Earlier you stated: Quote:
. . .I never tried Dex Alone.
You have problems expressing yourself.
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You prolly got rejected from whereever you were trying to apply yourself so now you have to show off at the Shroomery.org telling everyone you know the name of receptors and the break-down enzymes of a harmful chemical.
That's an ad hominem attack.
No, I didn't get rejected. I got accepted. Once again you're wrong.
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Good job! *bows* I can look up that info in a matter of seconds. Your knowledge is worthless.
You wouldn't know what it means in a matter of seconds.
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LIKE I SAID BEFORE (and you would have caught this the first time around if your English was so good),
Let me guess, you're still in High School right? That's why you're so fond of ignoring every point I make and resorting to insults. You're the one who can't reason. If you could, then maybe you could have come up with a thoughtful response by now.
Quote:
I REALIZE THERE IS A CHEMICAL THAT CAN KILL, MAKE ONE'S INTERNALS BLEED, ETC. IN CORICIDIN. What I have been trying to get into your stubborn, scientific wanna-be brain is that NOT ALL SUFFER THESE CONSEQUENCES.
I never claimed that everyone suffers these effects. I said that it was possible and therefore best to avoid the risk. You're the one who has reading comprehension problems if you think that I said that everyone who uses Coricidin suffers harmful side effects.
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The link I gave says "these are the symptomps that may occur".
I haven't suggested otherwise.
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And this is my point: Some people may have bad side effects from Coricidin and some may not. This principal applies to any drug.
Then we agree on something.
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So before you break down what I just said into "meaningless" phrases,
I suspect that the only reason that only reason you don't respond to my points is because you don't have any intelligent way to respond to them. Thus, part of your strategy is to try invalidating individual points. Unfortunately for you, anyone who is literate can clearly see that you are a buffoon.
Quote:
read it as a whole and try to UNDERSTAND what I am saying.
I suggest that you review your own literacy skills. When did I ever say that anyone who uses Coricidin will suffer harmful side effects from it?
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
YellowPurpleHills said:
so sad, a scientist who knows all, stuck at the shroomery, showing off his papers to teenage shroomheads
What is sad here is your display of your own lack of maturity. Smear campaigns don't work here. I have far outclassed you in this thread. It's clear to everyone who reads this thread that you've been completely humiliated.
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Anonymous
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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My ratings don't have anything to do with the fact that you are wrong.
Quote:
how have i been humiliated?
You have humiliated yourself by repeatedly attacking me ad hominem. I've humiliated you by responding to you, over and over, repeatedly pointing out that you are in error.
Anyway, that's enough for now. I'll leave it for a few hours, and come back to see how many more people respond to this thread just to tell you that you're a fool.
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cerealrat
Registered: 12/05/02
Posts: 123
Last seen: 5 months, 10 days
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Re: I got a question about DXM [Re: Galactica]
#1721964 - 07/16/03 03:09 PM (6 years, 3 months ago) |
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Here's my tip for DXM: Don't do it.
Unless you really enjoy seperating your mind from your body, it won't be much fun.
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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We agree on those 5 points, but you have said more than that, including statements that are completely false.
A review of your errors:
1) "Cordicidin is the choice if you want to experience dxm without having to drink that nasty shit."
Pure powder, an extraction, or Dexalone pills are the methods of choice.
2) "have u experimented with Cordicidin yourself to say that people who use it bleed and all that stupid shit you said?"
I don't have to use Coricidin to know that *other* people can bleed from it, or die from it.
3) "I never argued that Cordicidin is safe. I only said that is the most potent DXM supplier than any other over the counter drug."
Depends on how you define potency. Per unit dose, Dexalone is just as potent. Pure powder is far more potent in terms of volume:drug ratio.
4) "So those whose bodies cannot metabolize Cordicidin properly, should not take it!"
You said this after recommending people take Coricidin. The problem here is that if you use your methodology, you can't know how your body tolerates Coricidin until after you've eaten it. Thus it's best just to avoid it.
5) "you people who are bashing me with the knowledge you've gained from reading have never tried CORDICIDIN but talk about it like it's the DEVIL"
This is simply a lie.
6) "Look at all those people who have died from eating these chemicals. Everyone is different. You take the risk of death or permanent damage with ANY drug you chose, ANY drug. With some, you just have to be extra cautious."
Therefore it is bad advice to suggest that Coricidin is the choice method of using DXM, because using Coricidin involves an extra risk.
7) "READ+EAT= MORE KNOWLEDGE than simply READ"
#7 is so stupid that it's unbelieveable. This is basically proof that you are, in fact, a 100'% Grade A moron.
8) "The link I gave says "these are the symptomps that may occur". "
Which is exactly why it doesn't make any sense to recommend that people use Coricidin.
9) "there is nothing i said that is wrong"
Wrong. See above.
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Anonymous
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Anonymous
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Edited by geokills (07/16/03 06:02 PM)
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
Let me also make note (this comment not aimed at anyone . . . the discussions in this forum must be kept clean.
*me hangs head in shame like a little kid who was misbehaving while the teacher was away.
Sorry, Geo. I feel like I need a time out. LOL.
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Anonymous
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Anonymous
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DiMiTriSouljah
No left turn unstoned
Registered: 07/02/03
Posts: 1,057
Loc: ked in a Skin Pinata
Last seen: 1 month, 11 days
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Peace everyone. There's no need for all this nonsense. We have established the things that needed to be debunked and now it's just degrading into a schoolyard hair-pulling contest.
-Coricidin can be very dangerous, especially for someone lacking the cytochrome P450-2D6 liver enzyme (7% of caucasians have a highly inefficient version of this enzyme). The people lacking this enzyme seem to metabolize DXM differently and the users don't experience any of the effects of DXO (which could be desirable for some) because it converts the DXM into 3-methoxymorphinan (3MM) using the P450-3A4 and/or P450-3A5 enzyme as a catalyst. From there it converts into 3-hydroxymorphinan (3HM) via the (less efficient) P450-2D6. So the cycle goes DXM-DXO-3HM for people with functional cytochrome P450 enzymes, and DXM-3MM-3HM for people with deficiencies. (1)
-People have taken Coricidin in recreational doses many times and have not immediately shown adverse effect. Any negative effect from pure DXM seems to negate itself with time. However, to my knowledge, there have been no conclusive studies done on the reversibility of DXM + CPM induced brain damage (if there even is any).
1 - The Dextromethorphan FAQ, William E. White: http://www.erowid.org/chemicals/dxm/faq/dxm_physiological.shtml#toc.9.5
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In the end, my friend, we'll all be together again.
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shirley knott
not my real name
Registered: 11/11/02
Posts: 9,044
Loc: London
Last seen: 14 hours, 35 minutes
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Quote:
Phencyclidine said:
Quote:
YellowPurpleHills said: Cordicidin is the choice if you want to experience dxm without having to drink that nasty shit. Just take about 12-16 of the Cordicidin Pills and you will be gone for a long long time.
VERY BAD ADVICE.
Each Coricidin pill has 4mg of Chlorpheniramine maleate. 12 to 16 of these pills would include 48mg to 64mg of Chlorpheniramine maleate. That's a substantial overdose of an antihistamine / anticholinergic drug. Coricidin has killed people, as well as made people bleed from every orifice of their body. The problem with Chlorpheniramine is that you can't predict if you're hypersensitive to it, it has an extremely long half-life (12 to 15 hours) and it inhibits CYP-2D6.
Get a clue.
all true, except the bit about chlorpheniramine (generic name, no Capital needed unless call call it Piriton) inhibiting 2D6, which it doesn't.
but yes, you'd be an idiot to go messing around with large doses of antihistamines (sedative) or with large doses of opiates, for that matter.
get over the ratings, yellowpants. don't whine about them - change yourself, go earn some better ratings to put those 1s in the shade and in the past. if i click on your name, it tells a tale at the moment. i ain't gonna rate you down for what i read, but i sure ain't gonna give you any credit for it.
 to phencyclidine for stopping anyone followin your sorry opiate addict footsteps 
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meh
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
all true, except the bit about chlorpheniramine (generic name, no Capital needed unless call call it Piriton) inhibiting 2D6, which it doesn't.
Wrong.
These studies:
In Vitro Characterization of Cytochrome P450 2D6 Inhibition by Classic Histamine H1 Receptor Antagonists
Bettina A. Hamelin, Asm?a Bouayad, Beno?t Drolet, Anne Gravel, and Jacques Turgeon
Drug Metabolism and Disposition
Vol. 26, Issue 6, 536-539, June 1998
CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes.
Nakamura K, Yokoi T, Inoue K, Shimada N, Ohashi N, Kume T and Kamataki T
Pharmacogenetics
(6), 449-457, 1996
Say that it is in vitro. Since the mechanism isn't understood, and it's only been recently confirmed to inhibit 2D6 in vivo, it doesn't usually appear in pharm. chem books.
and this study:
Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes.
He N, Zhang WQ, Shockley D, Edeki T.
European Journal of Clinical Pharmacology
Volume: 57, Issue 12, February, 2002, 847-851
says that chlorpheniramine inhibits 2D6 in vivo. I'd be happy to send you the full text.
Of course, both the in vivo and in vitro studies are done on humans (enzymes).
As for the capitalizing, thanks for telling me.
Quote:
to phencyclidine for stopping anyone followin your sorry opiate addict footsteps
Depending on how you use the term opiate, DXM may not be an opiate. "Opiate" is typically defined as something that has morphine-like structure and effects like morphine. DXM does not possess traditional opiate-like effects, nor does it bind to opiate receptors. DXM is not considered an opiate the vast majority of the time.
DXM is not known to be physically addictive.
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shirley knott
not my real name
Registered: 11/11/02
Posts: 9,044
Loc: London
Last seen: 14 hours, 35 minutes
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hmm, well i have to respectfully disagree. if chlorpheniramine is a 2D6 inhibitor in vivo (the only time it matters) then its effects are clinically insignificant. i'd love to see the paper you mention. i work in this field.
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meh
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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I will either send you a .PDF, attach it here, or convert the .PDF to .JPG and post it.
I agree that the in vivo study is the only one that's relevant.
Perhaps I should be a little more cautious. I accidentally stumbled across the in vivo paper recently, so that's the only reason why I knew about. However, I will retract my statement and say that I don't call it a 2D6 inhibitor as a given fact, only that one study has observed it to do so in vivo, and thus it is likely to turn out to be a 2D6 inhibitor.
BTW, since you work in this field, do you happen to know if polycyclic aromatic hydrocarbons (such as benzo[a]pyrene) induce 2D6 strongly? I have only read that they induce P-450, but with no specifics.
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Here's the file converted from .PDF to .JPG
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Sorry if it's tough to read. You might want to copy and paste it to a paint program so that you can zoom in.
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shirley knott
not my real name
Registered: 11/11/02
Posts: 9,044
Loc: London
Last seen: 14 hours, 35 minutes
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there are no known 2D6 inducers. this is the only clinically interesting isoenzyme of this superfamily for which this is the case. 
you may be interested to know, though, on a slight tangent, that ecstasy (MDMA) 'poisons' all the body's 2D6, and a single pill can effectively render somebody into a 'poor metaboliser' for around 2 weeks, until they can regenerate more of the enzyme.
aromatic hydrocarbons (like those formed after barbecuing meat) may be implicated in the induction of several P450s, most commonly quoted as being 'nonspecific induction' though sometimes 1A2 (which is also induced by cigarette smoking and by brussels sprouts!) is named.
many substances are substrates as well as being inhibitors as well as being inducers of one or a handful of enzymes, and this action may be as a receptor agonist (partial, complete or 'reverse'), antagonist, mixed picture, or by some non-receptor mechanism. the subject is VAST!
hope some of this was interesting to you. i do not claim to know the subject inside out and am often wrong. 
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meh
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shirley knott
not my real name
Registered: 11/11/02
Posts: 9,044
Loc: London
Last seen: 14 hours, 35 minutes
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cool,thanks. i'll read and learn too
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meh
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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Quote:
shirley knott said:
there are no known 2D6 inducers. this is the only clinically interesting isoenzyme of this superfamily for which this is the case.
Wow. Crazy. There must be a steroid that they'll find soon. Apparently pregnant women have elevated levels.
Quote:
many substances are substrates as well as being inhibitors as well as being inducers of one or a handful of enzymes, and this action may be as a receptor agonist (partial, complete or 'reverse'), antagonist, mixed picture, or by some non-receptor mechanism. the subject is VAST!
Yes, it's all very complicated and hard to sort out sometimes. One enantiomeric product may inhibit the metabolism of the other enantiomer and lead to the build up of toxic effects. It's neat, even if it is complicated. I'm amazed by the heroic efforts the body puts into getting rid of foreign molecules.
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shirley knott
not my real name
Registered: 11/11/02
Posts: 9,044
Loc: London
Last seen: 14 hours, 35 minutes
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i just managed to print that out, and will read it later when i have my microscope and fuzzy eyes in! thankyou.
i believe that pregnant women have elevated levels because of the placenta's role in metabolism - it contains P450 enzymes. the state of being pregnant is supposed to be an enzyme inducing state, but whether this is the reason i am not sure.
cyP450 enzymes also play a part in cholesterol and steroid synthesis and metabolism among other roles. some members of the family are among the most conserved proteins between life forms (?phyla) - mammals, reptiles, plants, fungi, protozoa etc etc.
all quite fascinating, to me at least. i also rambled and droned on about this subject in a post containing the word 'grapefruit' in the FAQ forum a few months ago, if you want to do a search.
 sk
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meh
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bluedolphin
member
Registered: 07/09/03
Posts: 530
Last seen: 1 year, 2 months
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Wow this really got out of control.
The point is that have the choice of taking DXM safely (pure DXM or Tussin Max Cough) or you can make your DXM experience possibly life threatening.
Why be a complete dumbass and eat Corcidin when there are safe ways to use DXM?
Yes, people have died from E. But I don't know of any people that have died from pure mdma in an appropriate environment. Think of Corcidin as E laced with PMA, it is very easy to overdose. So why not just take the pure product, considering that its so easily available?
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Phencyclidine
Molecule
Registered: 06/02/03
Posts: 2,915
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When you read it tell me what you think, or if anything noteworthy sticks out to you. You're probably more educated in the field than I am if you actually work in this area.
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YUN_ONE
Registered: 07/22/03
Posts: 35
Loc: MEXICO
Last seen: 5 years, 4 months
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whoever does coricidin why dont just go and by keyboard duster and huff it.
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