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 BlackWidow
NotAStrangerAnymore
 
Registered: 09/25/11
Posts: 246
Loc: Canada 
Last seen: 2 hours, 24 minutes
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 Salvia Divinorum Exerts Potent Anti-inflammatory Effects Says a New Study 
#16775799 - 09/02/12 12:25 PM (9 months, 11 days ago) |
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Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects.
This study assesses the effects and the mode of action of SA on formalin-induced persistent pain in mice. Specifically, the SA effects on long-term behavioural dysfuctions and changes in neuronal activity occurring at spinal level, after single peripheral formalin injection, have been investigated.
Moreover, the involvement of microglial and glial cells in formalin-induced chronic pain condition and in SA-mediated effects has been evaluated.
Results: Formalin induced a significant decrease of mechanical withdrawal threshold at the injected and contralateral paw as well as an increase in the duration and frequency, and a rapid decrease in the onset of evoked activity of the nociceptive neurons 7 days after formalin injection. SA daily treatment significantly reduced mechanical allodynia in KOR and cannabinoid receptor 1 (CB1R) sensitive manner.
SA treatment also normalized the spinal evoked activity. SA significantly reduced the formalin-mediated microglia and astrocytes activation and modulated pro and anti-inflammatory mediators in the spinal cord.
Conclusion: SA is effective in reducing formalin-induced mechanical allodynia and spinal neuronal hyperactivity.
Our findings suggest that SA reduces glial activation and contributes in the establishment of dysfunctions associated with chronic pain with mechanisms involving KOR and CB1R. SA may provide a new lead compound for developing anti-allodynic agents via KOR and CB1R activation.
Author: Francesca GuidaLivio LuongoGabriella AvielloEnza PalazzoMaria De ChiaroLuisa GattaSerena BoccellaIda MarabeseJordan K ZjawionyRaffaele CapassoAngelo IzzoVito de NovellisSabatino Maione
Credits/Source: Molecular Pain 2012, 8:60
I found this article on: http://7thspace.com/headlines/419645/salvinorin_a_reduces_mechanical_allodynia_and_spinal_neuronal_hyperexcitability_induced_by_peripheral_formalin_injection.html
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Kratom For Social Anxiety
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gref
Philosoraptor
Registered: 01/28/10
Posts: 848
Last seen: 1 hour, 29 minutes
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 Re: Salvia Divinorum Exerts Potent Anti-inflammatory Effects Says a New Study [Re: BlackWidow]
#16778689 - 09/02/12 11:11 PM (9 months, 11 days ago) |
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I could take some aspirin, or how about some salvia! 
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EscapeVelocity
.. : ..
Registered: 06/12/11
Posts: 62
Loc: getting closer
Last seen: 2 months, 26 days
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Re: Salvia Divinorum Exerts Potent Anti-inflammatory Effects Says a New Study [Re: gref]
#16780671 - 09/03/12 11:59 AM (9 months, 10 days ago) |
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it'll make you forget what a headache is
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Sales of salvia divinorum not legal in Canada, but not enforced |
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State senator wants to outlaw salvia divinorum [PA] |
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North Dakota Man Facing Years in Prison After Buying Salvia Divinorum On eBay
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Committee Opts Not To Ban Salvia Divinorum [ME] |
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by Leanin |
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