

Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!
|
allseeingike



Registered: 04/07/11
Posts: 1,913
Loc: elgin ill-miami fl
Last seen: 1 hour, 1 minute
|
1 million billion billion billion billion billion billion: Number of undiscovered drugs
#16351436 - 06/08/12 12:59 PM (11 months, 4 days ago) |
|
|
http://phys.org/news/2012-06-million-billion-undiscovered-drugs.html
Jean-Louis Reymond and Mahendra Awale explain that small molecules, which are able to cross cell walls and interact with biological molecules in the body, are prime targets for scientists who develop new medicines. Most existing medications are small molecules. The authors focused on the "chemical space" inhabited by all of the small molecules that could possibly exist according to the laws of physics and chemistry. Researchers have identified millions of these compounds – the ACS' Chemical Abstracts Service database contains almost 67 million substances. Reymond and Awale estimate that the molecules synthesized and tested as potential drugs so far represent less than 0.1 percent of chemical space. To aid researchers looking for new ways to prevent and treat disease, they set out to find the best ways to search for new small molecules.
The authors discuss several ways of getting a handle on chemical space, including by the size, shape and makeup of molecules. They show how computers can help researchers efficiently narrow a search for a new drug candidate. Computer modeling of chemical interactions can help researchers find a handful of promising molecules to synthesize and test in the lab. "Small molecule drugs are essential to the success of modern medicine," the authors note, and suggest that their methods may be particularly useful for finding new pharmaceuticals that target the central nervous system.
More information: “Exploring Chemical Space for Drug Discovery Using the Chemical Universe Database” ACS Chem. Neurosci., Article ASAP. DOI: 10.1021/cn3000422
Abstract Herein we review our recent efforts in searching for bioactive ligands by enumeration and virtual screening of the unknown chemical space of small molecules. Enumeration from first principles shows that almost all small molecules (>99.9%) have never been synthesized and are still available to be prepared and tested. We discuss open access sources of molecules, the classification and representation of chemical space using molecular quantum numbers (MQN), its exhaustive enumeration in form of the chemical universe generated databases (GDB), and examples of using these databases for prospective drug discovery. MQN-searchable GDB, PubChem, and DrugBank are freely accessible at http://www.gdb.unibe.ch
|
Rail_Gun
wizard



Registered: 06/30/01
Posts: 9,266
Loc: Knockturn Alley
Last seen: 4 hours, 23 minutes
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: allseeingike]
#16351463 - 06/08/12 01:05 PM (11 months, 4 days ago) |
|
|
Nice! But I bet they still won't find anything better than good old THC in all those molecules.
--------------------
|
allseeingike



Registered: 04/07/11
Posts: 1,913
Loc: elgin ill-miami fl
Last seen: 1 hour, 1 minute
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: Rail_Gun]
#16351646 - 06/08/12 01:47 PM (11 months, 4 days ago) |
|
|
thc is thc nothing can replace it or substitute it same with lsd and any thing else for that matter
|
senorcafe
pass the wasabi



Registered: 09/23/11
Posts: 1,478
Last seen: 5 months, 13 days
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: allseeingike]
#16351741 - 06/08/12 02:05 PM (11 months, 4 days ago) |
|
|

its like amphetimine and methamphetimine
the diffierence is a methyl group (CH3) both have similar effects but are all together different same thang with mephedrone, or bath salts
walnuts
-------------------- if you can you should
-senorcafe
.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.
little brown mushroom-so hard to identify-look alikes common
varied habitats-the mycophile wonders-edible deadly
underneath blue sky-you spread from grass to tree line-popping up when rains
little brown mushroom-maybe one day i shall know-who you really are
-senorcafe
.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.,.
|
Lucid Dreaming
a



Registered: 04/15/12
Posts: 464
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: allseeingike] 1
#16351792 - 06/08/12 02:18 PM (11 months, 4 days ago) |
|
|
Quote:
allseeingike said: thc is thc nothing can replace it or substitute it same with lsd and any thing else for that matter
there are definitely drugs that can be considered perfect substitutes. Lsd has Ald. The differences are supposed to be so incomparable that to even a novice psychonaut wouldn't be able to tell differences. Now I would never suggest psilocin as a lsd substitute, but I would definitly suggest 4-aco-dmt as one as a sub for mushrooms.
When talking about Thc you could say hu-210(if not for the differences in potency) are two compounds that are remarkably identical in effects. I would never suggest compounds like jwh-xxx as a substitute for marijuana.
I'm sure there are arguments to be made that these can't be substitutes. So I will put what definition I'm using as "Substitute" Any drug that can be given without the takers knowledge and completely fool that user as to what drug he really took. If you can't tell that the drug you are on is substitute from the real thing, then it did a good job substituting.
--------------------

|
At My Peak
Creator



Registered: 05/13/12
Posts: 629
Loc: underground mole society
Last seen: 2 months, 6 hours
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: Lucid Dreaming]
#16351935 - 06/08/12 02:46 PM (11 months, 4 days ago) |
|
|
Interesting
-------------------- DISCLAIMER:
Everything I say is completely and 100% true and is a widely known and personally tested fact.
|
allseeingike



Registered: 04/07/11
Posts: 1,913
Loc: elgin ill-miami fl
Last seen: 1 hour, 1 minute
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: Lucid Dreaming]
#16351947 - 06/08/12 02:48 PM (11 months, 4 days ago) |
|
|
i have to admit that 4 aco dmt is pretty damn close to psilocybin but if both are taken at higher doses i can tell the big difference is in the visuals on mushrooms i get more sacred geometry and symbols on the 4 aco it was wierd idk how to explain triangles in everything then tunnels of ligth then my wifes face changing into other peoples faces and into faces of animals along with desings also i saw my body melting at one point never had anything of that sort on mushrooms. i found visuals on 3.5mg of 25i to be almost identical to those from mushrooms maybe more glowing and in gold colors unlike the deep reds greens and blues i get from mushrooms
|
pfshroomer
MASTER OF MY DOMAIN



Registered: 10/19/03
Posts: 3,461
Loc: seeking the truth
Last seen: 24 seconds
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: allseeingike]
#16352045 - 06/08/12 03:14 PM (11 months, 4 days ago) |
|
|
Yeah I have to agree with the 25i and mushroom visuals too man.. With a high dose of 25i they are dam close,dam close!!
-------------------- "Follow the medicine path with an open mind and a clear heart, and you will surely find inner peace and enlightenment."
|
Almond Flour



Registered: 12/26/08
Posts: 9,102
Last seen: 18 days, 17 hours
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: allseeingike]
#16352060 - 06/08/12 03:20 PM (11 months, 4 days ago) |
|
|
How funny! Think of all the spice blends that will be able to bypass whatever law they try to throw at us! They will HAVE To legalize it just to stop the flood of weird ass synthetic cannabinoids
-------------------- In other words, thinking outside the box might be facilitated by having a somewhat less intact box. -Random Doctor
Women who seek to be equal with men lack ambition -Timothy Leary
Everyone has their own unique brand of toxic psychosis -Alexander Shulgin
living forever would be a terrible curse if there were not also quality of life to match it. -Unknown
There may be flies on you and me, but there are no flies on Jesus -Hunter Thompson
|
allseeingike



Registered: 04/07/11
Posts: 1,913
Loc: elgin ill-miami fl
Last seen: 1 hour, 1 minute
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: pfshroomer]
#16352088 - 06/08/12 03:26 PM (11 months, 4 days ago) |
|
|
Quote:
pfshroomer said: Yeah I have to agree with the 25i and mushroom visuals too man.. With a high dose of 25i they are dam close,dam close!!
im glad im not the only one
|
JacksonMetaller
Stranger

Registered: 03/14/11
Posts: 5,409
Last seen: 34 minutes, 37 seconds
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: Rail_Gun] 1
#16352445 - 06/08/12 05:11 PM (11 months, 4 days ago) |
|
|
Quote:
Rail_Gun said: Nice! But I bet they still won't find anything better than good old THC in all those molecules.
lol already did. it's called DMT. sorry i just think THC is super overhyped
-------------------- Drugs to try: Alcohol, Weed, LSD, Mushrooms, DMT , LSA, Ayahuasca, Changa, Mescaline, 2c-b, MDMA, DXM, Ketamine, N2O, MXE, Salvia, Kratom, and some day farrrr down the road Ibogaine
|
Absent Minded



Registered: 04/13/12
Posts: 2,852
Loc: New Jersey
Last seen: 2 days, 3 hours
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: Lucid Dreaming]
#16352491 - 06/08/12 05:20 PM (11 months, 4 days ago) |
|
|
Quote:
Lucid Dreaming said:
Quote:
allseeingike said: thc is thc nothing can replace it or substitute it same with lsd and any thing else for that matter
there are definitely drugs that can be considered perfect substitutes. Lsd has Ald. The differences are supposed to be so incomparable that to even a novice psychonaut wouldn't be able to tell differences. Now I would never suggest psilocin as a lsd substitute, but I would definitly suggest 4-aco-dmt as one as a sub for mushrooms.
When talking about Thc you could say hu-210(if not for the differences in potency) are two compounds that are remarkably identical in effects. I would never suggest compounds like jwh-xxx as a substitute for marijuana.
I'm sure there are arguments to be made that these can't be substitutes. So I will put what definition I'm using as "Substitute" Any drug that can be given without the takers knowledge and completely fool that user as to what drug he really took. If you can't tell that the drug you are on is substitute from the real thing, then it did a good job substituting.
you seem quite knowledgeable of all these new "research chemicals." That's one field I never cared much to look into - way too many, complicated names, and difficult to obtain. Do you really think it's worthwhile to get into? I forget what forum I was in, maybe ODD, and they had a thread along the lines of "show your current goodies" and this one kid had like a gram each of K, like 10 different RCs, blotters, etc. Seems overwhelming to me.
--------------------
sheekle: fuck peace love and unity
sheekle: death despair and misery
sheekle: is where it's
"Foremost among them was the suspicion that my strange and ungovernable instincts might do me in before I had a chance to get rich. No matter how much I wanted all those things that I needed money to buy, there was some devilish current pushing me off in another direction – toward anarchy and poverty and craziness. That maddening delusion that a man can lead a decent life without hiring himself out as a Judas Goat." - The good Doctor
|
nooneman
Stranger

Registered: 04/25/09
Posts: 5,737
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: allseeingike]
#16352756 - 06/08/12 06:33 PM (11 months, 4 days ago) |
|
|
It's really ironic how drug prohibition is causing the discovery of hundreds of new psychedelics, stimulants, cannabinoids, dissociatives, and opiates.
Edited by nooneman (06/08/12 06:33 PM)
|
JacksonMetaller
Stranger

Registered: 03/14/11
Posts: 5,409
Last seen: 34 minutes, 37 seconds
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: Absent Minded]
#16352821 - 06/08/12 06:52 PM (11 months, 4 days ago) |
|
|
Quote:
Absent Minded said:
you seem quite knowledgeable of all these new "research chemicals." That's one field I never cared much to look into - way too many, complicated names, and difficult to obtain. Do you really think it's worthwhile to get into? I forget what forum I was in, maybe ODD, and they had a thread along the lines of "show your current goodies" and this one kid had like a gram each of K, like 10 different RCs, blotters, etc. Seems overwhelming to me.
just depends what you like and which ones you get into. if you're into dissociatives MXE has been REALLY hot lately. if you're into psychedelics people are talking about 4-aco-dmt and 25i-nbome a decent bit.
so yeah, if you're one of those people who likes to go explore new things then by all means RC's are great. but if you're the kind of guy whos just happy with weed/shrooms/acid or whatever then it's really not a big deal. a lot of them are slight variances of drugs that already exists. youre bound to come across some that you like and some that you don't so don't let that be a discouragement. for example i didn't think 2c-b was all that special. i'd much prefer acid. but others are saying 25i is on par with the classics. so it just depends what you try and what you like.
its not too overwhelming though. just see what people are getting into in the ODD. the most popular ones are generally the best obviously
-------------------- Drugs to try: Alcohol, Weed, LSD, Mushrooms, DMT , LSA, Ayahuasca, Changa, Mescaline, 2c-b, MDMA, DXM, Ketamine, N2O, MXE, Salvia, Kratom, and some day farrrr down the road Ibogaine
|
Magick
Thinker


Registered: 01/25/09
Posts: 732
Last seen: 20 hours, 2 minutes
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: Almond Flour]
#16352911 - 06/08/12 07:15 PM (11 months, 4 days ago) |
|
|
Quote:
Real CA Milk said: How funny! Think of all the spice blends that will be able to bypass whatever law they try to throw at us! They will HAVE To legalize it just to stop the flood of weird ass synthetic cannabinoids
No, just the opposite will happen. They will pass legislation which bans drugs based on their EFFECTS, not their chemical structure.
In other words, we'll have effectual drug analogs. Those new psychedelics that come out will all be immediately banned based on a certain affinity for the 5-HT2a receptors for instance.
I've long seen it coming. It's the secret weapon of those who seek to criminalize all methods of getting 'high' or otherwise changing your mind-state. It's only a matter of time with all the new psychologically active chemicals constantly coming out at such a fast rate - the laws won't be able to keep up with banning structural analogs.
The only way that won't happen, is if the drug war ends first. I'm sorry to say, but the last time I took LSD I seem to have landed in the wrong quantum universe, that is this one, and as things stand right now, I don't see drugs as a whole being legalized any time soon.
|
JacksonMetaller
Stranger

Registered: 03/14/11
Posts: 5,409
Last seen: 34 minutes, 37 seconds
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: Magick]
#16352966 - 06/08/12 07:31 PM (11 months, 4 days ago) |
|
|
Quote:
Magick said: No, just the opposite will happen. They will pass legislation which bans drugs based on their EFFECTS, not their chemical structure.
In other words, we'll have effectual drug analogs. Those new psychedelics that come out will all be immediately banned based on a certain affinity for the 5-HT2a receptors for instance.
I've long seen it coming. It's the secret weapon of those who seek to criminalize all methods of getting 'high' or otherwise changing your mind-state. It's only a matter of time with all the new psychologically active chemicals constantly coming out at such a fast rate - the laws won't be able to keep up with banning structural analogs.
The only way that won't happen, is if the drug war ends first. I'm sorry to say, but the last time I took LSD I seem to have landed in the wrong quantum universe, that is this one, and as things stand right now, I don't see drugs as a whole being legalized any time soon.
i don't think so. describing effects of drugs is a very broad way of categorizing things and would also make illegal a lot of the medicines we currently have. think about it. description of marijuana could easily take down opiates with it
-------------------- Drugs to try: Alcohol, Weed, LSD, Mushrooms, DMT , LSA, Ayahuasca, Changa, Mescaline, 2c-b, MDMA, DXM, Ketamine, N2O, MXE, Salvia, Kratom, and some day farrrr down the road Ibogaine
|
downlowfunk
Retired Festival Veteran



Registered: 09/25/04
Posts: 644
Loc: Physical Realm
Last seen: 5 days, 14 hours
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: JacksonMetaller]
#16353280 - 06/08/12 08:57 PM (11 months, 4 days ago) |
|
|
=DEA was here yesterday and today. they got 5 oz of shrooms 6+ oz of weed. They said I was facing multiple felonies for being in a school zone. I said that sucks hopefully yall can see I got a sick mom and honme lucrative business is the only chance I got of getting whole foods evefy week. Yep I admitted sales, etc. I dont give a damn lock me up throw away the key. I dont give a shit fuck em fuck em extra I hope they have a copy for court cause Im fighting this on my own and Im screaming and yelling and swearing just like Ricky from TPB fuck em and fuck em extra. I showed em silk road said yep.. I order everything from there I dont give a damn. I bring California prices to people on the east coast and I dont give a shit fuck em fuck em extra. hell im still here facing 3 felonies for being in a school zone. damn 1000 ft. I honestly thought I was more than 1k but they know. im still here typing didnt get arrested just raided.
|
Lucid Dreaming
a



Registered: 04/15/12
Posts: 464
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: downlowfunk]
#16353398 - 06/08/12 09:30 PM (11 months, 4 days ago) |
|
|
Downlowfunk, sounds to me you should just do your best to be as respectful as possible during court. Explain your case and cross your fingers you don't spend 5 years in jail. Dress nice. When its your future on the line I don't think its anytime to have a "I'll show you" attitude. Try a 9 to 5 for cash and grow your own shrooms for personal use ONLY.
--------------------

|
imachavel
Stranger



Registered: 06/06/07
Posts: 8,709
Loc: Florida - not listed
Last seen: 16 hours, 40 minutes
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: Rail_Gun]
#16355492 - 06/09/12 11:36 AM (11 months, 3 days ago) |
|
|
Quote:
Rail_Gun said: Nice! But I bet they still won't find anything better than good old THC in all those molecules.
yes, and I still think it's over estimated. In our time on earth, with millions of chemists, researchers, what not etc. we've only discovered less then 100 elements, and less then two million molecules. Now it's theorised that it's possibly to create another hundred million? Well I suppose it's possible, but I doubt it exists. In the universe it may be possibly to create another few hundred million molecules, but the conditions for probably just a few million of those molecules are only possible here on earth. The conditions for the other molecules may be present on other planets, and may them self be possible to create synthetically here on earth, but how many of them aren't poisonous to a human body, and how many are active psycho actively or medically?
That being said, the potential for new and undiscovered drugs is, hundreds, thousands of possibilities that we have not heard of or discovered yet. Going to be a lot of lab rats this shit will be tested on don't know if that bothers anybody
--------------------
|
bloodsheen
ChemChaplin



Registered: 09/24/08
Posts: 2,664
Last seen: 1 day, 6 hours
|
Re: 1 million billion billion billion billion billion billion: Number of undiscovered drugs [Re: imachavel]
#16355545 - 06/09/12 11:58 AM (11 months, 3 days ago) |
|
|
I just saw a piece on the news about how the federal govt is thinking of doing a national ban on synthetic drugs, but they don't think the DEA has the resources to actually enforce it. So even if the law gets passed it's pretty much a lip-service law. Yah recession!
-------------------- A cautious young fellow named Lodge / Had seat belts installed in his Dodge. / When his date was strapped in / He committed a sin / Without even leaving the garage. That's clever, isn't it?-A boy and his dog
| |
|
|
You cannot start new topics / You cannot reply to topics HTML is disabled / BBCode is enabled
Moderator: Alan Rockefeller 3,053 topic views. 3 members, 55 guests and 0 web crawlers are browsing this forum.
[ Toggle Favorite | Print Topic ]
| | |
|
|
|