Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!
|
 Jessica Swift
यन्त्र
Registered: 01/13/12
Posts: 1,723
Loc: 
|
 The Piss Police is getting lapped on the track. 1
#15807393 - 02/14/12 08:02 AM (3 months, 13 days ago) |
|
|
Basically: underground rational drug design is synthesizing new psychoactive compounds at an exponential speed that makes it difficult to test for (mostly unknown) metabolites.
The text:
"If publication of metabolic studies in the peer-reviewed literature
is awaited before beginning work on preparing standards, the
lead time from the identification of a new psychoactive substance
through to availability of reference materials for the metabolites is
therefore likely to be around two years. Metabolites of one of the
JWH compounds (JWH-018) first became commercially available
as reference materials in mid- to late 2010, slightly ahead of this
prediction. Their appearance is assisting forensic toxicology and
workplacedrugtesting laboratories todevelopanalyticalprotocols
to detect the use of such materials. However, there has been a long
delay between the appearance of the new drug and laboratories
having the ability to screen for use in impairment testing."
From: Referencematerials for new psychoactive
substances, 2011
Roland P. Archer,a Ric Trebleb and Keith Williamsc∗
|
Jessica Swift
यन्त्र
Registered: 01/13/12
Posts: 1,723
Loc:
|
 Re: The Piss Police is getting lapped on the track. [Re: Jessica Swift]
#15807404 - 02/14/12 08:09 AM (3 months, 13 days ago) |
|
|
[Excerpt]
"The shift from full-scan mass spectrometry towards the more
sensitive targeted screening of samples through selected ion
monitoring (SIM) or multiple reaction monitoring (MRM) runs
the risk that the new legal highs will not be detected as, quite
simply, the samples are not being examined for the relevant
target materials. The absence of reference materials prevents
the appropriate validation of methodology and validation of
legally (and clinically) defensible identification and quantitative
methodology. For example, the traditional approach to workplace
drug testing is to use an immunoassay screen followed by GC-MS
confirmation in the SIM mode to maximize the trueness of the
final analytical result. The parameters required for the correct
identification of a target analyte have been defined by many
guidelines such as European Laboratory Guidelines for Legally
Defensible Workplace Drug Testing.[15] These guidelines precisely
define acceptable criteria for the legally defensible identificationof
a target substance, such as amphetamine, Ecstasy or mephedrone.
However, if no suitable reference material had existed for
mephedrone to identify a retention time and suitable ions for SIM
or SRM, the selectivity of these two mass spectrometry techniques
is such that it is unlikely that the instrument would produce any
response to the presence of mephedrone in the sample."
[Conclusion]
"The challenge posed to laboratories, reference material producers,
and legislative bodies by these new and emerging psychoactive
substances shows no signs of abating. No single approach
to reference material production is likely to fully satisfy the
requirements of all forensic drugs and toxicology laboratories.
Reference material suppliers will have to work in conjunction with
end users to prioritize themanufacture and supply of high quality,
appropriately certified drug and metabolite reference materials.
This is likely to require national or international authorities to
commission the production of certain key, commercially unviable
materials."
|
 Brennus
Student of Life
 
Registered: 05/31/08
Posts: 3,091
Loc: SE United States 
Last seen: 6 hours, 28 minutes
|
Re: The Piss Police is getting lapped on the track. [Re: Jessica Swift]
#15807415 - 02/14/12 08:13 AM (3 months, 13 days ago) |
|
|
Hilarious. I hope piss testing becomes so complicated and expensive that it'll go the way of the dinosaur.
I'm thankful I have a well-paying union job that doesn't piss test - what we do on our own time is our business.
|
Jessica Swift
यन्त्र
Registered: 01/13/12
Posts: 1,723
Loc:
|
Re: The Piss Police is getting lapped on the track. [Re: Brennus]
#15807428 - 02/14/12 08:18 AM (3 months, 13 days ago) |
|
|
Quote:
Brennus said:
what we do on our own time is our business.
This is the only logical stance. Job performance tests are more effective measures of competency. Even sensitive public sector jobs shouldn't be tested. Mandating otherwise is equivalent of legislating "pre-crimes."
It is becoming complicated and expensive. More and more reference materials are needed in laboratories to screen for these chemicals.
Also, even their development - once they are identified - is taking awhile. Not to mention how long it takes to distribute.
From the article:
"The traditional route for the commercial production of a
drug reference material is a lengthy process, typically taking
between six and twelve months to complete."
|
Ollo
Psycho-Knot
Registered: 02/11/12
Posts: 52
Loc: AK
Last seen: 7 days, 19 minutes
|
Re: The Piss Police is getting lapped on the track. [Re: Brennus]
#15807431 - 02/14/12 08:19 AM (3 months, 13 days ago) |
|
|
haha. sweet. yay for underground. stick it to em!
--------------------
< Insert Wisdom Here >
|
Jessica Swift
यन्त्र
Registered: 01/13/12
Posts: 1,723
Loc:
|
Re: The Piss Police is getting lapped on the track. [Re: Ollo]
#15807450 - 02/14/12 08:27 AM (3 months, 13 days ago) |
|
|
They are being gradually outsourced by intelligence, just like the fucking churches and politicians.
One of the last barriers is breaking the attraction of greed, money, and power that lures brilliance towards the control of the government. The sciences are being drafted into military programs, police control, international regulation, hauled through bureaucratic/legal red tape, exploited by financial organizations, etc. because so many cocksuckers wish to control either money or other people. "Information is negative entropy," it wants out!
Not to circle jerk around the internet again, but its conception has been the fire-starter for resistance and autonomy, from protest organization all the way up to international quantum physics projects.
And we all know internet technology was born in the time frame and geography of the psychedelic revolution. Just a coincidence, I'm sure. 
| |
|
|
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator:
110 topic views. 38 members, 121 guests and 3 web crawlers are browsing this forum.
[ Toggle Favorite | Print Topic ]
| | |
|
|
|
Previous
Index
Next
Threaded
Shop for: 
Edit 
Reply 
