Home | Community | Message Board

Cannabis Seeds UK
This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: Left Coast Kratom Buy Kratom Capsules   Kraken Kratom Buy Kratom Powder & Leaf   Bridgetown Botanicals Bridgetown Botanicals   North Spore Cultivation Supplies   Unfolding Nature Unfolding Nature: Being in the Implicate Order   PhytoExtractum Kratom Powder for Sale

Jump to first unread post Pages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | Next >  [ show all ]
OfflineMorphogenesis
Theatre Semiotics

Registered: 11/19/11
Posts: 1,132
Loc: ∞
Last seen: 11 years, 10 months
2-MeO-Ketamine - Coming Soon to a Theater Near You * 4
    #15663882 - 01/14/12 03:39 AM (12 years, 2 months ago)

This will be hitting RC vendors soon (2-3 weeks). There are custom synths in China now.

Since ketamine is a schedule 3 (S3), 2-MeO-Ketamine does not fall under the analogue act in the US. It's also legal in the UK.

The drug is basically the chloro group substituted by methoxy group. Experientially it feels more or less identical to ketamine. Or so I've read.

:specialk:


--------------------
Machine Age Maya

Extras: Filter Print Post Top
Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 4 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis]
    #15663888 - 01/14/12 03:41 AM (12 years, 2 months ago)

Another RC I have 0 interest in :frown:

Where are the damn lysergamide methyl esters and all that business I ask :megapsycrankey:


--------------------

Extras: Filter Print Post Top
OfflineMorphogenesis
Theatre Semiotics

Registered: 11/19/11
Posts: 1,132
Loc: ∞
Last seen: 11 years, 10 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: mellowparty] * 1
    #15663899 - 01/14/12 03:49 AM (12 years, 2 months ago)

Marketability seems to be the main driving force behind the RC scene. Shulgin, Nichols, Nick Sand, Ott, Siebert, and a whole slew of others were pushing the early investigations into tryptamines. Dissociatives and substituted amphetamines/cathinones are selling for the same reason than synthetic cannabinoids are: people just want to get really high.

Phenethylamines aren't as magical either. I wish development was going on with lysergamides (Al-LAD, etc.), but until we kill dubstep it ain't happening.

:randysavage:


--------------------
Machine Age Maya

Extras: Filter Print Post Top
InvisibleSamuel L Jackson
Bad Motherfucker
Male

Registered: 12/10/09
Posts: 8,395
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis] * 1
    #15663904 - 01/14/12 03:56 AM (12 years, 2 months ago)

Quote:

Morphogenesis said:
This will be hitting RC vendors soon (2-3 weeks). There are custom synths in China now.

Since ketamine is a schedule 3 (S3), 2-MeO-Ketamine does not fall under the analogue act in the US. It's also legal in the UK.

The drug is basically the chloro group substituted by methoxy group. Experientially it feels more or less identical to ketamine. Or so I've read.

:specialk:




i have a feeling it will be as similar to ketamine as mxe is.

not at all.


--------------------


Extras: Filter Print Post Top
OfflineMorphogenesis
Theatre Semiotics

Registered: 11/19/11
Posts: 1,132
Loc: ∞
Last seen: 11 years, 10 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Samuel L Jackson] * 1
    #15663921 - 01/14/12 04:15 AM (12 years, 2 months ago)

MXE is usually compared subjectively to PCP.

There are a couple of insightful threads at Bluelight discussing the pharmacokinetics of 2-MeO-Ket.

Our page is now the 2nd search result on Google for this compound.


--------------------
Machine Age Maya

Extras: Filter Print Post Top
InvisibleHiei
8======><=====8
Male User Gallery

Registered: 01/23/08
Posts: 2,648
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis]
    #15663965 - 01/14/12 04:51 AM (12 years, 2 months ago)

A guy I met talked about "meta-ketamine" and I was laughing hard inside. Could it be he was talking bout this?

naah no way!? where did you get this kind of info if the product is being synthesized now? :heart:



Could be a good way of by-passing the new laws against ketamine production in India and such places? I've heard a main compound of the synth has been made illegal and thats why ketamine is very hard to find now.


--------------------
◄►۞◄►

Edited by Hiei (01/14/12 04:54 AM)

Extras: Filter Print Post Top
OfflineMorphogenesis
Theatre Semiotics

Registered: 11/19/11
Posts: 1,132
Loc: ∞
Last seen: 11 years, 10 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Hiei] * 2
    #15663976 - 01/14/12 05:03 AM (12 years, 2 months ago)

India is indeed clamping down on distribution (also their domestic hash trade) and the effects have apparently been felt in the UK. 2-MeO was chosen because one vendor polled its members awhile back and this came out on top. It's just another way to skirt the laws. I say bring it on. This new research development is exciting. Ironically, the government who wishes to suppress drug use is creating incentive to synthesize new compounds. How about that for the snake eating its tail!

I get most of my information from other forums and individuals. I'm not personally involved in manufacturing or distribution in any way (and I'm not just saying that to cover my ass, lol). I just feel the need to spread information.

4-EAR is also coming out. It's just an ethyl analogue of 4-Methylaminorex, which is a tweaker drug with like an 18 hour half life.

Newer research shows is isn't neurotoxic though.


--------------------
Machine Age Maya

Extras: Filter Print Post Top
Invisiblevenetianblinds
cabbage

Registered: 05/25/11
Posts: 2,532
Loc: Flag
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis]
    #15663985 - 01/14/12 05:09 AM (12 years, 2 months ago)

someone should make a crazy salvinorin analogue


--------------------
How do you know but ev’ry Bird that cuts the airy way,
Is an immense world of delight, clos’d by your senses five?

Extras: Filter Print Post Top
OfflineMorphogenesis
Theatre Semiotics

Registered: 11/19/11
Posts: 1,132
Loc: ∞
Last seen: 11 years, 10 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: venetianblinds] * 1
    #15664000 - 01/14/12 05:16 AM (12 years, 2 months ago)

I vaped 98% pure salvinorin A. Talk about a Godsmack.

Quote:

venetianblinds said:
someone should make a crazy salvinorin analogue




Analogues are already being investigated.

2-Ethoxymethyl salvinorin B (symmetry, 2-EtOMe-Sal B) is a semi-synthetic analogue of the natural product salvinorin A, with a longer duration of action of around 3 hours (compared to less than 30 minutes for salvinorin A), and increased affinity and intrinsic activity at the κ-opioid receptor. Like the related compound herkinorin, 2-ethoxymethyl salvinorin B is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation,[1] as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.[2]

2-Ethoxymethyl salvinorin B has a Ki of 0.32 nM at the κ-opioid receptor, and around 3,000 times selectivity over the μ- and δ-opioid receptors, making it one of the most potent and selective kappa agonists yet discovered.[3] In animal studies it fully substituted for salvinorin A and the synthetic kappa agonist U-69593, and was active at doses as low as 0.005 mg/kg.[4] Human bioassays found the compound to be active at 50 μg.[5]


--------------------
Machine Age Maya

Extras: Filter Print Post Top
InvisibleaNeway2sayHooray
Cresley Wusher
 User Gallery


Folding@home Statistics
Registered: 07/07/05
Posts: 7,653
Loc: Orphic Trench
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis] * 1
    #15664008 - 01/14/12 05:21 AM (12 years, 2 months ago)

Quote:

Morphogenesis said:
I vaped 98% pure salvinorin A. Talk about a Godsmack.

Quote:

venetianblinds said:
someone should make a crazy salvinorin analogue




Analogues are already being investigated.

a longer duration of action of around 3 hours

Human bioassays found the compound to be active at 50 μg.[5]




:mindexpanding:


--------------------
Mad_Larkin said:  Death is just a thang.
:clementine:
MrJellineck said:  Profits, prophets. That's all you jews think about.
sheekle said: life is drugs... and music... and cat... :snowman:

Extras: Filter Print Post Top
OfflineMorphogenesis
Theatre Semiotics

Registered: 11/19/11
Posts: 1,132
Loc: ∞
Last seen: 11 years, 10 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: aNeway2sayHooray] * 2
    #15664013 - 01/14/12 05:25 AM (12 years, 2 months ago)

After peaking behind the curtain, it now seems as though we're trying to get backstage passes.

:learyharvard:


--------------------
Machine Age Maya

Extras: Filter Print Post Top
Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 4 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis] * 2
    #15664017 - 01/14/12 05:28 AM (12 years, 2 months ago)

Quote:

Morphogenesis said:
I vaped 98% pure salvinorin A. Talk about a Godsmack.

Quote:

venetianblinds said:
someone should make a crazy salvinorin analogue




Analogues are already being investigated.

2-Ethoxymethyl salvinorin B (symmetry, 2-EtOMe-Sal B) is a semi-synthetic analogue of the natural product salvinorin A, with a longer duration of action of around 3 hours (compared to less than 30 minutes for salvinorin A), and increased affinity and intrinsic activity at the κ-opioid receptor. Like the related compound herkinorin, 2-ethoxymethyl salvinorin B is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation,[1] as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.[2]

2-Ethoxymethyl salvinorin B has a Ki of 0.32 nM at the κ-opioid receptor, and around 3,000 times selectivity over the μ- and δ-opioid receptors, making it one of the most potent and selective kappa agonists yet discovered.[3] In animal studies it fully substituted for salvinorin A and the synthetic kappa agonist U-69593, and was active at doses as low as 0.005 mg/kg.[4] Human bioassays found the compound to be active at 50 μg.[5]



I've read some trip reports from these and not trying to sound like a drug elitist but damn that sounds like on awful, awful RC :lol:

Who in the right mind would like a 3 hours salvia trip? kappa-opioid dysphoria sounds like the least desired feeling to me.

How I wish there was more interest in the lysergamide field.


--------------------

Extras: Filter Print Post Top
OfflineMorphogenesis
Theatre Semiotics

Registered: 11/19/11
Posts: 1,132
Loc: ∞
Last seen: 11 years, 10 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: mellowparty] * 2
    #15664021 - 01/14/12 05:30 AM (12 years, 2 months ago)

Quote:

How I wish there was more interest in the lysergamide field.




Do your own research then. What stops you?


--------------------
Machine Age Maya

Extras: Filter Print Post Top
Offlinemellowparty
legitimate researcher


Registered: 05/17/09
Posts: 18,467
Last seen: 10 years, 4 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis] * 1
    #15664023 - 01/14/12 05:32 AM (12 years, 2 months ago)

Quote:

Morphogenesis said:
Quote:

How I wish there was more interest in the lysergamide field.




Do your own research then. What stops you?



1. Lack of laboratory and other related resources
2. Connections
3. Time


--------------------

Extras: Filter Print Post Top
InvisibleAsante
Omnicyclion prophet
Male User Gallery

Registered: 02/06/02
Posts: 87,230
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis]
    #15664024 - 01/14/12 05:33 AM (12 years, 2 months ago)

There is a blanket ban over lysergamides, the first analog act in existence. Also, getting the precursor is prohibitively difficult.


--------------------
Omnicyclion.org
higher knowledge starts here

Extras: Filter Print Post Top
OfflineMorphogenesis
Theatre Semiotics

Registered: 11/19/11
Posts: 1,132
Loc: ∞
Last seen: 11 years, 10 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Asante] * 1
    #15664031 - 01/14/12 05:38 AM (12 years, 2 months ago)

Rational drug design is largely a theoretical process. It's possible to develop novel syntheses and share notes with biochemists, which is the crux of research and is what propelled earlier communities like The Hive. Trial and error occurs at the level of bioassay, but most of the work is on paper.


--------------------
Machine Age Maya

Extras: Filter Print Post Top
OfflineMorphogenesis
Theatre Semiotics

Registered: 11/19/11
Posts: 1,132
Loc: ∞
Last seen: 11 years, 10 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: mellowparty] * 1
    #15664040 - 01/14/12 05:48 AM (12 years, 2 months ago)

Quote:

mellowparty said:
Who in the right mind would like a 3 hours salvia trip? kappa-opioid dysphoria sounds like the least desired feeling to me.





There is also N-Methylamide-Salvinorin A, and herkinorin - which "is a selective κ-opioid agonist with no significant μ-opioid receptor affinity." Binding at the μ-opioid receptor is what makes mitragynine (kratom) euphoric as an analgesic. If other analogues can manage peripheral binding it may retain the psychedelic effects but still feel more pleasurable.

Personally, I enjoy pure salvinorin A. Where you end up - if you retain consciousness - doesn't resemble normal reality, to say the least.


--------------------
Machine Age Maya

Extras: Filter Print Post Top
InvisibleHiei
8======><=====8
Male User Gallery

Registered: 01/23/08
Posts: 2,648
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis]
    #15664042 - 01/14/12 05:50 AM (12 years, 2 months ago)

for every drug they ban, there will be a thousand new ones!

Hurray for research. :heartpump:


PS: whats the easy way to get pure salvinorin A, I guess extraction from salvia leafs?


--------------------
◄►۞◄►

Edited by Hiei (01/14/12 05:52 AM)

Extras: Filter Print Post Top
Offlinelove2shpongleIRL
Opiophile
Male

Registered: 06/11/11
Posts: 4,784
Last seen: 11 years, 10 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: Morphogenesis] * 1
    #15664187 - 01/14/12 07:58 AM (12 years, 2 months ago)

Quote:

Morphogenesis said:
After peaking behind the curtain, it now seems as though we're trying to get backstage passes.

:learyharvard:


:awehigh:


--------------------
Only those who will risk going too far can possibly find out how far one can go.
T. S. Eliot

Extras: Filter Print Post Top
Offlinedwtk
it all rolls into one
Male User Gallery

Registered: 02/24/07
Posts: 4,482
Loc: Franklin's Tower
Last seen: 5 years, 5 months
Re: 2-MeO-Ketamine - Coming Soon to a Theater Near You [Re: love2shpongleIRL]
    #15664228 - 01/14/12 08:19 AM (12 years, 2 months ago)

ahhh im excited about this (the original topic)


--------------------
       

Extras: Filter Print Post Top
Jump to top Pages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | Next >  [ show all ]

Shop: Left Coast Kratom Buy Kratom Capsules   Kraken Kratom Buy Kratom Powder & Leaf   Bridgetown Botanicals Bridgetown Botanicals   North Spore Cultivation Supplies   Unfolding Nature Unfolding Nature: Being in the Implicate Order   PhytoExtractum Kratom Powder for Sale


Similar ThreadsPosterViewsRepliesLast post
* The Festival Express is coming! (it's here!) kindkesey 1,833 16 11/02/04 02:43 PM
by Silven
* Terence McKenna on ketamine and ecstasy (mp3's)
( 1 2 all )
LearyfanS 6,065 21 06/07/04 05:16 AM
by filthysock
* 5-Meo-DMT AuroricDistortions 1,295 5 02/20/04 03:05 PM
by shroom_muncher
* Coming down again...
( 1 2 all )
OldSpice 799 22 05/30/04 10:06 PM
by IAmTheWalrus212
* ER ketamine (TV doper-docs) gnrm23 666 3 04/30/04 02:02 PM
by TinTree
* The Harder They Come Ripple 1,156 7 09/22/03 02:18 PM
by Big Fi52
* Morning comes Ripple 2,334 16 01/08/04 02:03 PM
by kosmic_charlie
* Thailand here we come..... trev 1,937 15 08/16/03 07:50 AM
by trev

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: Entire Staff
14,829 topic views. 3 members, 39 guests and 32 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.033 seconds spending 0.01 seconds on 15 queries.