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Dawks said:
Mescaline Synthesis

You people seriously never heard of PIHKAL?

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I own a copy.

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drr said:
Free doses for loved ones only.

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That's how I roll with my extractions as well.

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eqt146 said:
When you do a mescaline extraction, you're actually getting a mix of various alkaloids, including mescaline. Many of these are psychoactive as well. That's why a Peyote trip, San Pedro trip, and Peruvian Torch trip are slightly qualitatively different. They have a somewhat different blend of alkaloids. It's also why a trip on extracted mescaline or cactus material sometimes seems to come in "waves". Some of the alkaloids kick in faster than others so the trip isn't necessarily linear in intensity.

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eqt146 said:
If you want PURE mescaline, synthesis is still probably the least practical way to get it. This would definitely be easier than a synthesis.

There's a reason you don't see much mescaline on the streets. Extraction doesn't give very good yields in relation to the amount you need to trip, and synthesis is just too hard and impractical.

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This is just all out wrong. Hate to say it but synthesis is much easier and cost-effective means for obtaining LARGE yeilds of PURE mescaline HCl.
In fact, if you want PURE mesc you have to synthesize, as mentioned earlier when extracting from cacti you do, in fact get more than just mesc.
If you find a source for 3,4,5-trimethoxybenzaldehyde then theres a 2-step, very safe, reaction to the corresponding beta-nitrostyrene.
Then you have to set up and know how to operate a hydrogenation apparatus that can withstand 80psi and hydrogenat over Pd/C. If any meth cook can do this I think some of the fartsmell.....er smart fellers on here can figure it out.
It goes like so;
1. 1000g of 3,4,5TMB is mixed with 280ml Nitromethane and 2100ml EtOH  in one container

2. In another container 420g KOH is mixed with 420ml d-H20 and 840ml MeOH

3. These are mixed together in an Ice bath to keep the temperature down and, upon full addition, is removed from the ice bath and left to sit at room temp for 30min

4. In another 5 gallon glass carboy, make 3gallons of 10%HCl.

5. After the full half-hour of reacting, the reaction mixture is poured into the carboy and submerged in an Ice bath.

6. A yellow precipitate will settle/crystallize out and after it all settles the liquids can be siphoned off throug a funnel and filter to catch and nytrostyrene that may be sucked through.

7. Dissolve all yellow precipitates in boiling MeOH, Filter and cool to form yellow crystal, vaccuum filter off, recrystallize again if needed or desired and store in an air tight "blacked-out" jar for future use.
This yeilds around 800-900g 3,4,5-Trimethoxy-beta-nitrostyrene.

To reduce to 345TMPEA via catalytic hydrogenation, I will quote erowid;

Hydrogenation

    15g Pd/C 5%
    175g 3,4,5TMBnitrostyrene
    2.5L Anhydrous EtOH
    100ml 31.45% HCl

Procedure

    Add reagents to the keg, begin vigorous stirring
    Remove atmosphere and pressurize to 75psi with H2
    React for 8-10 hours or until H2 uptake has completely ceased
    Evacuate H2 outside, vacuum out interior of vessel, allow H2 to clear, THEN open the vessel
    Vacuum filter off Pd/C
    Re-filter through celite for maximum Pd/C recovery/removal
    Distill the mixture down until the Ethanol fraction begins to cease
    Cool and take up what is left in 2L 3N HCl

        Your remainder may look somewhat black/brown here, but don't worry, this will all be cleared up. If the hydrogenation did not go to completion some unreacted nitrostyrene will remain, this should be filtered from the solution.

    Wash with 2x125ml DCM
    Basify to pH>11 dropwise and with stirring with saturated NaOH solution
    Extract 3x125ml DCM
    Dry over NaSO4 (250g) for 15 minutes
    Filter off NaSO4 and bubble DCM with HCl(g) anhydrous. After crystalization ceases it can be advantageous to filter and redry the DCM with another 100g NaSO4, then bubble some more.
    Collect HCl salt crystals by filtration

Final mass yield = 168.74g Mescaline•HCl

Scale up if you can find a big enough reaction pressure vessel or do it in batches.

As you can see, though, if you can find the right sources this is a much less expensive way to get around 5-600g pure mescaline HCl than buying 60+ kilos of dry cactus chips. I actually added up the cost of doing all of this once not too long ago and its less that $1500 including the 345TMB and the Pd/C, which will be the only thing that's actually hard to get a hold of, everything else is available all over, but you can find anything in China