Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!
|
 ThorAxe1
Stranger
Registered: 08/09/08
Posts: 118
Last seen: 19 hours, 45 minutes
|
 DXM, Dimenhydrinate, and Diphenhydramine 
#9916209 - 03/05/09 11:04 AM (3 years, 2 months ago) |
|
|
I have a few questions as to the combination of these three. About two hours ago, I consumed 200mg of Dimenhydrinate. An hour following, I consumed 400mg of DXM and 150 of Diphenhydramine.
Im not necessarily asking about whether or not its a good idea, Im moreso curious as to whether or not its been done before, and what to expect.
|
 Cognitive_Shift
@shroomery.org
Registered: 12/11/07
Posts: 22,230
Loc: OhighO 
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: ThorAxe1]
#9916216 - 03/05/09 11:07 AM (3 years, 2 months ago) |
|
|
Yes its been done before, expect sedation.
--------------------
L'enfer est plein de bonnes volontés et désirs
|
LSDreamer
Psychedelic Atheist
Registered: 03/11/08
Posts: 8,638
Last seen: 8 months, 29 days
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: ThorAxe1]
#9916232 - 03/05/09 11:10 AM (3 years, 2 months ago) |
|
|
I have no idea if that's safe or not, but are you fully aware of just how fucked up you're about to be?
--------------------
|
ThorAxe1
Stranger
Registered: 08/09/08
Posts: 118
Last seen: 19 hours, 45 minutes
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: Cognitive_Shift]
#9916238 - 03/05/09 11:11 AM (3 years, 2 months ago) |
|
|
As far as the DXM-esque hallucinations being combined with the Diphenhydramine hallucinations, I'd automatically assume that they won't be synergistic. Will the Diphenhydramine/Dimenhydramate affect the nature of the hallucinations? Or is the sedation that I feel at the moment all that I am going to get?
I'm also considering consuming a few nutmeg nuts.
|
Cognitive_Shift
@shroomery.org
Registered: 12/11/07
Posts: 22,230
Loc: OhighO
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: ThorAxe1]
#9916253 - 03/05/09 11:13 AM (3 years, 2 months ago) |
|
|
Your going to be in a head space where your feel really fucking weird. This dissociated mind set where your not really awake, but your not asleep. Just stuck in this fucked up state between the two.
--------------------
L'enfer est plein de bonnes volontés et désirs
|
ThorAxe1
Stranger
Registered: 08/09/08
Posts: 118
Last seen: 19 hours, 45 minutes
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: Cognitive_Shift]
#9916268 - 03/05/09 11:16 AM (3 years, 2 months ago) |
|
|
Ah, I love both the DXM and dramamine headspaces. Combining the two, so far, has proven a good idea. Thanks for the confirmation. I'm going to capsulate freshly ground nutmeg and consume in about 30 minutes. I'll report back with the results.
|
LSDreamer
Psychedelic Atheist
Registered: 03/11/08
Posts: 8,638
Last seen: 8 months, 29 days
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: ThorAxe1]
#9916280 - 03/05/09 11:17 AM (3 years, 2 months ago) |
|
|
Does anyone know which enzyme nutmeg is metabolized by? Is this guy about to die?
--------------------
|
Cognitive_Shift
@shroomery.org
Registered: 12/11/07
Posts: 22,230
Loc: OhighO
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: LSDreamer]
#9916315 - 03/05/09 11:24 AM (3 years, 2 months ago) |
|
|
DXM inhibits the reuptake of serotonin as well as other things, he could be in for a potentially deadly experience.
--------------------
L'enfer est plein de bonnes volontés et désirs
|
Cognitive_Shift
@shroomery.org
Registered: 12/11/07
Posts: 22,230
Loc: OhighO
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: Cognitive_Shift]
#9916329 - 03/05/09 11:26 AM (3 years, 2 months ago) |
|
|
Dextromethorphan is one of the most widely used antitussives for the treatment of cough. In the present study, we investigated the effect of dextromethorphan on 5-hydroxytryptamine (5-HT)-induced currents in acutely dissociated rat nodose ganglion neurons using nystatin-perforated patch-clamp recording configuration. The 5-HT-induced current was inhibited by the 5-HT3 receptor antagonist tropisetron, while the selective 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide hydrochloride (mCPBG) induced a similar current. Dextromethorphan reversibly and concentration-dependently inhibited the 5-HT-induced inward current. The inhibition did not appear to be voltage-dependent. Both the peak and steady-state 5-HT-induced currents were inhibited by dextromethorphan, although the peak current was more sensitive to dextromethorphan block. The IC50 values for the inhibition of peak and steady currents evoked by 3 μM 5-HT were 16.4 and 34.4 μM, respectively. In the presence of 10 μM dextromethorphan, the concentration–response curve for 5-HT was shifted to the right without changing the maximum response, while high concentrations reduced the maximum current. The 5-HT EC50 values in the presence of 0, 10, 30 and 60 μM dextromethorphan were 4.3, 6.8, 15.5 and 40.6 μM, respectively. The results indicate that dextromethorphan inhibits the 5-HT-induced current of rat nodose ganglion neurons, and further suggest that dextromethorphan at a low concentration acts as a competitive inhibitor of 5-HT3 receptors.
--------------------
L'enfer est plein de bonnes volontés et désirs
|
LSDreamer
Psychedelic Atheist
Registered: 03/11/08
Posts: 8,638
Last seen: 8 months, 29 days
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: Cognitive_Shift]
#9916334 - 03/05/09 11:26 AM (3 years, 2 months ago) |
|
|
C'est la vie, I suppose. If you Darwin yourself, try not to make the rest of us drug users look TOO bad on the way out.
--------------------
|
ThorAxe1
Stranger
Registered: 08/09/08
Posts: 118
Last seen: 19 hours, 45 minutes
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: Cognitive_Shift]
#9916351 - 03/05/09 11:29 AM (3 years, 2 months ago) |
|
|
Well, I haven't consumed the nutmeg yet. I'm assuming the Nutmeg is not that great of an idea?
Edited by ThorAxe1 (03/05/09 11:31 AM)
|
ThorAxe1
Stranger
Registered: 08/09/08
Posts: 118
Last seen: 19 hours, 45 minutes
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: ThorAxe1]
#9916379 - 03/05/09 11:34 AM (3 years, 2 months ago) |
|
|
Shit. I just realized that I was about to encapsulate Nutmeg with emptied St. John's Wort capsules right after consuming Dextromethorphan.
I'm glad I realized that as soon as I did.
|
deCypher
Registered: 02/10/08
Posts: 52,515
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: ThorAxe1]
#9916599 - 03/05/09 12:04 PM (3 years, 2 months ago) |
|
|
Quote:
ThorAxe1 said:
I have a few questions as to the combination of these three. About two hours ago, I consumed 200mg of Dimenhydrinate. An hour following, I consumed 400mg of DXM and 150 of Diphenhydramine.
Im not necessarily asking about whether or not its a good idea, Im moreso curious as to whether or not its been done before, and what to expect.
A lot of people rave about the synergistic mixture of DXM and anticholinergics such as DPH or DMH, but bear in mind this is a heavy, heavy hitting mixture and probably isn't too healthy. I've only tried the combination once (600 mg DXM and 300 mg DPH), and I didn't like it too much--I was too drowsy and anxious to properly enjoy the DXM trip, and I didn't notice any significant visual enhancement which is the reason most people combine DXM with anticholinergics (DPH as an antihistamine drastically potentiates DXM).
Hit up http://disc.420chan.org/del/ if you want some reports from people who regularly enjoy the mixture. I try to stay away from pharmaceutical deliriants in favor of low dose Datura, though--too many peripheral antihistaminic side effects to properly enjoy the anticholinergia. I'd also skip the nutmeg; you'll already have enough for quite a formidable trip without the potential for liver damage.
--------------------
We are all in the gutter, but some of us are looking at the stars.
  
|
FunkMasterShroom
Stranger
Registered: 03/05/09
Posts: 1,250
Loc: Canada
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: ThorAxe1]
#9920994 - 03/06/09 12:08 AM (3 years, 2 months ago) |
|
|
Okay, Idono where else to post this regarding DXM, so the most recent thread seems best.
I had repeatedly used DMX, experimenting with various amounts, up to 1000mg. In my inmaturity at the times, i was drinking it straight as cough syrup, and experienced a GREAT DEAL of physical strain. My stomach would cramp, naseau followed me for the first hour or two, and Pure liquide shit had to be expelled a number of times throughout the first half of the "trips".
Now on Erowid, there is some information about Onley's Lesions, and this is what I wanted to bring up.
The last time I tried DXM, i was in a pretty low mood and state of mind about a year ago. I fastd for 2 days, and took aprox 300mg of dmx, and another 600mg within 45 minutes later (trying to read sigma).. I ended up passing out on my bed, and waking up about 11 hours later.
I woke up to a shock.
My Entire body was drentched in sweat, the bed was soaked in it as well, so much so that i may have even urinated. Every muscle through my limbs was very soar and heavy. I could barely use my muscles as it felt like I had just weight trained my entire structure for hours and hours straight.. as well, I had awoken on my right side, with my right arm out in front of me, and it had rubbed up continueously against the corner of my bedside table, and scratched/ground a large rash/scrape across my arm.
Not only this, but also, there was a large Hole Chewed through the side of my tongue.
Heres My Conclusion..
I had a seizure of sorts. A lesion as it were..
Somepoint after passing out I must have went into spasm. Since I was lying on my side, my arm rubbed constantly against the side table, causing the scratch.. my teeth must have been clenching, and being still- on my side, my tongue must have slipped between my teeth via gravity.. as I said, all my muscles were Incredibly sore, and that would be accounted from the seizuring...
I didn't end up going to the bathroom like nomrally, so I take it I sweated all the liquid out..
I know this post is kinda hap hazard, and more of a trip report, but I felt it would do well to be noted at least one of the major dangers of DXM on this forum.
Please Be very Careful with dissasociates..
When too much of this kind of activity goes on in the brain, it cannot handle it, and to stop of complete overload, the brain basically melts away the overactive cells, causeing a lesion (a gash, or wound in the brain!)..
Eventually my tongue healed, and is as good as new, but ever since waking up that day, my perception of reality has been forever altered, and i dont know if this is direct, but I never before had anything i'd really call a headache until after this experience. PLEASE PLEASE BE VERY CAREFUL!
I have yet to actually scan my brain and see what effects are there if any.. but do know, basically, if you over dissacociate, the body will basically dissolve the cells that are being olver effected!
Dissacociate-Dissolve!
Safe Explorations and Journeys.
--------------------
Why did the chicken cross the road?
To get to the other side.
"I don't mean to sound bitter, cold, or cruel, but I am, so that's how it comes out...
Professional help is being thought." -Bill Hicks
|
polantis
Prototype v7.3 Alpha
Registered: 05/24/08
Posts: 2,363
Loc: Austraalis 
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: FunkMasterShroom]
#9921006 - 03/06/09 12:13 AM (3 years, 2 months ago) |
|
|
Quote:
FunkMasterShroom said:
but do know, basically, if you over dissacociate, the body will basically dissolve the cells that are being over effected!
Really?
--------------------
We do not know what we want and yet we are responsible for what we are - that is the fact.
Jean-Paul Sartre
|
FunkMasterShroom
Stranger
Registered: 03/05/09
Posts: 1,250
Loc: Canada
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: polantis]
#9921043 - 03/06/09 12:38 AM (3 years, 2 months ago) |
|
|
From what I remember reading, the cells in the brain, as they are overstimulated with activity, they begin to suicide themselves, so as not to overload other systems.. It's a safreguard mechanism as it was explained. That by causion the lesion, the brain is saving itself from greater damage.. but cutting out the chaotic cells.. Idono if this actually happened to me, but I wouldn't be at all surprised. there is tests of it happening on lab rats, and I read 2 reports I belive, mentioning lesions and brain damage.
Be (A)ware!
--------------------
Why did the chicken cross the road?
To get to the other side.
"I don't mean to sound bitter, cold, or cruel, but I am, so that's how it comes out...
Professional help is being thought." -Bill Hicks
|
LSDreamer
Psychedelic Atheist
Registered: 03/11/08
Posts: 8,638
Last seen: 8 months, 29 days
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: FunkMasterShroom]
#9921677 - 03/06/09 07:43 AM (3 years, 2 months ago) |
|
|
^Definitely going to have to cite a source for that, especially since This Is Your Brain on Dissociatives was retracted.
--------------------
|
Jade
<3
Registered: 10/06/08
Posts: 2,850
Loc: Montréal 
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: LSDreamer]
#9921941 - 03/06/09 08:57 AM (3 years, 2 months ago) |
|
|
If dxm really did kill brain cells I'd be retarded by now 
|
clemens
Lover
Registered: 10/22/06
Posts: 4,072
Loc: FL
Last seen: 8 days, 10 hours
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: Jade]
#9921993 - 03/06/09 09:12 AM (3 years, 2 months ago) |
|
|
lol OP that sounds like a crazy mix and I wouldn't ever do it myself.
Have fun tho
Also does this belong in the psychedelic board?
--------------------
    
I ain't willy wonka I don't sugarcoat shit
I keep codeine in my cup with a sprite mix
|
ThorAxe1
Stranger
Registered: 08/09/08
Posts: 118
Last seen: 19 hours, 45 minutes
|
Re: DXM, Dimenhydrinate, and Diphenhydramine [Re: clemens]
#9925860 - 03/06/09 09:14 PM (3 years, 2 months ago) |
|
|
A day later, and I'm proud to say that I've discovered possibly my favorite combination of OTC psychoactive substances. Dextremethorphan and Dimenhydrinate seem to cancel out each other's negative effects, as it were. Dimenhydrinate reduces any nausea present, while Dextromethorphan stimulates the user so as to not sleep through the trip. All while combining the two distinct types of hallucinations and headspaces for an overall pleasant and incredibly feel-good trip.
I also noticed that my speech and walking were less impaired (usually due to DXM) when combining DXM with Dimenhydrinate.
| |
|
|
|
|
Previous
Index
Next
Threaded
Shop for: 
Edit 
Reply 
