|
 murac
Stranger
Registered: 01/10/08
Posts: 6
Last seen: 4 years, 10 months
|
 Do shrooms cause a flood of serotonin? 
#7864153 - 01/11/08 11:48 AM (5 years, 4 months ago) |
|
|
Because if that's so, it would explain why my DXM trip last night was dumbed down and this frightens me for tonight's Acid trip or lack of one if i'm totally depleted of serotonin. I'm just searching around drug sites now and found this:
"The release of serotonin, however, also causes serotonin receptors in the brain to down-regulate, which basically means turn themselves off for a while. The up-and-down regulation of receptors is one of the primary ways the brain tries to achieve homeostasis, or balance. These receptors work in conjunction with the amount of serotonin around and are just as important in the regulation of mood as serotonin itself (see our Ecstasy Slide Show for details). In trying to maintain a balanced mood, these receptors respond to the amount of serotonin around by turning themselves on and off (up-regulation and down-regulation). When they are flooded with serotonin as a result of taking Ecstasy, many of them down-regulate."
So if my receptors have down regulated as a result of shrooms (from wednesday), the tolerance is most definitely partly due to this. DXM releases serotonin and I took a strong dose last night but somehow it didn't affect like it does usually. I could almost sense a lingering shroom feeling which made me suspect a connection. Today I planned on tripping for the first time on acid but I wonder if it will even be worth it? I only have one hit anyways and about 2g of shrooms left which I am considering taking (but again, will it just be a waste?)
I understand that the above reference might have nothing to do with my scenario but many drugs affect serotonin and it doesnt matter if its E or whathaveyou the same result described should happen. right? Any insight will be greatly appreciated.
Edited by murac (01/11/08 01:35 PM)
|
HeadFood
Shroomer
Registered: 12/30/07
Posts: 390
Last seen: 4 months, 27 days
|
 Re: Do shrooms cause a flood of serotonin? [Re: murac]
#7864492 - 01/11/08 01:16 PM (5 years, 4 months ago) |
|
|
so you did shrooms, DXM, and now you wanna do acid 3 days in a row? maybe you should take a day off and reflect on your trips. Do the acid in a day or two.
--------------------
Phi Alpha
|
murac
Stranger
Registered: 01/10/08
Posts: 6
Last seen: 4 years, 10 months
|
Re: Do shrooms cause a flood of serotonin? [Re: HeadFood]
#7864645 - 01/11/08 01:44 PM (5 years, 4 months ago) |
|
|
theres not much to reflect on. the shrooms were less than intense along with my trip last night. i think i've pinpointed that to the fact that i've taken vyvanse both mornings. the uppers are killing the psychedelic effects. i didn't take it today so hopefully the acid should work.
and on a side note. i'm not asking you to judge what i'm doing. I simply want feedback on the serotonin query.
|
implee
Cyber Hippie
Registered: 07/27/06
Posts: 5,824
Loc: Houston, Texas. 
Last seen: 7 months, 17 days
|
Re: Do shrooms cause a flood of serotonin? [Re: murac]
#7864788 - 01/11/08 02:22 PM (5 years, 4 months ago) |
|
|
When you take mushrooms or lsd over and over tolerance builds up
|
HeadFood
Shroomer
Registered: 12/30/07
Posts: 390
Last seen: 4 months, 27 days
|
Re: Do shrooms cause a flood of serotonin? [Re: murac]
#7864886 - 01/11/08 02:46 PM (5 years, 4 months ago) |
|
|
i was not judging what you do. i was saying you should take a break so that your body can get ready for the acid trip. by all means trip all you want...that's what i'll be doing once my first shrooms have been harvested.
--------------------
Phi Alpha
|
Divinatory
Rubber Tramp
Registered: 05/15/07
Posts: 690
Loc: Texas
Last seen: 7 months, 20 hours
|
Re: Do shrooms cause a flood of serotonin? [Re: murac]
#7865001 - 01/11/08 03:15 PM (5 years, 4 months ago) |
|
|
take 5-htp, it'll help bring your seretonin levels back up
|
notapillow
I want to be a fisherman
Registered: 09/29/03
Posts: 31,050
Loc: A rare and different tune
Last seen: 9 days, 7 hours
|
Re: Do shrooms cause a flood of serotonin? [Re: Divinatory]
#7865231 - 01/11/08 04:09 PM (5 years, 4 months ago) |
|
|
no. it dosent
in face its blocking seretonin from being resepted to your synapsis
however there are mushrooms that are known to contain seretonin.
thats exotic tho
--------------------
|
wildchild68
lion in a coma
Registered: 11/19/07
Posts: 5,115
Last seen: 5 months, 21 days
|
Re: Do shrooms cause a flood of serotonin? [Re: notapillow]
#7865553 - 01/11/08 05:28 PM (5 years, 4 months ago) |
|
|
Yeah, they don't cause a flood of serotonin.
Also realize that acid and mushrooms are cross tolerant to an extent, so taking acid today would probably be a diminished trip...Just wait man.
--------------------
|
 g00ru
the kava crow
Registered: 08/09/07
Posts: 17,466
Loc: atlantis
Last seen: 39 seconds
|
Re: Do shrooms cause a flood of serotonin? [Re: wildchild68]
#7865560 - 01/11/08 05:30 PM (5 years, 4 months ago) |
|
|
Too many substances, too little time.
|
EllisDSox
Robin Hood
Registered: 01/23/07
Posts: 2,491
Last seen: 23 hours, 17 minutes
|
Re: Do shrooms cause a flood of serotonin? [Re: murac]
#7865564 - 01/11/08 05:31 PM (5 years, 4 months ago) |
|
|
Take breaks in between, and stop wasting drugs.
--------------------
"Rather than continuing to seek the truth, simply let go of your views." Gautama Buddha.
crumblebum said-
"Women really aren't that complicated. They're just like humans, but with different priorities. Quantum physics they are not."
|
 Land_Crab
NeuroticPsychonaut
Registered: 08/29/04
Posts: 2,149
Loc: U.S.
|
Re: Do shrooms cause a flood of serotonin? [Re: murac]
#7866100 - 01/11/08 07:28 PM (5 years, 4 months ago) |
|
|
The first thing to understand is that tolerance to hallucinogens such as psilocybin or LSD builds very rapidly (it starts becoming a factor within hours). Second is that this tolerance takes roughly one week to subside, so if you have to dose more often than that you're going to need a larger dose to achieve the same effects.
Third is cross-tolerance between drugs with similar actions, i.e. psilocybin and LSD.
Quote:
murac said:(...)many drugs affect serotonin and it doesnt matter if its E or whathaveyou the same result described should happen. right?
Not exactly. Some drugs you can roughly group together because they work in a similar enough fashion on the brain, but it gets much more complicated than simply putting things in terms of whether or not they affect the same neurotransmitter (such as serotonin). For example, both LSD and MDMA are thought to work primarily via serotonin, but the down-regulation of serotonin receptors works differently between the two. This is where we start talking about things like receptor "agonists" and "antagonists", the synapse (the gap between neurons/nerve cells/brain cells), neurotransmitter sub-types (there is more than one kind of serotonin), effects on multiple neurotransmitter systems at the same time, different regions of the brain, and so on and so forth. (Part of the problem is also that we still don't have a very complete understanding of how these kinds of drugs work.)
Regarding the drugs you mentioned--mushrooms, acid, E, and DXM -- mushrooms and LSD are (probably) the most similar in that they are 5-HT2(serotonin subtype) agonists (agonists enhance or excite neurotransmission; antagonists inhibit it). MDMA works not only as a mixed serotonin agonist/antagonist* (meaning it not only squirts more serotonin into the synapse but keeps it there, which causes major effects) -- but also affects the neurotransmitter dopamine. DXM is different in that (like PCP and ketamine) it seems to exert its primary effects on a neurotransmitter system known as NMDA. The way all of these drugs work is a lot more complicated than what I've just written, but that's sort of the point.
*(someone correct me if I'm wrong on that one)
|
awesomebastard
Lost
Registered: 12/16/07
Posts: 4,891
|
Re: Do shrooms cause a flood of serotonin? [Re: Land_Crab]
#7868556 - 01/12/08 12:04 PM (5 years, 4 months ago) |
|
|
i believe land crab is right 4hodmt is a seretonin anogist meaning it acts on the seretonin receptors an antagonist is what you described such as mdma but bening overwellmed the 5ht recepters might shut themselves off for a while. ive never had a problem crashing off of shrooms or acid like i do off of coke this is probably a sign that that doesnt happen.
--------------------
"Absolute certainty is a privilege of uneducated minds and fanatics." ~ C.J. Keyser
Mr. Cypher said: "I just tell the girls how sexy I am and their panties melt."
|
awesomebastard
Lost
Registered: 12/16/07
Posts: 4,891
|
Re: Do shrooms cause a flood of serotonin? [Re: notapillow]
#7868569 - 01/12/08 12:08 PM (5 years, 4 months ago) |
|
|
Quote:
notapillow said:
no. it dosent
in face its blocking seretonin from being resepted to your synapsis
however there are mushrooms that are known to contain seretonin.
thats exotic tho
no what are you talking about it doesnt block seretonin it acts as seretonin also it doesnt matter if something you eat contians seretonin it cannot break through the blood brian barrier.
--------------------
"Absolute certainty is a privilege of uneducated minds and fanatics." ~ C.J. Keyser
Mr. Cypher said: "I just tell the girls how sexy I am and their panties melt."
|
Cubie
Moderator
Registered: 01/11/08
Posts: 8,840
Loc: Down the rabbit hole...
Last seen: 1 year, 1 day
|
Re: Do shrooms cause a flood of serotonin? [Re: awesomebastard]
#7868570 - 01/12/08 12:08 PM (5 years, 4 months ago) |
|
|
psylocibin simulates serotonin
tolerance goes down after A few days as with pretty much any halucigen.
|
awesomebastard
Lost
Registered: 12/16/07
Posts: 4,891
|
Re: Do shrooms cause a flood of serotonin? [Re: Cubie]
#7868583 - 01/12/08 12:12 PM (5 years, 4 months ago) |
|
|
sorry to be a know it all but an anagist mimics the effects of a neurotransmitter does not antagonize it thus creating more that is an antagonist 4-ho-dmt or psilicin is an anogist meaning it acts as seretonin on the seretonin recepters.
--------------------
"Absolute certainty is a privilege of uneducated minds and fanatics." ~ C.J. Keyser
Mr. Cypher said: "I just tell the girls how sexy I am and their panties melt."
|
Cubie
Moderator
Registered: 01/11/08
Posts: 8,840
Loc: Down the rabbit hole...
Last seen: 1 year, 1 day
|
Re: Do shrooms cause a flood of serotonin? [Re: awesomebastard]
#7868586 - 01/12/08 12:15 PM (5 years, 4 months ago) |
|
|
thats what i said. except you did it much fancyer, props to you
|
badchad
Mad Scientist
Registered: 03/02/05
Posts: 9,152
|
Re: Do shrooms cause a flood of serotonin? [Re: Cubie]
#7868591 - 01/12/08 12:18 PM (5 years, 4 months ago) |
|
|
Technically, most hallucinogens are partial agonists at 5-HT2 receptors, although it depends on the second messenger system that you are using to classify the response.
--------------------
...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did.
Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27.
...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.
Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
|
awesomebastard
Lost
Registered: 12/16/07
Posts: 4,891
|
Re: Do shrooms cause a flood of serotonin? [Re: badchad]
#7869346 - 01/12/08 04:57 PM (5 years, 4 months ago) |
|
|
oh sorry i thought it siad stimulates
--------------------
"Absolute certainty is a privilege of uneducated minds and fanatics." ~ C.J. Keyser
Mr. Cypher said: "I just tell the girls how sexy I am and their panties melt."
|
redgreenvines
irregular verb
Registered: 04/08/04
Posts: 14,965
|
Re: Do shrooms cause a flood of serotonin? [Re: awesomebastard]
#7869668 - 01/12/08 06:28 PM (5 years, 4 months ago) |
|
|
the psychedelic idea is to get excess serotonin in the synapses so that once the synapse is triggerred by a primary signal, the cells keep firing longer, and the events seem to fade more slowly.
this adjustment is an anomoly to the system so it compensates and we get brought down until the pools are more normal and we can tweak it again - 3 days minumum between for decent effects and more for full effects.
all the psychedelics engage this 5ht/serotonin system. 5ht is serotonin. how they do it is not clear, whether by mimickry, or somehow affecting a hormonal/neurotransmission command chain.
--------------------
~~~~~
|
clover606
Stranger
Registered: 08/14/07
Posts: 656
Last seen: 1 year, 6 months
|
Re: Do shrooms cause a flood of serotonin? [Re: murac]
#7870640 - 01/12/08 09:56 PM (5 years, 4 months ago) |
|
|
id say dont trip tonight, youll prbly trip, but not nearly as much as you would if you waited 48 hours for your brain to recover.
--------------------
grassman said:
I remember being in DARE when i was much younger and some of the stories they would tell you are not only ridiculous, but completely untrue. One story was that a woman was on LSD and thought her infant was a turkey so she baked it in the oven. Now I look back and think thats hilarious, but at the time I guess it scared me.
|
|
Images only 
Threaded
Previous
Index
Next
Shop for: 
Edit 
Reply 
