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 ExplosiveMango
HallucinogenusDigitallus
 
Registered: 07/12/05
Posts: 3,222
Last seen: 2 years, 6 months
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 Time Constants On Metabolics 
#6202774 - 10/23/06 04:20 PM (5 years, 7 months ago) |
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Hi everyone, I was interested in finding information about the exact biochemical reactions involved in psilocybe cubensis, in the process of tryptophan --> psilocybin conversion, specifically.
The pieces of information I am most interested in are:
-the time constants of the reactions
-the availabilities of each of the reactants
But any similar information links or pointers would be greatly appreciated.
Thanks guys.
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Know your self.
Know your substance.
Know your source.
The most distorted perspective possible is the perspective that yours is not distorted.
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ExplosiveMango
HallucinogenusDigitallus
Registered: 07/12/05
Posts: 3,222
Last seen: 2 years, 6 months
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Also, another question, are there other routes of reaction for the DMT in the mushroom? If it did not get utilized immediately is it possible it would break down?
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Know your self.
Know your substance.
Know your source.
The most distorted perspective possible is the perspective that yours is not distorted.
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 fastfred
Old Hand
Registered: 05/17/04
Posts: 6,242
Loc: Dark side of the moon
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I've posted on the topic a few times. You might want to search my username in advanced. You can also try adding "tryptophan decarboxylase" as a keyword to narrow things down.
Here, read this thread...
http://www.shroomery.org/forums/showflat.php?Cat=0&Board=Forum4&Number=5906463
It's almost certainly...
Tryptophan -> Tryptamine -> N-methyltryptamine -> N,N-dimethyltryptamine -> Psilocin -> Psilocybin
The reactions are decarboxylation, N-methylation, N-methylation, 4-hydroxylation, and O-phosphorylation.
Proper enzyme names, based on current understanding, would be...
tryptophan decarboxylase, N-methylase, 4-hydroxylase, and phosphorylase.
> time constants of the reactions
Kinetics data is usually not known for most biochemical reactions unless they are key parts of important pathways. It's not like they're happening in a flask that you can do one of those pain-in-the-ass kinetics experiments on.
> availabilities of each of the reactants
Availability of tryptamine seems to be the limiting part of the pathway. So production of tryptophan decarboxylase seems to be the limiting factor.
-FF
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fastfred
Old Hand
Registered: 05/17/04
Posts: 6,242
Loc: Dark side of the moon
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Re: Time Constants On Metabolics [Re: fastfred]
#6206393 - 10/24/06 12:46 PM (5 years, 7 months ago) |
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> are there other routes of reaction for the DMT in the mushroom?
Not that I know of or can think of.
> If it did not get utilized immediately is it possible it would break down?
Probably not. I wouldn't expect it to be very reactive. It's usually broken down by monoamineoxidase (MAO), but I'm pretty sure there's none of that to worry about in mushrooms.
-FF
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ExplosiveMango
HallucinogenusDigitallus
Registered: 07/12/05
Posts: 3,222
Last seen: 2 years, 6 months
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Re: Time Constants On Metabolics [Re: fastfred]
#6206901 - 10/24/06 02:39 PM (5 years, 7 months ago) |
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Thanks for the information fast, I'm happy to be able to learn so much about mushrooms here.
Do you happen to know if there has been any research put into triggers of enzyme production? As in, are there any established ways to stimulate or impede production of any of the enzymes, particularly 4-hydroxylase, and phosphorylase?
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Know your self.
Know your substance.
Know your source.
The most distorted perspective possible is the perspective that yours is not distorted.
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fastfred
Old Hand
Registered: 05/17/04
Posts: 6,242
Loc: Dark side of the moon
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I don't know of any ways to stimulate production of any of the enzymes, but as with all biological systems nutrition plays a role.
Adding tryptamine has been shown to increase the actives. Otherwise there's no good ways to tinker with the system. At least not any easy ways.
-FF
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ExplosiveMango
HallucinogenusDigitallus
Registered: 07/12/05
Posts: 3,222
Last seen: 2 years, 6 months
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Re: Time Constants On Metabolics [Re: fastfred]
#6217928 - 10/27/06 12:05 PM (5 years, 6 months ago) |
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Quote:
I don't know of any ways to stimulate production of any of the enzymes, but as with all biological systems nutrition plays a role.
Adding tryptamine has been shown to increase the actives. Otherwise there's no good ways to tinker with the system. At least not any easy ways.
-FF
Tryptamine or higher though, correct? (MT or DMT)
--------------------
Know your self.
Know your substance.
Know your source.
The most distorted perspective possible is the perspective that yours is not distorted.
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fastfred
Old Hand
Registered: 05/17/04
Posts: 6,242
Loc: Dark side of the moon
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Yep.
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