Quote:

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There are earlier reports that St John's wort had monoamine oxidase inhibitory (MAOI) activity and concerns that (in large doses) it may potentiate MAOI therapy. However, it is now generally accepted that monoamine oxidase inhibition plays little or no part in the antidepressant activity of St John's wort.


Barnes J., Anderson L. A., Phillipson J. D. Herbal medicines. A guide for
healthcare professionals. London: Pharmaceutical Press, 2002

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Now it's known that MAOIs will increase the potential intensity and duration of tryptamines effects, and SSRIs have been known to greatly dull the effects of psychedelics in general...


Since it takes several weeks for SSRIs to take full effect, and only an hour or so for MAOIs to take effect and "inhibit" the activity of monoamine oxidase...This got me thinking

I'm thinking taking approx 900mg-1200mg of St.JW extract (standardized @ .3% Hypericin content) 60-90 minutes before ingesting 1g of Cyanescens Friscosas...Hoping to take advantage of the weak MAOI.




Not sure how well it's gonna work. As it is a rather weak MAOI...Only one way to find out, experiment...

From what i've researched online of others experimenting with this, people either experienced no difference in the trip, or increased effects...Some claim the trip was considerably more intense. But no one mentioned the trip being dulled.




So what do you guys think?....I might do this tonight...I'll let you all know how it went....