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 squeakerpie
Heavyweight Champion
Registered: 09/03/08
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Loc: Limbic Region
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 Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer 
#10094584 - 04/02/09 01:09 PM (3 years, 1 month ago) |
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NORML's Weekly News Bulletin - April 2, 2009
April 2, 2009 - Salerno, Italy
Salerno, Italy: Naturally occurring compounds in cannabis possess anti-tumor properties and present a novel approach for cancer treatment, according to a scientific review published in the February issue of the journal Best Practice & Research: Clinical Endocrinology & Metabolism.
Investigators at the University of Salerno in Italy report that cannabinoids limit cancer cell proliferation and induce tumor-selective cell death.
Cannabinoids inhibit "tumor growth and migration, angiogenesis (the formation of new blood vessels to cancerous tumors), [and] metastasis (the transfer of malignant cells from one site to another)," authors concluded. "Emerging evidence suggests that agonists of cannabinoid receptors ... may offer a novel strategy to treat cancer."
A 2008 review in the journal Cancer Research reported that the administration of cannabinoids halts the spread of a wide range of cancers, including brain cancer, prostate cancer, breast cancer, lung cancer, skin cancer, pancreatic cancer, and lymphoma.
To date, only one clinical trial assessing the use of cannabinoids as anti-cancer agents has been conducted. That trial reported that THC administration decreases recurrent glioblastoma multiforme (GBM) tumor growth in patients afflicted with the disease.
For more information, please contact Paul Armentano, NORML Deputy Director, at: paul@norml.org
Full text of the study, "Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents," appears in the journal Best Practice & Research: Clinical Endocrinology & Metabolism. Additional information on the anti-cancer properties of cannabinoids appears online at:
http://norml.org//index.cfm?Group_ID=7008
DL: http://norml.org/index.cfm?Group_ID=7842
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"The man who has no sense of history, is like a man who has no ears or eyes" - Adolf Hitler
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supernovasky
Comrade
Registered: 01/10/08
Posts: 8,394
Loc: Louisiana
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: squeakerpie]
#10094662 - 04/02/09 01:19 PM (3 years, 1 month ago) |
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Yup.
I've pointed this out in my own compilation of the research out there.
There are actually 35 studies showing this!
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RoosterCogburn
Fearless,one-eyed U.S.Marshall
Registered: 08/25/06
Posts: 8,508
Loc: Dirty South, NJ
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: squeakerpie]
#10094704 - 04/02/09 01:23 PM (3 years, 1 month ago) |
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Quote:
squeakerpie said:
recurrent glioblastoma multiforme (GBM) tumor
This is what killed my mom. 
I guess she should have been hitting my bong along with the chemo.
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Cubie
Moderator
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: RoosterCogburn]
#10094732 - 04/02/09 01:27 PM (3 years, 1 month ago) |
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:1upmushroom: 1 up for truth
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sjacobn
not so strange
Registered: 04/26/07
Posts: 930
Loc: Midwest babeh
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: Cubie]
#10095396 - 04/02/09 03:02 PM (3 years, 1 month ago) |
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Fuck I love these studies! They really show the idiocy of the war on marijuana.
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clover606
Stranger
Registered: 08/13/07
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: sjacobn]
#10095831 - 04/02/09 04:07 PM (3 years, 1 month ago) |
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i wish i could tell my cousin, who is currently undergoing cancer treatment to start smoking weed to help, but her whole family would kill me.
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grassman said:
I remember being in DARE when i was much younger and some of the stories they would tell you are not only ridiculous, but completely untrue. One story was that a woman was on LSD and thought her infant was a turkey so she baked it in the oven. Now I look back and think thats hilarious, but at the time I guess it scared me.
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 DragonChaser
Ice in Her Ass and Pussy
Registered: 04/27/06
Posts: 6,053
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: clover606]
#10096300 - 04/02/09 05:33 PM (3 years, 1 month ago) |
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Quote:
clover606 said:
i wish i could tell my cousin, who is currently undergoing cancer treatment to start smoking weed to help, but her whole family would kill me.
Don't tell her to, just send her the studies. If her family wants to argue with scientific studies, well... too bad for your cousin.
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My name is Mud
The OP shall return.
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MacklinReed
Open Mind
Registered: 03/26/09
Posts: 128
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: DragonChaser]
#10096346 - 04/02/09 05:39 PM (3 years, 1 month ago) |
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Man, imagine how bad your cousin's family would feel if this is the new chemotherapy in a decade or two.
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"You don't know you're wearing a leash if you sit by the peg all day."
-Michael Parenti
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badchad
Mad Scientist
Registered: 03/02/05
Posts: 7,890
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: supernovasky]
#10096397 - 04/02/09 05:48 PM (3 years, 1 month ago) |
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Quote:
supernovasky said:
There are actually 35 studies showing this!
Any in humans? Or are they all in petri dishes and mice?
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...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did.
Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27.
...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.
Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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PoopSoap
Capri Sun Kings
Registered: 01/24/09
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: badchad]
#10096694 - 04/02/09 06:33 PM (3 years, 1 month ago) |
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awesome to hear! lets keep it illegal
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supernovasky
Comrade
Registered: 01/10/08
Posts: 8,394
Loc: Louisiana
Last seen: 2 days, 19 hours
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: PoopSoap]
#10098527 - 04/02/09 11:59 PM (3 years, 1 month ago) |
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badchad, many in humans. Go to the stickie thread in the pub.
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badchad
Mad Scientist
Registered: 03/02/05
Posts: 7,890
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: supernovasky]
#10099040 - 04/03/09 05:59 AM (3 years, 1 month ago) |
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Quote:
supernovasky said:
badchad, many in humans. Go to the stickie thread in the pub.
Is there a specific reference? I'm aware of the data suggesting MJ use is not associated with cancer, but I am not aware of a full scale, human study showing "curative" effects of MJ on cancer.
All I'm saying is there is a significant difference between mice, petri dishes, and humans.
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...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did.
Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27.
...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.
Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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supernovasky
Comrade
Registered: 01/10/08
Posts: 8,394
Loc: Louisiana
Last seen: 2 days, 19 hours
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: badchad]
#10099542 - 04/03/09 09:16 AM (3 years, 1 month ago) |
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Many of these were done on humans, but here are studies supporting the cancer protective properties of marijuana.
All of these are different studies, peer reviewed, put in academic journals.
Quote:
The new findings "were against our expectations," said Donald Tashkin of the University of California at Los Angeles, a pulmonologist who has studied marijuana for 30 years.
"We hypothesized that there would be a positive association between marijuana use and lung cancer, and that the association would be more positive with heavier use," he said. "What we found instead was no association at all, and even a suggestion of some protective effect."
http://www.washingtonpost.com/wp-dyn/content/article/2006/05/25/AR2006052501729_pf.html
S. Sidney (September 1997). "Marijuana use and cancer incidence (California, United States)". Cancer Causes and Control 8 (5): 722-728.
J. Huff & P. Chan (October 2000). "Antitumor Effects of THC". Environmental Health Perspectives 108 (10): A442-3.
K.A. Rosenblatt et al. (1 June 2004). "Marijuana Use and Risk of Oral Squamous Cell Carcinoma". Cancer Research 64: 4049-4054.
Parolaro and Massi. 2008. Cannabinoids as a potential new drug therapy for the treatment of gliomas. Expert Reviews of Neurotherapeutics 8: 37-49
Galanti et al. 2007. Delta9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells. Acta Oncologica 12: 1-9.
Calatozzolo et al. 2007. Expression of cannabinoid receptors and neurotrophins in human gliomas. Neurological Sciences 28: 304-310.
Ramer and Hinz. 2008. Inhibition of cancer cell invasion by cannabinoids via increased cell expression of tissue inhibitor of matrix metalloproteinases-1. Journal of the National Cancer Institute 100: 59-69.
Preet et al. 2008. Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 10: 339-346.
McAllister et al. 2007. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Molecular Cancer Therapeutics 6: 2921-2927.
A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. British Journal of Cancer (2006) 95, 197-203. doi:10.1038/sj.bjc.6603236 Published online 27 June 2006.
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Biochem Pharmacol 2001 Sep 15;62(6):755-63.
Relative involvement of cannabinoid CB(1) and CB(2) receptors in the Delta(9)-tetrahydrocannabinol-induced inhibition of natural killer activity. Massi P, Fuzio D, Vigano D, Sacerdote P, Parolaro D. Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via Vanvitelli 32/A, 20129, Milan, Italy.
Antineoplastic activity of cannabinoid.Cancer Res 1976 Jan;36(1):95-100.
Endocannabinoids in the immune system and cancer. J Pharmacol Exp Ther 2001 Dec;299(3):951-9.
There are more. Some of the above are done on human beings. Tashkin has at least 4 or 5 studies showing a decrease or no change in the incidence of cancer when smoking marijuana. For there to be no change in lung cancer even though you're inhaling smoke with carcinogens seems to say to me, by the way, that THC and a few other compounds in marijuana must have fairly potent anti-carcinogenic properties.
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badchad
Mad Scientist
Registered: 03/02/05
Posts: 7,890
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: supernovasky]
#10100105 - 04/03/09 11:11 AM (3 years, 1 month ago) |
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Well, in playing devil's advocate let me rephrase: I do believe there is ample epidemiologic, evidence suggesting no association between MJ and cancer.
However, the best evidence for a "curative" cancer cure is going to be a double-blind, placebo controlled study. To my knowledge this does not exist (despite the hypothetical proposal and animal literature).
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...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did.
Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27.
...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.
Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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CurdledCave
Seeker
Registered: 04/02/09
Posts: 118
Loc: Tennessee
Last seen: 1 year, 7 months
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: badchad]
#10100118 - 04/03/09 11:13 AM (3 years, 1 month ago) |
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shoot, i know if i was ever diagnosed with cancer i would be gettin that G14 shit.....Yea that stuff is real. Not just from "American Beauty"
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"I have never had a problem with drugs, only problems with the police"--Keith Richards
"Think for yourself, Question Authority"--Timothy Leary
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supernovasky
Comrade
Registered: 01/10/08
Posts: 8,394
Loc: Louisiana
Last seen: 2 days, 19 hours
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: badchad]
#10100520 - 04/03/09 12:51 PM (3 years, 1 month ago) |
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Quote:
badchad said:
Well, in playing devil's advocate let me rephrase: I do believe there is ample epidemiologic, evidence suggesting no association between MJ and cancer.
However, the best evidence for a "curative" cancer cure is going to be a double-blind, placebo controlled study. To my knowledge this does not exist (despite the hypothetical proposal and animal literature).
Yes, but you have to say, the evidence is certainly quite striking and strong. This though is exactly why we need to have medical marijuana and allow schools to grow marijuana for study.
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Green_T
Getting to the chopper
Registered: 10/02/08
Posts: 4,024
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Re: Marijuana Compounds Have "Palliative" And "Curative" Effects On Cancer [Re: supernovasky]
#10100580 - 04/03/09 01:03 PM (3 years, 1 month ago) |
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Marijuana causes cancer and kills thousands of people every year. We pay the brunt of this by lost work days due to sickness, early death, burden on family members' productivity, and other healthcare costs. It should be banned.
Oh wait, thats tobacco 
I wonder...how many studies are going to have to be published before marijuana's positive effects are going to have an effect on scheduling, and federal medicinal marijuana laws are enacted?
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"I have sworn upon the altar of god eternal hostility against every form of tyranny over the mind of man" - Thomas Jefferson
Legalize Meth | Drug War Victims
Their vial of acid, which is on the table over there, tastes vile because they're incompetent chemists.
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