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Can I use coarse grade vermiculite for substrate?

Yes but the coarser type will hold a little less water



Yes, you can.
Both types, the finer type, individual particles measuring around 1-2 mm, and the coarser type, with particles measuring around 5-8 mm are suitable for substrate.
The coarser type will hold a little less water, so make sure to adjust the amount of water used.

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